{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T19:56:29Z","timestamp":1791575789521,"version":"4.3.4"},"reference-count":262,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T00:00:00Z","timestamp":1739491200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Science Committee of the Ministry of Science and Higher Education of the Republic of Kazakhstan","award":["AP19677517"],"award-info":[{"award-number":["AP19677517"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Selenium (Se) is a vital trace element for children, playing a crucial role in numerous physiological processes, including antioxidant defense, immune regulation, thyroid function, and bone metabolism. Emerging evidence highlights its potential impact on child development and growth while also underscoring the complexity of its mechanisms and the global variations in Se intake. The aim of this review is to comprehensively elucidate the significance of Se in various biological processes within the human body, with a focus on its role in child development and growth; its biochemical effects on the nervous system, thyroid function, immune system, and bone tissue; and the implications of Se deficiency and toxicity. This review integrates findings from experimental models, epidemiological studies, and clinical trials to explore Se\u2019s role in neurodevelopment, growth regulation, and immune competence in children. Selenoproteins, which regulate oxidative stress and thyroid hormone and bone metabolism, are essential for normal growth and cognitive development in children. Se deficiency and toxicity has been linked to impaired immune function, growth retardation, and decreased immune function. The findings underscore Se\u2019s influence on various biological pathways that are critical for healthy child development and its broader importance for child health. Public health strategies aimed at optimizing selenium intake may play a pivotal role in improving pediatric health outcomes worldwide.<\/jats:p>","DOI":"10.3390\/jcm14041274","type":"journal-article","created":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T11:14:41Z","timestamp":1739531681000},"page":"1274","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Unveiling the Role of Selenium in Child Development: Impacts on Growth, Neurodevelopment and Immunity"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7970-4059","authenticated-orcid":false,"given":"Gulnara","family":"Batyrova","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory Diagnostics, West Kazakhstan Marat Ospanov Medical University, Aktobe 030019, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gulaim","family":"Taskozhina","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Diagnostics, West Kazakhstan Marat Ospanov Medical University, Aktobe 030019, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gulmira","family":"Umarova","sequence":"additional","affiliation":[{"name":"Department of Evidence-Based Medicine and Scientific Management, West Kazakhstan Marat Ospanov Medical University, Aktobe 030019, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeskendir","family":"Umarov","sequence":"additional","affiliation":[{"name":"Department of Natural Sciences, West Kazakhstan Marat Ospanov Medical University, Aktobe 030019, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Morenko","sequence":"additional","affiliation":[{"name":"Department of Children\u2019s Diseases, Astana Medical University, Astana 010000, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bakhtiyar","family":"Iriskulov","sequence":"additional","affiliation":[{"name":"Department of Normal and Pathological Physiology, Tashkent Medical Academy, Tashkent 100109, Uzbekistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khatimya","family":"Kudabayeva","sequence":"additional","affiliation":[{"name":"Department of Internal Diseases 1, West Kazakhstan Marat Ospanov Medical University, Aktobe 030019, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4350-3455","authenticated-orcid":false,"given":"Yerlan","family":"Bazargaliyev","sequence":"additional","affiliation":[{"name":"Department of Internal Diseases 1, West Kazakhstan Marat Ospanov Medical University, Aktobe 030019, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,2,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2141","DOI":"10.1007\/s11010-022-04638-3","article-title":"Exploring the potential function of trace elements in human health: A therapeutic perspective","volume":"478","author":"Islam","year":"2023","journal-title":"Mol. Cell. Biochem."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"100698","DOI":"10.1016\/j.envc.2023.100698","article-title":"Review on environmental selenium: Occurrence, public health implications and biological treatment strategies","volume":"11","author":"Werkneh","year":"2023","journal-title":"Environ. Chall."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2491","DOI":"10.5194\/acp-24-2491-2024","article-title":"Influences of sources and weather dynamics on atmospheric deposition of Se species and other trace elements","volume":"24","author":"Breuninger","year":"2024","journal-title":"Atmos. Chem. Phys."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"125289","DOI":"10.1016\/j.chemosphere.2019.125289","article-title":"Distribution of selenium and zinc in soil-crop system and their relationship with environmental factors","volume":"242","author":"Xu","year":"2020","journal-title":"Chemosphere"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"El-Ramady, H.R., Domokos-Szabolcsy, \u00c9., Shalaby, T.A., Prokisch, J., and F\u00e1ri, M. (2015). Selenium in agriculture: Water, air, soil, plants, food, animals and nanoselenium. CO2 Sequestration, Biofuels and Depollution, Springer.","DOI":"10.1007\/978-3-319-11906-9_5"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.chemosphere.2018.11.099","article-title":"Selenium and mercury in Brazilian Cerrado soils and their relationships with physical and chemical soil characteristics","volume":"218","author":"Carvalho","year":"2019","journal-title":"Chemosphere"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"dos Reis, A.R., El-Ramady, H., Santos, E.F., Grat\u00e3o, P.L., and Schomburg, L. (2017). Overview of selenium deficiency and toxicity worldwide: Affected areas, selenium-related health issues, and case studies. Selenium in Plants. Plant Ecophysiology, Springer.","DOI":"10.1007\/978-3-319-56249-0_13"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"110468","DOI":"10.1016\/j.jece.2023.110468","article-title":"Selenium-contaminated water: Recent advances in material function and adsorption performance","volume":"11","author":"Guo","year":"2023","journal-title":"J. Environ. Chem. Eng."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Gali\u0107, L., Gali\u0107, V., Ivezi\u0107, V., Zebec, V., Jovi\u0107, J., \u0110iki\u0107, M., Filipovi\u0107, A., Manojlovi\u0107, M., Alm\u00e5s, \u00c5.R., and Lon\u010dari\u0107, Z. (2023). Modelling Leverage of Different Soil Properties on Selenium Water-Solubility in Soils of Southeast Europe. Agronomy, 13.","DOI":"10.3390\/agronomy13030824"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Genchi, G., Lauria, G., Catalano, A., Sinicropi, M.S., and Carocci, A. (2023). Biological Activity of Selenium and Its Impact on Human Health. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24032633"},{"key":"ref_11","first-page":"104","article-title":"Guidelines for drinking-water quality","volume":"38","author":"Edition","year":"2011","journal-title":"WHO Chron."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"112926","DOI":"10.1016\/j.jenvman.2021.112926","article-title":"Recent advances in technologies for removal and recovery of selenium from (waste) water: A systematic review","volume":"294","author":"Ali","year":"2021","journal-title":"J. Environ. Manag."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"e122","DOI":"10.1017\/S1368980024000703","article-title":"Effect of dietary selenium intake on CVD: A retrospective cohort study based on China Health and Nutrition Survey (CHNS) data","volume":"27","author":"Wen","year":"2024","journal-title":"Public Health Nutr."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1111\/ppl.12144","article-title":"Dietary mineral supplies in Africa","volume":"151","author":"Joy","year":"2014","journal-title":"Physiol. Plant."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Mutonhodza, B., Chagumaira, C., Dembedza, M.P., Joy, E.J., Manzeke-Kangara, M.G., Njovo, H., Nyadzayo, T.K., Lark, R.M., Kalimbira, A.A., and Bailey, E.H. (2023). A pilot survey of selenium status and its geospatial variation among children and women in three rural districts of Zimbabwe. Front. Nutr., 10.","DOI":"10.3389\/fnut.2023.1235113"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Belay, A., Joy, E.J., Chagumaira, C., Zerfu, D., Ander, E.L., Young, S.D., Bailey, E.H., Lark, R.M., Broadley, M.R., and Gashu, D. (2020). Selenium deficiency is widespread and spatially dependent in Ethiopia. Nutrients, 12.","DOI":"10.3390\/nu12061565"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1038\/ejcn.2016.27","article-title":"Association of serum selenium with thyroxin in severely iodine-deficient young children from the Amhara region of Ethiopia","volume":"70","author":"Gashu","year":"2016","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.scitotenv.2007.03.027","article-title":"Selenium level in the environment and the population of Zhoukoudian area, Beijing, China","volume":"381","author":"Li","year":"2007","journal-title":"Sci. Total Environ."