{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T06:18:05Z","timestamp":1789539485112,"version":"build-2803163510"},"reference-count":65,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2025,3,14]],"date-time":"2025-03-14T00:00:00Z","timestamp":1741910400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background\/Objectives: The efficacy and safety of laser therapy in periodontal treatment are comprehensively reviewed in this study, focusing on efficacy, safety, patient experiences, and cost-effectiveness. Methods: This review encompasses a literature survey, analyzing studies from 2010 to 2024, and a search was conducted in January 2024 across various electronic databases, including PubMed, SCOPUS, EMBASE, COCHRANE library, and Science Direct. The search utilized Mesh terms\/keywords such as \u201cLaser therapy\u201d, \u201cPeriodontal disease\u201d, \u201cEfficacy\u201d, and \u201cSafety.\u201d Results: Out of the initial 884 articles identified, 98 were selected based on their titles and abstracts. After evaluating the full texts and applying the inclusion and exclusion criteria, 16 articles were chosen for the review, meeting the study\u2019s criteria. Conclusions: This review identifies gaps in current research and points to emerging trends and potential future advancements in laser therapy, emphasizing the need for standardized protocols, long-term studies, and technological innovations to enhance treatment efficacy and accessibility.<\/jats:p>","DOI":"10.3390\/jcm14061962","type":"journal-article","created":{"date-parts":[[2025,3,14]],"date-time":"2025-03-14T04:29:18Z","timestamp":1741926558000},"page":"1962","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Laser Technology in Periodontal Treatment: Benefits, Risks, and Future Directions\u2014A Mini Review"],"prefix":"10.3390","volume":"14","author":[{"given":"Dhafer","family":"Al Asmari","sequence":"first","affiliation":[{"name":"Department of Periodontology and Implant Dentistry, College of Dentistry, Qassim University, Buraydah 51452, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6929-974X","authenticated-orcid":false,"given":"Ali","family":"Alenezi","sequence":"additional","affiliation":[{"name":"Department of Prosthetic Dental Sciences, College of Dentistry, Qassim University, Buraydah 51452, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,3,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/sj.bdj.2014.912","article-title":"Is periodontal disease a public health problem?","volume":"217","author":"Batchelor","year":"2014","journal-title":"Br. Dent. J."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"How, K.Y., Song, K.P., and Chan, K.G. (2016). Porphyromonas gingivalis: An Overview of Periodontopathic Pathogen below the Gum Line. Front. Microbiol., 7.","DOI":"10.3389\/fmicb.2016.00053"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1136\/jech.2006.046896","article-title":"Inequity in access to dental care services explains current socioeconomic disparities in oral health: The Swedish National Surveys of Public Health 2004\u20132005","volume":"60","author":"Wamala","year":"2006","journal-title":"J. Epidemiol. Community Health"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1034\/j.1600-0757.2001.22250103.x","article-title":"Relationship between periodontal disease and systemic health","volume":"25","author":"Garcia","year":"2001","journal-title":"Periodontology 2000"},{"key":"ref_5","first-page":"e12188","article-title":"Efficacy of Scaling and Root Planing with and Without Adjunctive use of Diode Laser or Tetracycline Fibers in Patients with Generalised Chronic Periodontitis: A Comparative study","volume":"8","author":"Ramesh","year":"2017","journal-title":"J. Investig. Clin. Dent."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1111\/idj.12630","article-title":"Current Concepts in the Management of Periodontitis","volume":"71","author":"Kwon","year":"2021","journal-title":"Int. Dent. J."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1007\/s11427-016-0406-x","article-title":"A CRISPR\/Cas9 toolkit for efficient targeted base editing to induce genetic variations in rice","volume":"60","author":"Ren","year":"2017","journal-title":"Sci. China Life Sci."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"e099","DOI":"10.1590\/1807-3107bor-2021.vol35.0099","article-title":"LASER in periodontal treatment: Is it an effective treatment or science fiction?","volume":"35","author":"Theodoro","year":"2021","journal-title":"Braz. Oral. Res."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1007\/s10103-016-2047-z","article-title":"The effect of low-level laser therapy on non-surgical periodontal treatment: A randomized controlled, single-blind, split-mouth clinical trial","volume":"31","author":"Erciyas","year":"2016","journal-title":"Lasers Med. Sci."