{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T02:48:37Z","timestamp":1792205317906,"version":"4.4.0"},"reference-count":50,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2025,2,16]],"date-time":"2025-02-16T00:00:00Z","timestamp":1739664000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Different techniques have been proposed to manage Cholecysto-choledocholithiasis (CCL) advantageously in one stage. Among these, Laparoendoscopic Rendezvous (LERV) addresses the CCL issue with a laparoscopic cholecystectomy, with insertion of a guide wire into the common bile duct through an incision of the cystic duct, followed by the clearance of the bile duct carried out by the endoscopists. The aim of this study was to evaluate the safety and the efficacy of the one-stage vs. a two-stage approach (pre-operative ERCP followed by cholecystectomy), and to compare our results with data from the current literature. Methods: All patients that underwent LERV in our facilities between January 2018 and December 2023 were evaluated. As a control group, we included patients that underwent a two-stage technique called the \u201csequential approach\u201d. The primary outcome was to evaluate the efficacy in obtaining complete clearance of the common bile duct (CBD). The secondary outcomes included morbidity, mortality, operative time, conversion rate, hospital stay and CDB stone recurrence. Results: 120 patients in the LERV group were included; meanwhile, 70 patients underwent pre-operative ERCP plus cholecystectomy. A 97% bile duct clearance success rate in the LERV group and 93% in the ERCP group was observed, respectively. The median intraoperative time for the one-stage technique was 122 min (p &lt; 0.001) and the median hospital stay was 4 days (p &lt; 0.001). In the LERV group, an overall morbidity of 15% was reported (18\/120): 15 Clavien\u2013Dindo type 1, one type 3a and two type 3b (p &lt; 0.001). At a median follow-up of 14 months, five patients experienced stone recurrence. In the ERCP group, we had a 93% success rate; meanwhile, we had longer hospitalization (p &lt; 0.001), 27% post-ERCP pancreatitis (p &lt; 0.001) and a cumulative morbidity of 30%. Conclusions: LERV offers the advantages of a being single-stage procedure and shorter hospitalization, with a lower risk of clinically relevant post-ERCP pancreatitis and failed CBD cannulation.<\/jats:p>","DOI":"10.3390\/jcm14041310","type":"journal-article","created":{"date-parts":[[2025,2,17]],"date-time":"2025-02-17T03:41:47Z","timestamp":1739763707000},"page":"1310","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Laparoendoscopic Rendezvous: An Effective and Safe Approach in the Management of Cholecysto-Choledocholithiasis in Selected Patients"],"prefix":"10.3390","volume":"14","author":[{"given":"Rossana","family":"Percario","sequence":"first","affiliation":[{"name":"General Surgery Unit, \u201cF. Renzetti\u201d Hospital, 66043 Lanciano, Italy"},{"name":"Unit of General and Surgical Oncology, University \u201cG. D\u2019Annunzio\u201d Pierangeli Clinic, Piazza Luigi Pierangeli n1, 65124 Pescara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Panaccio","sequence":"additional","affiliation":[{"name":"General Surgery Unit, \u201cF. Renzetti\u201d Hospital, 66043 Lanciano, Italy"},{"name":"Unit of General and Surgical Oncology, University \u201cG. D\u2019Annunzio\u201d Pierangeli Clinic, Piazza Luigi Pierangeli n1, 65124 Pescara, Italy"},{"name":"Department of Innovative Technologies in Clinical Medicine & Dentistry, University \u201cG. D\u2019Annunzio\u201d, 66100 Chieti-Pescara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Pia","family":"Caldarella","sequence":"additional","affiliation":[{"name":"Unit of Diagnostic Endoscopy and Digestive Surgery, \u201cG. Bernabeo\u201d Hospital, 66026 Ortona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Trappoliere","sequence":"additional","affiliation":[{"name":"Unit of Diagnostic Endoscopy and Digestive Surgery, \u201cG. Bernabeo\u201d Hospital, 66026 Ortona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Marino","sequence":"additional","affiliation":[{"name":"Unit of Diagnostic Endoscopy and Digestive Surgery, \u201cG. Bernabeo\u201d Hospital, 66026 Ortona, Italy"},{"name":"Unit of Gastroenterology and Endoscopic Surgery, \u201cF. Renzetti\u201d Hospital, 66034 Lanciano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maira","family":"Farrukh","sequence":"additional","affiliation":[{"name":"Department of Innovative Technologies in Clinical Medicine & Dentistry, University \u201cG. D\u2019Annunzio\u201d, 66100 Chieti-Pescara, Italy"},{"name":"Unit of Diagnostic Endoscopy and Digestive Surgery, \u201cG. Bernabeo\u201d Hospital, 66026 Ortona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Di Giacomo","sequence":"additional","affiliation":[{"name":"Unit of Gastroenterology and Endoscopic Surgery, \u201cF. Renzetti\u201d Hospital, 66034 Lanciano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7047-7611","authenticated-orcid":false,"given":"Giuseppe","family":"Di Martino","sequence":"additional","affiliation":[{"name":"Department of Medicine and Ageing Sciences, \u201cG. D\u2019Annunzio\u201d University of Chieti-Pescara, 66100 Chieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9187-0834","authenticated-orcid":false,"given":"Giovanni","family":"De Nobili","sequence":"additional","affiliation":[{"name":"General Surgery Unit, \u201cF. Renzetti\u201d Hospital, 66043 Lanciano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaella Marina","family":"di Renzo","sequence":"additional","affiliation":[{"name":"Unit of General and Surgical Oncology, University \u201cG. D\u2019Annunzio\u201d Pierangeli Clinic, Piazza Luigi Pierangeli n1, 65124 Pescara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tommaso","family":"Grottola","sequence":"additional","affiliation":[{"name":"Unit of General and Surgical Oncology, University \u201cG. D\u2019Annunzio\u201d Pierangeli Clinic, Piazza Luigi Pierangeli n1, 65124 Pescara, Italy"},{"name":"Department of Innovative Technologies in Clinical Medicine & Dentistry, University \u201cG. D\u2019Annunzio\u201d, 66100 Chieti-Pescara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierluigi","family":"Di Sebastiano","sequence":"additional","affiliation":[{"name":"Unit of General and Surgical Oncology, University \u201cG. D\u2019Annunzio\u201d Pierangeli Clinic, Piazza Luigi Pierangeli n1, 65124 Pescara, Italy"},{"name":"Department of Innovative Technologies in Clinical Medicine & Dentistry, University \u201cG. D\u2019Annunzio\u201d, 66100 Chieti-Pescara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9877-2946","authenticated-orcid":false,"given":"Fabio Francesco","family":"di Mola","sequence":"additional","affiliation":[{"name":"Unit of General and Surgical Oncology, University \u201cG. D\u2019Annunzio\u201d Pierangeli Clinic, Piazza Luigi Pierangeli n1, 65124 Pescara, Italy"},{"name":"Department of Medical, Oral & Biotechnological Sciences, University \u201cG. D\u2019Annunzio\u201d, 66100 Chieti-Pescara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,2,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e001441","DOI":"10.1136\/bmjgast-2024-001441","article-title":"Prevalence of gallstone disease in Africa: A systematic review and meta-analysis","volume":"12","author":"Abdu","year":"2025","journal-title":"BMJ Open Gastroenterol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.jhep.2016.03.005","article-title":"EASL Clinical Practice Guidelines on the Prevention, Diagnosis and Treatment of Gallstones","volume":"65","author":"Lammert","year":"2016","journal-title":"J. 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