{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T07:02:53Z","timestamp":1790319773339,"version":"4.1.0"},"reference-count":229,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T00:00:00Z","timestamp":1741564800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>The extracellular matrix (ECM) is the common denominator of more than 50 chronic diseases. Some of these chronic pathologies lead to enhanced tissue formation and deposition, whereas others are associated with increased tissue degradation, and some exhibit a combination of both, leading to severe tissue alterations. To develop effective therapies for diseases affecting the lung, liver, kidney, skin, intestine, musculoskeletal system, heart, and solid tumors, we need to modulate the ECM\u2019s composition to restore its organization and function. Across diverse organ diseases, there are common denominators and distinguishing factors in this fibroinflammatory axis, which may be used to foster new insights into drug development across disease indications. The 2nd Extracellular Matrix Pharmacology Congress took place in Copenhagen, Denmark, from 17 to 19 June 2024 and was hosted by the International Society of Extracellular Matrix Pharmacology. The event was attended by 450 participants from 35 countries, among whom were prominent scientists who brought together state-of-the-art research on organ diseases and asked important questions to facilitate drug development. We highlight key aspects of the ECM in the liver, kidney, skin, intestine, musculoskeletal system, lungs, and solid tumors to advance our understanding of the ECM and its central targets in drug development. We also highlight key advances in the tools and technology that enable this drug development, thereby supporting the ECM.<\/jats:p>","DOI":"10.3390\/jcm14061856","type":"journal-article","created":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T06:59:59Z","timestamp":1741589999000},"page":"1856","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Advances in Extracellular Matrix-Associated Diagnostics and Therapeutics"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5026-8740","authenticated-orcid":false,"given":"Morten","family":"Karsdal","sequence":"first","affiliation":[{"name":"Nordic Bioscience, 2730 Herlev, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9294-1745","authenticated-orcid":false,"given":"Thomas R.","family":"Cox","sequence":"additional","affiliation":[{"name":"Garvan Institute of Medical Research, Sydney 2010, Australia"},{"name":"School of Clinical Medicine, St Vincent\u2019s Clinical Campus, UNSW Medicine & Health, UNSW, Sydney 2010, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amelia L.","family":"Parker","sequence":"additional","affiliation":[{"name":"Garvan Institute of Medical Research, Sydney 2010, Australia"},{"name":"School of Clinical Medicine, St Vincent\u2019s Clinical Campus, UNSW Medicine & Health, UNSW, Sydney 2010, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Willumsen","sequence":"additional","affiliation":[{"name":"Nordic Bioscience, 2730 Herlev, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jannie Marie B\u00fclow","family":"Sand","sequence":"additional","affiliation":[{"name":"Nordic Bioscience, 2730 Herlev, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gisli","family":"Jenkins","sequence":"additional","affiliation":[{"name":"Margaret Turner Warwick Centre for Fibrosing Lung Disease, National Heart and Lung Institute, NIHR Imperial Biomedical Research Centre, Imperial College London, London SW7 2AZ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3732-0281","authenticated-orcid":false,"given":"Henrik H.","family":"Hansen","sequence":"additional","affiliation":[{"name":"Gubra, 2970 H\u00f8rsholm, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anouk","family":"Oldenburger","sequence":"additional","affiliation":[{"name":"Global Drug Discovery, Novo Nordisk, 2760 Maaloev, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerstin E.","family":"Geillinger-Kaestle","sequence":"additional","affiliation":[{"name":"Department of Immunology and Respiratory Diseases Research, Boehringer Ingelheim Pharma GmbH & Co. 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