{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:01:04Z","timestamp":1760058064221,"version":"build-2065373602"},"reference-count":35,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T00:00:00Z","timestamp":1741651200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: A 69-year-old man with multiple myeloma and left-sided heart failure presented to the hospital with a two-month fever. Method: A transjugular liver biopsy was performed due to the rapid progression of liver failure. The procedure was complicated by an intraperitoneal hemorrhage. The bleeding was managed expectantly. Result: Significantly elevated serum bilirubin levels occurred on the 13th day after liver biopsy. Increasing serum bilirubin levels were observed until the patient\u2019s death due to a biliovenous fistula at the liver biopsy site. Simultaneously, his slightly elevated liver enzymes returned to normal. The patient died 23 days after liver biopsy due to acute respiratory distress syndrome. Fistulous communication between the biliary tree and the hepatic venous system with subsequent bile leakage into the venous system (bilhemia) can lead to bile deposition in the lungs. Bile deposition in the lungs may potentiate and accelerate the development of diffuse alveolar damage with hyaline membranes. Conclusions: Lambda and kappa light chain deposition in the pulmonary alveoli in patients with multiple myeloma can mimic typical hyaline membranes.<\/jats:p>","DOI":"10.3390\/jcm14061871","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T06:52:30Z","timestamp":1741675950000},"page":"1871","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Alveolar Bile and Light Chain Immunoglobulin Depositions as an Unusual Complication of Transjugular Liver Biopsy Resulting in Bilhemia in a Patient with Multiple Myeloma"],"prefix":"10.3390","volume":"14","author":[{"given":"Silvia","family":"Farka\u0161ov\u00e1 Iannaccone","sequence":"first","affiliation":[{"name":"Department of Forensic Medicine, Faculty of Medicine, Pavol Jozef \u0160af\u00e1rik University, Trieda SNP 1, 041 11 Ko\u0161ice, Slovakia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sylvia","family":"Dra\u017eilov\u00e1","sequence":"additional","affiliation":[{"name":"2nd Department of Internal Medicine, Pavol Jozef \u0160af\u00e1rik University, Louis Pasteur University Hospital, Trieda SNP 1, 040 11 Ko\u0161ice, Slovakia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6152-6343","authenticated-orcid":false,"given":"Radoslav","family":"Mat\u011bj","sequence":"additional","affiliation":[{"name":"Department of Pathology and Molecular Medicine, 3rd Faculty of Medicine, Charles University, Thomayer University Hospital, V\u00edde\u0148sk\u00e1 800, 140 59 Prague, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miroslava","family":"Tak\u00e1\u010dov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Pathology, Louis Pasteur University Hospital, Rastislavova 43, 040 01 Ko\u0161ice, Slovakia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Bohu\u0161","sequence":"additional","affiliation":[{"name":"Department of Pathology, Louis Pasteur University Hospital, Rastislavova 43, 040 01 Ko\u0161ice, Slovakia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Jar\u010du\u0161ka","sequence":"additional","affiliation":[{"name":"2nd Department of Internal Medicine, Pavol Jozef \u0160af\u00e1rik University, Louis Pasteur University Hospital, Trieda SNP 1, 040 11 Ko\u0161ice, Slovakia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adri\u00e1na","family":"\u0160mirj\u00e1kov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Pathology, Louis Pasteur University Hospital, Rastislavova 43, 040 01 Ko\u0161ice, Slovakia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Al\u017ebeta","family":"Ginelliov\u00e1","sequence":"additional","affiliation":[{"name":"Medicolegal Department of Health Care Surveillance Authority, Ipe\u013esk\u00e1 1, 043 74 Ko\u0161ice, Slovakia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucia","family":"Fr\u00f6hlichov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Pathology, Louis Pasteur University Hospital, Rastislavova 43, 040 01 Ko\u0161ice, Slovakia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u0160tefan","family":"Pataky","sequence":"additional","affiliation":[{"name":"Department of Radiodiagnostics and Imaging Techniques, Pavol Jozef \u0160af\u00e1rik University, Trieda SNP 1, 040 11 Ko\u0161ice, Slovakia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milo\u0161","family":"Ki\u010dka","sequence":"additional","affiliation":[{"name":"1st Department of Surgery, Louis Pasteur University Hospital, Rastislavova 43, 040 01 Ko\u0161ice, Slovakia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zuzana","family":"Szamosi","sequence":"additional","affiliation":[{"name":"Medicolegal Department of Health Care Surveillance Authority, Ipe\u013esk\u00e1 1, 043 74 