{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T07:16:25Z","timestamp":1776496585905,"version":"3.51.2"},"reference-count":28,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T00:00:00Z","timestamp":1741737600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Pulmonary embolism is a potentially life-threatening condition caused by the sudden occlusion of pulmonary arteries. Its non-specific and highly variable clinical presentation often leads to undiagnosed cases, making computed tomography pulmonary angiography (CTPA) essential for diagnosis. Hampton\u2019s hump is a rare radiological finding associated with pulmonary embolism, characterized by a wedge-shaped, pleural-based opacification due to pulmonary infarction. Methods: This study examines the correlation between pulmonary embolism severity and the presence of Hampton\u2019s hump in CTPA based on a database of 428 patients. Results: We observed a correlation between the presence of Hampton\u2019s hump and an increased likelihood of rider-type embolism, pleural effusion, and dilation of the pulmonary trunk and left pulmonary artery. The data indicate that patients with at least one risk factor for severe pulmonary embolism are more likely to present with Hampton\u2019s hump. Furthermore, the presence of this sign in patients diagnosed with pulmonary embolism and pleural effusion substantially increases the risk of in-hospital death. Conclusions: This study underscores the significance of Hampton\u2019s hump as a rare but clinically relevant radiological finding in patients with pulmonary embolism. Given the limited number of studies on this topic, our findings provide valuable insights into the role of Hampton\u2019s hump in the context of pulmonary embolism.<\/jats:p>","DOI":"10.3390\/jcm14061900","type":"journal-article","created":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T04:55:44Z","timestamp":1741755344000},"page":"1900","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Hampton\u2019s Hump\u2014A Rare Radiological Feature in Patients with Pulmonary Embolism in a Single-Center Study"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7626-5211","authenticated-orcid":false,"given":"Kinga","family":"Kubiak","sequence":"first","affiliation":[{"name":"Department of Diagnostic Imaging and Interventional Radiology, Pomeranian Medical University in Szczecin, 71-252 Szczecin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katarzyna","family":"Bazylewicz-Zakrzewska","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Imaging and Interventional Radiology, Pomeranian Medical University in Szczecin, 71-252 Szczecin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wojciech","family":"Poncyljusz","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Imaging and Interventional Radiology, Pomeranian Medical University in Szczecin, 71-252 Szczecin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,3,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1161\/CIRCULATIONAHA.105.592592","article-title":"Massive pulmonary embolism","volume":"113","author":"Kucher","year":"2006","journal-title":"Circulation"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1001\/jama.1994.03510270069042","article-title":"Frequent asymptomatic pulmonary embolism in patients with deep venous thrombosis","volume":"271","author":"Moser","year":"1994","journal-title":"JAMA"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"117","DOI":"10.15441\/ceem.16.146","article-title":"Pulmonary Embolism: The Diagnosis, Risk-Stratification, Treatment and Disposition of Emergency Department Patients","volume":"3","author":"Corrigan","year":"2016","journal-title":"Clin. 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