{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T00:51:10Z","timestamp":1760057470197,"version":"build-2065373602"},"reference-count":29,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2025,2,11]],"date-time":"2025-02-11T00:00:00Z","timestamp":1739232000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Preeclampsia (PE) and eclampsia are characterized by changes in cerebral hemodynamics, which may result in serious and even life-threatening neurological complications. The aim of the present work was to compare cerebral hemodynamic changes during the roll-over test in women with mild and severe PE. Patients and methods: Healthy pregnant and PE women in their third trimester were studied. Transcranial Doppler (TCD) measurements of the right middle cerebral artery (MCA) were performed in the left lateral position and 5 min after turning to the supine position (roll-over test = ROT). Besides cerebral blood flow measurements, the blood pressure was measured in the right arm using a standard mercury sphygmomanometer. An independent gynecologist categorized the preeclamptic patients into mild and severe groups based on the clinical and laboratory results. The TCD assessors were unaware of the patient grouping while performing the TCD and blood pressure measurements. Results: A total of 21 healthy pregnant females (mean age: 26.1 \u00b1 5.1 yrs), 11 females with mild PE (28.2 \u00b1 6.8 yrs), and 18 females with severe PE (29 \u00b1 7.4 yrs) were studied. A significant increase in the mean arterial pressure was observed in all of the groups during the roll-over test: healthy pregnant patients: from 106.3 \u00b1 16.3 to 113.8 \u00b1 15.9 mmHg; patients with mild PE: from 100 \u00b1 11.2 to 110 \u00b1 8.7 mmHg; and patients with severe PE: from 106.3 \u00b1 16.3 to 113.8 \u00b1 15.8 mmHg. The MCA mean blood flow velocities in the left lateral position were significantly lower in the control patients than in those with PE: MCAV control: 71.2 \u00b1 12.7 cm\/s; mild PE: 78.2 \u00b1 19.4 cm\/s; and severe PE: 96 \u00b1 15.6 cm\/s, p &lt; 0.001. Turning to the supine position resulted in a decrease in the MCAV in all of the groups, but the differences between the groups remained unchanged: controls: 69.5 \u00b1 9.1 cm\/s; mild PE: 75.7 \u00b1 17.5 cm\/s; and severe PE: 85.7 \u00b1 18.4 cm\/s, respectively, p = 0.014. A slight but statistically insignificant increase in the pulsatility index was observed in all of the groups. Conclusions: This is the first study comparing cerebral hemodynamic changes in healthy pregnant females and in those with mild and severe PE during a roll-over test. Changing the posture did not result in changes in the cerebral blood flow velocities in the healthy and preeclamptic pregnant patients. Our results indicate that static cerebral autoregulation is preserved both in the mild and severe preeclamptic patients.<\/jats:p>","DOI":"10.3390\/jcm14041182","type":"journal-article","created":{"date-parts":[[2025,2,11]],"date-time":"2025-02-11T11:01:08Z","timestamp":1739271668000},"page":"1182","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Assessment of Cerebral Hemodynamic Changes During Roll-Over Test in Healthy Pregnant Women and Those with Mild and Severe Preeclampsia"],"prefix":"10.3390","volume":"14","author":[{"given":"D\u00e1niel T.","family":"Nagy","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Intensive Care, University of Debrecen, Nagyerdei krt. 98, H-4032 Debrecen, Hungary"},{"name":"Neuroscience Doctoral School, University of Debrecen, H-4032 Debrecen, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2541-9740","authenticated-orcid":false,"given":"B\u00e9la","family":"F\u00fclesdi","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care, University of Debrecen, Nagyerdei krt. 98, H-4032 Debrecen, Hungary"},{"name":"Neuroscience Doctoral School, University of Debrecen, H-4032 Debrecen, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7341-5942","authenticated-orcid":false,"given":"Bence","family":"Kozma","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine, University of Debrecen, Nagyerdei krt. 98, H-4032 Debrecen, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1007-6549","authenticated-orcid":false,"given":"D\u00e9nes","family":"P\u00e1ll","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Internal Medicine University of Debrecen, H-4032 Debrecen, Hungary"},{"name":"Department of Medical Clinical Pharmacology, H-4032 Debrecen, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-0018-7247","authenticated-orcid":false,"given":"Szil\u00e1rd","family":"Szatm\u00e1ri","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care, University of Debrecen, Nagyerdei krt. 98, H-4032 Debrecen, Hungary"},{"name":"Neuroscience Doctoral School, University of Debrecen, H-4032 Debrecen, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1267-7364","authenticated-orcid":false,"given":"Petronella","family":"Hupuczi","sequence":"additional","affiliation":[{"name":"Neuroscience Doctoral School, University of Debrecen, H-4032 Debrecen, Hungary"},{"name":"Maternity Hospital Budapest, H-1126 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,2,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/S0140-6736(05)17987-2","article-title":"Pre-eclampsia","volume":"365","author":"Sibai","year":"2005","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.preghy.2021.09.008","article-title":"The 2021 International Society for the Study of Hypertension in Pregnancy classification, diagnosis & management recommendations for international practice","volume":"27","author":"Magee","year":"2022","journal-title":"Pregnancy Hypertens."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1080\/14767050701832833","article-title":"The maternal plasma soluble vascular endothelial growth factor receptor-1 concentration is elevated in SGA and the magnitude of the increase relates to Doppler abnormalities in the maternal and fetal circulation","volume":"21","author":"Chaiworapongsa","year":"2008","journal-title":"J. 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