{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T07:25:00Z","timestamp":1773300300181,"version":"3.50.1"},"reference-count":59,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T00:00:00Z","timestamp":1740009600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background\/Objectives: Tendinopathy is the preferred term to describe various tendon pathologies, including paratendinitis, tendinitis, and tendinosis, in the absence of histopathological evidence in biopsy specimens. The management of tendinopathies is challenging; rest, physiotherapy (such as eccentric training), injections, shock waves, orthotics, medical therapy, and surgery are the main therapeutic options offered to the patient. The conservative treatment of tendinopathies is still difficult, but several options have been proposed, including the use of anti-inflammatory molecules. In this retrospective study, we aimed to assess the efficacy of a conservative approach in improving pain and functional improvement in hip bursitis (HB) and biceps tendinitis (BT) patients. Methods: A series of data concerning the application of Polynucleotides High Purification Technology (PN HPTTM) in 47 patients with BT and HB was analyzed. All patients received three bi-weekly injections of PN HPTTM (T0\u2013T2). Follow-up visits were performed at T3 (8 weeks from T2) and T4 (24 weeks from T2). Both the visual analog scale (VAS) for pain assessment and functional impairment (FI) scores were processed in the form of anonymized series for clinical improvement evaluations. Results: Statistically significant differences (p &lt; 0.001) in pain reduction (\u221285%) and functional improvement (+86%) were found at the end of treatment. The levels of patient satisfaction (PS) and Clinical Global Improvement\u2014Impression (CGI-I) were equal to 93% and 98%, respectively. According to the analyses, other patient data (e.g., gender, age, and BMI) did not appear to influence the positive treatment outcomes. Conclusions: The application of High Purification Technology (PN HPTTM) was shown to improve both pain and functional deterioration in patients with tendonitis in a similar manner to other conservative treatments. These retrospective analyses may open up new avenues for the implementation of conservative approaches in patients with tendinitis.<\/jats:p>","DOI":"10.3390\/jcm14051404","type":"journal-article","created":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T04:03:17Z","timestamp":1740024197000},"page":"1404","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Polynucleotides High Purification Technology (PN HPTTM) Injection Improves Pain Status and Functional Impairment in Hip and Shoulder Tendinitis"],"prefix":"10.3390","volume":"14","author":[{"given":"Paolo","family":"Gervaso","sequence":"first","affiliation":[{"name":"Orthopedics Section, Division of Pavia, Bioanalysis Mutlidisciplinary Medical Center, Via Rivo Brignolo, Codevilla, 27050 Pavia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimiliano","family":"Minale","sequence":"additional","affiliation":[{"name":"Independent Researcher, Via R. De Blasio, Marigliano, 80034 Napoli, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5028-2363","authenticated-orcid":false,"given":"Niccola","family":"Funel","sequence":"additional","affiliation":[{"name":"Section of Laboratory Analysis, Division of Immunohematology, Department of Laboratory Diagnostics, Azienda Ospedaliera USL Nordovest, Via Lippi Francesconi, 55100 Lucca, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,2,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1136\/bjsm.2006.029769","article-title":"Chronic Tendinopathy: Effectiveness of Eccentric Exercise","volume":"41","author":"Woodley","year":"2007","journal-title":"Br. J. 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