{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T11:26:34Z","timestamp":1780572394653,"version":"3.54.1"},"reference-count":109,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2025,3,25]],"date-time":"2025-03-25T00:00:00Z","timestamp":1742860800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Tinnitus is defined as the conscious awareness of a tonal or composite noise for which there is no identifiable corresponding external acoustic source, which becomes tinnitus disorder when the phantom sound is associated with suffering and\/or disability. There is only limited knowledge about the time course of tinnitus disorder. Bereavement science has identified four different trajectories: resilience, recovery, chronic, and delayed. The question arises whether these four trajectories exist in tinnitus as well if one considers tinnitus as the loss of silence (at will). To verify whether these four trajectories exist, short-term tinnitus progression was analyzed retrospectively using an Ecological Momentary Assessment (EMA) approach, extracting the data from patients who started using the TrackYourTinnitus (TYT) app (version 1, Ulm University, 2013) from the start of their tinnitus perception. Four patients were identified retrospectively via the TYT app with acute tinnitus, and the bereavement trajectories were reconstructed based on EMA. In conclusion, this perspective suggests that the four known bereavement trajectories may exist in tinnitus, and prospective evaluations of larger samples are warranted to confirm or disprove this analogy between bereavement and tinnitus, in which tinnitus is conceived as the loss of (controllable) silence.<\/jats:p>","DOI":"10.3390\/jcm14072218","type":"journal-article","created":{"date-parts":[[2025,3,25]],"date-time":"2025-03-25T10:45:08Z","timestamp":1742899508000},"page":"2218","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Mourning for Silence: Bereavement and Tinnitus\u2014A Perspective"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4625-268X","authenticated-orcid":false,"given":"Dirk","family":"De Ridder","sequence":"first","affiliation":[{"name":"Section of Neurosurgery, Department of Surgical Sciences, University of Otago, Dunedin 9016, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berthold","family":"Langguth","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, University of Regensburg, 93053 Regensburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7942-1788","authenticated-orcid":false,"given":"Winfried","family":"Schlee","sequence":"additional","affiliation":[{"name":"Institute for Information and Process Management, Eastern Switzerland University of Applied Sciences, 9000 St. Gallen, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,3,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/bs.pbr.2020.12.002","article-title":"Tinnitus and tinnitus disorder: Theoretical and operational definitions (an international multidisciplinary proposal)","volume":"260","author":"Schlee","year":"2021","journal-title":"Prog. Brain Res."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/0378-5955(87)90054-2","article-title":"The analogy between tinnitus and pain: A suggestion for a physiological basis of chronic tinnitus","volume":"28","author":"Tonndorf","year":"1987","journal-title":"Hear. Res."},{"key":"ref_3","first-page":"577","article-title":"Similarities between chronic pain and tinnitus","volume":"18","author":"Moller","year":"1997","journal-title":"Am. J. Otol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"149137","DOI":"10.1016\/j.brainres.2024.149137","article-title":"The brain\u2019s duck test in phantom percepts: Multisensory congruence in neuropathic pain and tinnitus","volume":"1844","author":"Adhia","year":"2024","journal-title":"Brain Res."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"8075","DOI":"10.1073\/pnas.1018466108","article-title":"Phantom percepts: Tinnitus and pain as persisting aversive memory networks","volume":"108","author":"Elgoyhen","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"fcad132","DOI":"10.1093\/braincomms\/fcad132","article-title":"A parahippocampal-sensory Bayesian vicious circle generates pain or tinnitus: A source-localized EEG study","volume":"5","author":"Friston","year":"2023","journal-title":"Brain Commun."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0079-6123(07)66005-1","article-title":"The Darwinian plasticity hypothesis for tinnitus and pain","volume":"166","year":"2007","journal-title":"Prog. Brain Res."