{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:27:18Z","timestamp":1789000038141,"version":"build-2803163510"},"reference-count":22,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T00:00:00Z","timestamp":1741564800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Despite the vast evidence of the beneficial effect of vagus nerve stimulation on the course of myocardial infarction confirmed in studies using animal models, the introduction of this method into actual clinical practice remains uncommon. Objective: The objective of our study was to evaluate the effect of transcutaneous vagus nerve stimulation (tVNS) on in-hospital and long-term outcomes for patients with ST-elevation myocardial infarction. Materials and Methods: A blind, randomized, placebo-controlled clinical trial was conducted. The participants were randomly split into two groups. The Active tVNS group was subjected to stimulation of the tragus containing the auricular branch of the vagus nerve. The Sham tVNS group underwent stimulation of the lobule. Stimulation was performed immediately on admission before the start of the percutaneous coronary intervention (PCI). Then, tVNS continued throughout the entire PCI procedure and 30 min after its completion. The primary endpoints were hospital mortality and 12-month mortality. The secondary endpoints were in-hospital and remote non-lethal cardiovascular events. The combined endpoint consisted of major adverse cardiovascular events (MACEs)\u2014recurrent myocardial infarction, stroke\/TIA, and overall mortality. Results: A total of 110 patients were randomized into the Active tVNS group (n = 55) and the Sham tVNS group (n = 55). The incidences of hospital mortality, cardiogenic shock, and AV block 3 were statistically less common in the Active tVNS group than in the Sham tVNS group (p = 0.024*, p = 0.044*, and p = 0.013*, respectively). In the long-term period, no statistical differences were found in the studied outcomes obtained following the construction of Kaplan\u2013Meyer survival curves. When comparing groups by total mortality, taking into account hospital mortality, we observed a tendency for the survival curves to diverge (Logrank test, p = 0.066). Statistical significance was revealed by the composite endpoint, taking into account hospital events (Logrank test, p = 0.0016*). Conclusions: tVNS significantly reduced hospital mortality (p = 0.024*), the level of markers of myocardial damage, and the frequency of severe cardiac arrhythmias in patients with acute myocardial infarction. In the long term, the prognostic value of tVNS was revealed by the composite endpoint major adverse cardiovascular events. Further studies with an expanded sample are needed for a more detailed verification of the data obtained to confirm the effectiveness of tVNS and allow an in-depth analysis of the safety and feasibility of its use in routine clinical practice. This clinical trial is registered with ClinicalTrials database under a unique identifier: NCT05992259.<\/jats:p>","DOI":"10.3390\/jcm14061866","type":"journal-article","created":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T12:02:59Z","timestamp":1741608179000},"page":"1866","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Low-Frequency Electrical Stimulation of the Auricular Branch of the Vagus Nerve in Patients with ST-Elevation Myocardial Infarction: A Randomized Clinical Trial"],"prefix":"10.3390","volume":"14","author":[{"given":"Sofia","family":"Kruchinova","sequence":"first","affiliation":[{"name":"Scientific Research Institute of Regional Clinical Hospital #1 Ochapovsky, 350086 Krasnodar, Russia"},{"name":"Department of Therapy #1, Kuban State Medical University, 350063 Krasnodar, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milana","family":"Gendugova","sequence":"additional","affiliation":[{"name":"Department of Therapy #1, Kuban State Medical University, 350063 Krasnodar, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5866-506X","authenticated-orcid":false,"given":"Alim","family":"Namitokov","sequence":"additional","affiliation":[{"name":"Scientific Research Institute of Regional Clinical Hospital #1 Ochapovsky, 350086 Krasnodar, Russia"},{"name":"Department of Therapy #1, Kuban State Medical University, 350063 Krasnodar, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6037-1327","authenticated-orcid":false,"given":"Maria","family":"Sokolskaya","sequence":"additional","affiliation":[{"name":"Bakoulev Scientific Center for Cardiovascular Surgery, 121552 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina","family":"Gilevich","sequence":"additional","affiliation":[{"name":"Scientific Research Institute of Regional Clinical Hospital #1 Ochapovsky, 350086 Krasnodar, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoya","family":"Tatarintseva","sequence":"additional","affiliation":[{"name":"Scientific Research Institute of Regional Clinical Hospital #1 Ochapovsky, 350086 Krasnodar, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-0159-9182","authenticated-orcid":false,"given":"Maria","family":"Karibova","sequence":"additional","affiliation":[{"name":"Department of Therapy #1, Kuban State Medical University, 350063 Krasnodar, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasiliy","family":"Danilov","sequence":"additional","affiliation":[{"name":"Autonomous Non-Profit Organization Sports School \u201cBecome a Champion\u201d, 350063 Krasnodar, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7671-0806","authenticated-orcid":false,"given":"Nikita","family":"Simakin","sequence":"additional","affiliation":[{"name":"Cardiology Department, Novorossiysk City Hospital, 353915 Novorossiysk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8638-7327","authenticated-orcid":false,"given":"Elena","family":"Shvartz","sequence":"additional","affiliation":[{"name":"National Medical Research Center for Therapy and Preventive Medicine, 101990 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Kosmacheva","sequence":"additional","affiliation":[{"name":"Scientific Research Institute of Regional Clinical Hospital #1 Ochapovsky, 350086 Krasnodar, Russia"},{"name":"Department of Therapy #1, Kuban State Medical University, 350063 Krasnodar, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8931-0376","authenticated-orcid":false,"given":"Vladimir","family":"Shvartz","sequence":"additional","affiliation":[{"name":"Bakoulev Scientific Center for Cardiovascular Surgery, 121552 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,3,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1172\/JCI67541","article-title":"Cardiovascular science: Opportunities for translating research into improved care","volume":"123","author":"Braunwald","year":"2013","journal-title":"J. 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