{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T12:21:17Z","timestamp":1790770877170,"version":"4.1.0"},"reference-count":95,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T00:00:00Z","timestamp":1740096000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Objective: This review article aims to analyze the existing relevant literature comparing the clinical outcomes and underlining the most common complications associated with immediate, early, and delayed dental implant placement in order to determine the most favorable timing for achieving optimal functional and esthetic results for the patient. Methods: A comprehensive review of the literature was conducted using PubMed-MEDLINE and Cochrane Library and a number of keywords, including \u201cdental implant placement timing\u201d, \u201cimmediate implant\u201d, \u201cearly implant\u201d, \u201cdelayed implant\u201d, \u201cclinical outcomes\u201d, \u201ccomplications\u201d, and \u201cimplant success\u201d, focusing on studies comparing immediate, early, and delayed implant placement. The primary outcome variable was implant survival rate, while secondary outcome variables included implant success rate, complications, and patient-reported outcomes. Results: A total of 9774 articles were identified. The articles included a variety of studies, including randomized controlled trials, prospective cohort studies, and retrospective studies. Immediate implant placement was associated with a high survival rate (93.8\u2013100%), but also with an increased risk of complications, such as gingival recession and implant exposure. Early implant placement (4\u20138 weeks or 12\u201316 weeks after extraction) showed similar survival rates (95\u2013100%) and fewer complications compared with immediate placement. Delayed implant placement (more than 4 months after extraction) was the most commonly used protocol and demonstrated high survival rates (92\u2013100%) with predictable outcomes. Implant success rates varied depending on the criteria used, but all types of placements showed acceptable success rates (83.3\u2013100%). The choice of loading protocol (immediate, early, or conventional) also influences treatment outcomes. Conclusions: The timing of dental implant placement and loading should be individualized based on patient-specific factors, such as bone and soft tissue conditions, medical history, esthetic considerations, and patient preferences. Immediate placement can be successful in ideal conditions but requires careful patient selection and surgical expertise. Early and delayed placement offer more predictable outcomes and are suitable for a wider range of patients.<\/jats:p>","DOI":"10.3390\/jcm14051442","type":"journal-article","created":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T06:39:07Z","timestamp":1740119947000},"page":"1442","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Optimizing Implant Placement Timing and Loading Protocols for Successful Functional and Esthetic Outcomes: A Narrative Literature Review"],"prefix":"10.3390","volume":"14","author":[{"given":"Panagiotis Rafail","family":"Peitsinis","sequence":"first","affiliation":[{"name":"Department of Periodontology, School of Dental Medicine, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aikaterini","family":"Blouchou","sequence":"additional","affiliation":[{"name":"Department of Periodontology, School of Dental Medicine, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgios S.","family":"Chatzopoulos","sequence":"additional","affiliation":[{"name":"Department of Periodontology, School of Dental Medicine, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9863-4949","authenticated-orcid":false,"given":"Ioannis D.","family":"Vouros","sequence":"additional","affiliation":[{"name":"Department of Periodontology, School of Dental Medicine, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,2,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/S0022-3913(83)80101-2","article-title":"Osseointegration and its experimental background","volume":"50","year":"1983","journal-title":"J. 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