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/bs.pbr.2020.07.012","article-title":"The Bayesian brain in imbalance: Medial, lateral and descending pathways in tinnitus and pain: A perspective","volume":"262","author":"Vanneste","year":"2021","journal-title":"Prog. Brain Res."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.neubiorev.2021.08.013","article-title":"The anatomy of pain and suffering in the brain and its clinical implications","volume":"130","author":"Adhia","year":"2021","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1097\/j.pain.0000000000001365","article-title":"The IASP classification of chronic pain for ICD-11: Chronic neuropathic pain","volume":"160","author":"Scholz","year":"2019","journal-title":"Pain"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1097\/j.pain.0000000000001384","article-title":"Chronic pain as a symptom or a disease: The IASP Classification of Chronic Pain for the International Classification of Diseases (ICD-11)","volume":"160","author":"Treede","year":"2019","journal-title":"Pain"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Cederroth, C.R., Gallus, S., Hall, D.A., Kleinjung, T., Langguth, B., Maruotti, A., Meyer, M., Norena, A., Probst, T., and Pryss, R. (2019). Editorial: Towards an Understanding of Tinnitus Heterogeneity. Front. Aging Neurosci., 11.","DOI":"10.3389\/fnagi.2019.00053"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"e041290","DOI":"10.1136\/bmjopen-2020-041290","article-title":"Natural history of tinnitus in adults: A cross-sectional and longitudinal analysis","volume":"10","author":"Dawes","year":"2020","journal-title":"BMJ Open"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1001\/jamaneurol.2022.2189","article-title":"Global Prevalence and Incidence of Tinnitus: A Systematic Review and Meta-analysis","volume":"79","author":"Jarach","year":"2022","journal-title":"JAMA Neurol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"53","DOI":"10.3109\/03005368909077819","article-title":"Tinnitus\u2014A study of its prevalence and characteristics","volume":"23","author":"Axelsson","year":"1989","journal-title":"Br. J. Audiol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1093\/occmed\/43.1.35","article-title":"Tinnitus in noise-exposed workers","volume":"43","author":"Phoon","year":"1993","journal-title":"Occup. Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.heares.2017.01.013","article-title":"Prevalence of hearing loss and tinnitus in Iraq and Afghanistan Veterans: A Chronic Effects of Neurotrauma Consortium study","volume":"349","author":"Swan","year":"2017","journal-title":"Hear. Res."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Kreuzer, P.M., Landgrebe, M., Schecklmann, M., Staudinger, S., Langguth, B., and The TRI Database Study Group (2012). Trauma-associated tinnitus: Audiological, demographic and clinical characteristics. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0045599"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1097\/HTR.0b013e31829d3129","article-title":"Trauma-associated tinnitus","volume":"29","author":"Kreuzer","year":"2014","journal-title":"J. head trauma Rehabil."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Fagelson, M. (2022). Tinnitus and Traumatic Memory. Brain Sci., 12.","DOI":"10.3390\/brainsci12111585"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1044\/1059-0889(2007\/015)","article-title":"The association between tinnitus and posttraumatic stress disorder","volume":"16","author":"Fagelson","year":"2007","journal-title":"Am. J. Audiol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1093\/milmed\/usaa288","article-title":"Mental Health Symptoms Among Veteran VA Users by Tinnitus Severity:A Population-based Survey","volume":"186","author":"Prewitt","year":"2021","journal-title":"Mil. Med."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1097\/PSY.0000000000000978","article-title":"A longitudinal exploration of self-reported hearing loss, tinnitus and PTSD treatment outcomes in Australian veterans","volume":"83","author":"Terhaag","year":"2021","journal-title":"Psychosom. Med."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1002\/lary.26107","article-title":"Relationships between tinnitus and the prevalence of anxiety and depression","volume":"127","author":"Bhatt","year":"2017","journal-title":"Laryngoscope"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1002\/lio2.1037","article-title":"Clinical characteristics and psychoacoustic analysis of acute and chronic subjective tinnitus","volume":"8","author":"Zhang","year":"2023","journal-title":"Laryngoscope Investig. Otolaryngol."