{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T20:01:39Z","timestamp":1789070499615,"version":"build-2803163510"},"reference-count":84,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2025,2,27]],"date-time":"2025-02-27T00:00:00Z","timestamp":1740614400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Cardiac sarcoidosis (CS) and inherited cardiomyopathies (inherited CM) are associated with advanced heart failure, cardiac conduction defects, ventricular arrhythmias and sudden cardiac death. Both conditions can have similar clinical presentations. Differentiating between the two disease cohorts is important in delivering specific management to patients, such as immunosuppressive therapy for CS patients and genetic screening for inherited CM. In this review, we examined the existing evidence on the overlap between CS and common inherited CM, such as hypertrophic cardiomyopathy, arrhythmogenic cardiomyopathy, restrictive cardiomyopathy and dilated cardiomyopathy. In patients where both CS and inherited CM were implicated, CS tended to be diagnosed much later, often when patients presented with complications warranting a workup or cardiac histological confirmation. CS can masquerade as an inherited CM, leading to delays in the instigation of CS therapy. Confirmed dual pathology overlap between inherited CM and CS is rarer. Advanced cardiac imaging, such as cardiovascular magnetic resonance, plays an important role in the clinical workup of both CS and inherited CM. However, findings on cardiac imaging alone often cannot differentiate between the two conditions. Definitive differentiation between CS and inherited CM requires both clinical experience and, at times, a myocardial biopsy.<\/jats:p>","DOI":"10.3390\/jcm14051609","type":"journal-article","created":{"date-parts":[[2025,2,27]],"date-time":"2025-02-27T05:13:58Z","timestamp":1740633238000},"page":"1609","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Cardiac Sarcoidosis and Inherited Cardiomyopathies: Clinical Masquerade or Overlap?"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-0833-2127","authenticated-orcid":false,"given":"Sami","family":"Fouda","sequence":"first","affiliation":[{"name":"West Middlesex Hospital, London TW7 6AF, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Godfrey","sequence":"additional","affiliation":[{"name":"Sussex Cardiac Centre, Royal Sussex County Hospital, Brighton BN2 5BE, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Pavitt","sequence":"additional","affiliation":[{"name":"Sussex Cardiac Centre, Royal Sussex County Hospital, Brighton BN2 5BE, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2930-3219","authenticated-orcid":false,"given":"Thomas","family":"Alway","sequence":"additional","affiliation":[{"name":"Sussex Cardiac Centre, Royal Sussex County Hospital, Brighton BN2 5BE, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6512-0490","authenticated-orcid":false,"given":"Steven","family":"Coombs","sequence":"additional","affiliation":[{"name":"Sussex Cardiac Centre, Royal Sussex County Hospital, Brighton BN2 5BE, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan M.","family":"Ellery","sequence":"additional","affiliation":[{"name":"Sussex Cardiac Centre, Royal Sussex County Hospital, Brighton BN2 5BE, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Parish","sequence":"additional","affiliation":[{"name":"Sussex Cardiac Centre, Royal Sussex County Hospital, Brighton BN2 5BE, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Silberbauer","sequence":"additional","affiliation":[{"name":"Sussex Cardiac Centre, Royal Sussex County Hospital, Brighton BN2 5BE, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-4086-1886","authenticated-orcid":false,"given":"Alexander","family":"Liu","sequence":"additional","affiliation":[{"name":"Sussex Cardiac Centre, Royal Sussex County Hospital, Brighton BN2 5BE, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,2,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2697","DOI":"10.1093\/eurheartj\/ehae356","article-title":"Management of cardiac sarcoidosis","volume":"45","author":"Sharma","year":"2024","journal-title":"Eur. Heart J."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1136\/heartjnl-2019-316442","article-title":"Cardiac sarcoidosis: State-of-the-art review","volume":"107","author":"Kouranos","year":"2021","journal-title":"Heart"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1016\/j.hrthm.2014.03.043","article-title":"HRS Expert Consensus Statement on the Diagnosis and Management of Arrhythmias Associated with Cardiac Sarcoidosis","volume":"11","author":"Birnie","year":"2014","journal-title":"Heart Rhythm."