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Wang, X., Li, H., Yang, L., Kong, C., Wang, J., and Li, Y. (2020). Selenium nutritional status of rural residents and its correlation with dietary intake patterns in a typical low-selenium area in China. Nutrients, 12.","DOI":"10.3390\/nu12123816"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"2848","DOI":"10.1073\/pnas.1611576114","article-title":"Selenium deficiency risk predicted to increase under future climate change","volume":"114","author":"Jones","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Hao, L., Han, Y., Zhang, S., Luo, Y., Luo, K., Zhang, L., and Chen, W. (2024). Estimated daily intake and health risk assessment of total and organic selenium in crops across areas with different selenium levels. J. Trace Elem. Med. Biol., 86.","DOI":"10.1016\/j.jtemb.2024.127525"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"443","DOI":"10.26444\/aaem\/90886","article-title":"Serum selenium levels are associated with age-related cataract","volume":"25","author":"Post","year":"2018","journal-title":"Ann. Agric. Environ. Med."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"EFSA Panel on Nutrition, Novel Foods and Food Allergens, Turck, D., Bohn, T., Castenmiller, J., de Henauw, S., Hirsch-Ernst, K., Knutsen, H.K., Maciuk, A., Mangelsdorf, I., and McArdle, H.J. (2023). Scientific opinion on the tolerable upper intake level for selenium. EFSA J., 21, e07704.","DOI":"10.2903\/j.efsa.2023.7704"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/j.jhydrol.2015.12.016","article-title":"Selenium in groundwater and its contribution towards daily dietary Se intake under different hydrogeological zones of Punjab, India","volume":"533","author":"Dhillon","year":"2016","journal-title":"J. Hydrol."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Nie, X., Yang, X., He, J., Liu, P., Shi, H., Wang, T., and Zhang, D. (2023). Bioconversion of inorganic selenium to less toxic selenium forms by microbes: A review. Front. Bioeng. Biotechnol., 11.","DOI":"10.3389\/fbioe.2023.1167123"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Wang, Y., Wu, Y., Chen, T., Wu, X., Yuan, W., Zhu, Q., Wang, X., and Zi, C. (2025). Selenium and Selenoproteins: Mechanisms, Health Functions, and Emerging Applications. Molecules, 30.","DOI":"10.3390\/molecules30030437"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1007\/s10787-020-00690-x","article-title":"Selenium and selenoproteins: It\u2019s role in regulation of inflammation","volume":"28","author":"Hariharan","year":"2020","journal-title":"Inflammopharmacology"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Kieliszek, M., and Sandoval, S.N.S. (2023). The importance of selenium in food enrichment processes. A comprehensive review. J. Trace Elem. Med. Biol., 79.","DOI":"10.1016\/j.jtemb.2023.127260"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Pecoraro, B.M., Leal, D.F., Frias-De-Diego, A., Browning, M., Odle, J., and Crisci, E. (2022). The health benefits of selenium in food animals: A review. J. Anim. Sci. Biotechnol., 13.","DOI":"10.1186\/s40104-022-00706-2"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/s00394-022-02990-0","article-title":"First review on the selenium status in Germany covering the last 50 years and on the selenium content of selected food items","volume":"62","author":"Liaskos","year":"2023","journal-title":"Eur. J. Nutr."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.jfca.2017.01.001","article-title":"Selenium content of Brazilian foods: A review of the literature values","volume":"58","year":"2017","journal-title":"J. Food Compos. Anal."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s40543-020-00227-5","article-title":"Fast and simple selenium speciation by solid phase extraction and laser-induced breakdown spectroscopy","volume":"11","author":"Lee","year":"2020","journal-title":"J. Anal. Sci. Technol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1021\/acs.chemrestox.5b00254","article-title":"Detoxification of selenite to form selenocyanate in mammalian cells","volume":"28","author":"Anan","year":"2015","journal-title":"Chem. Res. Toxicol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/s40635-019-0281-y","article-title":"Selenium and hydrogen selenide: Essential micronutrient and the fourth gasotransmitter?","volume":"7","author":"Kuganesan","year":"2019","journal-title":"Intensive Care Med. Exp."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.scitotenv.2008.06.024","article-title":"Selenium in food and the human body: A review","volume":"400","year":"2008","journal-title":"Sci. Total Environ."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"418","DOI":"10.3923\/pjbs.2012.418.425","article-title":"Inorganic versus organic selenium supplementation: A review","volume":"15","author":"Verma","year":"2012","journal-title":"Pak. J. Biol. Sci. PJBS"},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Nasim, M.J., Zuraik, M.M., Abdin, A.Y., Ney, Y., and Jacob, C. (2021). Selenomethionine: A pink trojan redox horse with implications in aging and various age-related diseases. Antioxidants, 10.","DOI":"10.3390\/antiox10060882"},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Hu, Y., Chai, X., Men, J., Rao, S., Cong, X., Cheng, S., and Qiao, Z. (2022). Does methionine status influence the outcome of selenomethinione supplementation? A comparative study of metabolic and selenium levels in HepG2 cells. Nutrients, 14.","DOI":"10.3390\/nu14183705"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Adebayo, A.H., Yakubu, O.F., and Bakare-Akpata, O. (2020). Uptake, metabolism and toxicity of selenium in tropical plants. Importance of Selenium in the Environment and Human Health, IntechOpen.","DOI":"10.5772\/intechopen.90295"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"uhac270","DOI":"10.1093\/hr\/uhac270","article-title":"Selenium species transforming along soil\u2013plant continuum and their beneficial roles for horticultural crops","volume":"10","author":"Guo","year":"2023","journal-title":"Hortic. Res."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Zhou, C., Xiao, R., Li, M., Wang, Q., Cong, W., and Zhang, F. (2022). Highland barley grain and soil surveys reveal the widespread deficiency of dietary selenium intake of Tibetan adults living along Yalung Zangpo River. Front. Sustain. Food Syst., 6.","DOI":"10.3389\/fsufs.2022.1007876"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1017\/S0029665120006904","article-title":"Selenium deficiency risks in sub-Saharan African food systems and their geospatial linkages","volume":"79","author":"Ligowe","year":"2020","journal-title":"Proc. Nutr. Soc."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"2763","DOI":"10.3168\/jds.2017-13112","article-title":"Invited review: Mineral absorption mechanisms, mineral interactions that affect acid\u2013base and antioxidant status, and diet considerations to improve mineral status","volume":"101","author":"Goff","year":"2018","journal-title":"J. Dairy Sci."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1007\/s12011-019-01771-x","article-title":"From selenium absorption to selenoprotein degradation","volume":"192","author":"Ha","year":"2019","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Hadrup, N., and Ravn-Haren, G. (2021). Absorption, distribution, metabolism and excretion (ADME) of oral selenium from organic and inorganic sources: A review. J. Trace Elem. Med. Biol., 67.","DOI":"10.1016\/j.jtemb.2021.126801"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"3292","DOI":"10.3390\/molecules18033292","article-title":"Selenium in the environment, metabolism and involvement in body functions","volume":"18","author":"Mehdi","year":"2013","journal-title":"Molecules"},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Seale, L.A. (2019). Selenocysteine \u03b2-lyase: Biochemistry, regulation and physiological role of the selenocysteine decomposition enzyme. Antioxidants, 8.","DOI":"10.3390\/antiox8090357"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1111\/nph.12596","article-title":"OsPT2, a phosphate transporter, is involved in the active uptake of selenite in rice","volume":"201","author":"Zhang","year":"2014","journal-title":"New Phytol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/j.mam.2012.07.009","article-title":"The SLC26 gene family of anion transporters and channels","volume":"34","author":"Alper","year":"2013","journal-title":"Mol. Aspects Med."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"7581","DOI":"10.1039\/D3SC01936E","article-title":"Direct hydrogen selenide (H2Se) release from activatable selenocarbamates","volume":"14","author":"Newton","year":"2023","journal-title":"Chem. Sci."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.jtemb.2015.10.003","article-title":"Selenium and its relationship with selenoprotein P and glutathione peroxidase in children and adolescents with Hashimoto\u2019s thyroiditis and hypothyroidism","volume":"34","author":"Nourbakhsh","year":"2016","journal-title":"J. Trace Elem. Med. Biol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"2771","DOI":"10.1016\/j.celrep.2017.06.019","article-title":"Hepatocyte hyperproliferation upon liver-specific co-disruption of thioredoxin-1, thioredoxin reductase-1, and glutathione reductase","volume":"19","author":"Prigge","year":"2017","journal-title":"Cell Rep."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Schwarz, M., L\u00f6ser, A., Cheng, Q., Wichmann-Costaganna, M., Sch\u00e4del, P., Werz, O., Arn\u00e9r, E.S., and Kipp, A.P. (2023). Side-by-side comparison of recombinant human glutathione peroxidases identifies overlapping substrate specificities for soluble hydroperoxides. Redox Biol., 59.","DOI":"10.1016\/j.redox.2022.102593"},{"key":"ref_54","first-page":"287","article-title":"First line defence antioxidants-superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX): Their fundamental role in the entire antioxidant defence grid","volume":"54","author":"Ighodaro","year":"2018","journal-title":"Alex. J. Med."