{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T11:05:45Z","timestamp":1792839945668,"version":"4.5.0"},"reference-count":42,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2025,3,27]],"date-time":"2025-03-27T00:00:00Z","timestamp":1743033600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background\/Objectives: Patch testing is a valuable clinical tool for identifying the causes of allergic contact dermatitis (ACD). This study aimed to identify common allergens in southern Taiwan. Methods: A retrospective review of patch test data from April 2019 to May 2023 was conducted at a tertiary medical center. The European Baseline Series of allergens was utilized to evaluate and identify the causes of dermatitis. The prevalence rates of contact sensitization to each allergen were calculated. Results: A total of 57 patients (mean age 41.8 years) with contact dermatitis who underwent patch testing were included. The most common allergens were cobalt chloride (24.6%), followed by fragrance mix I (19.3%), Peru balsam (17.5%), nickel (II) sulfate hexahydrate (15.8%), benzisothiazolinone (15.8%), 4-Phenylenediamine (PPD) base (10.5%), and methyldibromo glutaronitrile (10.5%). Patients with positive patch test results frequently had a history of allergic rhinitis (26.3%), atopic dermatitis (24.6%), urticaria (21.1%), and elevated immunoglobulin E (IgE) levels (28.1%). The hairdressing profession was associated with a higher risk of hand eczematous dermatitis. Conclusions: Positive patch test results were observed in 86% of patients diagnosed with contact dermatitis. This study found that cobalt, rather than nickel, was the most prevalent allergen in patients with contact dermatitis. Elevated IgE levels were observed in ACD patients, with the hands being the most frequently affected area. Occupations as accountants, secretaries, and in the hairdressing and cosmetics industries were strongly associated with hand eczematous dermatitis. The early identification of allergens and appropriate treatment strategies significantly reduced recurrence rates and improved outcomes. For individuals with specific allergies, ongoing avoidance of identified allergens is crucial to managing and preventing allergic reactions. Further research is needed to elucidate the mechanisms and responses to novel therapies, including biologic agent- and nanotechnology-based treatments.<\/jats:p>","DOI":"10.3390\/jcm14072291","type":"journal-article","created":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T03:35:28Z","timestamp":1743132928000},"page":"2291","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Clinical Characteristics and Patch Test Results in 57 Patients with Contact Dermatitis in Southern Taiwan"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7069-6993","authenticated-orcid":false,"given":"Shang-Hung","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Dermatology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung 833, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yin-Cheng","family":"Chao","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung 833, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,3,27]]},"reference":[{"key":"ref_1","unstructured":"Litchman, G., Nair, P.A., Atwater, A.R., and Bhutta, B.S. (2025). Contact Dermatitis. StatPearls, StatPearls Publishing."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1111\/cod.13119","article-title":"Prevalence of contact allergy in the general population: A systematic review and meta-analysis","volume":"80","author":"Alinaghi","year":"2019","journal-title":"Contact Dermat."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1016\/j.jaad.2015.02.1139","article-title":"Allergic contact dermatitis: Patient diagnosis and evaluation","volume":"74","author":"Mowad","year":"2016","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_4","first-page":"201","article-title":"Occupational Hand Dermatitis","volume":"23","author":"Karagounis","year":"2023","journal-title":"Curr. Allergy Asthma Rep."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1038\/s41572-021-00271-4","article-title":"Contact Dermatitis","volume":"7","author":"Scheinman","year":"2021","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1007\/s00403-024-03685-8","article-title":"Analysis of patch test results in 716 pediatric patients with type IV hypersensitivity dermatosis","volume":"317","author":"Niu","year":"2025","journal-title":"Arch. Dermatol. Res."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1111\/cod.13795","article-title":"Changing trends of contact allergens: A 40-year retrospective study from a referral centre in northern Taiwan","volume":"85","author":"Lin","year":"2021","journal-title":"Contact Dermat."