{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T17:40:47Z","timestamp":1760031647183,"version":"build-2065373602"},"reference-count":33,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2025,3,29]],"date-time":"2025-03-29T00:00:00Z","timestamp":1743206400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: There is a large overlap in the risk profiles and pathophysiologies of coronary artery disease (CAD) and cerebrovascular macroangiopathy. Therefore, this study aimed to analyse whether findings in CAD examination by coronary angiography or cardio-computer tomography (cardio-CT) are predictive of cerebrovascular macroangiopathy. Methods: Our study was a prospective, bicentric, cross-sectional cohort study. A total of 191 patients without earlier CAD diagnosis who underwent a cardio-CT scan or coronary angiography for the screening of CAD during clinical routine were serially included. Two groups were formed based on the criterion of CAD (yes\/no), and both were subsequently examined using sonography of the carotids. The CAD scores Syntax score I, Agatston equivalent score, and CAD-RADS score as well as AHA classification were determined. In cerebrovascular examinations, plaques and stenoses of the internal carotid artery (ICA) and the intima-media thickness (IMT) of the common carotid artery were analysed. Demographic and medical data such as the presence of arterial hypertension, diabetes mellitus, obesity, nicotine abuse, and dyslipidaemia were documented. The primary endpoint was the nominal association between CAD and ICA stenosis controlled for age and gender; secondary endpoints were correlations between ICA stenoses and CAD scores. Results: Of the 191 serially recruited patients (58% male, 65 \u00b1 11 yrs.), 101 fulfilled CAD criteria; 90 did not. Of all patients, 137 had ICA plaques, and 11 thereof had an ICA stenosis \u2265 50%. No association was found between CAD and ICA stenosis (Wald = 0.24; p = 0.624). Accordingly, there was no association between IMT and Syntax score I (Wald = 0.38; p = 0.706), Agatston equivalent score (Wald = 0.89; p = 0.380), CAD-RADS score (Wald = 0.90; p = 0.377), or AHA classification (Wald = 0.21; p = 0.837). Common cardiovascular risk factors, i.e., arterial hypertension (Wald = 4.47; p = 0.034), diabetes mellitus (Wald = 7.61; p = 0.006), and nicotine abuse (Wald = 0.83; p = 0.028), were associated with newly diagnosed CAD but not with ICA plaques, stenosis, or increased IMT. Conclusions: In our cohort, newly diagnosed CAD was associated with typical risk factors. However, neither CAD nor these risk factors were associated with cerebrovascular disease. This suggests that in patients without prior CAD diagnosis, findings from CAD examinations might not be reliably predictive of cerebrovascular disease.<\/jats:p>","DOI":"10.3390\/jcm14072366","type":"journal-article","created":{"date-parts":[[2025,3,31]],"date-time":"2025-03-31T02:50:16Z","timestamp":1743389416000},"page":"2366","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Results from Cardiovascular Examination Do Not Predict Cerebrovascular Macroangiopathy: Data from a Prospective, Bicentric Cohort Study"],"prefix":"10.3390","volume":"14","author":[{"given":"Johanna","family":"Lepek","sequence":"first","affiliation":[{"name":"Medical Clinic, Knappschaftskrankenhaus Bochum, 44892 Bochum, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Linnebank","sequence":"additional","affiliation":[{"name":"Faculty of Health, University Witten\/Herdecke, 58455 Witten, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars","family":"Bansemir","sequence":"additional","affiliation":[{"name":"Deptartment of Cardiology, Klinikum Niederberg, 42549 Velbert, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Axel","family":"Kloppe","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Angiology and Intensive Care Medicine, Marienhospital, 45886 Gelsenkirchen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,3,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3227","DOI":"10.1093\/eurheartj\/ehab484","article-title":"2021 ESC Guidelines on cardiovascular disease prevention in clinical practice","volume":"42","author":"Visseren","year":"2021","journal-title":"Eur. Heart J."