Ko\u0161ice, Slovakia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Farka\u0161","sequence":"additional","affiliation":[{"name":"Medicolegal Department of Health Care Surveillance Authority, Ipe\u013esk\u00e1 1, 043 74 Ko\u0161ice, Slovakia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,3,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1055\/s-0032-1312572","article-title":"Transjugular liver biopsy","volume":"29","author":"Behrens","year":"2012","journal-title":"Semin. Interv. Radiol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1055\/s-0029-1242207","article-title":"Hemorrhage after transjugular liver biopsy requiring embolization","volume":"26","author":"Funaki","year":"2009","journal-title":"Semin. Interv. Radiol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.jhep.2007.05.001","article-title":"Transjugular liver biopsy-indications, adequacy, quality of specimens, and complications-a systematic review","volume":"47","author":"Kalambokis","year":"2007","journal-title":"J. Hepatol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"947014","DOI":"10.1155\/2009\/947014","article-title":"Clinical relevance of transjugular liver biopsy in comparison with percutaneous and laparoscopic liver biopsy","volume":"2009","author":"Beckmann","year":"2009","journal-title":"Gastroenterol. Res. Pract."},{"key":"ref_5","first-page":"544","article-title":"Risk factors for post-ERCP complications","volume":"125","author":"Roskovicova","year":"2024","journal-title":"Bratisl. Lek. Listy"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1055\/s-0034-1396963","article-title":"Complications of transjugular biopsies","volume":"32","author":"Navuluri","year":"2015","journal-title":"Semin. Interv. Radiol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/S1665-2681(19)32101-5","article-title":"Transjugular liver biopsy. An update","volume":"3","year":"2004","journal-title":"Ann. Hepatol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"e00063","DOI":"10.14309\/ctg.0000000000000063","article-title":"Transjugular liver biopsy: Safe even in patients with severe coagulopathies and multiple biopsies","volume":"10","author":"Sue","year":"2019","journal-title":"Clin. Transl. Gastroenterol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1097\/MEG.0b013e3282748f32","article-title":"Fatal hemobilia resulting from an iatrogenic arteriobiliary fistula as a rare complication of transjugular liver biopsy","volume":"20","author":"Gurakuqi","year":"2008","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.diii.2015.02.006","article-title":"Major complications due to transjugular liver biopsy: Incidence, management and outcome","volume":"96","author":"Dohan","year":"2015","journal-title":"Diagn. Interv. Imaging"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1007\/s12024-021-00394-w","article-title":"Bile pulmonary embolism-related sudden death following an abdominal firearm injury: An autopsy case report and review of literature","volume":"17","author":"Fnon","year":"2021","journal-title":"Forensic Sci. Med. Pathol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1067\/msy.2000.103488","article-title":"Fatal bilhemia","volume":"127","author":"Sandblom","year":"2000","journal-title":"Surgery"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.7326\/0003-4819-36-6-1529","article-title":"Fatal bile embolism following liver biopsy","volume":"36","author":"Brown","year":"1952","journal-title":"Ann. Intern. Med."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1177\/000331979304400909","article-title":"Fatal bile pulmonary embolism following percutaneous transhepatic cholangiodrainage: Case report and literature review","volume":"44","author":"Kihira","year":"1993","journal-title":"Angiology"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1097\/00004836-198106000-00006","article-title":"Bile emboli: A complication of PTD","volume":"3","author":"Brozinsky","year":"1981","journal-title":"J. Clin. Gastroenterol."},{"key":"ref_16","first-page":"269","article-title":"Delayed bilhemia complicating percutaneous transhepatic biliary drainage: Successful treatment with primary coil embolization","volume":"14","author":"Guzelbey","year":"2018","journal-title":"Radiol. Case Rep."},{"key":"ref_17","first-page":"814","article-title":"Pulmonary bile emboli. Sequelae of iatrogenic trauma","volume":"108","author":"Balogh","year":"1984","journal-title":"Arch. Pathol. Lab. Med."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0016-5107(04)02448-4","article-title":"Fatal air and bile embolism after percutaneous liver biopsy and ERCP","volume":"61","author":"Siddiqui","year":"2005","journal-title":"Gastrointest. Endosc."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"2028","DOI":"10.1007\/s00464-003-4239-4","article-title":"Fatal bile pulmonary embolism after radiofrequency treatment of a hepatocellular carcinoma","volume":"17","author":"Breining","year":"2003","journal-title":"Surg. Endosc."