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Vielsmeier, V., Santiago Stiel, R., Kwok, P., Langguth, B., and Schecklmann, M. (2020). From Acute to Chronic Tinnitus: Pilot Data on Predictors and Progression. Front. Neurol., 11.","DOI":"10.3389\/fneur.2020.00997"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Simoes, J.P., Neff, P.K.A., Langguth, B., Schlee, W., and Schecklmann, M. (2021). The progression of chronic tinnitus over the years. Sci. Rep., 11.","DOI":"10.1038\/s41598-021-83068-5"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1111\/j.1460-9568.2011.07793.x","article-title":"The neural network of phantom sound changes over time: A comparison between recent-onset and chronic tinnitus patients","volume":"34","author":"Vanneste","year":"2011","journal-title":"Eur. J. Neurosci."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1037\/0003-066X.59.1.20","article-title":"Loss, trauma, and human resilience: Have we underestimated the human capacity to thrive after extremely aversive events?","volume":"59","author":"Bonanno","year":"2004","journal-title":"Am. Psychol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"e2342675","DOI":"10.1001\/jamanetworkopen.2023.42675","article-title":"Comorbid Prolonged Grief, PTSD, and Depression Trajectories for Bereaved Family Surrogates","volume":"6","author":"Wen","year":"2023","journal-title":"JAMA Netw. Open"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/S0079-6123(07)66050-6","article-title":"Consensus for tinnitus patient assessment and treatment outcome measurement: Tinnitus Research Initiative meeting","volume":"166","author":"Langguth","year":"2007","journal-title":"Prog. Brain Res."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1080\/14992020400050077","article-title":"Rapid Assessment of tinnitus-related psychological distress using the Mini-TQ","volume":"43","author":"Hiller","year":"2004","journal-title":"Int J Audiol."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Mohan, A., Leong, S.L., De Ridder, D., and Vanneste, S. (2022). Symptom dimensions to address heterogeneity in tinnitus. Neurosci. Biobehav. Rev., 134.","DOI":"10.1016\/j.neubiorev.2022.104542"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Moller, A., Langguth, B., De Ridder, D., and Kleinjung, T. (2011). A heuristic pathophysiological model of tinnitus. Chapter 21. Textbook of Tinnitus, Springer.","DOI":"10.1007\/978-1-60761-145-5"},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Masten, A.S., and Barnes, A.J. (2018). Resilience in Children: Developmental Perspectives. Children, 5.","DOI":"10.3390\/children5070098"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"215","DOI":"10.5271\/sjweh.3420","article-title":"Occurrence of delayed-onset post-traumatic stress disorder: A systematic review and meta-analysis of prospective studies","volume":"40","author":"Breinegaard","year":"2014","journal-title":"Scand. J. Work. Environ. Health"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.joto.2021.08.001","article-title":"The study on psychological resilience of tinnitus and associated influencing factors","volume":"17","author":"Xin","year":"2022","journal-title":"J. Otol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1055\/a-1709-4912","article-title":"Perception of Tinnitus: Direct and Indirect Effects of Resilience, Personality Traits, and Psychiatric Symptoms","volume":"33","author":"Martins","year":"2022","journal-title":"J. Am. Acad. Audiol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0079-6123(07)66020-8","article-title":"Tinnitus severity, depression, and the big five personality traits","volume":"166","author":"Langguth","year":"2007","journal-title":"Prog. Brain Res."},{"key":"ref_40","first-page":"370307","article-title":"Tinnitus-related distress and the personality characteristic resilience","volume":"2014","author":"Delb","year":"2014","journal-title":"Neural Plast."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1017\/dmp.2015.17","article-title":"The Incidence of Posttraumatic Stress Disorder After Floods: A Meta-Analysis","volume":"9","author":"Chen","year":"2015","journal-title":"Disaster Med. Public Health Prep."