{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T20:02:27Z","timestamp":1790625747288,"version":"4.1.0"},"reference-count":37,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2025,3,14]],"date-time":"2025-03-14T00:00:00Z","timestamp":1741910400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Objectives: To evaluate whether the diagnostic delay in patients with radiographic axial spondyloarthritis (r-axSpA) is associated with poorer short-term outcomes after two years of follow-up. Methods: This was an observational, longitudinal, and prospective study including patients with r-axSpA from the national multicentre Spanish REGISPONSER-AS registry. Patients were divided into two groups according to the mean diagnostic delay (&lt;5 years, \u22655 years). Binary logistic regression models adjusted for disease duration were constructed and used to evaluate the association between diagnostic delay and disease outcomes at two years. The retention rate for first-line treatment with anti-TNF across the groups was evaluated using a log-rank test. Results: A total of 565 patents were included. The mean diagnostic delay was 5.6 \u00b1 6.2 years, with 325 patients experiencing a delay of &lt;5 years and 240 patients experiencing a delay of \u22655 years. A diagnostic delay of \u22655 years was associated, after 2 years, with a higher prevalence of inflammatory bowel disease (IBD) (OR 2.01 (95%CI 1.06\u20133.83)), a lower prevalence of synovitis (OR 0.68 (95%CI 0.47\u20130.98)) and dactylitis (OR 0.24 (95%CI 0.11\u20130.55)), and worse disease activity after adjusting by disease duration. However, no impact was observed on quality of life, structural damage, or work disability, probably due to the short follow-up period. Finally, no differences between the groups were found with regard to the retention rate for first-line anti-TNF treatment. Conclusions: Diagnostic delay is associated with poorer short-term outcomes in terms of structural damage, dactylitis, and disability in patients with r-axSpA.<\/jats:p>","DOI":"10.3390\/jcm14061977","type":"journal-article","created":{"date-parts":[[2025,3,14]],"date-time":"2025-03-14T07:02:16Z","timestamp":1741935736000},"page":"1977","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Association Between Diagnostic Delay and Short-Term Outcomes in Patients with Radiographic Axial Spondyloarthritis: Results from the Regisponser-AS Registry"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3890-2224","authenticated-orcid":false,"given":"Mar\u00eda Lourdes","family":"Ladehesa-Pineda","sequence":"first","affiliation":[{"name":"Rheumatology Department, Reina Sofia University Hospital, 14004 Cordoba, Spain"},{"name":"Maimonides Biomedical Research Institute of Cordoba (IMIBIC), 14004 Cordoba, Spain"},{"name":"Medical and Surgical Department, University of Cordoba, 14004 Cordoba, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Desir\u00e9e","family":"Ruiz-Vilchez","sequence":"additional","affiliation":[{"name":"Maimonides Biomedical Research Institute of Cordoba (IMIBIC), 14004 Cordoba, Spain"},{"name":"Medical and Surgical Department, University of Cordoba, 14004 Cordoba, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-2142-284X","authenticated-orcid":false,"given":"Antonio Manuel","family":"Barranco","sequence":"additional","affiliation":[{"name":"Maimonides Biomedical Research Institute of Cordoba (IMIBIC), 14004 Cordoba, Spain"},{"name":"Medical and Surgical Department, University of Cordoba, 14004 Cordoba, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1526-0978","authenticated-orcid":false,"given":"Mar\u00eda \u00c1ngeles","family":"Puche-Larrubia","sequence":"additional","affiliation":[{"name":"Rheumatology Department, Reina Sofia University Hospital, 14004 Cordoba, Spain"},{"name":"Maimonides Biomedical Research Institute of Cordoba (IMIBIC), 14004 Cordoba, Spain"},{"name":"Medical and Surgical Department, University of Cordoba, 14004 Cordoba, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0811-9079","authenticated-orcid":false,"given":"Pilar","family":"Font-Ugalde","sequence":"additional","affiliation":[{"name":"Maimonides Biomedical Research Institute of Cordoba (IMIBIC), 14004 Cordoba, Spain"},{"name":"Medical and Surgical Department, University of Cordoba, 14004 Cordoba, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4932-9299","authenticated-orcid":false,"given":"Raquel Ena Mar\u00eda","family":"Granados","sequence":"additional","affiliation":[{"name":"Rheumatology Department, Reina Sofia University Hospital, 14004 Cordoba, Spain"},{"name":"Maimonides Biomedical Research Institute of Cordoba (IMIBIC), 14004 Cordoba, Spain"},{"name":"Medical and Surgical Department, University of Cordoba, 14004 Cordoba, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4007-4103","authenticated-orcid":false,"given":"Jordi","family":"Gratac\u00f3s-Mastmij\u00e0","sequence":"additional","affiliation":[{"name":"Rheumatology Department, University Hospital Parc Tauli, 08208 Sabadell, Spain"},{"name":"Universitat Autonoma de Barcelona, 08193 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Juanola","sequence":"additional","affiliation":[{"name":"Rheumatology Department, Bellvitge University Hospital, L\u2019Hospitalet de Llobregat, 08907 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5891-5527","authenticated-orcid":false,"given":"Alejandro","family":"Escudero-Contreras","sequence":"additional","affiliation":[{"name":"Rheumatology Department, Reina Sofia University Hospital, 14004 Cordoba, Spain"},{"name":"Maimonides Biomedical Research Institute of Cordoba (IMIBIC), 14004 Cordoba, Spain"},{"name":"Medical and Surgical Department, University of Cordoba, 14004 Cordoba, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7647-6289","authenticated-orcid":false,"given":"Eduardo","family":"Collantes-Est\u00e9vez","sequence":"additional","affiliation":[{"name":"Maimonides Biomedical Research Institute of Cordoba (IMIBIC), 14004 Cordoba, Spain"},{"name":"Medical and Surgical Department, University of Cordoba, 14004 Cordoba, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2309-5837","authenticated-orcid":false,"given":"Clementina","family":"L\u00f3pez-Medina","sequence":"additional","affiliation":[{"name":"Rheumatology Department, Reina Sofia University Hospital, 14004 Cordoba, Spain"},{"name":"Maimonides Biomedical Research Institute of Cordoba (IMIBIC), 14004 Cordoba, Spain"},{"name":"Medical and Surgical Department, University of Cordoba, 14004 Cordoba, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,3,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1136\/ard.2009.108233","article-title":"The development of Assessment of SpondyloArthritis international Society classification criteria for axial spondyloarthritis (part II): Validation and final selection","volume":"68","author":"Rudwaleit","year":"2009","journal-title":"Ann. 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