},{"key":"ref_8","first-page":"e69764","article-title":"Current insights on treatment adherence in prevalent dermatological conditions and strategies to optimize adherence rates","volume":"16","author":"Radu","year":"2024","journal-title":"Cureus"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"258","DOI":"10.4103\/ijd.ijd_965_21","article-title":"Standard patch test results and clinical relevance: A cross-sectional study of 10-year retrospective experience","volume":"67","author":"Bilgic","year":"2022","journal-title":"Indian J. Dermatol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1586\/eci.10.4","article-title":"Diagnostic approach in allergic and irritant contact dermatitis","volume":"6","author":"Ale","year":"2010","journal-title":"Expert Rev. Clin. Immunol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1097\/DER.0000000000000417","article-title":"North American Contact Dermatitis Group patch test results: 2015\u20132016","volume":"29","author":"DeKoven","year":"2018","journal-title":"Dermatitis"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.anai.2020.10.003","article-title":"A review of contact dermatitis","volume":"126","author":"Brar","year":"2021","journal-title":"Ann. Allergy Asthma Immunol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1111\/cod.12284","article-title":"Contact sensitization to cobalt\u2014Multifactorial analysis of risk factors based on long-term data of the information network of departments of dermatology","volume":"71","author":"Uter","year":"2014","journal-title":"Contact Dermat."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1111\/j.1600-0536.2012.02133.x","article-title":"Nickel, chromium, and cobalt sensitization in a patch test population in North-Eastern Italy (1996\u20132010)","volume":"68","author":"Rui","year":"2013","journal-title":"Contact Dermat."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1111\/bjd.14167","article-title":"Prevalence of contact allergy in the general population in different European regions","volume":"174","author":"Diepgen","year":"2016","journal-title":"Br. J. Dermatol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1111\/jdv.12735","article-title":"Patch test results of hand eczema patients: Relation to clinical types","volume":"29","author":"Boonstra","year":"2015","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1111\/cod.13289","article-title":"Changing trends of contact allergens in Thailand: A 12-year retrospective study","volume":"81","author":"Sukakul","year":"2019","journal-title":"Contact Dermat."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1111\/cod.13833","article-title":"European Surveillance System on Contact Allergies (ESSCA): Characteristics of patients patch tested and diagnosed with irritant contact dermatitis","volume":"85","author":"Loman","year":"2021","journal-title":"Contact Dermat."},{"key":"ref_19","unstructured":"U.S. Bureau of Labor Statistics (2022, December 06). Survey of Occupational Injuries and Illnesses Data, Available online: https:\/\/www.bls.gov\/iif\/nonfatal-injuries-and-illnesses-tables.htm#charts."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1136\/oemed-2022-108230","article-title":"Occupational hand eczema reduces career length in hairdressers: A prospective cohort study of Danish hairdressers graduating from 1985 to 2007","volume":"79","author":"Havmose","year":"2022","journal-title":"Occup. Environ. Med."},{"key":"ref_21","unstructured":"Centers for Disease Control and Prevention (CDC) (2022, December 06). Skin Exposures and Effects, Available online: https:\/\/www.cdc.gov\/niosh\/topics\/skin\/."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.mcna.2021.04.003","article-title":"Diagnosis and Management of Dermatitis, Including Atopic, Contact, and Hand Eczemas","volume":"105","author":"Chan","year":"2021","journal-title":"Med. Clin. N. Am."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.jaad.2005.02.045","article-title":"Occupational contact dermatitis: Etiology, prevalence, and resultant impairment\/disability","volume":"53","author":"Belsito","year":"2005","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.shaw.2014.08.001","article-title":"Wet-work exposure: A main risk factor for occupational hand dermatitis","volume":"5","author":"Behroozy","year":"2014","journal-title":"Saf. Health Work"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1111\/cod.14066","article-title":"Exposure and work-related factors in subjects with hand eczema: Data from a cross-sectional questionnaire within the Lifelines Cohort Study","volume":"86","author":"Brands","year":"2022","journal-title":"Contact Dermat."