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1161\/STROKEAHA.120.033994","article-title":"Optimal Medical Management of Asymptomatic Carotid Stenosis","volume":"52","author":"Hackam","year":"2021","journal-title":"Stroke"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"M35","DOI":"10.1093\/eurheartj\/suaa162","article-title":"Management of carotid stenosis for primary and secondary prevention of stroke: State-of-the-art 2020: A critical review","volume":"22","author":"Messas","year":"2020","journal-title":"Eur. Heart J. Suppl."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1159\/000047680","article-title":"Prevalence of and risk factors associated with carotid artery stenosis: The Troms\u00f8 Study","volume":"12","author":"Mathiesen","year":"2001","journal-title":"Cerebrovasc. Dis."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1016\/j.lpm.2009.02.015","article-title":"Indications for carotid screening in patients with coronary artery disease","volume":"38","author":"Aboyans","year":"2009","journal-title":"Presse Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1053\/euhj.1999.2006","article-title":"Prognostic implications of intima-media thickness and plaques in the carotid and femoral arteries in patients with stable angina pectoris","volume":"22","author":"Held","year":"2001","journal-title":"Eur. Heart J."},{"key":"ref_7","first-page":"648","article-title":"Coexisting Coronary and Carotid Artery Disease: What We Did, What Happened","volume":"37","author":"Albay","year":"2022","journal-title":"Rev. Bras. Cir. Cardiovasc."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1016\/j.jcmg.2018.04.036","article-title":"Estimating Pre-Test Probability of Coronary Artery Disease: Battle of the Scores in an Evolving CAD Landscape","volume":"12","author":"Gupta","year":"2019","journal-title":"JACC Cardiovasc. Imaging"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/0735-1097(90)90282-T","article-title":"Quantification of coronary artery calcium using ultrafast computed tomography","volume":"15","author":"Agatston","year":"1990","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1093\/eurheartj\/ehz425","article-title":"2019 ESC guidelines on the diagnosis and management of chronic coronary syndromes: The task force for diagnosis and management of chronic coronary syndromes of the European society of cardiology (ESC)","volume":"41","author":"Knuuti","year":"2020","journal-title":"Eur. Heart J."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s00059-022-05098-7","article-title":"Morphological and functional diagnostics of coronary artery disease by computed tomography","volume":"48","author":"Baumann","year":"2023","journal-title":"Herz"},{"key":"ref_12","unstructured":"Bundes\u00e4rztekammer (B\u00c4K) KrBK, Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften (AWMF) (2025, March 09). Nationale Versorgungsleitlinie Chronische KHK\u2014Langfassung, Version 6.0. Available online: https:\/\/register.awmf.org\/assets\/guidelines\/nvl-004l_S3_KHK_2022-09.pdf."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Hartmann, A., and Heiss, W.D. (2001). Der Schlaganfall. Pathogenese, Klinik, Diagnostik und Therapie Akuter Zerebrovaskul\u00e4rer Erkrankungen, Steinkopff.","DOI":"10.1007\/978-3-642-57629-4"},{"key":"ref_14","unstructured":"Hepp, W., and Kogel, H. (2007). Gef\u00e4\u00dfchirurgie, Urban & Fischer."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.jvs.2007.09.031","article-title":"Ultrasound criteria for severe in-stent restenosis following carotid artery stenting","volume":"47","author":"Zhou","year":"2008","journal-title":"J. Vasc. Surg."},{"key":"ref_16","first-page":"217","article-title":"Endovaskul\u00e4re Behandlung der Karotisstenose","volume":"11","author":"Mathias","year":"2004","journal-title":"J. F\u00fcr Kardiol.-Austrian J. Cardiol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1097\/HCO.0000000000001185","article-title":"Beyond the Agatston calcium score: Role of calcium density and other calcified plaque markers for cardiovascular disease prediction","volume":"40","author":"Razavi","year":"2025","journal-title":"Curr. Opin. Cardiol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/s12181-018-0251-8","article-title":"Aktueller Stellenwert der kardialen Computertomographie in der Diagnostik der koronaren Herzerkrankung","volume":"12","author":"Tesche","year":"2018","journal-title":"Die Kardiol."