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Cicatiello, A., Di Girolamo, D., and Dentice, M. (2018). Metabolic effects of the intracellular regulation of thyroid hormone: Old players, new concepts. Front. Endocrinol., 9.","DOI":"10.3389\/fendo.2018.00474"},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Sherlock, L.G., Sjostrom, K., Sian, L., Delaney, C., Tipple, T.E., Krebs, N.F., Nozik-Grayck, E., and Wright, C.J. (2020). Hepatic-specific decrease in the expression of selenoenzymes and factors essential for selenium processing after endotoxemia. Front. Immunol., 11.","DOI":"10.3389\/fimmu.2020.595282"},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Ojeda, M.L., Carreras, O., and Nogales, F. (2022). The role of selenoprotein tissue homeostasis in MetS programming: Energy balance and cardiometabolic implications. Antioxidants, 11.","DOI":"10.3390\/antiox11020394"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"mfad067","DOI":"10.1093\/mtomcs\/mfad067","article-title":"Selenomethionine supplementation and expression of selenosugars, selenocysteine, and other selenometabolites in rat liver","volume":"15","author":"Bierla","year":"2023","journal-title":"Metallomics"},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Sunde, R.A., Sunde, G.R., Sunde, C.M., Sunde, M.L., and Evenson, J.K. (2015). Cloning, sequencing, and expression of selenoprotein transcripts in the turkey (Meleagris gallopavo). PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0129801"},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Mizuno, A., Toyama, T., Ichikawa, A., Sakai, N., Yoshioka, Y., Nishito, Y., Toga, R., Amesaka, H., Kaneko, T., and Arisawa, K. (2023). An efficient selenium transport pathway of selenoprotein P utilizing a high-affinity ApoER2 receptor variant and being independent of selenocysteine lyase. J. Biol. Chem., 299.","DOI":"10.1016\/j.jbc.2023.105009"},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Turrubiates-Hern\u00e1ndez, F.J., M\u00e1rquez-Sandoval, Y.F., Gonz\u00e1lez-Estevez, G., Reyes-Castillo, Z., and Mu\u00f1oz-Valle, J.F. (2020). The relevance of selenium status in rheumatoid arthritis. Nutrients, 12.","DOI":"10.3390\/nu12103007"},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Gorini, F., Sabatino, L., Pingitore, A., and Vassalle, C. (2021). Selenium: An element of life essential for thyroid function. Molecules, 26.","DOI":"10.3390\/molecules26237084"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"2832","DOI":"10.1021\/acs.accounts.9b00379","article-title":"Chemical biology approaches to interrogate the selenoproteome","volume":"52","author":"Peeler","year":"2019","journal-title":"Acc. Chem. Res."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.1016\/j.celrep.2019.05.001","article-title":"Selenium deficiency is associated with pro-longevity mechanisms","volume":"27","author":"Yim","year":"2019","journal-title":"Cell Rep."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"2480","DOI":"10.1016\/j.bbagen.2018.05.010","article-title":"Translation regulation of mammalian selenoproteins","volume":"1862","author":"Vindry","year":"2018","journal-title":"Biochim. Biophys. Acta BBA-Gen. Subj."},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Santesmasses, D., Mariotti, M., and Guig\u00f3, R. (2017). Computational identification of the selenocysteine tRNA (tRNASec) in genomes. PLoS Comput. Biol., 13.","DOI":"10.1371\/journal.pcbi.1005383"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1830","DOI":"10.1093\/jn\/132.7.1830","article-title":"Selenium influences the turnover of selenocysteine tRNA [Ser] Sec in Chinese hamster ovary cells","volume":"132","author":"Jameson","year":"2002","journal-title":"J. Nutr."},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Chung, C.Z., Krahn, N., Crnkovi\u0107, A., and S\u00f6ll, D. (2022). Intein-based design expands diversity of selenocysteine reporters. J. Mol. Biol., 434.","DOI":"10.1016\/j.jmb.2021.167199"},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Zoidis, E., Seremelis, I., Kontopoulos, N., and Danezis, G.P. (2018). Selenium-dependent antioxidant enzymes: Actions and properties of selenoproteins. Antioxidants, 7.","DOI":"10.3390\/antiox7050066"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"24036","DOI":"10.1074\/jbc.M116.756155","article-title":"Selenoprotein gene nomenclature","volume":"291","author":"Gladyshev","year":"2016","journal-title":"J. Biol. Chem."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.aninu.2022.04.001","article-title":"Microbiome and ileum transcriptome revealed the boosting effects of selenium yeast on egg production in aged laying hens","volume":"10","author":"Liu","year":"2022","journal-title":"Anim. Nutr."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1210\/er.2018-00275","article-title":"Paradigms of dynamic control of thyroid hormone signaling","volume":"40","author":"Bianco","year":"2019","journal-title":"Endocr. Rev."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.freeradbiomed.2017.07.029","article-title":"Redox regulation of the tumor suppressor PTEN by the thioredoxin system and cumene hydroperoxide","volume":"112","author":"Han","year":"2017","journal-title":"Free Radic. Biol. Med."},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Ye, R., Huang, J., Wang, Z., Chen, Y., and Dong, Y. (2022). The role and mechanism of essential selenoproteins for homeostasis. Antioxidants, 11.","DOI":"10.3390\/antiox11050973"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"7580","DOI":"10.1093\/nar\/gkad482","article-title":"A homozygous mutation in the human selenocysteine tRNA gene impairs UGA recoding activity and selenoproteome regulation by selenium","volume":"51","author":"Vindry","year":"2023","journal-title":"Nucleic Acids Res."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1038\/s41467-022-28385-7","article-title":"Selenophosphate synthetase 1 deficiency exacerbates osteoarthritis by dysregulating redox homeostasis","volume":"13","author":"Kang","year":"2022","journal-title":"Nat. Commun."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"427318","DOI":"10.1155\/2014\/427318","article-title":"Oxidative stress in Alzheimer\u2019s disease: Why did antioxidant therapy fail?","volume":"2014","author":"Persson","year":"2014","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Lee, B.W.L., Ghode, P., and Ong, D.S.T. (2019). Redox regulation of cell state and fate. Redox Biol., 25.","DOI":"10.1016\/j.redox.2018.11.014"},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Lou, M.F. (2022). Glutathione and glutaredoxin in redox regulation and cell signaling of the lens. Antioxidants, 11.","DOI":"10.3390\/antiox11101973"},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Pei, J., Pan, X., Wei, G., and Hua, Y. (2023). Research progress of glutathione peroxidase family (GPX) in redoxidation. Front. Pharmacol., 14.","DOI":"10.3389\/fphar.2023.1147414"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1093\/toxsci\/kfy297","article-title":"Kidney toxicity and response of selenium containing protein-glutathione peroxidase (Gpx3) to CdTe QDs on different levels","volume":"168","author":"Zhao","year":"2019","journal-title":"Toxicol. Sci."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.cell.2017.11.048","article-title":"Selenium utilization by GPX4 is required to prevent hydroperoxide-induced ferroptosis","volume":"172","author":"Ingold","year":"2018","journal-title":"Cell"},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Abdalkader, M., Lampinen, R., Kanninen, K.M., Malm, T.M., and Liddell, J.R. (2018). Targeting Nrf2 to suppress ferroptosis and mitochondrial dysfunction in neurodegeneration. Front. Neurosci., 12.","DOI":"10.3389\/fnins.2018.00466"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.freeradbiomed.2019.05.035","article-title":"The role of thiols in antioxidant systems","volume":"140","author":"Ulrich","year":"2019","journal-title":"Free Radic. Biol. Med."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1002\/iub.1756","article-title":"The glutathione cycle: Glutathione metabolism beyond the \u03b3-glutamyl cycle","volume":"70","author":"Bachhawat","year":"2018","journal-title":"Iubmb Life"},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Va\u0161kov\u00e1, J., Ko\u010dan, L., Va\u0161ko, L., and Perj\u00e9si, P. (2023). Glutathione-related enzymes and proteins: A review. Molecules, 28.","DOI":"10.3390\/molecules28031447"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s10787-014-0199-7","article-title":"Endocellular regulation by free radicals and hydrogen peroxide: Key determinants of the inflammatory response","volume":"22","author":"Vitetta","year":"2014","journal-title":"Inflammopharmacology"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1002\/biof.1476","article-title":"Glutathione compartmentalization and its role in glutathionylation and other regulatory processes of cellular pathways","volume":"45","author":"Cianfruglia","year":"2019","journal-title":"Biofactors"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.immuni.2017.03.019","article-title":"Glutathione primes T cell metabolism for inflammation","volume":"46","author":"Mak","year":"2017","journal-title":"Immunity"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"105440","DOI":"10.18632\/oncotarget.22241","article-title":"Nuclear membrane-localised NOX4D generates pro-survival ROS in FLT3-ITD-expressing AML","volume":"8","author":"Moloney","year":"2017","journal-title":"Oncotarget"},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Sinenko, S.A., Starkova, T.Y., Kuzmin, A.A., and Tomilin, A.N. (2021). Physiological signaling functions of reactive oxygen species in stem cells: From flies to man. Front. Cell Dev. Biol., 9.","DOI":"10.3389\/fcell.2021.714370"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/s13045-018-0575-7","article-title":"Inhibition of thioredoxin activates mitophagy and overcomes adaptive bortezomib resistance in multiple myeloma","volume":"11","author":"Zheng","year":"2018","journal-title":"J. Hematol. Oncol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"112310","DOI":"10.1016\/j.plantsci.2024.112310","article-title":"Functional Analysis of the Extraplastidial TRX System in Germination and Early Stages of Development of Arabidopsis thaliana","volume":"350","author":"Nascimento","year":"2024","journal-title":"Plant Sci."