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Lim, I., Tam, W.W.S., Chudzicka-Czupala, A., McIntyre, R.S., Teopiz, K.M., Ho, R.C., and Ho, C.S.H. (2022). Prevalence of depression, anxiety and post-traumatic stress in war- and conflict-afflicted areas: A meta-analysis. Front. Psychiatry, 13.","DOI":"10.3389\/fpsyt.2022.978703"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"4982","DOI":"10.1038\/s41380-021-01036-x","article-title":"Prevalence of posttraumatic stress disorder after infectious disease pandemics in the twenty-first century, including COVID-19: A meta-analysis and systematic review","volume":"26","author":"Yuan","year":"2021","journal-title":"Mol. Psychiatry"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Yuan, M.D., Wang, Z.Q., Fei, L., and Zhong, B.L. (2022). Prevalence of prolonged grief disorder and its symptoms in Chinese parents who lost their only child: A systematic review and meta-analysis. Front. Public Health, 10.","DOI":"10.3389\/fpubh.2022.1016160"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.jad.2017.01.030","article-title":"Prevalence of prolonged grief disorder in adult bereavement: A systematic review and meta-analysis","volume":"212","author":"Lundorff","year":"2017","journal-title":"J. Affect. Disord."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"100508","DOI":"10.1016\/j.puhip.2024.100508","article-title":"The prevalence of prolonged grief disorder (PGD) after the natural disasters: A systematic review and meta-analysis","volume":"7","author":"Zareiyan","year":"2024","journal-title":"Public Health Pract."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"e101216","DOI":"10.1136\/gpsych-2023-101216","article-title":"Prevalence of prolonged grief disorder and its symptoms among bereaved individuals in China: A systematic review and meta-analysis","volume":"37","author":"Yuan","year":"2024","journal-title":"Gen. Psychiatr."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1146\/annurev-clinpsy-032210-104526","article-title":"Resilience to loss and potential trauma","volume":"7","author":"Bonanno","year":"2011","journal-title":"Annu. Rev. Clin. Psychol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1521\/psyc.2012.75.1.76","article-title":"Bereavement and mental health after sudden and violent losses: A review","volume":"75","author":"Kristensen","year":"2012","journal-title":"Psychiatry"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/bs.pbr.2020.05.023","article-title":"Long-lasting total remission of tinnitus: A systematic collection of cases","volume":"260","author":"Sanchez","year":"2021","journal-title":"Prog Brain Res."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Morstead, T., Rights, J.D., Sin, N.L., and DeLongis, A. (2024). Predictors of Complicated Grief During the COVID-19 Pandemic: A Cross-Classified Analysis. Omega (Westport).","DOI":"10.1177\/00302228241239698"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1080\/07481187.2018.1446059","article-title":"Five-factor model in bereaved adults with and without complicated grief","volume":"43","author":"Goetter","year":"2019","journal-title":"Death Stud."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.sleep.2023.12.009","article-title":"Trajectories of insomnia following bereavement","volume":"114","author":"Lancel","year":"2024","journal-title":"Sleep Med."},{"key":"ref_54","first-page":"961","article-title":"Incidence and risk factors of prolonged grief in relatives of patients with terminal cancer in French palliative care units: The Fami-Life multicenter cohort study","volume":"22","author":"Marche","year":"2023","journal-title":"Palliat. Support. Care"},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Basso, L., Boecking, B., Brueggemann, P., Pedersen, N.L., Canlon, B., Cederroth, C.R., and Mazurek, B. (2020). Gender-Specific Risk Factors and Comorbidities of Bothersome Tinnitus. Front. Neurosci., 14.","DOI":"10.3389\/fnins.2020.00706"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/S0272-7358(00)00062-3","article-title":"The varieties of grief experience","volume":"21","author":"Bonanno","year":"2001","journal-title":"Clin. Psychol. Rev."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"165","DOI":"10.3109\/01050399109074949","article-title":"Tinnitus in old age","volume":"20","author":"Rosenhall","year":"1991","journal-title":"Scand. Audiol."},{"key":"ref_58","first-page":"47","article-title":"The influence of ageing on noise-induced hearing loss","volume":"5","author":"Rosenhall","year":"2003","journal-title":"Noise Health"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.heares.2015.11.004","article-title":"Effects of noise exposure on development of tinnitus and hyperacusis: Prevalence rates 12 months after exposure in middle-aged rats","volume":"334","author":"Turner","year":"2016","journal-title":"Hear. Res."