{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T02:59:55Z","timestamp":1770519595581,"version":"3.49.0"},"reference-count":27,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T00:00:00Z","timestamp":1740528000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background\/Objective: Condyloma acuminatum, also known as genital warts, results from infections of the basal epithelium or mucous membranes by human papillomavirus (HPV). These lesions can significantly impact patients\u2019 quality of life. Recent advances in laser technology, particularly ablative lasers such as CO2 and Erbium\u2013YAG (Er:YAG), have introduced new treatment opportunities. The Er:YAG laser has gained recognition as a safe and effective treatment for viral warts. This study aimed to evaluate the efficacy of Er:YAG laser treatment of male genital warts and to identify risk factors that might influence its effectiveness. Methods: A retrospective chart review of 102 patients who underwent Er:YAG laser wart removal between January 2019 and April 2024 was conducted. Results: Of the 102 patients, 61 (60%) achieved complete response by the 12-month follow-up visit. The response rates were significantly lower when there was a high number of sessions required for complete response, long duration between wart onset and laser treatment, high number of warts treated, positive smoking status, concurrent immunosuppressed state, or active metabolic disease. Conclusions: The Er:YAG laser is an effective method for treating recalcitrant warts. Various factors were shown to influence its efficacy.<\/jats:p>","DOI":"10.3390\/jcm14051575","type":"journal-article","created":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T08:28:31Z","timestamp":1740558511000},"page":"1575","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Role of Erbium\u2013YAG in Treating Male Genital Warts"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8045-0682","authenticated-orcid":false,"given":"Badea","family":"Jiryis","sequence":"first","affiliation":[{"name":"Department of Dermatology, Rambam Health Care Campus, Haifa 3109601, Israel"},{"name":"Bruce Rappaport Faculty of Medicine, Technion Institute of Technology, Haifa 3200003, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khozayma","family":"Khamaysi","sequence":"additional","affiliation":[{"name":"The Azrieli Faculty of Medicine, Bar-Ilan University, Safed 1311502, Israel"},{"name":"Clalit Medical Services, 101 Arlozorov, Tel Aviv-Yafo 6209804, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2154-7609","authenticated-orcid":false,"given":"Emily","family":"Avitan-Hersh","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Rambam Health Care Campus, Haifa 3109601, Israel"},{"name":"Bruce Rappaport Faculty of Medicine, Technion Institute of Technology, Haifa 3200003, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5154-7984","authenticated-orcid":false,"given":"Jonathan","family":"Shapiro","sequence":"additional","affiliation":[{"name":"Maccabi Healthcare Services, Tel Aviv-Yafo 6816330, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marwan","family":"Dawood","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Rambam Health Care Campus, Haifa 3109601, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Majd","family":"Shehadeh","sequence":"additional","affiliation":[{"name":"Bruce Rappaport Faculty of Medicine, Technion Institute of Technology, Haifa 3200003, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9586-2807","authenticated-orcid":false,"given":"Ziad","family":"Khamaysi","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Rambam Health Care Campus, Haifa 3109601, Israel"},{"name":"Bruce Rappaport Faculty of Medicine, Technion Institute of Technology, Haifa 3200003, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,2,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e13750","DOI":"10.1111\/dth.13750","article-title":"LASER safety measures for the treatment of genital warts in HIV+ patients during the COVID-19 pandemic","volume":"33","author":"Cameli","year":"2020","journal-title":"Dermatol. 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