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"4843","DOI":"10.1074\/jbc.RA118.006219","article-title":"Pancreatic \u03b2-cells detoxify H2O2 through the peroxiredoxin\/thioredoxin antioxidant system","volume":"294","author":"Stancill","year":"2019","journal-title":"J. Biol. Chem."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1038\/s41467-018-04274-w","article-title":"The thioredoxin-1 system is essential for fueling DNA synthesis during T-cell metabolic reprogramming and proliferation","volume":"9","author":"Muri","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Lamontagne, F., Trejo, C.P., Cuervo, N.Z., and Grandvaux, N. (2024). Redox signaling in cell fate: Beyond damage. Biochim. Biophys. Acta BBA-Mol. Cell Res., 1871.","DOI":"10.1016\/j.bbamcr.2024.119722"},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"Shi, W., Sun, S., Liu, H., Meng, Y., Ren, K., Wang, G., Liu, M., Wu, J., Zhang, Y., and Huang, H. (2024). Guiding bar motif of thioredoxin reductase 1 modulates enzymatic activity and inhibitor binding by communicating with the co-factor FAD and regulating the flexible C-terminal redox motif. Redox Biol., 70.","DOI":"10.1016\/j.redox.2024.103050"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.bj.2017.06.002","article-title":"Thioredoxin promotes survival signaling events under nitrosative\/oxidative stress associated with cancer development","volume":"40","author":"Monteiro","year":"2017","journal-title":"Biomed. J."},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Chen, C., Wang, K., Zhang, H., Zhou, H.J., Chen, Y., and Min, W. (2019). A unique SUMO-interacting motif of Trx2 is critical for its mitochondrial presequence processing and anti-oxidant activity. Front. Physiol., 10.","DOI":"10.3389\/fphys.2019.01089"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"6621292","DOI":"10.1155\/2021\/6621292","article-title":"Molecular basis for the interactions of human thioredoxins with their respective reductases","volume":"2021","author":"Hossain","year":"2021","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_101","doi-asserted-by":"crossref","unstructured":"Hern\u00e1ndez-Aguirre, L.E., Fuentes-Sidas, Y.I., Rivera-Rangel, L.R., Guti\u00e9rrez-M\u00e9ndez, N., Yepiz-Plascencia, G., Ch\u00e1vez-Flores, D., Zavala-D\u00edaz de la Serna, F.J., Peralta-P\u00e9rez, M.d.R., and Garc\u00eda-Triana, A. (2022). cDNA characterization and expression of selenium-dependent CqGPx3 isoforms in the crayfish Cherax quadricarinatus under high temperature and hypoxia. Genes, 13.","DOI":"10.3390\/genes13020179"},{"key":"ref_102","doi-asserted-by":"crossref","unstructured":"Zhang, Y., Roh, Y.J., Han, S.-J., Park, I., Lee, H.M., Ok, Y.S., Lee, B.C., and Lee, S.-R. (2020). Role of selenoproteins in redox regulation of signaling and the antioxidant system: A review. Antioxidants, 9.","DOI":"10.3390\/antiox9050383"},{"key":"ref_103","doi-asserted-by":"crossref","unstructured":"Shcholok, T., and Eftekharpour, E. (2024). Insights into the Multifaceted Roles of Thioredoxin-1 System: Exploring Knockout Murine Models. Biology, 13.","DOI":"10.3390\/biology13030180"},{"key":"ref_104","doi-asserted-by":"crossref","unstructured":"Solovyev, N., Drobyshev, E., Blume, B., and Michalke, B. (2021). Selenium at the neural barriers: A review. Front. Neurosci., 15.","DOI":"10.3389\/fnins.2021.630016"},{"key":"ref_105","doi-asserted-by":"crossref","unstructured":"Shetty, S.P., Kiledjian, N.T., and Copeland, P.R. (2022). The selenoprotein P 3\u2032untranslated region is an RNA binding protein platform that fine tunes selenocysteine incorporation. PLoS ONE, 17.","DOI":"10.1371\/journal.pone.0271453"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.freeradbiomed.2018.03.037","article-title":"Relationship between selenoprotein P and selenocysteine lyase: Insights into selenium metabolism","volume":"127","author":"Seale","year":"2018","journal-title":"Free Radic. Biol. Med."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"3579","DOI":"10.1096\/fj.14-252874","article-title":"Selenoprotein P and apolipoprotein E receptor-2 interact at the blood-brain barrier and also within the brain to maintain an essential selenium pool that protects against neurodegeneration","volume":"28","author":"Burk","year":"2014","journal-title":"FASEB J."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.jinorgbio.2017.01.002","article-title":"Delineating hierarchy of selenotranscriptome expression and their response to selenium status in chicken central nervous system","volume":"169","author":"Jiang","year":"2017","journal-title":"J. Inorg. Biochem."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"e18014","DOI":"10.15252\/emmm.202318014","article-title":"LRP8-mediated selenocysteine uptake is a targetable vulnerability in MYCN-amplified neuroblastoma","volume":"15","author":"Alborzinia","year":"2023","journal-title":"EMBO Mol. Med."},{"key":"ref_110","doi-asserted-by":"crossref","unstructured":"Jehan, C., Cartier, D., Bucharles, C., Anouar, Y., and Lihrmann, I. (2022). Emerging roles of ER-resident selenoproteins in brain physiology and physiopathology. Redox Biol., 55.","DOI":"10.1016\/j.redox.2022.102412"},{"key":"ref_111","doi-asserted-by":"crossref","unstructured":"Dogaru, C.B., Du\u021b\u0103, C., Muscurel, C., and Stoian, I. (2023). \u201cAlphabet\u201d selenoproteins: Implications in pathology. Int. J. Mol. Sci., 24.","DOI":"10.20944\/preprints202309.1449.v1"},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"Turovsky, E.A., Baryshev, A.S., and Plotnikov, E.Y. (2024). Selenium nanoparticles in protecting the brain from stroke: Possible signaling and metabolic mechanisms. Nanomaterials, 14.","DOI":"10.3390\/nano14020160"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"3988","DOI":"10.1016\/j.apsb.2023.07.010","article-title":"Oxidative stress, the blood\u2013brain barrier and neurodegenerative diseases: The critical beneficial role of dietary antioxidants","volume":"13","author":"Feng","year":"2023","journal-title":"Acta Pharm. Sin. B"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1016\/j.ajcnut.2024.09.004","article-title":"The association between selenium status and global and attention-specific cognition in very old adults in the Newcastle 85+ Study: Cross-sectional and longitudinal analyses","volume":"120","author":"Perri","year":"2024","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.freeradbiomed.2022.07.021","article-title":"New insights on selenoproteins and neuronal function","volume":"190","author":"Nicholson","year":"2022","journal-title":"Free Radic. Biol. Med."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"247","DOI":"10.2174\/1570159X16666180911124605","article-title":"Neuroprotective strategies for neurological disorders by natural products: An update","volume":"17","author":"Rehman","year":"2019","journal-title":"Curr. Neuropharmacol."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1016\/j.bbagen.2014.11.010","article-title":"Oxidative stress, redox regulation and diseases of cellular differentiation","volume":"1850","author":"Ye","year":"2015","journal-title":"Biochim. Biophys. Acta BBA-Gen. Subj."},{"key":"ref_118","doi-asserted-by":"crossref","unstructured":"Elgendey, F., Al Wakeel, R.A., Hemeda, S.A., Elshwash, A.M., Fadl, S.E., Abdelazim, A.M., Alhujaily, M., and Khalifa, O.A. (2022). Selenium and\/or vitamin E upregulate the antioxidant gene expression and parameters in broilers. BMC Vet. Res., 18.","DOI":"10.1186\/s12917-022-03411-4"},{"key":"ref_119","doi-asserted-by":"crossref","unstructured":"Zhang, F., Li, X., and Wei, Y. (2023). Selenium and selenoproteins in health. Biomolecules, 13.","DOI":"10.3390\/biom13050799"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/s41580-020-0230-3","article-title":"Reactive oxygen species (ROS) as pleiotropic physiological signalling agents","volume":"21","author":"Sies","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_121","doi-asserted-by":"crossref","unstructured":"Li, S., Sun, W., Zhang, K., Zhu, J., Jia, X., Guo, X., Zhao, Q., Tang, C., Yin, J., and Zhang, J. (2021). Selenium deficiency induces spleen pathological changes in pigs by decreasing selenoprotein expression, evoking oxidative stress, and activating inflammation and apoptosis. J. Anim. Sci. Biotechnol., 12.","DOI":"10.1186\/s40104-021-00587-x"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.bbrc.2019.02.139","article-title":"Identification of FAM96B as a novel selenoprotein W binding partner in the brain","volume":"512","author":"Chen","year":"2019","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_123","doi-asserted-by":"crossref","unstructured":"Zhang, Z.-H., and Song, G.-L. (2021). Roles of selenoproteins in brain function and the potential mechanism of selenium in Alzheimer\u2019s disease. Front. Neurosci., 15.","DOI":"10.3389\/fnins.2021.646518"},{"key":"ref_124","doi-asserted-by":"crossref","unstructured":"K\u00f6hrle, J. (2023). Selenium, iodine and iron\u2013essential trace elements for thyroid hormone synthesis and metabolism. