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Understanding the alterations in brain connectivity associated with PD remains a challenge that is crucial for enhancing diagnosis and clinical management. Methods: This study utilized Magnetoencephalography (MEG) to investigate brain connectivity in PD patients compared to healthy controls (HCs) by applying eigenvector centrality (EC) measures across different frequency bands. Results: Our findings revealed significant differences in EC between PD patients and HCs in the alpha (8\u201312 Hz) and beta (13\u201330 Hz) frequency bands. To go into further detail, in the alpha frequency band, PD patients in the frontal lobe showed higher EC values compared to HCs. Additionally, we found statistically significant correlations between EC measures and clinical impairment scores (UPDRS-III). Conclusions: The proposed results suggest that MEG-derived EC measures can reveal important alterations in brain connectivity in PD, potentially serving as biomarkers for disease severity.<\/jats:p>","DOI":"10.3390\/jcm14031020","type":"journal-article","created":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T04:47:31Z","timestamp":1738817251000},"page":"1020","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Analyzing Information Exchange in Parkinson\u2019s Disease via Eigenvector Centrality: A Source-Level Magnetoencephalography Study"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3669-8183","authenticated-orcid":false,"given":"Michele","family":"Ambrosanio","sequence":"first","affiliation":[{"name":"Department of Economics, Law, Cybersecurity and Sports Sciences (DiSEGIM), University of Naples \u201cParthenope\u201d, 80035 Nola, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0220-2672","authenticated-orcid":false,"given":"Emahnuel","family":"Troisi Lopez","sequence":"additional","affiliation":[{"name":"Department of Education and Sport Sciences, Pegaso Telematic University, 80143 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9033-8838","authenticated-orcid":false,"given":"Maria Maddalena","family":"Autorino","sequence":"additional","affiliation":[{"name":"Department of Engineering, University of Napoli \u201cParthenope\u201d, 80143 Napoli, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7608-6686","authenticated-orcid":false,"given":"Stefano","family":"Franceschini","sequence":"additional","affiliation":[{"name":"Department of Engineering, University of Napoli \u201cParthenope\u201d, 80143 Napoli, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"De Micco","sequence":"additional","affiliation":[{"name":"Department of Advanced Medical and Surgical Sciences, University of Campania \u201cLuigi Vanvitelli\u201d, 81100 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Tessitore","sequence":"additional","affiliation":[{"name":"Department of Advanced Medical and Surgical Sciences, University of Campania \u201cLuigi Vanvitelli\u201d, 81100 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5623-9657","authenticated-orcid":false,"given":"Antonio","family":"Vettoliere","sequence":"additional","affiliation":[{"name":"Institute of Applied Sciences and Intelligent Systems, National Research Council, 80078 Pozzuoli, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5724-0994","authenticated-orcid":false,"given":"Carmine","family":"Granata","sequence":"additional","affiliation":[{"name":"Department of Education and Sport Sciences, Pegaso Telematic University, 80143 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0800-2433","authenticated-orcid":false,"given":"Giuseppe","family":"Sorrentino","sequence":"additional","affiliation":[{"name":"Department of Economics, Law, Cybersecurity and Sports Sciences (DiSEGIM), University of Naples \u201cParthenope\u201d, 80035 Nola, Italy"},{"name":"Institute of Applied Sciences and Intelligent Systems, National Research Council, 80078 Pozzuoli, Italy"},{"name":"ICS Maugeri Hermitage Napoli, via Miano, 80145 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9556-9800","authenticated-orcid":false,"given":"Pierpaolo","family":"Sorrentino","sequence":"additional","affiliation":[{"name":"Institute of Applied Sciences and Intelligent Systems, National Research Council, 80078 Pozzuoli, Italy"},{"name":"Institut de Neurosciences des Syst\u00e8mes, Aix-Marseille Universit\u00e9, 13007 Marseille, France"},{"name":"Department of Biomedical Sciences, University of Sassari, 07100 Sassari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5964-8667","authenticated-orcid":false,"given":"Fabio","family":"Baselice","sequence":"additional","affiliation":[{"name":"Department of Engineering, University of Napoli \u201cParthenope\u201d, 80143 Napoli, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,2,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"371","DOI":"10.7861\/clinmedicine.16-4-371","article-title":"Imaging in Parkinson\u2019s Disease","volume":"16","author":"Pagano","year":"2016","journal-title":"Clin. 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