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1159\/000511932","article-title":"First report of a late lethal pulmonary biliary embolism following hepatic microwave ablation","volume":"37","author":"Jusufi","year":"2021","journal-title":"Visc. Med."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1055\/s-0030-1249697","article-title":"Bilhemia, an unusual complication after blunt liver trauma in a child: Case report and review of the literature","volume":"20","author":"Turk","year":"2010","journal-title":"Eur. J. Pediatr. Surg."},{"key":"ref_22","first-page":"1000259","article-title":"Bilhemia: A rare complication of hepatic blunt trauma, non-interventional Management and present aspect","volume":"4","author":"Malgoire","year":"2015","journal-title":"J. Trauma Treat."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"54","DOI":"10.5114\/pjp.2024.135762","article-title":"Fatal pulmonary bile embolism associated with acute pancreatitis\u2014A case report and review of the literature","volume":"75","author":"Knapik","year":"2024","journal-title":"Pol. J. Pathol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"60","DOI":"10.14309\/crj.2015.101","article-title":"Bilhemia: A rare complication of transjugular intraheptic portosytemic shunt","volume":"3","author":"Zhang","year":"2015","journal-title":"ACG Case Rep. J."},{"key":"ref_25","first-page":"e61414","article-title":"Bilhemia after percutaneous liver tumor core biopsy with the percutaneous embolization of bilio-venous fistula with coils and onyx","volume":"16","author":"Breznik","year":"2024","journal-title":"Cureus"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S0009-2797(01)00209-5","article-title":"Prooxidant and antioxidant activities of bilirubin and its metabolic precursor biliverdin: A structure-activity study","volume":"137","author":"Asad","year":"2001","journal-title":"Chem. Biol. Interact."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.21037\/atm-22-1737","article-title":"Total bilirubin is associated with all-cause mortality in patients with acute respiratory distress syndrome: A retrospective study","volume":"10","author":"Zheng","year":"2022","journal-title":"Ann. Transl. Med."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1136\/thx.2009.113464","article-title":"Serum bilirubin levels on ICU admission are associated with ARDS development and mortality in sepsis","volume":"64","author":"Zhai","year":"2009","journal-title":"Thorax"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Lee, M., Jang, M., Jo, J., Yu, B., Lee, G., Lee, J., Lee, S., Jeon, Y., and Choi, K. (2023). Hyperbilirubinemia as a risk factor for mortality and morbidity in trauma patients. J. Clin. Med., 12.","DOI":"10.3390\/jcm12134203"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/s40635-020-00337-9","article-title":"Liver-lung interactions in acute respiratory distress syndrome","volume":"8","author":"Herrero","year":"2020","journal-title":"Intensive Care Med. Exp."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1002\/ajh.10257","article-title":"Case of multiple myeloma mimicking an infectious disease with fever, intrahepatic cholestasis, renal failure, and pulmonary insufficiency","volume":"72","author":"Vella","year":"2003","journal-title":"Am. J. Hematol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1111\/j.1365-2141.1994.tb08338.x","article-title":"A patient with multiple myeloma and respiratory insufficiency due to accumulation of paraprotein in the alveolar space","volume":"87","author":"Meijer","year":"1994","journal-title":"Br. J. Haematol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"4321","DOI":"10.1182\/blood-2011-08-375816","article-title":"Vascular endothelial hyperpermeability induces the clinical symptoms of Clarkson disease (the systemic capillary leak syndrome)","volume":"119","author":"Xie","year":"2012","journal-title":"Blood"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1111\/j.1365-2249.1993.tb08195.x","article-title":"The paraproteins in systemic capillary leak syndrome","volume":"93","author":"Zhang","year":"1993","journal-title":"Clin. Exp. Immunol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.7754\/Clin.Lab.2019.191127","article-title":"Confirmed Cryoglobulinemia and Hyperviscosity Syndrome Secondary to Multiple Myeloma-IgA Kappa from Routine Blood Test: A Case Report","volume":"66","author":"Yu","year":"2020","journal-title":"Clin. Lab."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/6\/1871\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T16:50:20Z","timestamp":1760028620000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/6\/1871"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,11]]},"references-count":35,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2025,3]]}},"alternative-id":["jcm14061871"],"URL":"https:\/\/doi.org\/10.3390\/jcm14061871","relation":{},"ISSN":["2077-0383"],"issn-type":[{"type":"electronic","value":"2077-0383"}],"subject":[],"published":{"date-parts":[[2025,3,11]]}}}