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24043393"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"e34975","DOI":"10.1016\/j.heliyon.2024.e34975","article-title":"A comprehensive review on potential role of selenium, selenoproteins and selenium nanoparticles in male fertility","volume":"10","author":"Yuan","year":"2024","journal-title":"Heliyon"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.ejogrb.2016.06.002","article-title":"Serum anti-M\u00fcllerian hormone levels in euthyroid adolescent girls with Hashimoto\u2019s thyroiditis: Relationship to antioxidant status","volume":"203","author":"Erol","year":"2016","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1038\/s41392-024-01839-8","article-title":"Mitochondrial dysfunction: Mechanisms and advances in therapy","volume":"9","author":"Zong","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_128","doi-asserted-by":"crossref","unstructured":"Kochman, J., Jakubczyk, K., Bargiel, P., and Janda-Milczarek, K. (2021). The influence of oxidative stress on thyroid diseases. Antioxidants, 10.","DOI":"10.3390\/antiox10091442"},{"key":"ref_129","doi-asserted-by":"crossref","unstructured":"Wang, F., Li, C., Li, S., Cui, L., Zhao, J., and Liao, L. (2023). Selenium and thyroid diseases. Front. Endocrinol., 14.","DOI":"10.3389\/fendo.2023.1133000"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1089\/ars.2019.7905","article-title":"Regulatory phenomena in the glutathione peroxidase superfamily","volume":"33","year":"2020","journal-title":"Antioxid. Redox Signal."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/0378-1119(94)90023-X","article-title":"The human plasma glutathione peroxidase-encoding gene: Organization, sequence and localization to chromosome 5q32","volume":"145","author":"Shinichi","year":"1994","journal-title":"Gene"},{"key":"ref_132","doi-asserted-by":"crossref","unstructured":"Chang, C., Worley, B.L., Pha\u00ebton, R., and Hempel, N. (2020). Extracellular glutathione peroxidase GPx3 and its role in cancer. Cancers, 12.","DOI":"10.3390\/cancers12082197"},{"key":"ref_133","unstructured":"Ashgan, M.M. (2020). Expression Stem Cells in Mice Thyroid Gland Against Age Changes and the Possible Prophylactic Role of Selenium. [Ph.D. Dissertation, King Abdulaziz University]."},{"key":"ref_134","doi-asserted-by":"crossref","unstructured":"G\u0159e\u0161kov\u00e1, A., and Pet\u0159ivalsk\u00fd, M. (2024). Thioredoxin System in Insects: Uncovering the Roles of Thioredoxins and Thioredoxin Reductase beyond the Antioxidant Defences. Insects, 15.","DOI":"10.3390\/insects15100797"},{"key":"ref_135","doi-asserted-by":"crossref","unstructured":"Peng, S., Yu, S., Zhang, J., and Zhang, J. (2023). 6-shogaol as a novel thioredoxin reductase inhibitor induces oxidative-stress-mediated apoptosis in HeLa cells. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24054966"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"105854","DOI":"10.1016\/j.phrs.2021.105854","article-title":"Thioredoxin reductase as a pharmacological target","volume":"174","author":"Zou","year":"2021","journal-title":"Pharmacol. Res."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"952","DOI":"10.3803\/EnM.2021.1198","article-title":"Deiodinases and the three types of thyroid hormone deiodination reactions","volume":"36","author":"Sabatino","year":"2021","journal-title":"Endocrinol. Metab."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.freeradbiomed.2022.09.024","article-title":"Deiodinases control local cellular and systemic thyroid hormone availability","volume":"193","year":"2022","journal-title":"Free Radic. Biol. Med."},{"key":"ref_139","doi-asserted-by":"crossref","unstructured":"Jing, L., and Zhang, Q. (2022). Intrathyroidal feedforward and feedback network regulating thyroid hormone synthesis and secretion. Front. Endocrinol., 13.","DOI":"10.3389\/fendo.2022.992883"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"2356","DOI":"10.1210\/en.2016-1043","article-title":"Pituitary adenylate cyclase-activating polypeptide (PACAP) regulates the hypothalamo-pituitary-thyroid (HPT) axis via type 2 deiodinase in male mice","volume":"157","author":"Egri","year":"2016","journal-title":"Endocrinology"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1038\/s41574-019-0218-2","article-title":"Deiodinases and their intricate role in thyroid hormone homeostasis","volume":"15","author":"Luongo","year":"2019","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_142","unstructured":"Bertolini, A. (2025, January 30). Investigation on the Role of Thyroid Hormones and Their Derivatives in Different Physiopathogenetic Mechanisms Using HPLC-MS\/MS. Available online: https:\/\/usiena-air.unisi.it\/handle\/11365\/1258876."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"201","DOI":"10.2741\/4803","article-title":"Iodothyronine deiodinases and reduced sensitivity to thyroid hormones","volume":"25","author":"Paragliola","year":"2020","journal-title":"Front. Biosci. Landmark"},{"key":"ref_144","doi-asserted-by":"crossref","unstructured":"Guillin, O.M., Vindry, C., Ohlmann, T., and Chavatte, L. (2019). Selenium, selenoproteins and viral infection. Nutrients, 11.","DOI":"10.3390\/nu11092101"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"85","DOI":"10.2147\/JIR.S288412","article-title":"Selenium-containing amino acids protect dextran sulfate sodium-induced colitis via ameliorating oxidative stress and intestinal inflammation","volume":"14","author":"Shi","year":"2021","journal-title":"J. Inflamm. Res."},{"key":"ref_146","doi-asserted-by":"crossref","unstructured":"Afzal, S., Abdul Manap, A.S., Attiq, A., Albokhadaim, I., Kandeel, M., and Alhojaily, S.M. (2023). From imbalance to impairment: The central role of reactive oxygen species in oxidative stress-induced disorders and therapeutic exploration. Front. Pharmacol., 14.","DOI":"10.3389\/fphar.2023.1269581"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"e519","DOI":"10.1002\/mco2.519","article-title":"Roles of reactive oxygen species in inflammation and cancer","volume":"5","author":"Yu","year":"2024","journal-title":"MedComm"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.nutos.2024.09.004","article-title":"Molecular Mechanisms and Therapeutic Effects of Natural Products in Inflammatory Bowel Disease","volume":"58","author":"Sendani","year":"2024","journal-title":"Clin. Nutr. Open Sci."},{"key":"ref_149","doi-asserted-by":"crossref","unstructured":"Uribe-Querol, E., and Rosales, C. (2017). Control of phagocytosis by microbial pathogens. Front. Immunol., 8.","DOI":"10.3389\/fimmu.2017.01368"},{"key":"ref_150","doi-asserted-by":"crossref","unstructured":"Canton, M., S\u00e1nchez-Rodr\u00edguez, R., Spera, I., Venegas, F.C., Favia, M., Viola, A., and Castegna, A. (2021). Reactive oxygen species in macrophages: Sources and targets. Front. Immunol., 12.","DOI":"10.3389\/fimmu.2021.734229"},{"key":"ref_151","doi-asserted-by":"crossref","unstructured":"Ofori, E.A., Garcia-Senosiain, A., Naghizadeh, M., Kana, I.H., Dziegiel, M.H., Adu, B., Singh, S., and Theisen, M. (2023). Human blood neutrophils generate ROS through Fc\u03b3R-signaling to mediate protection against febrile P. falciparum malaria. Commun. Biol., 6.","DOI":"10.1038\/s42003-023-05118-0"},{"key":"ref_152","doi-asserted-by":"crossref","unstructured":"Herb, M., and Schramm, M. (2021). Functions of ROS in macrophages and antimicrobial immunity. Antioxidants, 10.","DOI":"10.3390\/antiox10020313"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.etap.2016.09.003","article-title":"Protective role of selenium in the activities of antioxidant enzymes in piglet splenic lymphocytes exposed to deoxynivalenol","volume":"47","author":"Wang","year":"2016","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"ref_154","doi-asserted-by":"crossref","unstructured":"Deng, Z., Li, D., Wang, L., Lan, J., Wang, J., and Ma, Y. (2024). Activation of GABABR Attenuates Intestinal Inflammation by Reducing Oxidative Stress through Modulating the TLR4\/MyD88\/NLRP3 Pathway and Gut Microbiota Abundance. Antioxidants, 13.","DOI":"10.3390\/antiox13091141"},{"key":"ref_155","doi-asserted-by":"crossref","unstructured":"Tourkochristou, E., Triantos, C., and Mouzaki, A. (2021). The influence of nutritional factors on immunological outcomes. Front. Immunol., 12.","DOI":"10.3389\/fimmu.2021.665968"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1039\/D0FO03067H","article-title":"Toward improved human health: Efficacy of dietary selenium on immunity at the cellular level","volume":"12","author":"Xia","year":"2021","journal-title":"Food Funct."},{"key":"ref_157","doi-asserted-by":"crossref","unstructured":"Mal\u2019tseva, V.N., Goltyaev, M.V., Turovsky, E.A., and Varlamova, E.G. (2022). Immunomodulatory and anti-inflammatory properties of selenium-containing agents: Their role in the regulation of defense mechanisms against COVID-19. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23042360"},{"key":"ref_158","doi-asserted-by":"crossref","unstructured":"Zhao, X., Gao, J., Hogenkamp, A., Knippels, L.M., Garssen, J., Bai, J., Yang, A., Wu, Y., and Chen, H. (2021). Selenium-enriched soy protein has antioxidant potential via modulation of the NRF2-HO1 signaling pathway. Foods, 10.","DOI":"10.3390\/foods10112542"},{"key":"ref_159","doi-asserted-by":"crossref","unstructured":"Glanzner, W.G., da Silva Sousa, L.R., Gutierrez, K., de Macedo, M.P., Currin, L., Perecin, F., and Bordignon, V. (2024). NRF2 attenuation aggravates detrimental consequences of metabolic stress on cultured porcine parthenote embryos. Sci. Rep., 14.","DOI":"10.1038\/s41598-024-53480-8"},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/s41392-020-00312-6","article-title":"Targeting NF-\u03baB pathway for the therapy of diseases: Mechanism and clinical study","volume":"5","author":"Yu","year":"2020","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"407","DOI":"10.2147\/JIR.S140188","article-title":"Mechanisms of NF-\u03baB p65 and strategies for therapeutic manipulation","volume":"11","author":"Giridharan","year":"2018","journal-title":"J. Inflamm. Res."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"jcs225615","DOI":"10.1242\/jcs.225615","article-title":"NIK\u2013IKK complex interaction controls NF-\u03baB-dependent inflammatory activation of endothelium in response to LT\u03b2R ligation","volume":"132","author":"Kucharzewska","year":"2019","journal-title":"J. Cell Sci."