{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:50:56Z","timestamp":1787028656081,"version":"build-2736575974"},"reference-count":15,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T00:00:00Z","timestamp":1740528000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Severe hypothermia is a medical emergency that can be fatal if not promptly and effectively managed. Background: This case report examines a patient with severe hypothermia and describes the advanced approaches utilized in treatment, highlighting the challenges encountered and the clinical decisions that led to a favorable outcome. Methods: We report a case of an approximately 60-year-old adult, who was found unconscious in low-temperature conditions, presenting with bradycardia and a measured core temperature of 25 \u00b0C. Results: Medical intervention included active internal rewarming and the use of a controlled intravascular active heating system to support vital functions. Conclusions: This case underscores the importance of a multidisciplinary approach and the advantages of utilizing modern technologies in the management of severe hypothermia for selected cases.<\/jats:p>","DOI":"10.3390\/jcm14051584","type":"journal-article","created":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T11:22:12Z","timestamp":1740568932000},"page":"1584","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Management of Severe Hypothermia: Challenges and Advanced Strategies"],"prefix":"10.3390","volume":"14","author":[{"given":"Bogdan","family":"Oprita","sequence":"first","affiliation":[{"name":"Faculty of Medicine, University of Medicine and Pharmacy \u201cCarol Davila\u201d, 4192910 Bucharest, Romania"},{"name":"Emergency Department, Clinical Emergency Hospital of Bucharest, 050463 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ionut","family":"Olaru","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Medicine and Pharmacy \u201cCarol Davila\u201d, 4192910 Bucharest, Romania"},{"name":"Emergency Department, Clinical Emergency Hospital of Bucharest, 050463 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liviu","family":"Botezatu","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Medicine and Pharmacy \u201cCarol Davila\u201d, 4192910 Bucharest, Romania"},{"name":"Emergency Department, Clinical Emergency Hospital of Bucharest, 050463 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice Elena","family":"Diaconu","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Medicine and Pharmacy \u201cCarol Davila\u201d, 4192910 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruxandra","family":"Oprita","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Medicine and Pharmacy \u201cCarol Davila\u201d, 4192910 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,2,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Savioli, G., Ceresa, I.F., Bavestrello Piccini, G., Gri, N., Nardone, A., La Russa, R., Saviano, A., Piccioni, A., Ricevuti, G., and Esposito, C. (2023). Hypothermia: Beyond the Narrative Review\u2014The point of view of emergency physicians and medico-legal considerations. J. Pers. Med., 13.","DOI":"10.3390\/jpm13121690"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1053\/ajem.2002.32633","article-title":"Electrocardiographic manifestations of hypothermia","volume":"20","author":"Mattu","year":"2002","journal-title":"Am. J. Emerg. Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.resuscitation.2019.10.035","article-title":"Systematic review and meta-analysis of intravascular temperature management vs. surface cooling in comatose patients resuscitated from cardiac arrest","volume":"146","author":"Bartlett","year":"2019","journal-title":"Resuscitation"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.resuscitation.2021.02.038","article-title":"Clinical staging of accidental hypothermia: The Revised Swiss System","volume":"162","author":"Musi","year":"2021","journal-title":"Resuscitation"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"e046806","DOI":"10.1136\/bmjopen-2020-046806","article-title":"Accidental hypothermia in Denmark: A nationwide cohort study of incidence and outcome","volume":"11","author":"Wiberg","year":"2021","journal-title":"BMJ Open"},{"key":"ref_6","unstructured":"PMC (2024, November 18). Management of Hypothermia in Emergency Medicine, Available online: https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10745126\/."},{"key":"ref_7","unstructured":"HMP Global Learning Network (2024, November 18). Intravascular Temperature Management (IVTM) Techniques for Therapeutic Hypothermia. Available online: https:\/\/www.hmpgloballearningnetwork.com\/site\/eplab\/articles\/intravascular-temperature-management-ivtm-techniques-therapeutic-hypothermia."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1080\/08998280.2008.11928375","article-title":"Active intravascular rewarming for hypothermia associated with traumatic injury: Early experience with a new technique","volume":"21","author":"Taylor","year":"2008","journal-title":"Bayl. Univ. Med. Cent. Proc."},{"key":"ref_9","unstructured":"ZOLL Medical Corporation (2024, November 18). Thermogard XP. Available online: https:\/\/pdf.medicalexpo.com\/pdf\/zoll-medical-corporation\/thermogard-xp\/70628-158966.html."},{"key":"ref_10","first-page":"42","article-title":"Intravascular temperature management techniques for therapeutic hypothermia in emergency settings","volume":"28","author":"Holmberg","year":"2020","journal-title":"Scand. J. Trauma Resusc. Emerg. Med."},{"key":"ref_11","unstructured":"Mayo Clinic Staff (2024, December 01). Hypothermia. Mayo Clinic., Available online: https:\/\/www.mayoclinic.org\/diseases-conditions\/hypothermia\/symptoms-causes\/syc-20352682."},{"key":"ref_12","first-page":"4221","article-title":"Recent advances in clinical hypothermia applications","volume":"13","author":"Zhang","year":"2023","journal-title":"J. Clin. Med."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1007\/s41669-021-00272-9","article-title":"Hospital Costs of Extracorporeal Membrane Oxygenation in Adults: A systematic Review","volume":"5","author":"Vermeulen","year":"2021","journal-title":"Pharmacoecon. Open"},{"key":"ref_14","unstructured":"NICE (2024, December 01). Thermogard XP for Therapeutic Hypothermia After Cardiac Arrest. Available online: https:\/\/www.nice.org.uk\/advice\/mib37\/resources\/thermogard-xp-for-therapeutic-hypothermia-after-cardiac-arrest-63499110633925."},{"key":"ref_15","unstructured":"AAFP (2019). Treatment and management of hypothermia in family medicine. Am. Fam. Physician, 100, 680\u2013685."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/5\/1584\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T16:43:20Z","timestamp":1760028200000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/5\/1584"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,26]]},"references-count":15,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2025,3]]}},"alternative-id":["jcm14051584"],"URL":"https:\/\/doi.org\/10.3390\/jcm14051584","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,26]]}}}