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Schlee, W., Langguth, B., De Ridder, D., Vanneste, S., Kleinjung, T., and Moller, A. (2024). Trauma-associated Tinnitus. Chapter 38. Textbook of Tinnitus, Springer. [2nd ed.].","DOI":"10.1007\/978-3-031-35647-6"},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Patil, J.D., Alrashid, M.A., Eltabbakh, A., and Fredericks, S. (2023). The association between stress, emotional states, and tinnitus: A mini-review. Front. Aging Neurosci., 15.","DOI":"10.3389\/fnagi.2023.1131979"},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"De Ridder, D., Vanneste, S., and Congedo, M. (2011). The distressed brain: A group blind source separation analysis on tinnitus. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0024273"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"205","DOI":"10.21053\/ceo.2022.00815","article-title":"Tinnitus and the triple network model: A perspective","volume":"15","author":"Vanneste","year":"2022","journal-title":"Clin. Exp. Otorhinolaryngol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.pneurobio.2017.05.004","article-title":"Uncertainty and stress: Why it causes diseases and how it is mastered by the brain","volume":"156","author":"Peters","year":"2017","journal-title":"Prog. Neurobiol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"2349","DOI":"10.1523\/JNEUROSCI.5587-06.2007","article-title":"Dissociable intrinsic connectivity networks for salience processing and executive control","volume":"27","author":"Seeley","year":"2007","journal-title":"J. Neurosci."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1038\/nri1571","article-title":"Stress-induced immune dysfunction: Implications for health","volume":"5","author":"Glaser","year":"2005","journal-title":"Nat. Rev. Immunol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1898","DOI":"10.1038\/s41467-020-15655-5","article-title":"A double-hit of stress and low-grade inflammation on functional brain network mediates posttraumatic stress symptoms","volume":"11","author":"Kim","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"264","DOI":"10.2174\/1745017901814010264","article-title":"Tinnitus: The Sound of Stress?","volume":"14","author":"Ciminelli","year":"2018","journal-title":"Clin. Pract. Epidemiol. Ment. Health"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1080\/14992027.2020.1827306","article-title":"Tinnitus and stress in adults: A scoping review","volume":"60","author":"Elarbed","year":"2021","journal-title":"Int. J. Audiol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1038\/nrrheum.2017.172","article-title":"The brain and immune system prompt energy shortage in chronic inflammation and ageing","volume":"13","author":"Straub","year":"2017","journal-title":"Nat. Rev. Rheumatol."},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Turunen-Taheri, S., Carlsson, P.I., Ternevall, E., and Hellstrom, S. (2023). Mental Fatigue in Patients with Hearing Loss and\/or Tinnitus Undergoing Audiological Rehabilitation\u2014A Pilot Study. J. Clin. Med., 12.","DOI":"10.3390\/jcm12216756"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1016\/j.neubiorev.2010.11.003","article-title":"An integrative model of tinnitus based on a central gain controlling neural sensitivity","volume":"35","author":"Norena","year":"2011","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Wang, W., Zhang, L.S., Zinsmaier, A.K., Patterson, G., Leptich, E.J., Shoemaker, S.L., Yatskievych, T.A., Gibboni, R., Pace, E., and Luo, H. (2019). Neuroinflammation mediates noise-induced synaptic imbalance and tinnitus in rodent models. PLoS Biol., 17.","DOI":"10.1371\/journal.pbio.3000307"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.neubiorev.2013.03.021","article-title":"An integrative model of auditory phantom perception: Tinnitus as a unified percept of interacting separable subnetworks","volume":"44","author":"Vanneste","year":"2014","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/j.tins.2016.10.004","article-title":"An Integrative Tinnitus Model Based on Sensory Precision","volume":"39","author":"Sedley","year":"2016","journal-title":"Trends Neurosci."},{"key":"ref_76","first-page":"4","article-title":"The Bayesian brain: Phantom percepts resolve sensory uncertainty","volume":"44C","author":"Vanneste","year":"2014","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.heares.2006.09.003","article-title":"High-frequency tinnitus without hearing loss does not mean absence of deafferentation","volume":"222","author":"Weisz","year":"2006","journal-title":"Hear. Res."