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/s41392-024-01757-9","article-title":"NF-\u03baB in biology and targeted therapy: New insights and translational implications","volume":"9","author":"Guo","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_164","doi-asserted-by":"crossref","unstructured":"Ma, B., and Hottiger, M.O. (2016). Crosstalk between Wnt\/\u03b2-Catenin and NF-\u03baB signaling pathway during inflammation. Front. Immunol., 7.","DOI":"10.3389\/fimmu.2016.00378"},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"17023","DOI":"10.1038\/sigtrans.2017.23","article-title":"NF-\u03baB signaling in inflammation","volume":"2","author":"Liu","year":"2017","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1017\/S0007114520003128","article-title":"Selenium and viral infection: Are there lessons for COVID-19?","volume":"125","author":"Bermano","year":"2021","journal-title":"Br. J. Nutr."},{"key":"ref_167","doi-asserted-by":"crossref","unstructured":"Li, M., Deng, F., Qiao, L., Wen, X., and Han, J. (2024). The Critical Role of Trace Elements in Bone Health. Nutrients, 16.","DOI":"10.3390\/nu16223867"},{"key":"ref_168","doi-asserted-by":"crossref","unstructured":"Wawrzyniak, A., and Balawender, K. (2022). Structural and metabolic changes in bone. Animals, 12.","DOI":"10.3390\/ani12151946"},{"key":"ref_169","doi-asserted-by":"crossref","unstructured":"\u0160romov\u00e1, V., Sobola, D., and Kaspar, P. (2023). A brief review of bone cell function and importance. Cells, 12.","DOI":"10.3390\/cells12212576"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1007\/s00223-021-00936-y","article-title":"Silibinin can promote bone regeneration of selenium hydrogel by reducing the oxidative stress pathway in ovariectomized rats","volume":"110","author":"Tao","year":"2022","journal-title":"Calcif. Tissue Int."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"3246","DOI":"10.1016\/j.bbagen.2014.08.001","article-title":"Selenoproteins and selenium status in bone physiology and pathology","volume":"1840","author":"Zhang","year":"2014","journal-title":"Biochim. Biophys. Acta BBA-Gen. Subj."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1039\/C4MT00003J","article-title":"Selenoprotein P is the essential selenium transporter for bones","volume":"6","author":"Pietschmann","year":"2014","journal-title":"Metallomics"},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1038\/s41418-021-00904-x","article-title":"The osteoprotective role of USP26 in coordinating bone formation and resorption","volume":"29","author":"Li","year":"2022","journal-title":"Cell Death Differ."},{"key":"ref_174","doi-asserted-by":"crossref","unstructured":"Cameron, S.J., Sheng, J., Hosseinian, F., and Willmore, W.G. (2022). Nanoparticle effects on stress response pathways and nanoparticle\u2013protein interactions. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23147962"},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"104228","DOI":"10.1016\/j.jff.2020.104228","article-title":"Effects of loach skin collagen peptides in reducing osteoporosis in mice","volume":"75","author":"Liu","year":"2020","journal-title":"J. Funct. Foods"},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.yexcr.2004.07.035","article-title":"Reactive oxygen species mediate RANK signaling in osteoclasts","volume":"301","author":"Ha","year":"2004","journal-title":"Exp. Cell Res."},{"key":"ref_177","doi-asserted-by":"crossref","unstructured":"Ren, X., Liu, H., Wu, X., Weng, W., Wang, X., and Su, J. (2022). Reactive oxygen species (ROS)-responsive biomaterials for the treatment of bone-related diseases. Front. Bioeng. Biotechnol., 9.","DOI":"10.3389\/fbioe.2021.820468"},{"key":"ref_178","doi-asserted-by":"crossref","unstructured":"Reis, J., and Ramos, A. (2021). In sickness and in health: The oxygen reactive species and the bone. Front. Bioeng. Biotechnol., 9.","DOI":"10.3389\/fbioe.2021.745911"},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"143214","DOI":"10.1016\/j.chemosphere.2024.143214","article-title":"Selenium toxicity in fishes: A current perspective","volume":"364","author":"Uddin","year":"2024","journal-title":"Chemosphere"},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"3323","DOI":"10.3892\/mmr.2017.6377","article-title":"Health risk assessment of environmental selenium: Emerging evidence and challenges","volume":"15","author":"Vinceti","year":"2017","journal-title":"Mol. Med. Rep."},{"key":"ref_181","unstructured":"Standing Committee on the Scientific Evaluation of Dietary Reference Intakes, Subcommittee on Interpretation, Uses of Dietary Reference Intakes, Subcommittee on Upper Reference Levels of Nutrients, Panel on Dietary Antioxidants, and Related Compounds (2000). Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids, National Academies Press."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1079\/BJN20031015","article-title":"Selenium and its relationship to cancer: An update","volume":"91","author":"Pd","year":"2004","journal-title":"Br. J. Nutr."},{"key":"ref_183","doi-asserted-by":"crossref","unstructured":"Ren, X., Wang, Y., Sun, J., Liang, K., Zhu, H., Li, Y., Gao, J., Zhang, Y., Huang, S., and Zhu, D. (2024). Legal Standards for Selenium Enriched Foods and Agricultural Products: Domestic and International Perspectives. Nutrients, 16.","DOI":"10.3390\/nu16213659"},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1021\/es4051082","article-title":"New insights into traditional health risk assessments of mercury exposure: Implications of selenium","volume":"48","author":"Zhang","year":"2014","journal-title":"Environ. Sci. Technol."},{"key":"ref_185","doi-asserted-by":"crossref","unstructured":"Wahyuni, E.A., Yii, C.-Y., Liang, H.-L., Luo, Y.-H., Yang, S.-H., Wu, P.-Y., Hsu, W.-L., Nien, C.-Y., and Chen, S.-C. (2022). Selenocystine induces oxidative-mediated DNA damage via impairing homologous recombination repair of DNA double-strand breaks in human hepatoma cells. Chem. Biol. Interact., 365.","DOI":"10.1016\/j.cbi.2022.110046"},{"key":"ref_186","doi-asserted-by":"crossref","unstructured":"Maia, L.B., Maiti, B.K., Moura, I., and Moura, J.J. (2023). Selenium\u2014More than just a fortuitous sulfur substitute in redox biology. Molecules, 29.","DOI":"10.3390\/molecules29010120"},{"key":"ref_187","doi-asserted-by":"crossref","unstructured":"Sk, U.H., RoyMahapatra, D., and Bhattacharya, S. (2022). Selenium Nanoparticle in the Management of Oxidative Stress During Cancer Chemotherapy. Handbook of Oxidative Stress in Cancer: Therapeutic Aspects, Springer.","DOI":"10.1007\/978-981-16-1247-3_116-1"},{"key":"ref_188","doi-asserted-by":"crossref","unstructured":"Juan, C.A., P\u00e9rez de la Lastra, J.M., Plou, F.J., and P\u00e9rez-Lebe\u00f1a, E. (2021). The chemistry of reactive oxygen species (ROS) revisited: Outlining their role in biological macromolecules (DNA, lipids and proteins) and induced pathologies. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22094642"},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"E4782","DOI":"10.1073\/pnas.1703683114","article-title":"Manipulating DNA damage-response signaling for the treatment of immune-mediated diseases","volume":"114","author":"McNally","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"146","DOI":"10.15430\/JCP.2019.24.3.146","article-title":"Effect of the interaction between selenium and zinc on DNA repair in association with cancer prevention","volume":"24","author":"Yildiz","year":"2019","journal-title":"J. Cancer Prev."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"3536","DOI":"10.3390\/nu7053536","article-title":"Redox-active selenium compounds\u2014From toxicity and cell death to cancer treatment","volume":"7","author":"Misra","year":"2015","journal-title":"Nutrients"},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/j.jtemb.2014.06.017","article-title":"Effects of selenium compounds on proliferation and epigenetic marks of breast cancer cells","volume":"28","author":"Dagli","year":"2014","journal-title":"J. Trace Elem. Med. Biol."},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"2977","DOI":"10.1016\/j.bbamcr.2016.09.012","article-title":"Activation of apoptosis signalling pathways by reactive oxygen species","volume":"1863","year":"2016","journal-title":"Biochim. Biophys. Acta BBA-Mol. Cell Res."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"2499","DOI":"10.1007\/s00204-023-03562-9","article-title":"Reactive oxygen species, toxicity, oxidative stress, and antioxidants: Chronic diseases and aging","volume":"97","author":"Jomova","year":"2023","journal-title":"Arch. Toxicol."