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2329","DOI":"10.1253\/circj.CJ-19-0508","article-title":"JCS 2016 Guideline on Diagnosis and Treatment of Cardiac Sarcoidosis\u2014Digest Version","volume":"83","author":"Terasaki","year":"2019","journal-title":"Circ. J."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"3503","DOI":"10.1093\/eurheartj\/ehad194","article-title":"2023 ESC Guidelines for the management of cardiomyopathies","volume":"44","author":"Arbelo","year":"2023","journal-title":"Eur. Heart J."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1093\/bmb\/ldae003","article-title":"The development of inherited cardiac conditions services: Current position and future perspectives","volume":"150","author":"Alway","year":"2024","journal-title":"Br. Med. Bull."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Mariani, M.V., Pierucci, N., Fanisio, F., Laviola, D., Silvetti, G., Piro, A., La Fazia, V.M., Chimenti, C., Rebecchi, M., and Drago, F. (2024). Inherited Arrhythmias in the Pediatric Population: An Updated Overview. Medicina, 60.","DOI":"10.3390\/medicina60010094"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Ebbinghaus, H., Ueberham, L., Husser-Bollmann, D., Bollmann, A., Paetsch, I., Jahnke, C., Laufs, U., and Dinov, B. (2023). Case Report: Four cases of cardiac sarcoidosis in patients with inherited cardiomyopathy\u2014A phenotypic overlap, co-existence of two rare cardiomyopathies or a second-hit disease. Front. Cardiovasc. Med., 10.","DOI":"10.3389\/fcvm.2023.1328802"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1536\/ihj.20-552","article-title":"Hypertrophic Cardiomyopathy Complicated by Cardiac Sarcoidosis Diagnosed by Both the Morphological Abnormalities and the Time Course of the Disease","volume":"62","author":"Miki","year":"2021","journal-title":"Int. Heart J."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"e57","DOI":"10.1093\/ehjci\/jead240","article-title":"Biopsy-proven cardiac sarcoidosis mimicking apical hypertrophic cardiomyopathy","volume":"25","author":"Kawakami","year":"2023","journal-title":"Eur. Heart J. Cardiovasc. Imaging"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2060","DOI":"10.1016\/j.jaccas.2020.07.034","article-title":"Cardiac Sarcoidosis Mimicking Hypertrophic Cardiomyopathy","volume":"2","author":"Feldman","year":"2020","journal-title":"JACC Case Rep."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1093\/ehjci\/jey170","article-title":"A 30-day drastic thinning of the basal interventricular septum in isolated cardiac sarcoidosis masquerading as a hypertrophic cardiomyopathy","volume":"20","author":"Saitou","year":"2019","journal-title":"Eur. Heart J. Cardiovasc. Imaging"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"ytab208","DOI":"10.1093\/ehjcr\/ytab208","article-title":"Case report of isolated cardiac sarcoidosis presenting as hypertrophic obstructive cardiomyopathy\u2014A clinical picture printed on lenticular paper","volume":"5","author":"Mathias","year":"2021","journal-title":"Eur. Heart J. Case Rep."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"E138","DOI":"10.1111\/echo.12536","article-title":"Cardiac Sarcoid: A Chameleon Masquerading as Hypertrophic Cardiomyopathy and Dilated Cardiomyopathy in the Same Patient","volume":"31","author":"Agarwal","year":"2014","journal-title":"Echocardiography"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"107234","DOI":"10.1016\/j.carpath.2020.107234","article-title":"Hypertrophic cardiomyopathy masquerading as sarcoidosis: Cases illustrating cardiac imaging overlap relative to pathology","volume":"49","author":"Sellers","year":"2020","journal-title":"Cardiovasc. Pathol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"2377","DOI":"10.1093\/eurheartj\/ehx132","article-title":"Cardiac sarcoidosis presenting as hypertrophic cardiomyopathy","volume":"38","author":"Haley","year":"2017","journal-title":"Eur. Heart J."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1016\/j.jaccas.2021.04.017","article-title":"Cardiac Sarcoidosis With Prominent Epsilon Waves","volume":"3","author":"Omotoye","year":"2021","journal-title":"JACC Case Rep."