{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T16:12:12Z","timestamp":1790439132272,"version":"4.1.0"},"reference-count":38,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2025,3,21]],"date-time":"2025-03-21T00:00:00Z","timestamp":1742515200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Purpose: The aim of this study was to investigate the factors that affect ocular growth in children with primary congenital glaucoma (PCG) who have undergone surgical treatment. We designed an analysis like that proposed by Al-Obaida et al. to assess whether similar results could be obtained in the Caucasian population. Methods: Data on axial length (AxL), intraocular pressure (IOP), and corneal diameter of PCG patients were recorded and analyzed. Results: Patients\u2019 age was significantly influencing the increase in AxL. Also, levels of IOP, number of glaucoma medications, and number of surgeries along the follow-up period were found to significantly influence AxL progression. Conclusions: This study confirms that in PCG patients, there is a curvilinear relationship between AxL and age, which is strongly influenced by IOP, gender, the number of surgical interventions, and the number of anti-glaucoma medications. These data seem to suggest that maintaining IOP values closer to normal ones for age is crucial in the first up to three years of life to avoid permanent ocular anatomic and functional damage caused by elevated intraocular pressure.<\/jats:p>","DOI":"10.3390\/jcm14072152","type":"journal-article","created":{"date-parts":[[2025,3,21]],"date-time":"2025-03-21T10:10:08Z","timestamp":1742551808000},"page":"2152","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The Role of Axial Length and Intraocular Pressure in the Follow-Up of Growing Children with Primary Congenital Glaucoma"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7619-3281","authenticated-orcid":false,"given":"Rosa","family":"Longo","sequence":"first","affiliation":[{"name":"Ophthalmic Unit, Department of Surgical Odontostomatological Maternal and Child Sciences, Integrated University Hospital of Verona, 37134 Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elia","family":"Franzolin","sequence":"additional","affiliation":[{"name":"Ophthalmic Unit, Department of Surgical Odontostomatological Maternal and Child Sciences, Integrated University Hospital of Verona, 37134 Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2350-6560","authenticated-orcid":false,"given":"Elena","family":"Gusson","sequence":"additional","affiliation":[{"name":"Ophthalmic Unit, Department of Surgical Odontostomatological Maternal and Child Sciences, Integrated University Hospital of Verona, 37134 Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Chemello","sequence":"additional","affiliation":[{"name":"Ophthalmic Unit, Department of Surgical Odontostomatological Maternal and Child Sciences, Integrated University Hospital of Verona, 37134 Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Panunzi","sequence":"additional","affiliation":[{"name":"Unit of Epidemiology and Medical Statistics, Department of Diagnostic and Public Health, University of Verona, 37129 Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4657-3168","authenticated-orcid":false,"given":"Giorgio","family":"Marchini","sequence":"additional","affiliation":[{"name":"Ophthalmic Unit, Department of Surgical Odontostomatological Maternal and Child Sciences, Integrated University Hospital of Verona, 37134 Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,3,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.ogla.2019.12.007","article-title":"International Study of Childhood Glaucoma","volume":"3","author":"Papadopoulos","year":"2020","journal-title":"Ophthalmol. Glaucoma"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.sjopt.2019.10.002","article-title":"Primary congenital glaucoma: An updated review","volume":"33","author":"Badawi","year":"2019","journal-title":"Saudi J. Ophthalmol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1016\/j.ajo.2015.01.019","article-title":"Primary congenital glaucoma outcomes: Lessons from 23 years of follow-up","volume":"159","author":"Zagora","year":"2015","journal-title":"Am. J. Ophthalmol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"e29","DOI":"10.1111\/j.1755-3768.2012.02519.x","article-title":"Biomechanical profile of the cornea in primary congenital glaucoma","volume":"91","author":"Gatzioufas","year":"2013","journal-title":"Acta Ophthalmol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1159\/000309028","article-title":"Congenital glaucoma and its inheritance","volume":"181","year":"1980","journal-title":"Ophthalmologica"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1159\/000152978","article-title":"Consanguinity in multifactorial inheritance. Application to data on congenital glaucoma","volume":"28","author":"Demenais","year":"1978","journal-title":"Hum. Hered."