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1038\/jid.2011.435","article-title":"Skin barrier disruption: A requirement for allergen sensitization?","volume":"132","author":"Kubo","year":"2012","journal-title":"J. Investig. Dermatol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"16","DOI":"10.2310\/6620.2010.10061","article-title":"Patch-testing with hairdressing chemicals","volume":"22","author":"Wang","year":"2011","journal-title":"Dermatitis"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1111\/j.1600-0536.2012.02105.x","article-title":"Hand eczema: Prevalence and risk factors of hand eczema in a population of 2,274 healthcare workers","volume":"67","author":"Ibler","year":"2012","journal-title":"Contact Dermat."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1111\/j.1600-0536.2010.01813.x","article-title":"Hand dermatitis among university hospital nursing staff with or without atopic eczema: Assessment of risk factors","volume":"64","author":"Lan","year":"2011","journal-title":"Contact Dermat."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1111\/cod.13618","article-title":"Onset of occupational hand eczema among healthcare workers during the SARS-CoV-2 pandemic: Comparing a single surgical site with a COVID-19 intensive care unit","volume":"83","author":"Guertler","year":"2020","journal-title":"Contact Dermat."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1111\/cod.13042","article-title":"Hand eczema and occupational contact allergies in healthcare workers with a focus on rubber additives","volume":"79","author":"Hamnerius","year":"2018","journal-title":"Contact Dermat."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1097\/DER.0000000000000342","article-title":"Rubber accelerators in medical examination and surgical gloves","volume":"29","author":"Goodier","year":"2018","journal-title":"Dermatitis"},{"key":"ref_33","unstructured":"Justiz Vaillant, A.A., Vashisht, R., and Zito, P.M. (2025). Immediate hypersensitivity reactions (archived). StatPearls, StatPearls Publishing."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1046\/j.1440-1592.2001.00215.x","article-title":"Evaluation of Patch Testing in Atopic Dermatitis Using Commercially Available Environmental Antigens","volume":"50","author":"Isobe","year":"2001","journal-title":"Allergol. Int."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1007\/s40257-017-0340-7","article-title":"The role and diagnosis of allergic contact dermatitis in patients with atopic dermatitis","volume":"19","author":"Owen","year":"2018","journal-title":"Am. J. Clin. Dermatol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1001\/jamadermatol.2016.6136","article-title":"Pediatric Contact Dermatitis Registry data on contact allergy in children with atopic dermatitis","volume":"153","author":"Jacob","year":"2017","journal-title":"JAMA Dermatol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"2853","DOI":"10.1016\/j.jaip.2021.03.028","article-title":"Prevalence and trend of allergen sensitization in adults and children with atopic dermatitis referred for patch testing, North American Contact Dermatitis Group data, 2001\u20132016","volume":"9","author":"Silverberg","year":"2021","journal-title":"J. Allergy Clin. Immunol. Pract."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1111\/cod.12874","article-title":"Are the Spanish baseline series markers sufficient to detect contact allergy to corticosteroids in Spain? A GEIDAC prospective study","volume":"78","year":"2018","journal-title":"Contact Dermat."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1001\/archderm.140.4.457","article-title":"Induction of rosaceiform dermatitis during treatment of facial inflammatory dermatoses with tacrolimus ointment","volume":"140","author":"Antille","year":"2004","journal-title":"Arch. Dermatol."},{"key":"ref_40","first-page":"232","article-title":"Topical steroid-induced facial rosaceiform dermatitis","volume":"12","author":"Tatu","year":"2016","journal-title":"Acta Endocrinol."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Bungau, S., Vesa, C.M., Abid, A., Behl, T., Tit, D.M., Purza, A.L., Pasca, B., Todan, L.M., and Endres, L. (2021). Withaferin A\u2014A promising phytochemical compound with multiple results in dermatological diseases. Molecules, 26.","DOI":"10.3390\/molecules26092407"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"32605","DOI":"10.1007\/s11356-021-18429-8","article-title":"Targeting therapeutic approaches and highlighting the potential role of nanotechnology in atopic dermatitis","volume":"29","author":"Singh","year":"2022","journal-title":"Environ. Sci. Pollut. Res. Int."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/7\/2291\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T17:03:18Z","timestamp":1760029398000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/7\/2291"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,27]]},"references-count":42,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2025,4]]}},"alternative-id":["jcm14072291"],"URL":"https:\/\/doi.org\/10.3390\/jcm14072291","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,27]]}}}