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1007\/s00259-007-0650-8","article-title":"Myocardial imaging with 18F-fluoro-2-deoxyglucose positron emission tomography and magnetic resonance imaging in sarcoidosis","volume":"35","author":"Ohira","year":"2008","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1093\/ehjci\/jex340","article-title":"Diagnostic accuracy and prognostic value of simultaneous hybrid 18F-fluorodeoxyglucose positron emission tomography\/magnetic resonance imaging in cardiac sarcoidosis","volume":"19","author":"Wicks","year":"2018","journal-title":"Eur. Heart J. Cardiovasc. Imaging"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1007\/s00259-020-05066-5","article-title":"Procedural recommendations of cardiac PET\/CT imaging: Standardization in inflammatory-, infective-, infiltrative-, and innervation (4Is)-related cardiovascular diseases: A joint collaboration of the EACVI and the EANM","volume":"48","author":"Slart","year":"2021","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"e000867","DOI":"10.1161\/CIRCIMAGING.113.000867","article-title":"Evaluation of Known or Suspected Cardiac Sarcoidosis","volume":"9","author":"Blankstein","year":"2016","journal-title":"Circ. Cardiovasc. Imaging"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1378\/chest.109.1.62","article-title":"Doppler Echocardiographic Detection of Left Ventricular Diastolic Dysfunction in Patients with Pulmonary Sarcoidosis","volume":"109","author":"Fahy","year":"1996","journal-title":"Chest"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"3601","DOI":"10.1002\/ehf2.12854","article-title":"Atrial fibrillation, anticoagulation management and risk of stroke in the Cardiomyopathy\/Myocarditis registry of the EURObservational Research Programme of the European Society of Cardiology","volume":"7","author":"Caforio","year":"2020","journal-title":"ESC Heart Fail."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1093\/ehjqcco\/qcaa075","article-title":"Prospective follow-up in various subtypes of cardiomyopathies: Insights from the ESC EORP Cardiomyopathy Registry","volume":"7","author":"Gimeno","year":"2021","journal-title":"Eur. Heart J. Qual. Care Clin. Outcomes"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"e006174","DOI":"10.1161\/CIRCIMAGING.117.006174","article-title":"Prevalence and Prognostic Significance of Left Ventricular Noncompaction in Patients Referred for Cardiac Magnetic Resonance Imaging","volume":"10","author":"Ivanov","year":"2017","journal-title":"Circ. Cardiovasc. Imaging"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1093\/ehjci\/jew229","article-title":"Comprehensive multi-modality imaging approach in arrhythmogenic cardiomyopathy\u2014An expert consensus document of the European Association of Cardiovascular Imaging","volume":"18","author":"Haugaa","year":"2017","journal-title":"Eur. Heart J. Cardiovasc. Imaging"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1093\/ehjci\/jet123","article-title":"Expert consensus for multi-modality imaging evaluation of cardiovascular complications of radiotherapy in adults: A report from the European Association of Cardiovascular Imaging and the American Society of Echocardiography","volume":"14","author":"Lancellotti","year":"2013","journal-title":"Eur. Heart J. Cardiovasc. Imaging"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"2715","DOI":"10.1093\/eurheartj\/ehq271","article-title":"Genetic counselling and testing in cardiomyopathies: A position statement of the European Society of Cardiology Working Group on Myocardial and Pericardial Diseases","volume":"31","author":"Charron","year":"2010","journal-title":"Eur. Heart J."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/s12968-021-00827-z","article-title":"Society for Cardiovascular Magnetic Resonance (SCMR) guidelines for reporting cardiovascular magnetic resonance examinations","volume":"24","author":"Hundley","year":"2022","journal-title":"J. Cardiovasc. Magn. Reson."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1161\/CIRCULATIONAHA.114.011522","article-title":"Cardiac Sarcoidosis","volume":"131","author":"Kandolin","year":"2015","journal-title":"Circulation"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1093\/eurheartj\/ehad067","article-title":"Cardiac sarcoidosis: Phenotypes, diagnosis, treatment, and prognosis","volume":"44","author":"Lehtonen","year":"2023","journal-title":"Eur. Heart J."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"2287","DOI":"10.1002\/ejhf.3057","article-title":"Predictors of outcome in a contemporary cardiac sarcoidosis population: Role of brain natriuretic peptide, left ventricular function and myocardial inflammation","volume":"25","author":"Kouranos","year":"2023","journal-title":"Eur. J. Heart Fail."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"e26","DOI":"10.1164\/rccm.202002-0251ST","article-title":"Diagnosis and Detection of Sarcoidosis. An Official American Thoracic Society Clinical Practice Guideline","volume":"201","author":"Crouser","year":"2020","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_34","first-page":"907","article-title":"\u2018Hot phase\u2019 clinical presentation in arrhythmogenic cardiomyopathy","volume":"23","author":"Bariani","year":"2021","journal-title":"EP Eur."