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1086\/338709","article-title":"Digenic inheritance of early-onset glaucoma: CYP1B1, a potential modifier gene","volume":"70","author":"Vincent","year":"2002","journal-title":"Am. J. Hum. Genet."},{"key":"ref_8","first-page":"76","article-title":"Epidemiology and genetics of primary congenital glaucoma in Slovakia. Description of a form of primary congenital glaucoma in gypsies with autosomal-recessive inheritance and complete penetrance","volume":"16","year":"1989","journal-title":"Dev. Ophthalmol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/BF00296440","article-title":"Population genetical aspects of primary congenital glaucoma. I. Incidence, prevalence, gene frequency, and age of onset","volume":"61","author":"Gencik","year":"1982","journal-title":"Hum. Genet."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"3861","DOI":"10.1007\/s10792-021-01957-0","article-title":"Primary congenital glaucoma surgery: Outcomes and visual function","volume":"41","author":"Gusson","year":"2021","journal-title":"Int. Ophthalmol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.jaapos.2014.05.012","article-title":"Effect of intraocular pressure control on central corneal thickness, horizontal corneal diameter, and axial length in primary congenital glaucoma","volume":"18","author":"Cronemberger","year":"2014","journal-title":"J. Am. Assoc. Pediatr. Ophthalmol. Strabismus"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Al-Obaida, I., Al Owaifeer, A.M., Ahmad, K., and Malik, R. (2020). The relationship between axial length, age and intraocular pressure in children with primary congenital glaucoma. Sci. Rep., 10.","DOI":"10.1038\/s41598-020-74126-5"},{"key":"ref_13","unstructured":"Zarate, J. (2009). The Glaucomas Volume I: Pediatric Glaucomas, Springer."},{"key":"ref_14","unstructured":"American Academy of Ophthalmology (2021). Pediatric Ophthalmology and Strabismus. Basic and Clinical Science Course, Springer Science & Business Media."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1097\/ICU.0000000000000516","article-title":"New classification system for pediatric glaucoma: Implications for clinical care and a research registry","volume":"29","author":"Thau","year":"2018","journal-title":"Curr. Opin. Ophthalmol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/j.ajo.2006.11.061","article-title":"The effects of sevoflurane and ketamine on intraocular pressure in children during examination under anesthesia","volume":"143","author":"Blumberg","year":"2007","journal-title":"Am. J. Ophthalmol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1097\/IJG.0000000000000355","article-title":"Do Intraocular Pressure Measurements Under Anesthesia Reflect the Awake Condition?","volume":"26","author":"Gofman","year":"2017","journal-title":"J. Glaucoma"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0039-6257(83)90174-1","article-title":"Primary infantile glaucoma (congenital glaucoma)","volume":"28","author":"deLuise","year":"1983","journal-title":"Surv. Ophthalmol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.ajo.2017.08.008","article-title":"Circumferential Trabeculotomy Versus Conventional Angle Surgery: Comparing Long-term Surgical Success and Clinical Outcomes in Children With Primary Congenital Glaucoma","volume":"183","author":"Neustein","year":"2017","journal-title":"Am. J. Ophthalmol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1136\/bjophthalmol-2019-314804","article-title":"Glaucoma following cataract surgery in the first 2 years of life: Frequency, risk factors and outcomes from IoLunder2","volume":"104","author":"Solebo","year":"2019","journal-title":"Br. J. Ophthalmol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1136\/bjophthalmol-2019-315131","article-title":"Long-Term Functional Outcomes of Different Subtypes of Primary Congenital Glaucoma","volume":"104","author":"Chaudhary","year":"2019","journal-title":"Br. J. Ophthalmol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.jaapos.2010.11.025","article-title":"Long-term outcome of primary congenital glaucoma","volume":"15","author":"Khaw","year":"2011","journal-title":"J. Am. Assoc. Pediatr. Ophthalmol. Strabismus"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"2216","DOI":"10.1016\/j.ophtha.2015.07.028","article-title":"Long-Term