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1756-9966-33-8","article-title":"The activation of c-Jun NH 2-terminal kinase is required for dihydroartemisinin-induced autophagy in pancreatic cancer cells","volume":"33","author":"Jia","year":"2014","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"ref_196","doi-asserted-by":"crossref","unstructured":"La Marca, J.E., and Richardson, H.E. (2020). Two-faced: Roles of JNK signalling during tumourigenesis in the Drosophila model. Front. Cell Dev. Biol., 8.","DOI":"10.3389\/fcell.2020.00042"},{"key":"ref_197","doi-asserted-by":"crossref","unstructured":"Ajmone-Cat, M.A., De Simone, R., Tartaglione, A.M., Di Biase, A., Di Benedetto, R., D\u2019Archivio, M., Var\u00ec, R., Ricceri, L., Aureli, F., and Iacoponi, F. (2022). Critical role of maternal selenium nutrition in neurodevelopment: Effects on offspring behavior and neuroinflammatory profile. Nutrients, 14.","DOI":"10.3390\/nu14091850"},{"key":"ref_198","doi-asserted-by":"crossref","unstructured":"Ahmed, T., Van der Jeugd, A., Caillierez, R., Bu\u00e9e, L., Blum, D., D\u2019hooge, R., and Balschun, D. (2020). Chronic sodium selenate treatment restores deficits in cognition and synaptic plasticity in a murine model of tauopathy. Front. Mol. Neurosci., 13.","DOI":"10.3389\/fnmol.2020.570223"},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s12011-019-01908-y","article-title":"Selenium deficiency induces inflammation via the iNOS\/NF-\u03baB pathway in the brain of pigs","volume":"196","author":"Zhang","year":"2020","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1007\/s12011-015-0534-x","article-title":"Effect of dietary selenium deficiency on the cell apoptosis and the level of thyroid hormones in chicken","volume":"171","author":"Huang","year":"2016","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/s12011-014-0083-8","article-title":"Selenium deficiency inhibits the conversion of thyroidal thyroxine (T 4) to triiodothyronine (T 3) in chicken thyroids","volume":"161","author":"Lin","year":"2014","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1007\/s12011-018-1396-9","article-title":"Selenium deficiency affects immune function by influencing selenoprotein and cytokine expression in chicken spleen","volume":"187","author":"Khoso","year":"2019","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1039\/C8MT00039E","article-title":"Selenium deficiency inhibits differentiation and immune function and imbalances the Th1\/Th2 of dendritic cells","volume":"10","author":"Sun","year":"2018","journal-title":"Metallomics"},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1007\/s12011-017-1110-3","article-title":"Lower selenoprotein T expression and immune response in the immune organs of broilers with exudative diathesis due to selenium deficiency","volume":"182","author":"Pan","year":"2018","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/s12011-019-01775-7","article-title":"Impact of selenium deficiency on inflammation, oxidative stress, and phagocytosis in mouse macrophages","volume":"194","author":"Xu","year":"2020","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1007\/s12011-015-0282-y","article-title":"Selenium deficiency downregulates selenoproteins and suppresses immune function in chicken thymus","volume":"167","author":"Khoso","year":"2015","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_207","doi-asserted-by":"crossref","unstructured":"Li, Z., Dong, Y., Chen, S., Jia, X., Jiang, X., Che, L., Lin, Y., Li, J., Feng, B., and Fang, Z. (2021). Organic selenium increased gilts antioxidant capacity, immune function, and changed intestinal microbiota. Front. Microbiol., 12.","DOI":"10.3389\/fmicb.2021.723190"},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1359\/jbmr.2001.16.8.1556","article-title":"Selenium deficiency-induced growth retardation is associated with an impaired bone metabolism and osteopenia","volume":"16","author":"Egrise","year":"2001","journal-title":"J. Bone Miner. Res."},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1111\/apm.12404","article-title":"Abnormality of epiphyseal plate induced by selenium deficiency diet in two generation DA rats","volume":"123","author":"Min","year":"2015","journal-title":"Apmis"},{"key":"ref_210","doi-asserted-by":"crossref","unstructured":"Rayman, M. (2017). Selenium intake and status in health & disease. Free Radic. Biol. Med., 112.","DOI":"10.1016\/j.freeradbiomed.2017.10.353"},{"key":"ref_211","doi-asserted-by":"crossref","unstructured":"Gupta, M., and Gupta, S. (2017). An overview of selenium uptake, metabolism, and toxicity in plants. Front. Plant Sci., 7.","DOI":"10.3389\/fpls.2016.02074"},{"key":"ref_212","doi-asserted-by":"crossref","unstructured":"Wu, Z., Ba\u00f1uelos, G.S., Lin, Z.-Q., Liu, Y., Yuan, L., Yin, X., and Li, M. (2015). Biofortification and phytoremediation of selenium in China. Front. Plant Sci., 6.","DOI":"10.3389\/fpls.2015.00136"},{"key":"ref_213","doi-asserted-by":"crossref","unstructured":"Hadrup, N., and Ravn-Haren, G. (2023). Toxicity of repeated oral intake of organic selenium, inorganic selenium, and selenium nanoparticles: A review. J. Trace Elem. Med. Biol., 79.","DOI":"10.1016\/j.jtemb.2023.127235"},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1007\/s10653-022-01354-1","article-title":"A critical analysis of sources, pollution, and remediation of selenium, an emerging contaminant","volume":"45","author":"Ullah","year":"2023","journal-title":"Environ. Geochem. Health"},{"key":"ref_215","doi-asserted-by":"crossref","unstructured":"Nem\u010dek, L., Hagarov\u00e1, I., and Mat\u00fa\u0161, P. (2024). Layered Double Hydroxides as Next-Generation Adsorbents for the Removal of Selenium from Water. Appl. Sci., 14.","DOI":"10.3390\/app14188513"},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"3319","DOI":"10.1007\/s12011-020-02480-6","article-title":"Revisiting the effects of different dietary sources of selenium on the health and performance of dairy animals: A review","volume":"199","author":"Arshad","year":"2021","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.aquatox.2010.12.020","article-title":"Dietary selenomethionine exposure in adult zebrafish alters swimming performance, energetics and the physiological stress response","volume":"102","author":"Thomas","year":"2011","journal-title":"Aquat. Toxicol."},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.aquatox.2006.07.008","article-title":"Bioaccumulation and chronic toxicity of dietary l-selenomethionine in juvenile white sturgeon (Acipenser transmontanus)","volume":"79","author":"Tashjian","year":"2006","journal-title":"Aquat. Toxicol."},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"125898","DOI":"10.1016\/j.chemosphere.2020.125898","article-title":"Effects of chronic exposure to selenomethionine on social learning outcomes in zebrafish (Danio rerio): Serotonergic dysregulation and oxidative stress in the brain","volume":"247","author":"Attaran","year":"2020","journal-title":"Chemosphere"},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"12879","DOI":"10.1021\/acs.est.7b03937","article-title":"Chronic dietary selenomethionine exposure induces oxidative stress, dopaminergic dysfunction, and cognitive impairment in adult zebrafish (Danio rerio)","volume":"51","author":"Naderi","year":"2017","journal-title":"Environ. Sci. Technol."},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1007\/s12011-017-1224-7","article-title":"The adverse effects of Se toxicity on inflammatory and immune responses in chicken spleens","volume":"185","author":"Wang","year":"2018","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1007\/s12011-015-0596-9","article-title":"Excessive selenium supplementation induced oxidative stress and endoplasmic reticulum stress in chicken spleen","volume":"172","author":"Wang","year":"2016","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_223","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1751-0147-55-8","article-title":"Structural changes in femoral bone tissue of rats after subchronic peroral exposure to selenium","volume":"55","author":"Omelka","year":"2013","journal-title":"Acta Vet. Scand."},{"key":"ref_224","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.vetimm.2018.12.002","article-title":"Dietary selenium supplementation enhances antiviral immunity in chickens challenged with low pathogenic avian influenza virus subtype H9N2","volume":"207","author":"Shojadoost","year":"2019","journal-title":"Vet. Immunol. Immunopathol."},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"6529","DOI":"10.3390\/nu7085297","article-title":"Dietary selenium levels affect selenoprotein expression and support the interferon-\u03b3 and IL-6 immune response pathways in mice","volume":"7","author":"Tsuji","year":"2015","journal-title":"Nutrients"},{"key":"ref_226","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.jtemb.2018.03.003","article-title":"Effects of dietary sodium selenite and organic selenium sources on immune and inflammatory responses and selenium deposition in growing pigs","volume":"50","author":"Falk","year":"2018","journal-title":"J. Trace Elem. Med. Biol."},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"102420","DOI":"10.1016\/j.psj.2022.102420","article-title":"Effects of selenium supplementation on the growth performance, slaughter characteristics, and blood biochemistry of naked neck chicken","volume":"102","author":"Khan","year":"2023","journal-title":"Poult. Sci."},{"key":"ref_228","doi-asserted-by":"crossref","unstructured":"Awadallah, H.A.M.A. (2019). Effect of Dietary Modulation of Selenium Form and Level on Performance, Tissue Retention, Quality of Frozen Stored Meat and Gene Expression of Antioxidant Status in Ross Broiler Chickens. Animals, 9.","DOI":"10.3390\/ani9060342"},{"key":"ref_229","doi-asserted-by":"crossref","unstructured":"Liu, Z., Cao, Y., Ai, Y., Lin, G., Yin, X., Wang, L., Wang, M., Zhang, B., Wu, K., and Guo, Y. (2023). Effects of selenium yeast on egg quality, plasma antioxidants, selenium deposition and eggshell formation in aged laying hens. Animals, 13.","DOI":"10.3390\/ani13050902"},{"key":"ref_230","doi-asserted-by":"crossref","unstructured":"Arnaut, P.R., da Silva Viana, G., da Fonseca, L., Alves, W.J., Muniz, J.C.L., Pettigrew, J.E., e Silva, F.F., Rostagno, H.S., and Hannas, M.I. (2021). Selenium source and level on performance, selenium retention and biochemical responses of young broiler chicks. BMC Vet. Res., 17.","DOI":"10.1186\/s12917-021-02855-4"},{"key":"ref_231","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/s12937-016-0155-z","article-title":"Stunting, selenium deficiency and anemia are associated with poor cognitive performance in preschool children from rural Ethiopia","volume":"15","author":"Gashu","year":"2015","journal-title":"Nutr. J."},{"key":"ref_232","doi-asserted-by":"crossref","first-page":"S217","DOI":"10.1016\/j.joca.2020.02.355","article-title":"Different incidence of the same diet composition and diversity of fecal microbiota may be an important risk factor for children with kashin-beck disease","volume":"28","author":"Tao","year":"2020","journal-title":"Osteoarthr. Cartil."