{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T00:59:34Z","timestamp":1760057974393,"version":"build-2065373602"},"reference-count":33,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T00:00:00Z","timestamp":1740960000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Gaziantep University Scientific Research Projects Unit","award":["TF.ALT.19.11."],"award-info":[{"award-number":["TF.ALT.19.11."]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Hashimoto\u2019s thyroiditis (HT), which is an autoimmune condition and the primary cause of hypothyroidism, has numerous impacts on the cardiovascular system. This research aimed to compare TIMP-1 levels and LV strain values in euthyroid HT, hypothyroid HT, and healthy control persons. Materials and Methods: This study included 40 hypothyroid HT patients, 42 HT patients who became euthyroid with thyroid hormone replacement therapy, and 40 healthy controls. All subjects had conventional echocardiography and STE. Global and segmental LV longitudinal strain values (LVGLS) were calculated. Participants\u2019 blood was tested for TIMP-1, thyroid function, and anti-TPO. Results: Higher serum TIMP-1 levels were found in euthyroid and hypothyroid HT patients than in the control group. Additionally, patients with euthyroid and hypothyroid HT displayed lower segmental and global LV strain values than the control group. A negative correlation was observed between strain values and TIMP-1 and anti-TPO levels. No significant difference was observed in serum TIMP-1 and strain values between euthyroid and hypothyroid HT patients. Patients with hypothyroid HT exhibited impaired diastolic function and reduced ejection fraction when compared to both euthyroid HT and control groups. However, euthyroid HT patients and the controls had similar diastolic function and ejection fractions. Conclusions: Hashimoto\u2019s thyroiditis causes impairment of LV strain, regardless of thyroid hormone levels. Additionally, the condition is associated with elevated TIMP-1 levels. The relationship between LV strain values and anti-TPO levels indicates that the autoimmune component of the disease may be responsible for the impaired LV strain.<\/jats:p>","DOI":"10.3390\/jcm14051705","type":"journal-article","created":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T10:15:03Z","timestamp":1740996903000},"page":"1705","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Assessment of Left Ventricular Strain Echocardiography in Individuals with Hashimoto\u2019s Thyroiditis and Its Association with Serum TIMP-1 Concentration"],"prefix":"10.3390","volume":"14","author":[{"given":"Irfan V.","family":"Duzen","sequence":"first","affiliation":[{"name":"Department of Cardiology, Faculty of Medicine, Gaziantep University Sahinbey Education and Research Hospital, Gaziantep University, Gaziantep 27310, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Selcen Y.","family":"Tuluce","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiology Clinic, Heart Izmir Clinic, Izmir 35610, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sadettin","family":"Ozturk","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolic Disease, Gaziantep City Hospital, Gaziantep 27470, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9783-173X","authenticated-orcid":false,"given":"Mert D.","family":"Savc\u0131l\u0131oglu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiology Clinic, Gaziantep City Hospital, Gaziantep 27470, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huseyin","family":"Goksuluk","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiology Clinic, Bursa Anadolu Hospital, Bursa 16320, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gokhan","family":"Altunbas","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Faculty of Medicine, Gaziantep University Sahinbey Education and Research Hospital, Gaziantep University, Gaziantep 27310, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet","family":"Kaplan","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Faculty of Medicine, Gaziantep University Sahinbey Education and Research Hospital, Gaziantep University, Gaziantep 27310, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ertan","family":"Vuruskan","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Faculty of Medicine, Gaziantep University Sahinbey Education and Research Hospital, Gaziantep University, Gaziantep 27310, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzan","family":"Tabur","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolic Disease, Faculty of Medicine, Gaziantep University Sahinbey Education and Research Hospital, Gaziantep University, Gaziantep 27310, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Murat","family":"Sucu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Faculty of Medicine, Gaziantep University Sahinbey Education and Research Hospital, Gaziantep University, Gaziantep 27310, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1251-3148","authenticated-orcid":false,"given":"Seyithan","family":"Taysi","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, Faculty of Medicine, Gaziantep University Sahinbey Education and Research Hospital, Gaziantep University, Gaziantep 27310, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,3,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"101367","DOI":"10.1016\/j.beem.2019.101367","article-title":"Hashimotos\u2019 Thyroiditis: Epidemiology, Pathogenesis, Clinic and Therapy","volume":"33","author":"Ragusa","year":"2019","journal-title":"Best Pract. 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