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Although the individual contribution of both of these factors is well documented, their combined effect has yet to be studied in a clinical population with GAD. The aim of the present study was to examine the relative contribution of intolerance of uncertainty and emotion dysregulation to the prediction of worry and GAD severity in adults with GAD. Methods: The sample consisted of 108 participants diagnosed with GAD. The participants completed measures of worry, GAD severity, depressive symptoms, intolerance of uncertainty, and emotion dysregulation. Results: Multiple regression indicated that both intolerance of uncertainty and emotion dysregulation significantly contributed to both worry and GAD severity, over and above the contribution of depressive symptoms. Of note, the model explained 36% of the variance in GAD severity scores. Conclusions: The present results provide preliminary evidence of complementarity among dominant models of GAD, and point to the potential role of integrative conceptualizations and treatment strategies for GAD.<\/jats:p>","DOI":"10.3390\/jcm14051502","type":"journal-article","created":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T05:36:47Z","timestamp":1740375407000},"page":"1502","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Intolerance of Uncertainty and Emotion Dysregulation as Predictors of Generalized Anxiety Disorder Severity in a Clinical Population"],"prefix":"10.3390","volume":"14","author":[{"given":"S\u00e9bastien","family":"Larochelle","sequence":"first","affiliation":[{"name":"D\u00e9partement de Psychologie et de Psycho\u00e9ducation, Universit\u00e9 du Qu\u00e9bec en Outaouais, Gatineau, QC J8X 3X7, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2615-1782","authenticated-orcid":false,"given":"Michel J.","family":"Dugas","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Psychologie et de Psycho\u00e9ducation, Universit\u00e9 du Qu\u00e9bec en Outaouais, Gatineau, QC J8X 3X7, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1421-9081","authenticated-orcid":false,"given":"Fr\u00e9d\u00e9ric","family":"Langlois","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Psychologie, Universit\u00e9 du Qu\u00e9bec \u00e0 Trois-Rivi\u00e8res, Trois-Rivi\u00e8res, QC G8Z 4M3, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Gosselin","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Psychologie, Universit\u00e9 de Sherbrooke, Sherbrooke, QC J1K 2R1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4995-3836","authenticated-orcid":false,"given":"Genevi\u00e8ve","family":"Belleville","sequence":"additional","affiliation":[{"name":"\u00c9cole de Psychologie, Universit\u00e9 Laval, Qu\u00e9bec, QC G1V 0A6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5995-340X","authenticated-orcid":false,"given":"St\u00e9phane","family":"Bouchard","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Psychologie et de Psycho\u00e9ducation, Universit\u00e9 du Qu\u00e9bec en Outaouais, Gatineau, QC J8X 3X7, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,2,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.4088\/JCP.09m05328gry","article-title":"Comorbidity of generalized anxiety disorder and substance use disorders: Results from the National Epidemiologic Survey on Alcohol and Related Conditions","volume":"71","author":"Alegria","year":"2010","journal-title":"J. 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