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"108356","DOI":"10.1016\/j.heares.2021.108356","article-title":"Is the posterior cingulate cortex an on-off switch for tinnitus?: A comparison between hearing loss subjects with and without tinnitus","volume":"411","author":"Lee","year":"2021","journal-title":"Hear. Res."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.neuroscience.2024.11.002","article-title":"Thalamocortical dysrhythmia and reward deficiency syndrome as uncertainty disorders","volume":"563","author":"Vanneste","year":"2024","journal-title":"Neuroscience"},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Ryan, M., and Ryznar, R. (2022). The Molecular Basis of Resilience: A Narrative Review. Front. Psychiatry, 13.","DOI":"10.3389\/fpsyt.2022.856998"},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Hoffmann, A., Sportelli, V., Ziller, M., and Spengler, D. (2017). Epigenomics of Major Depressive Disorders and Schizophrenia: Early Life Decides. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18081711"},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Raabe, F.J., and Spengler, D. (2013). Epigenetic Risk Factors in PTSD and Depression. Front. Psychiatry, 4.","DOI":"10.3389\/fpsyt.2013.00080"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.heares.2018.05.020","article-title":"COMT and the neurogenetic architecture of hearing loss induced tinnitus","volume":"365","author":"Vanneste","year":"2018","journal-title":"Hear. Res."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/bs.pbr.2020.08.005","article-title":"The BDNF Val66Met polymorphism regulates vulnerability to chronic stress and phantom perception","volume":"260","author":"Vanneste","year":"2021","journal-title":"Prog. Brain Res."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1038\/s41467-024-44842-x","article-title":"Genetic architecture distinguishes tinnitus from hearing loss","volume":"15","author":"Clifford","year":"2024","journal-title":"Nat. Commun."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.jad.2024.11.002","article-title":"Deciphering the genetic underpinnings of neuroticism: A Mendelian randomization study of druggable gene targets","volume":"370","author":"Hong","year":"2025","journal-title":"J. Affect. Disord."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1038\/s41588-018-0151-7","article-title":"Meta-analysis of genome-wide association studies for neuroticism in 449,484 individuals identifies novel genetic loci and pathways","volume":"50","author":"Nagel","year":"2018","journal-title":"Nat. Genet."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"6059","DOI":"10.1038\/s41467-023-41249-y","article-title":"Genome-wide association studies and cross-population meta-analyses investigating short and long sleep duration","volume":"14","author":"Levey","year":"2023","journal-title":"Nat. Commun."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1038\/s41588-022-01124-w","article-title":"Genome-wide meta-analysis of insomnia prioritizes genes associated with metabolic and psychiatric pathways","volume":"54","author":"Watanabe","year":"2022","journal-title":"Nat. Genet."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"e279","DOI":"10.1097\/AUD.0000000000000168","article-title":"The Role of Dysfunctional Cognitions in Patients With Chronic Tinnitus","volume":"36","author":"Conrad","year":"2015","journal-title":"Ear Hear."},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Simoes, J., Schlee, W., Schecklmann, M., Langguth, B., Farahmand, D., and Neff, P. (2019). Big Five Personality Traits are Associated with Tinnitus Improvement Over Time. Sci. Rep., 9.","DOI":"10.1038\/s41598-019-53845-4"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1038\/s41380-024-02688-1","article-title":"A meta-analysis of genome-wide studies of resilience in the German population","volume":"30","author":"Garvert","year":"2025","journal-title":"Mol. Psychiatry"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1007\/s43630-024-00613-7","article-title":"Transcranial photobiomodulation for neurodevelopmental disorders: A narrative review","volume":"23","author":"Coelho","year":"2024","journal-title":"Photochem. Photobiol. Sci."},{"key":"ref_94","doi-asserted-by":"crossref","unstructured":"Zielinski, M.R., Systrom, D.M., and Rose, N.R. (2019). Fatigue, Sleep, and Autoimmune and Related Disorders. Front. Immunol., 10.","DOI":"10.3389\/fimmu.2019.01827"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1038\/s41582-019-0174-4","article-title":"Immunoneuropsychiatry-novel perspectives on brain disorders","volume":"15","author":"Pape","year":"2019","journal-title":"Nat. Rev. Neurol."