{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T20:38:38Z","timestamp":1769373518646,"version":"3.49.0"},"reference-count":19,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2025,2,13]],"date-time":"2025-02-13T00:00:00Z","timestamp":1739404800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background and Objectives: First trimester medical abortion with the combination of mifepristone and misoprostol is highly effective. The aim of this study was to assess the efficacy and safety of a modified medical abortion protocol, offering a structured outpatient approach up to 9 weeks (63 days) of gestation. This study may contribute to existing evidence by evaluating a slightly altered regimen and its real-world effectiveness in clinical practice. Material and Methods: This was a retrospective cohort study conducted at the Third Department of Obstetrics and Gynecology, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, Greece, during a two-year period (2022\u20132024). Women aged 18 years or older with an intrauterine pregnancy \u226463 days confirmed by transvaginal ultrasound were included. Exclusion criteria included ectopic pregnancy, contraindications to study medications, or loss to follow-up. Mifepristone (200 mg) was administered orally on Day 1, and misoprostol (800 mcg) was administered vaginally on Day 3. Serial follow-up visits on Days 8, 15, and 21 were scheduled according to the success of each cycle. Results: In total, 130 women were included in the study. A high success rate of 96.9% (95% CI: 92.3\u201399.2%) was observed. Success was most frequently observed on Day 8 (60.8%). Success rates were 100% for the age group of 18 to 25 years, approximately 96% for both the groups of 26\u201335 and 36\u201345 years, and around 50% for those aged &gt;45 years. With regards to gestational age, success rates were 97.5% for \u22647 weeks (49 days) and 95.9% for &gt;7 weeks (p = 0.63). Side effects were reported by 13.2% of participants (95% CI: 7.8\u201320.1%) and mainly involved the gastrointestinal system. Pain intensity was reported as moderate; analgesics were used by 75.4% of patients. The satisfaction rate for the medical abortion process was 95.4% (95% CI: 90.2\u201398.3%). Conclusions: Early-first-trimester medical abortion on an outpatient basis is a feasible, patient-friendly method with high efficacy, exhibiting limited side effects and a high satisfaction rate.<\/jats:p>","DOI":"10.3390\/jcm14041235","type":"journal-article","created":{"date-parts":[[2025,2,13]],"date-time":"2025-02-13T08:01:19Z","timestamp":1739433679000},"page":"1235","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Efficacy and Safety of a Regimen for Medical Abortion up to 63 Days of Gestation: A Retrospective Study in Northern Greece"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6038-1560","authenticated-orcid":false,"given":"Vera","family":"Kelesidou","sequence":"first","affiliation":[{"name":"Third Department of Obstetrics and Gynaecology, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4337-7871","authenticated-orcid":false,"given":"Ioannis","family":"Tsakiridis","sequence":"additional","affiliation":[{"name":"Third Department of Obstetrics and Gynaecology, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyriaki","family":"Mitta","sequence":"additional","affiliation":[{"name":"Third Department of Obstetrics and Gynaecology, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andriana","family":"Virgiliou","sequence":"additional","affiliation":[{"name":"Third Department of Obstetrics and Gynaecology, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5646-8572","authenticated-orcid":false,"given":"Georgios","family":"Michos","sequence":"additional","affiliation":[{"name":"Third Department of Obstetrics and Gynaecology, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Kougioumtsidou","sequence":"additional","affiliation":[{"name":"Third Department of Obstetrics and Gynaecology, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2605-0765","authenticated-orcid":false,"given":"Apostolos","family":"Mamopoulos","sequence":"additional","affiliation":[{"name":"Third Department of Obstetrics and Gynaecology, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2863-5839","authenticated-orcid":false,"given":"Themistoklis","family":"Dagklis","sequence":"additional","affiliation":[{"name":"Third Department of Obstetrics and Gynaecology, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ioannis","family":"Kalogiannidis","sequence":"additional","affiliation":[{"name":"Third Department of Obstetrics and Gynaecology, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,2,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"S30","DOI":"10.2307\/2991869","article-title":"The incidence of abortion worldwide","volume":"25","author":"Henshaw","year":"1999","journal-title":"Int. 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