Outcomes of Trabeculectomy Augmented with Mitomycin C Undertaken within the First 2 Years of Life","volume":"122","author":"Jayaram","year":"2015","journal-title":"Ophthalmology"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/s00417-006-0415-2","article-title":"Long-term results of surgery in childhood glaucoma","volume":"245","author":"Alsheikheh","year":"2007","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1067\/mpa.2000.106201","article-title":"Long-term surgical and visual outcomes in primary congenital glaucoma: 360 degrees trabeculotomy versus goniotomy","volume":"4","author":"Mendicino","year":"2000","journal-title":"J. Am. Assoc. Pediatr. Ophthalmol. Strabismus"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"e681","DOI":"10.1097\/IJG.0000000000000337","article-title":"Long-term Surgical Outcomes of 180-Degree Suture Trabeculotomy in Korean Patients With Primary Congenital Glaucoma","volume":"25","author":"Park","year":"2016","journal-title":"J. Glaucoma"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1590\/S1807-59322009000600009","article-title":"Long-term surgical outcomes of primary congenital glaucoma in China","volume":"64","author":"Zhang","year":"2009","journal-title":"Clinics"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"705","DOI":"10.5301\/ejo.5000976","article-title":"Long-Term Visual Outcomes in Children with Primary Congenital Glaucoma","volume":"27","author":"Yassin","year":"2017","journal-title":"Eur. J. Ophthalmol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1001\/archophthalmol.2009.267","article-title":"Outcomes of Ahmed glaucoma valve implantation in children with primary congenital glaucoma","volume":"127","author":"Ou","year":"2009","journal-title":"Arch. Ophthalmol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1016\/S0002-9394(01)01183-7","article-title":"Serial axial length measurements in congenital glaucoma","volume":"132","author":"Law","year":"2001","journal-title":"Am. J. Ophthalmol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1001\/archopht.1982.01030030576003","article-title":"Ocular echometry in the diagnosis of congenital glaucoma","volume":"100","author":"Sampaolesi","year":"1982","journal-title":"Arch. Ophthalmol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"4774","DOI":"10.1167\/iovs.07-1564","article-title":"Corneal curvature and axial length values in children with congenital\/infantile cataract in the first 42 months of life","volume":"49","author":"Capozzi","year":"2008","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"581","DOI":"10.5301\/ejo.5000784","article-title":"Surgical outcomes in children with primary congenital glaucoma: A 20-year experience","volume":"26","author":"Yassin","year":"2016","journal-title":"Eur. J. Ophthalmol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.survophthal.2021.05.010","article-title":"Meta-analysis of ocular axial length in newborns and infants up to 3 years of age","volume":"67","author":"Groot","year":"2022","journal-title":"Surv. Ophthalmol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1111\/aos.12107","article-title":"Juvenile eye growth, when completed? An evaluation based on IOL-Master axial length data, cross-sectional and longitudinal","volume":"92","author":"Fledelius","year":"2014","journal-title":"Acta Ophthalmol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1007\/s00417-001-0377-3","article-title":"Correlation of postoperative axial length growth and intraocular pressure in congenital glaucoma\u2014A retrospective study in trabeculotomy and goniotomy","volume":"239","author":"Kiefer","year":"2001","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1111\/aos.15310","article-title":"Outcomes of early versus delayed trabeculotomy for primary congenital glaucoma","volume":"101","author":"Cronemberger","year":"2023","journal-title":"Acta Ophthalmol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1111\/aos.12566","article-title":"Outcome of surgical treatment of primary and secondary glaucoma in young children","volume":"93","author":"Zetterberg","year":"2015","journal-title":"Acta Ophthalmol."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/7\/2152\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T16:57:59Z","timestamp":1760029079000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/7\/2152"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,21]]},"references-count":38,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2025,4]]}},"alternative-id":["jcm14072152"],"URL":"https:\/\/doi.org\/10.3390\/jcm14072152","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,21]]}}}