},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Basso, L., Boecking, B., Neff, P., Brueggemann, P., El-Ahmad, L., Brasanac, J., Rose, M., Gold, S.M., and Mazurek, B. (2022). Negative Associations of Stress and Anxiety Levels With Cytotoxic and Regulatory Natural Killer Cell Frequency in Chronic Tinnitus. Front. Psychol., 13.","DOI":"10.3389\/fpsyg.2022.871822"},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"Mennink, L.M., Aalbers, M.W., van Dijk, P., and van Dijk, J.M.C. (2022). The Role of Inflammation in Tinnitus: A Systematic Review and Meta-Analysis. J. Clin. Med., 11.","DOI":"10.3390\/jcm11041000"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1016\/S2215-0366(15)00309-0","article-title":"Inflammatory markers in post-traumatic stress disorder: A systematic review, meta-analysis, and meta-regression","volume":"2","author":"Passos","year":"2015","journal-title":"Lancet Psychiatry"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"3150","DOI":"10.1038\/s41380-022-01564-0","article-title":"Inflammatory and oxidative stress markers in post-traumatic stress disorder: A systematic review and meta-analysis","volume":"27","author":"Peruzzolo","year":"2022","journal-title":"Mol. Psychiatry"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"24568","DOI":"10.1039\/C9RA03562A","article-title":"Current and future functional imaging techniques for post-traumatic stress disorder","volume":"9","author":"Prasad","year":"2019","journal-title":"RSC Adv."},{"key":"ref_101","doi-asserted-by":"crossref","unstructured":"Seiler, A., von Kanel, R., and Slavich, G.M. (2020). The Psychobiology of Bereavement and Health: A Conceptual Review From the Perspective of Social Signal Transduction Theory of Depression. Front. Psychiatry, 11.","DOI":"10.3389\/fpsyt.2020.565239"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1016\/j.bbi.2012.06.009","article-title":"When grief makes you sick: Bereavement induced systemic inflammation is a question of genotype","volume":"26","author":"Magpantay","year":"2012","journal-title":"Brain Behav. Immun."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.bbi.2013.12.017","article-title":"Divergent gene expression responses to complicated grief and non-complicated grief","volume":"37","author":"Irwin","year":"2014","journal-title":"Brain Behav. Immun."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"4071","DOI":"10.1007\/s00405-024-08561-9","article-title":"Phenotypic spectrum of tinnitus patients bearing rare ANK2 gene variants","volume":"281","author":"Lamolda","year":"2024","journal-title":"Eur. Arch. Otorhinolaryngol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s10162-024-00925-6","article-title":"A Systematic Review on the Genetic Contribution to Tinnitus","volume":"25","year":"2024","journal-title":"J. Assoc. Res. Otolaryngol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1038\/mp.2015.138","article-title":"Candidate genes in panic disorder: Meta-analyses of 23 common variants in major anxiogenic pathways","volume":"21","author":"Howe","year":"2016","journal-title":"Mol. Psychiatry"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41398-017-0025-2","article-title":"Polymorphism in Tmem132d regulates expression and anxiety-related behavior through binding of RNA polymerase II complex","volume":"8","author":"Naik","year":"2018","journal-title":"Transl. Psychiatry"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"338","DOI":"10.5414\/CP201617","article-title":"Treatment of tinnitus with cyclobenzaprine: An open-label study","volume":"50","author":"Vanneste","year":"2012","journal-title":"Int. J. Clin. Pharmacol. Ther."},{"key":"ref_109","first-page":"CD003852","article-title":"Ginkgo biloba for tinnitus","volume":"3","author":"Hilton","year":"2013","journal-title":"Cochrane Database Syst. Rev."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/7\/2218\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T16:59:41Z","timestamp":1760029181000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/7\/2218"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,25]]},"references-count":109,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2025,4]]}},"alternative-id":["jcm14072218"],"URL":"https:\/\/doi.org\/10.3390\/jcm14072218","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,25]]}}}