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1080\/14764172.2018.1525744","article-title":"Lasers in non-surgical periodontal treatment\u2014A review","volume":"21","author":"Sumra","year":"2019","journal-title":"J. Cosmet. Laser Ther."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"143","DOI":"10.3233\/THC-1999-72-306","article-title":"Principles and practice of the laser-Doppler perfusion technique","volume":"7","author":"Leahy","year":"1999","journal-title":"Technol. Health Care"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Reynolds, M., Aichelmann-Reidy, M., and Rosen, P. (2020). Lasers in Periodontal and Peri-implant Therapy: Challenges and Opportunities. Emerging Therapies in Periodontics, Springer.","DOI":"10.1007\/978-3-030-42990-4_15"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1089\/pho.2012.9894","article-title":"Laser dentistry, current advantages, and limits","volume":"30","author":"Nammour","year":"2012","journal-title":"Photomed. Laser Surg."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1111\/j.1600-0757.2008.00283.x","article-title":"Application of lasers in periodontics: True innovation or myth?","volume":"50","author":"Ishikawa","year":"2009","journal-title":"Periodontology 2000"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1097\/00042728-200503000-00016","article-title":"Low-level laser therapy for wound healing: Mechanism and efficacy","volume":"31","author":"Posten","year":"2005","journal-title":"Dermatol. Surg."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Capodiferro, S., Limongelli, L., D\u2019Agostino, S., Tempesta, A., Dolci, M., Maiorano, E., and Favia, G. (2021). Diode Laser Management of Primary Extranasopharyngeal Angiofibroma Presenting as Maxillary Epulis: Report of a Case and Literature Review. Healthcare, 9.","DOI":"10.3390\/healthcare9010033"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1111\/prd.12080","article-title":"Periodontal and peri-implant wound healing following laser therapy","volume":"68","author":"Aoki","year":"2015","journal-title":"Periodontology 2000"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"264","DOI":"10.7326\/0003-4819-151-4-200908180-00135","article-title":"Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement","volume":"151","author":"Moher","year":"2009","journal-title":"Ann. Intern. Med."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/s10103-009-0753-5","article-title":"Efficacy of high intensity diode laser as an adjunct to non-surgical periodontal treatment: A randomized controlled trial","volume":"26","author":"Alves","year":"2011","journal-title":"Lasers Med. Sci."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1097\/SCS.0000000000001727","article-title":"Clinical application of diode laser (980 nm) in maxillofacial surgical procedures","volume":"26","author":"Aldelaimi","year":"2015","journal-title":"J. Craniofacial Surg."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1007\/s10103-010-0808-7","article-title":"Study of the direct bactericidal effect of Nd: YAG and diode laser parameters used in endodontics on pigmented and nonpigmented bacteria","volume":"26","author":"Pirnat","year":"2011","journal-title":"Lasers Med. Sci."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1007\/s10103-018-2491-z","article-title":"Laser reduction of specific microorganisms in the periodontal pocket using Er: YAG and Nd: YAG lasers: A randomized controlled clinical study","volume":"33","author":"Sculean","year":"2018","journal-title":"Lasers Med. Sci."},{"key":"ref_23","first-page":"182","article-title":"Clinical and microbiological effects of the use of erbium: Yttrium\u2013aluminum\u2013garnet laser on chronic periodontitis in addition to nonsurgical periodontal treatment: A randomized clinical trial\u20146 months follow-up","volume":"37","author":"Saglam","year":"2019","journal-title":"Photobiomodul. Photomed. Laser Surg."},{"key":"ref_24","first-page":"9","article-title":"All Tissues Dental Laser Er: YAG laser-Review Article","volume":"1","author":"Abdulsamee","year":"2017","journal-title":"Biomed. J. Sci. Tech. Res."},{"key":"ref_25","unstructured":"Vinodhini, K. (2009). Effect of Two Different Laser Treatments on Removal of Root Surface Smear Layer After Root Planing: A SEM Study, Rajiv Gandhi University of Health Sciences."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Romanos, G.E. (2021). Advanced Laser Surgery in Dentistry, John Wiley & Sons.","DOI":"10.1002\/9781119583318"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1002\/JPER.23-0285","article-title":"Probing pocket depth reduction after non-surgical periodontal therapy: Tooth-related factors","volume":"95","author":"Werner","year":"2024","journal-title":"J. Periodontol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1111\/prd.12123","article-title":"Lasers in minimally invasive periodontal and peri-implant therapy","volume":"71","author":"Mizutani","year":"2016","journal-title":"Periodontology 2000"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1111\/jcpe.12304","article-title":"Er: YAG laser versus scaling and root planing as alternative or adjuvant for chronic periodontitis treatment: A systematic review","volume":"41","author":"Zhao","year":"2014","journal-title":"J. Clin. Periodontol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1007\/s10103-013-1293-6","article-title":"Nd: YAG laser as an adjunctive treatment to nonsurgical periodontal therapy: A meta-analysis","volume":"29","author":"Sgolastra","year":"2014","journal-title":"Lasers Med. Sci."