},{"key":"ref_233","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1007\/s10653-017-0033-4","article-title":"Selenium status of children in Kashin\u2013Beck disease endemic areas in Shaanxi, China: Assessment with mercury","volume":"40","author":"Du","year":"2018","journal-title":"Environ. Geochem. Health"},{"key":"ref_234","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1007\/s12011-019-1642-9","article-title":"Decreased expression of CHST-12, CHST-13, and UST in the proximal interphalangeal joint cartilage of school-age children with Kashin\u2013Beck disease: An endemic osteoarthritis in China caused by selenium deficiency","volume":"191","author":"Guo","year":"2019","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_235","doi-asserted-by":"crossref","unstructured":"Dobrzy\u0144ska, M., Drzyma\u0142a-Czy\u017c, S., Wo\u017aniak, D., Drzyma\u0142a, S., and Przys\u0142awski, J. (2023). Natural sources of selenium as functional food products for chemoprevention. Foods, 12.","DOI":"10.3390\/foods12061247"},{"key":"ref_236","doi-asserted-by":"crossref","unstructured":"Godos, J., Giampieri, F., Micek, A., Battino, M., Forbes-Hernandez, T.Y., Quiles, J.L., Paladino, N., Falzone, L., and Grosso, G. (2022). Effect of Brazil nuts on selenium status, blood lipids, and biomarkers of oxidative stress and inflammation: A systematic review and meta-analysis of randomized clinical trials. Antioxidants, 11.","DOI":"10.3390\/antiox11020403"},{"key":"ref_237","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.nut.2019.02.009","article-title":"Consumption of Brazil nuts with high selenium levels increased inflammation biomarkers in obese women: A randomized controlled trial","volume":"63","author":"Duarte","year":"2019","journal-title":"Nutrition"},{"key":"ref_238","doi-asserted-by":"crossref","unstructured":"Lima, L.W., Stonehouse, G.C., Walters, C., Mehdawi, A.F.E., Fakra, S.C., and Pilon-Smits, E.A. (2019). Selenium accumulation, speciation and localization in Brazil nuts (Bertholletia excelsa HBK). Plants, 8.","DOI":"10.3390\/plants8080289"},{"key":"ref_239","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1016\/j.nut.2015.05.005","article-title":"Selenium status in preschool children receiving a Brazil nut\u2013enriched diet","volume":"31","author":"Martens","year":"2015","journal-title":"Nutrition"},{"key":"ref_240","doi-asserted-by":"crossref","unstructured":"Varsi, K., Bolann, B., Torsvik, I., Rosvold Eik, T.C., H\u00f8l, P.J., and Bj\u00f8rke-Monsen, A.-L. (2017). Impact of maternal selenium status on infant outcome during the first 6 months of life. Nutrients, 9.","DOI":"10.3390\/nu9050486"},{"key":"ref_241","first-page":"741","article-title":"Selenium status during pregnancy: Influential factors and effects on neuropsychological development among Spanish infants","volume":"610\u2013611","author":"Murcia","year":"2018","journal-title":"Sci. Total Environ."},{"key":"ref_242","doi-asserted-by":"crossref","first-page":"108529","DOI":"10.1016\/j.envres.2019.108529","article-title":"Prenatal selenium status, neonatal cerebellum measures and child neurodevelopment at the age of 18 months","volume":"176","author":"Tratnik","year":"2019","journal-title":"Environ. Res."},{"key":"ref_243","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.envres.2018.06.002","article-title":"Maternal selenium status and neuropsychological development in Spanish preschool children","volume":"166","author":"Murcia","year":"2018","journal-title":"Environ. Res."},{"key":"ref_244","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1038\/pr.2016.32","article-title":"Selenium status during pregnancy and child psychomotor development\u2014Polish Mother and Child Cohort study","volume":"79","author":"Polanska","year":"2016","journal-title":"Pediatr. Res."},{"key":"ref_245","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1016\/j.clnu.2014.09.020","article-title":"Selenium status in pregnancy influences children\u2019s cognitive function at 1.5 years of age","volume":"34","author":"Hamadani","year":"2015","journal-title":"Clin. Nutr."},{"key":"ref_246","doi-asserted-by":"crossref","first-page":"117003","DOI":"10.1289\/EHP1691","article-title":"Early-life selenium status and cognitive function at 5 and 10 years of age in Bangladeshi children","volume":"125","author":"Kippler","year":"2017","journal-title":"Environ. Health Perspect."},{"key":"ref_247","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.plefa.2019.10.002","article-title":"Relationships between seafood consumption during pregnancy and childhood and neurocognitive development: Two systematic reviews","volume":"151","author":"Hibbeln","year":"2019","journal-title":"Prostaglandins Leukot. Essent. Fatty Acids"},{"key":"ref_248","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.jtemb.2017.11.016","article-title":"Early pregnancy maternal trace mineral status and the association with adverse pregnancy outcome in a cohort of Australian women","volume":"46","author":"Wilson","year":"2018","journal-title":"J. Trace Elem. Med. Biol."},{"key":"ref_249","doi-asserted-by":"crossref","unstructured":"Pieczy\u0144ska, J., P\u0142aczkowska, S., Soza\u0144ski, R., and Grajeta, H. (2024). Is Maternal Selenium Status Associated with Pregnancy Outcomes in Physiological and Complicated Pregnancy?. Nutrients, 16.","DOI":"10.20944\/preprints202404.0733.v1"},{"key":"ref_250","doi-asserted-by":"crossref","unstructured":"Atazadegan, M.A., Heidari-Beni, M., Riahi, R., and Kelishadi, R. (2022). Association of selenium, zinc and copper concentrations during pregnancy with birth weight: A systematic review and meta-analysis. J. Trace Elem. Med. Biol., 69.","DOI":"10.1016\/j.jtemb.2021.126903"},{"key":"ref_251","doi-asserted-by":"crossref","unstructured":"Str\u00e5vik, M., Gustin, K., Barman, M., Skr\u00f6der, H., Sandin, A., Wold, A.E., Sandberg, A.-S., Kippler, M., and Vahter, M. (2021). Infant iodine and selenium status in relation to maternal status and diet during pregnancy and lactation. Front. Nutr., 8.","DOI":"10.3389\/fnut.2021.733602"},{"key":"ref_252","doi-asserted-by":"crossref","unstructured":"Lewandowska, M., and Lubi\u0144ski, J. (2020). Serum microelements in early pregnancy and their risk of large-for-gestational age birth weight. Nutrients, 12.","DOI":"10.3390\/nu12030866"},{"key":"ref_253","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1017\/S0007114523000739","article-title":"Associations between maternal and infant selenium status and child growth in a birth cohort from Dhaka, Bangladesh","volume":"130","author":"Mehta","year":"2023","journal-title":"Br. J. Nutr."},{"key":"ref_254","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1007\/s12011-020-02124-9","article-title":"Prenatal maternal low selenium, high thyrotropin, and low birth weights","volume":"199","author":"Guo","year":"2021","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_255","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.freeradbiomed.2024.05.001","article-title":"Maternal selenium deficiency during pregnancy in association with autism and ADHD traits in children: The Odense Child Cohort","volume":"220","author":"Demircan","year":"2024","journal-title":"Free Radic. Biol. Med."},{"key":"ref_256","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.envres.2017.06.037","article-title":"Micronutrients during pregnancy and child psychomotor development: Opposite effects of Zinc and Selenium","volume":"158","author":"Polanska","year":"2017","journal-title":"Environ. Res."},{"key":"ref_257","doi-asserted-by":"crossref","unstructured":"Sol\u00e9-Navais, P., Brants\u00e6ter, A.L., Caspersen, I.H., Lundh, T., Muglia, L.J., Meltzer, H.M., Zhang, G., Jacobsson, B., Sengpiel, V., and Barman, M. (2020). Maternal dietary selenium intake during pregnancy is associated with higher birth weight and lower risk of small for gestational age births in the Norwegian mother, father and child cohort study. Nutrients, 13.","DOI":"10.3390\/nu13010023"},{"key":"ref_258","doi-asserted-by":"crossref","unstructured":"Filipowicz, D., Szczepanek-Parulska, E., K\u0142obus, M., Szymanowski, K., Chillon, T.S., Asaad, S., Sun, Q., Mikulska-Sauermann, A.A., Kara\u017aniewicz-\u0141ada, M., and G\u0142\u00f3wka, F.K. (2022). Selenium status and supplementation effects in pregnancy\u2014A study on mother\u2013child pairs from a single-center cohort. Nutrients, 14.","DOI":"10.3390\/nu14153082"},{"key":"ref_259","doi-asserted-by":"crossref","first-page":"e017883","DOI":"10.1136\/bmjopen-2017-017883","article-title":"Effects of five types of selenium supplementation for treatment of Kashin-Beck disease in children: A systematic review and network meta-analysis","volume":"8","author":"Xie","year":"2018","journal-title":"BMJ Open"},{"key":"ref_260","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s12011-015-0437-x","article-title":"Salt-rich selenium for prevention and control children with Kashin\u2013Beck disease: A meta-analysis of community-based trial","volume":"170","author":"Yu","year":"2016","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_261","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.nut.2014.09.008","article-title":"Increased plasma selenium is associated with better outcomes in children with systemic inflammation","volume":"31","author":"Leite","year":"2015","journal-title":"Nutrition"},{"key":"ref_262","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s12011-015-0394-4","article-title":"The prevention effect of selenium on prevalence of children kaschin-beck disease in active endemic areas in Qinghai plateau","volume":"169","author":"Li","year":"2016","journal-title":"Biol. Trace Elem. Res."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/4\/1274\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T16:34:39Z","timestamp":1760027679000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/4\/1274"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,14]]},"references-count":262,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2025,2]]}},"alternative-id":["jcm14041274"],"URL":"https:\/\/doi.org\/10.3390\/jcm14041274","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,14]]}}}