{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T11:31:29Z","timestamp":1790767889498,"version":"4.1.0"},"reference-count":25,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T00:00:00Z","timestamp":1739491200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Hallym University Research Fund","award":["RS-2022-NR071669"],"award-info":[{"award-number":["RS-2022-NR071669"]}]},{"name":"National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT)","award":["RS-2022-NR071669"],"award-info":[{"award-number":["RS-2022-NR071669"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Objective: The association between periodontitis and benign prostatic hyperplasia (BPH) has been controversial. This study aimed to estimate the association between recurrent periodontitis episodes and the occurrence of BPH in an adult male population in Korea. Methods: This study analyzed data from 79,497 matched cases and controls to examine the relationship between periodontitis and BPH, using Korean National Health Insurance Service-Health Screening Cohort data. Conditional logistic regression was used to calculate odds ratios (ORs) with 95% confidence intervals (CIs), adjusting for confounding factors. Results: The odds of BPH were significantly higher for participants with periodontitis \u2265 1 within 1 year (OR = 1.34, 95% CI = 1.31\u20131.37), particularly in low-income individuals (OR = 1.43, 95% CI = 1.38\u20131.48). Increased periodontitis frequency (\u22652 or \u22653 within 1 year) and a CCI score \u2265 2 were associated with progressively higher odds of BPH, indicating that periodontitis may be a significant risk factor for BPH, with variations depending on socioeconomic and health status. Conclusions: The occurrence of BPH was higher in participants with a history of recurrent periodontitis episodes, with stronger associations observed in those with low income or multiple comorbidities. Clinicians should be aware of the potential risk of BPH in patients with recurrent periodontitis episodes. This study\u2019s retrospective design, reliance on ICD-10 codes without details on disease severity, and focus on Korean citizens over 40 limit its ability to establish causality and generalizability to other populations and age groups, which should be considered when interpreting the findings.<\/jats:p>","DOI":"10.3390\/jcm14041279","type":"journal-article","created":{"date-parts":[[2025,2,17]],"date-time":"2025-02-17T03:41:47Z","timestamp":1739763707000},"page":"1279","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Chronic Periodontitis as a Risk Factor for Benign Prostatic Hyperplasia: A Cohort Study"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2441-0448","authenticated-orcid":false,"given":"Mi Jung","family":"Kwon","sequence":"first","affiliation":[{"name":"Department of Pathology, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang 14068, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ho Suk","family":"Kang","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang 14068, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1655-9549","authenticated-orcid":false,"given":"Hyo Geun","family":"Choi","sequence":"additional","affiliation":[{"name":"Suseo Seoul E.N.T. Clinic, 10, Bamgogae-ro 1-gil, Gangnam-gu, Seoul 06349, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joo Hee","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang 14068, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dae Myoung","family":"Yoo","sequence":"additional","affiliation":[{"name":"Hallym Data Science Laboratory, Hallym University College of Medicine, Anyang 14068, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na Eun","family":"Lee","sequence":"additional","affiliation":[{"name":"Hallym Data Science Laboratory, Hallym University College of Medicine, Anyang 14068, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-2849-9735","authenticated-orcid":false,"given":"Kyeong Min","family":"Han","sequence":"additional","affiliation":[{"name":"Hallym Data Science Laboratory, Hallym University College of Medicine, Anyang 14068, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Woo Jin","family":"Bang","sequence":"additional","affiliation":[{"name":"Department of Urology, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang 14068, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,2,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Abdulkareem, A.A., Al-Taweel, F.B., Al-Sharqi, A.J.B., Gul, S.S., Sha, A., and Chapple, I.L.C. 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