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Licordari, R., Trimarchi, G., Teresi, L., Restelli, D., Lofrumento, F., Perna, A., Campisi, M., de Gregorio, C., Grimaldi, P., and Calabr\u00f2, D. (2023). Cardiac Magnetic Resonance in HCM Phenocopies: From Diagnosis to Risk Stratification and Therapeutic Management. J. Clin. Med., 12.","DOI":"10.3390\/jcm12103481"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1093\/ehjci\/jex146","article-title":"A joint procedural position statement on imaging in cardiac sarcoidosis: From the Cardiovascular and Inflammation & Infection Committees of the European Association of Nuclear Medicine, the European Association of Cardiovascular Imaging, and the American Society of Nuclear Cardiology","volume":"18","author":"Slart","year":"2017","journal-title":"Eur. Heart J. Cardiovasc. Imaging"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1007\/s12350-013-9828-6","article-title":"Reduction in 18F-fluorodeoxyglucose uptake on serial cardiac positron emission tomography is associated with improved left ventricular ejection fraction in patients with cardiac sarcoidosis","volume":"21","author":"Osborne","year":"2014","journal-title":"J. Nucl. Cardiol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1007\/s10741-017-9628-1","article-title":"Role of PET to evaluate coronary microvascular dysfunction in non-ischemic cardiomyopathies","volume":"22","author":"Bravo","year":"2017","journal-title":"Heart Fail. Rev."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.2967\/jnumed.117.196287","article-title":"Joint SNMMI\u2013ASNC Expert Consensus Document on the Role of 18F-FDG PET\/CT in Cardiac Sarcoid Detection and Therapy Monitoring","volume":"58","author":"Chareonthaitawee","year":"2017","journal-title":"J. Nucl. Med."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"241","DOI":"10.2967\/jnumed.111.090662","article-title":"The Use of 18F-FDG PET in the Diagnosis of Cardiac Sarcoidosis: A Systematic Review and Metaanalysis Including the Ontario Experience","volume":"53","author":"Youssef","year":"2012","journal-title":"J. Nucl. Med."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"2064","DOI":"10.1007\/s12350-017-1057-y","article-title":"ASNC imaging guidelines for nuclear cardiology procedures","volume":"24","author":"Tilkemeier","year":"2017","journal-title":"J. Nucl. Cardiol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"3415","DOI":"10.1093\/eurheartj\/ehae177","article-title":"2024 ESC Guidelines for the management of chronic coronary syndromes","volume":"45","author":"Vrints","year":"2024","journal-title":"Eur. Heart J."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1016\/j.amjcard.2015.01.562","article-title":"Comparison of Outcomes in Patients with Probable Versus Definite Cardiac Sarcoidosis","volume":"115","author":"Takaya","year":"2015","journal-title":"Am. J. Cardiol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.ahj.2004.10.006","article-title":"A positive endomyocardial biopsy result for sarcoid is associated with poor prognosis in patients with initially unexplained cardiomyopathy","volume":"150","author":"Ardehali","year":"2005","journal-title":"Am. Heart J."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1038\/s41569-020-00435-x","article-title":"Myocarditis and inflammatory cardiomyopathy: Current evidence and future directions","volume":"18","author":"Ammirati","year":"2021","journal-title":"Nat. Rev. Cardiol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1111\/j.1365-2796.2011.02396.x","article-title":"Diagnosing isolated cardiac sarcoidosis","volume":"270","author":"Kandolin","year":"2011","journal-title":"J. Intern. Med."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1046\/j.1460-9592.2003.t01-1-00217.x","article-title":"Cardiac Sarcoidosis Masquerading as Right Ventricular Dysplasia","volume":"26","author":"Ott","year":"2003","journal-title":"Pacing Clin. Electrophysiol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"53","DOI":"10.4322\/acr.2015.030","article-title":"Cardiac sarcoidosis with severe involvement of the right ventricle: A case report","volume":"5","author":"Siqueira","year":"2015","journal-title":"Autops. Case Rep."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1161\/01.CIR.60.3.685","article-title":"Quantitative analysis of cardiac muscle cell disorganization in the ventricular septum. Comparison of fetuses and infants with and without congenital heart disease and patients with hypertrophic cardiomyopathy","volume":"60","author":"Maron","year":"1979","journal-title":"Circulation"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.jmoldx.2012.09.002","article-title":"Inherited Cardiomyopathies","volume":"15","author":"Teekakirikul","year":"2013","journal-title":"J. Mol. Diagn."