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"S185","DOI":"10.1002\/lary.20712","article-title":"Advances in office-based diagnosis and treatment in laryngology","volume":"119","author":"Rosen","year":"2009","journal-title":"Laryngoscope"},{"key":"ref_32","first-page":"203","article-title":"Lasers for Caries Removal and Cavity Preparation: State of the Art and Future Directions","volume":"2","author":"Hibst","year":"2002","journal-title":"J. Oral. Laser Appl."},{"key":"ref_33","unstructured":"Laser, C.D.S., and Surgical, C.D. (2022). Research in laser dentistry: Current and novel treatments and theranostics. Principles and Practice of Laser Dentistry, Elsevier. E-Book."},{"key":"ref_34","first-page":"522","article-title":"Laser Techniques for Advanced Medical Research","volume":"5","author":"Saxena","year":"2018","journal-title":"Laser"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1038\/bdj.2007.284","article-title":"Surgical laser use in implantology and endodontics","volume":"202","author":"Parker","year":"2007","journal-title":"Br. Dent. J."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1111\/prd.12580","article-title":"Radiographic diagnosis of periodontal diseases\u2014Current evidence versus innovations","volume":"95","author":"Jacobs","year":"2024","journal-title":"Periodontology 2000"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/S0011-8532(22)01332-5","article-title":"The future of lasers in dentistry","volume":"44","author":"Myers","year":"2000","journal-title":"Dent. Clin. N. Am."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Dobrza\u0144ski, L.A., Dobrza\u0144ski, L.B., Dobrza\u0144ska-Danikiewicz, A.D., and Dobrza\u0144ska, J. (2020). The Concept of Sustainable Development of Modern Dentistry. Processes, 8.","DOI":"10.3390\/pr8121605"},{"key":"ref_39","first-page":"199","article-title":"Comparison of Manual Tools, Ultrasonic and Erbium-Doped Yttrium Aluminum Garnet (Er: YAG) Laser on the Debridement Effect of the Surface of the Root of Teeth Suffering from Periodontitis","volume":"4","author":"Foroutan","year":"2013","journal-title":"J. Lasers Med. Sci."},{"key":"ref_40","first-page":"936","article-title":"Lasers and their Applications in the Dental Practice","volume":"7","author":"Pandarathodiyil","year":"2020","journal-title":"Int. J. Dent. Oral. Sci."},{"key":"ref_41","unstructured":"Basil, M. (2017). Evaluation of Conventional Flap Surgery and Lanap Therapy in Chronic Periodontitis Cases\u2014A Clinico Microbiological Study, Rajiv Gandhi University of Health Sciences."},{"key":"ref_42","first-page":"206","article-title":"Diode laser application in soft tissue oral surgery","volume":"4","author":"Azma","year":"2013","journal-title":"J. Lasers Med. Sci."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"33","DOI":"10.4103\/0976-2868.100989","article-title":"Use of Nd: YAG laser in the treatment of ankyloglossia for pediatric patient","volume":"6","author":"Musale","year":"2012","journal-title":"J. Dent. Lasers"},{"key":"ref_44","unstructured":"Aoki, A., Takasaki, A.A., Pourzarandian, A., Mizutani, K., Ruwanpura, S.M., Iwasaki, K., Noguchi, K., Oda, S., Watanabe, H., and Ishikawa, I. Photobiomodulation laser strategies in periodontal therapy. Proceedings of the Light-Activated Tissue Regeneration and Therapy Conference."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/j.1600-0757.2004.03679.x","article-title":"Lasers in nonsurgical periodontal therapy","volume":"36","author":"Aoki","year":"2004","journal-title":"Periodontology 2000"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1111\/j.1600-0765.2004.00738.x","article-title":"Potential applications of Erbium:YAG laser in periodontics","volume":"39","author":"Ishikawa","year":"2004","journal-title":"J. Periodontal Res."},{"key":"ref_47","first-page":"364","article-title":"Ex Vivo Evaluation of Gingival Ablation with Various Laser Systems and Electroscalpel","volume":"38","author":"Kawamura","year":"2020","journal-title":"Photobiomodul. Photomed. Laser Surg."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"507","DOI":"10.11607\/prd.2515","article-title":"A Novel Surgical Procedure for Er: YAG Laser-Assisted Periodontal Regenerative Therapy: Case Series","volume":"36","author":"Taniguchi","year":"2016","journal-title":"Int. J. Periodontics Restor. Dent."