{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T18:32:53Z","timestamp":1791484373845,"version":"4.3.4"},"reference-count":70,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2025,2,23]],"date-time":"2025-02-23T00:00:00Z","timestamp":1740268800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Tourette syndrome is a neurodevelopmental disorder characterized by multiple motor and vocal tics. Although Tourette syndrome is known to have various comorbidities, comprehensive data on its prevalence and associated conditions in a large, diverse population are limited. This study aimed to examine the prevalence of Tourette syndrome and its comorbidities in children aged 3 to 17 years using data from the 2021 National Survey of Children\u2019s Health (NSCH). Methods: Data from 79,236 children aged 3\u201317 years were analyzed. The prevalence of Tourette syndrome was assessed, and its association with socio-demographic factors and comorbid conditions, including prematurity and low birth weight, was examined using univariate and multivariate logistic regression models. Results: The prevalence of Tourette syndrome was 0.3% among children aged 3\u201317 years, with higher rates in males (74%) and adolescents aged 11\u201317 years (74%). Prematurity and low birth weight were associated with higher rates of Tourette syndrome and its comorbidities. Neurodevelopmental conditions such as ADHD (49% in Tourette syndrome vs. 10.2% in non-Tourette syndrome), autism spectrum disorder (21% vs. 3.2%), and learning disabilities were significantly more prevalent among children with Tourette syndrome. Similarly, psychiatric disorders such as anxiety (60% vs. 11.3%) and depression (25% vs. 5%) were more common in the Tourette syndrome group. Immune-based conditions, including asthma and allergies, and physical health conditions such as diabetes and vision or hearing problems, were also significantly associated with TS. Conclusions: The study highlights the significant burden of comorbidities in children with Tourette syndrome, emphasizing the need for early diagnosis and comprehensive management strategies to address the multifaceted challenges faced by these children.<\/jats:p>","DOI":"10.3390\/jcm14051485","type":"journal-article","created":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T05:36:47Z","timestamp":1740375407000},"page":"1485","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Unpacking Tourette Syndrome in Children: Insights into Prevalence and Comorbidities from NSCH Data"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6867-2394","authenticated-orcid":false,"given":"Sasidhar","family":"Gunturu","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Bronx Care Health System, Bronx, NY 10457, USA"},{"name":"Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahdieh","family":"Saeidi","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Bronx Care Health System, Bronx, NY 10457, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar","family":"Alzein","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Bronx Care Health System, Bronx, NY 10457, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamyar","family":"Jafari","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Bronx Care Health System, Bronx, NY 10457, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6055-2806","authenticated-orcid":false,"given":"Mona","family":"Salehi","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, School of Medicine, University of Minnesota, Minneapolis, MN 55455, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanobar","family":"Jaka","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences, Nassau University of Medical Center, East Meadow, NY 11554, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,2,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1001\/archneur.1996.00550060111024","article-title":"Gilles de la Tourette and the discovery of Tourette syndrome: Includes a translation of his 1884 article","volume":"53","author":"Lajonchere","year":"1996","journal-title":"Arch. 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