{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T19:54:40Z","timestamp":1792007680911,"version":"4.4.0"},"reference-count":243,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2025,3,24]],"date-time":"2025-03-24T00:00:00Z","timestamp":1742774400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Fundaci\u00f3n P\u00fablica Galega de Investigaci\u00f3n Biom\u00e9dica INIBIC"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Recovery from traumatic spinal cord injury (tSCI) is challenging due to the limited regenerative capacity of the central nervous system to restore cells, myelin, and neural connections. At the clinical level, the fundamental pillars of treatment are the reduction in secondary damage (neuroprotection) and rehabilitation; these are the tools we have to mitigate the disability caused by spinal cord injury (SCI). To date, the treatments on which neuroprotection has been based are the prevention of acute respiratory failure to avoid hypoxia, early hemodynamic control, neuroprotective drugs and surgical management. Optimizing early hemodynamic control to ensure adequate spinal cord perfusion may be key to the management of SCI. While neuroprotective agents like methylprednisolone have fallen into disuse, several promising therapies are currently being tested in clinical trials. In terms of surgical treatment, although their impact on neurological recovery remains debated, appropriate early bone decompression followed by duroplasty in selected cases is increasingly recommended. Advances in cell therapies hold significant potential for enhancing both clinical and functional outcomes in SCI patients. Moreover, emerging neuromodulation techniques, such as transcutaneous and epidural stimulation, along with innovations in rehabilitation technologies\u2014such as robotic systems and exoskeletons\u2014are becoming indispensable tools for improving locomotion and overall mobility in individuals with SCI. This article provides an update on the advances in neuroprotection against secondary damage caused by tSCI, in cellular therapies, and in new rehabilitation therapies.<\/jats:p>","DOI":"10.3390\/jcm14072203","type":"journal-article","created":{"date-parts":[[2025,3,24]],"date-time":"2025-03-24T06:21:38Z","timestamp":1742797298000},"page":"2203","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Advances and New Therapies in Traumatic Spinal Cord Injury"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1773-365X","authenticated-orcid":false,"given":"Antonio","family":"Montoto-Marqu\u00e9s","sequence":"first","affiliation":[{"name":"Unidad de Lesionados Medulares, Complejo Hospitalario Universitario de A Coru\u00f1a, Grupo de Investigaci\u00f3n en Terapia Celular y Medicina Regenerativa, Instituto de Investigaci\u00f3n Biom\u00e9dica de A Coru\u00f1a (INIBIC), 15006 A 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Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8205-8246","authenticated-orcid":false,"given":"Mark","family":"Andrew Wright","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n Institut Guttmann, Institut Universitari de Neurorehabilitaci\u00f3 Adscrit a la UAB, 08916 Barcelona, Spain"},{"name":"Institut Universitari de Neurorehabilitaci\u00f3 adscrit a la Universitat Aut\u00f3noma de Barcelona, Bellaterra, 08193 Barcelona, Spain"},{"name":"Fundaci\u00f3 Institut d\u2019Investigaci\u00f3 en Ci\u00e8ncies de la Salut Germans Trias i Pujol, 08916 Badalona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9810-7548","authenticated-orcid":false,"given":"Sebastian","family":"Salvador-De la Barrera","sequence":"additional","affiliation":[{"name":"Unidad de Lesionados Medulares, Instituto de Investigaci\u00f3n Biom\u00e9dica de A Coru\u00f1a (INIBIC), Complejo Hospitalario 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15006 A Coru\u00f1a, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-5485-413X","authenticated-orcid":false,"given":"Agustin","family":"Hern\u00e1ndez-Navarro","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n Institut Guttmann, Institut Universitari de Neurorehabilitaci\u00f3 Adscrit a la UAB, 08916 Barcelona, Spain"},{"name":"Institut Universitari de Neurorehabilitaci\u00f3 adscrit a la Universitat Aut\u00f3noma de Barcelona, Bellaterra, 08193 Barcelona, Spain"},{"name":"Fundaci\u00f3 Institut d\u2019Investigaci\u00f3 en Ci\u00e8ncies de la Salut Germans Trias i Pujol, 08916 Badalona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Rodr\u00edguez-Sotillo","sequence":"additional","affiliation":[{"name":"Unidad de Lesionados Medulares, Instituto de Investigaci\u00f3n Biom\u00e9dica de A Coru\u00f1a (INIBIC), Complejo Hospitalario Universitario de A Coru\u00f1a, 15006 A 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