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/j.jds.2020.05.030","article-title":"Clinical evaluation of ridge preservation and augmentation with buccal bone deficiency by Er: YAG laser-assisted bone regenerative therapy","volume":"15","author":"Lin","year":"2020","journal-title":"J. Dent. Sci."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1111\/prd.12137","article-title":"Lasers and the treatment of periodontitis: The essence and the noise","volume":"75","author":"Cobb","year":"2017","journal-title":"Periodontology 2000"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1111\/j.1464-410X.2010.09954.x","article-title":"Critical review of lasers in benign prostatic hyperplasia (BPH)","volume":"107","author":"Gravas","year":"2011","journal-title":"BJU Int."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1111\/jcpe.12266","article-title":"Risk factors associated with the longevity of multi-rooted teeth. Long-term outcomes after active and supportive periodontal therapy","volume":"41","author":"Salvi","year":"2014","journal-title":"J. Clin. Periodontol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1007\/s10103-013-1446-7","article-title":"A literature review and novel theoretical approach on the optical properties of whole blood","volume":"29","author":"Bosschaart","year":"2014","journal-title":"Lasers Med. Sci."},{"key":"ref_54","first-page":"7","article-title":"Medical Thermology 2018-a computer-assisted literature survey","volume":"29","author":"Ammer","year":"2019","journal-title":"Thermol. Int."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"553","DOI":"10.14219\/jada.archive.2010.0228","article-title":"Oral hygiene practices and dental service utilization among pregnant women","volume":"141","author":"Boggess","year":"2010","journal-title":"J. Am. Dent. Assoc."},{"key":"ref_56","first-page":"783","article-title":"Antimicrobial photodynamic therapy for the treatment of periodontitis and peri-implantitis: An American Academy of Periodontology best evidence review","volume":"89","author":"Chambrone","year":"2018","journal-title":"J. Periodontol."},{"key":"ref_57","unstructured":"Cuevas Cid, V.I. (2024). Efecto del L\u00e1ser Terap\u00e9utico en Pacientes con Lesiones Erosivas y\/o Ulcerativas de la Mucosa Oral. [Bachelor\u2019s Thesis, Universidad de Chile]."},{"key":"ref_58","unstructured":"Ansi, Z. (2018). 136.3 for the Safe Use of Lasers in Health Care Facilities, American National Standards Institute."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"87","DOI":"10.12788\/cutis.0025","article-title":"Laser safety: The need for protocols","volume":"106","author":"Daggett","year":"2020","journal-title":"Cutis"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1089\/clm.1999.17.193","article-title":"Diode laser (980 nm) in oral and maxillofacial surgical procedures: Clinical observations based on clinical applications","volume":"17","author":"Romanos","year":"1999","journal-title":"J. Clin. Laser Med. Surg."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1111\/j.1600-0501.2006.01278.x","article-title":"Neodymium: Yttrium aluminum garnet laser irradiation with low pulse energy: A potential tool for the treatment of peri-implant disease","volume":"17","author":"Giannini","year":"2006","journal-title":"Clin. Oral. Implant. Res."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1089\/pho.2012.3252","article-title":"A comparative evaluation of the efficacy of diode laser as an adjunct to mechanical debridement versus conventional mechanical debridement in periodontal flap surgery: A clinical and microbiological study","volume":"30","author":"Gokhale","year":"2012","journal-title":"Photomed. Laser Surg."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1902\/jop.2015.150212","article-title":"Effectiveness of Laser Application for Periodontal Surgical Therapy: Systematic Review and Meta-Analysis","volume":"86","author":"Behdin","year":"2015","journal-title":"J. Periodontol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"S880","DOI":"10.4103\/jpbs.jpbs_1072_23","article-title":"Efficacy of Laser-Assisted Periodontal Therapy vs Conventional Scaling and Root Planing","volume":"16","author":"Diwan","year":"2024","journal-title":"J. Pharm. Bioallied Sci."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"S164","DOI":"10.1902\/jop.2013.1340016","article-title":"Periodontitis and adverse pregnancy outcomes: Consensus report of the Joint EFP\/AAP Workshop on Periodontitis and Systemic Diseases","volume":"84","author":"Sanz","year":"2013","journal-title":"J. Periodontol."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/6\/1962\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T16:53:27Z","timestamp":1760028807000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/6\/1962"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,14]]},"references-count":65,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2025,3]]}},"alternative-id":["jcm14061962"],"URL":"https:\/\/doi.org\/10.3390\/jcm14061962","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,14]]}}}