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1086\/321978","article-title":"Many Roads Lead to a Broken Heart: The Genetics of Dilated Cardiomyopathy","volume":"69","author":"Seidman","year":"2001","journal-title":"Am. J. Hum. Genet."},{"key":"ref_52","first-page":"e015807","article-title":"New Method CMR-Guided Endomyocardial Biopsy in Suspicion Context of Isolated Cardiac Sarcoidosis","volume":"17","author":"Lecesne","year":"2024","journal-title":"Circ. Cardiovasc. Imaging"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/978-3-030-27371-2_2","article-title":"The Genetic Landscape of Cardiomyopathies","volume":"7","author":"Gerull","year":"2019","journal-title":"Genet. Causes Card. Dis."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Brodehl, A., and Gerull, B. (2022). Genetic Insights into Primary Restrictive Cardiomyopathy. J. Clin. Med., 11.","DOI":"10.20944\/preprints202203.0265.v1"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1038\/s41436-018-0039-z","article-title":"Genetic evaluation of cardiomyopathy: A clinical practice resource of the American College of Medical Genetics and Genomics (ACMG)","volume":"20","author":"Hershberger","year":"2018","journal-title":"Genet. Med."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/gim.2015.30","article-title":"Standards and guidelines for the interpretation of sequence variants: A joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology","volume":"17","author":"Richards","year":"2015","journal-title":"Genet. Med."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1161\/CIRCRESAHA.121.320449","article-title":"Transcriptional and Immune Landscape of Cardiac Sarcoidosis","volume":"131","author":"Liu","year":"2022","journal-title":"Circ. Res."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Vriz, O., AlSergani, H., Elshaer, A.N., Shaik, A., Mushtaq, A.H., Lioncino, M., Alamro, B., Monda, E., Caiazza, M., and Mauro, C. (2021). A complex unit for a complex disease: The HCM-Family Unit. Monaldi Arch. Chest Dis., 92.","DOI":"10.4081\/monaldi.2021.2147"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1007\/s00428-017-2221-0","article-title":"Guidelines for autopsy investigation of sudden cardiac death: 2017 update from the Association for European Cardiovascular Pathology","volume":"471","author":"Basso","year":"2017","journal-title":"Virchows Arch."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1038\/s41431-019-0445-y","article-title":"European recommendations integrating genetic testing into multidisciplinary management of sudden cardiac death","volume":"27","author":"Fellmann","year":"2019","journal-title":"Eur. J. Hum. Genet."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s11897-024-00688-4","article-title":"Artificial Intelligence Advancements in Cardiomyopathies: Implications for Diagnosis and Management of Arrhythmogenic Cardiomyopathy","volume":"22","author":"Salavati","year":"2025","journal-title":"Curr. Heart Fail. Rep."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1093\/ehjdh\/ztad078","article-title":"Artificial intelligence-enhanced electrocardiogram for arrhythmogenic right ventricular cardiomyopathy detection","volume":"5","author":"Haq","year":"2024","journal-title":"Eur. Heart J. Digit. Health"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1038\/s41591-024-02971-2","article-title":"Screening and diagnosis of cardiovascular disease using artificial intelligence-enabled cardiac magnetic resonance imaging","volume":"30","author":"Wang","year":"2024","journal-title":"Nat. Med."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"e256579","DOI":"10.1136\/bcr-2023-256579","article-title":"Great mimicker: Definite isolated cardiac sarcoidosis masquerading as hypertrophic cardiomyopathy","volume":"16","author":"Pham","year":"2023","journal-title":"BMJ Case Rep."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"e161","DOI":"10.1016\/j.jccase.2009.12.004","article-title":"A case of cardiac sarcoidosis masquerading as arrhythmogenic right ventricular cardiomyopathy awaiting heart transplant","volume":"1","author":"Hisaoka","year":"2010","journal-title":"J. Cardiol. Cases"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"835","DOI":"10.2169\/internalmedicine.9395-17","article-title":"Isolated Cardiac Sarcoidosis Mimicking Arrhythmogenic Right Ventricular Cardiomyopathy","volume":"57","author":"Waki","year":"2018","journal-title":"Intern. Med."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.hlc.2011.08.015","article-title":"Cardiac sarcoidosis masquerading as arrhythmogenic right ventricular cardiomyopathy","volume":"21","author":"Chia","year":"2012","journal-title":"Heart Lung Circ."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1161\/CIRCEP.113.000932","article-title":"Arrhythmogenic Right Ventricular Dysplasia\/Cardiomyopathy and Cardiac Sarcoidosis","volume":"7","author":"Philips","year":"2014","journal-title":"Circ. Arrhythm. Electrophysiol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.hrcr.2017.10.018","article-title":"A 16-year odyssey of cardiac sarcoid masquerading as idiopathic premature ventricular contractions and then arrhythmogenic cardiomyopathy","volume":"4","author":"Nakamura","year":"2018","journal-title":"HeartRhythm Case Rep."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1136\/heartjnl-2020-316944","article-title":"Arrhythmogenic left ventricular cardiomyopathy","volume":"108","author":"Corrado","year":"2022","journal-title":"Heart"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1111\/j.1540-8167.2008.01351.x","article-title":"Prospective Study of Cardiac Sarcoid Mimicking Arrhythmogenic Right Ventricular Dysplasia","volume":"20","author":"Vasaiwala","year":"2009","journal-title":"J. Cardiovasc. Electrophysiol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1111\/j.1540-8167.2009.01479.x","article-title":"Sarcoid Myocarditis with Ventricular Tachycardia Mimicking ARVD\/C","volume":"21","author":"Ladyjanskaia","year":"2010","journal-title":"J. Cardiovasc. Electrophysiol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.hlc.2011.08.013","article-title":"Cardiac Sarcoidosis Mimicking Arrhythmogenic Right Ventricular Dysplasia with High Defibrillation Threshold Requiring Subcutaneous Shocking Coil Implantation","volume":"21","author":"Mohsen","year":"2012","journal-title":"Heart Lung Circ."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"jnmt.124.268142","DOI":"10.2967\/jnmt.124.268142","article-title":"Assessment of Cardiac Sarcoidosis with PET\/CT","volume":"52","author":"Liu","year":"2025","journal-title":"J. Nucl. Med. Technol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"102577","DOI":"10.1016\/j.cpcardiol.2024.102577","article-title":"Comparing outcomes of an \u2018early\u2019 versus \u2018late\u2019 diagnosis of cardiac sarcoidosis following a baseline presentation of high-grade atrioventricular block","volume":"49","author":"Ahmed","year":"2024","journal-title":"Curr. Probl. Cardiol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1002\/ehf2.15113","article-title":"Outcomes of cardiac resynchronization therapy (CRT) in cardiac sarcoidosis patients with a range of ejection fractions","volume":"12","author":"Liu","year":"2025","journal-title":"ESC Heart Fail."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"102892","DOI":"10.1016\/j.cpcardiol.2024.102892","article-title":"Ascertaining the prognostic role of cardiac resynchronisation therapy in cardiac sarcoidosis: A comparison with ischaemic cardiomyopathy","volume":"50","author":"Dulay","year":"2025","journal-title":"Curr. Probl. Cardiol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1161\/CIRCULATIONAHA.121.055890","article-title":"Inflammation and Immune Response in Arrhythmogenic Cardiomyopathy: State-of-the-Art Review","volume":"144","author":"Asatryan","year":"2021","journal-title":"Circulation"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/j.jacep.2020.02.008","article-title":"Electroanatomical Voltage Mapping to Distinguish Right-Sided Cardiac Sarcoidosis from Arrhythmogenic Right Ventricular Cardiomyopathy","volume":"6","author":"Hoogendoorn","year":"2020","journal-title":"JACC Clin. Electrophysiol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1016\/j.hrthm.2021.04.032","article-title":"The precordial R\u2032 wave: A novel discriminator between cardiac sarcoidosis and arrhythmogenic right ventricular cardiomyopathy in patients presenting with ventricular tachycardia","volume":"18","author":"Hoogendoorn","year":"2021","journal-title":"Heart Rhythm."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1161\/CIRCEP.114.002145","article-title":"Ventricular Tachycardia in Cardiac Sarcoidosis","volume":"8","author":"Kumar","year":"2015","journal-title":"Circ. Arrhythm. Electrophysiol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1016\/j.hrcr.2020.06.028","article-title":"High-dose intravenous glucocorticoids are effective in the acute management of ventricular arrhythmias in cardiac sarcoidosis: A case series","volume":"6","author":"Slivnick","year":"2020","journal-title":"HeartRhythm Case Rep."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.hroo.2021.07.005","article-title":"Management of ventricular tachycardia in patients with cardiac sarcoidosis","volume":"2","author":"Viwe","year":"2021","journal-title":"Heart Rhythm O2"},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Kantor, A., McClements, M., and MacLaren, R. (2020). CRISPR-Cas9 DNA Base-Editing and Prime-Editing. Int. J. Mol. 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