},{"key":"ref_19","first-page":"704","article-title":"Syntax Score predicts clinical outcome in patients with three-vessel coronary artery disease undergoing percutaneous coronary intervention","volume":"124","author":"He","year":"2011","journal-title":"Chin. Med. J."},{"key":"ref_20","first-page":"355","article-title":"SYNTAX-, STS- und EuroSCORE\u2014Wie genau sind sie in der Risikobewertung bei Herzerkrankungen?","volume":"108","author":"Winkler","year":"2012","journal-title":"J. F\u00fcr Kardiol.-Austrian J. Cardiol."},{"key":"ref_21","first-page":"5","article-title":"Sonographie der Karotis-Intima-Media-Dicke","volume":"12","author":"Nagele","year":"2014","journal-title":"Z. F\u00fcr Gef\u00e4\u00dfmedizin"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1093\/eurjpc\/zwab154","article-title":"ESC Guidelines on cardiovascular disease prevention in clinical practice","volume":"29","author":"Visseren","year":"2022","journal-title":"Eur. J. Prev. Cardiol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.echo.2013.02.009","article-title":"Carotid artery plaque and progression of coronary artery calcium: The multi-ethnic study of atherosclerosis","volume":"26","author":"Polak","year":"2013","journal-title":"J. Am. Soc. Echocardiogr."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"e011701","DOI":"10.1161\/CIRCIMAGING.120.011701","article-title":"Association of Carotid Artery Plaque With Cardiovascular Events and Incident Coronary Artery Calcium in Individuals with Absent Coronary Calcification: The MESA","volume":"14","author":"Mehta","year":"2021","journal-title":"Circ. Cardiovasc. Imaging"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"120492","DOI":"10.1016\/j.jns.2022.120492","article-title":"Prevalence of carotid artery stenosis with coronary artery disease in Japanese patients: A single-center study","volume":"443","author":"Suzuki","year":"2022","journal-title":"J. Neurol. Sci."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1016\/S0002-9149(00)00784-0","article-title":"Carotid artery atherosclerosis in type-2 diabetic ans non diabetic subjects with and without symptomatic coronary artery disease (The Insulin Resistance Atherosclerosis Study)","volume":"85","author":"Haffner","year":"2000","journal-title":"Am. J. Cardiol."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"(2011). European Carotid Plaque Study Group. Carotid artery plaque composition\u2014Relationship to clinical presentation and ultrasound B-mode imaging. Eur. J. Vasc. Endovasc. Surg., 42, S32\u2013S38.","DOI":"10.1016\/j.ejvs.2011.06.022"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"3021","DOI":"10.1093\/eurheartj\/ehy339","article-title":"2018 ESC\/ESH Guidelines for the management of arterial hypertension","volume":"39","author":"Williams","year":"2018","journal-title":"Eur. Heart J."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.1001\/archinte.1996.00440160095012","article-title":"Hypertension and subclinical carotid artery atherosclerosis in blacks and whites. The Atherosclerosis Risk in Communities Study. ARIC Investigators","volume":"156","author":"Arnett","year":"1996","journal-title":"Arch. Intern. Med."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.1093\/ije\/dyv337","article-title":"Cohort Profile: The Framingham Heart Study (FHS): Overview of milestones in cardiovascular epidemiology","volume":"44","author":"Tsao","year":"2015","journal-title":"Int. J. Epidemiol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1159\/000512407","article-title":"Association between Pre-Existing Coronary Artery Disease and 5-Year Mortality in Stroke Patients with High-Grade Carotid Artery Stenosis","volume":"84","author":"Wu","year":"2021","journal-title":"Eur. Neurol."},{"key":"ref_32","first-page":"605","article-title":"Diabetes als Schlaganfallrisikofaktor","volume":"5","author":"Heckmann","year":"2009","journal-title":"Epidemiol. Und Pathog."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"53","DOI":"10.2478\/prilozi-2021-0004","article-title":"The Role of Carotid Stenosis in a Prediction of Prognosis of Coronary Artery Disease","volume":"42","author":"Jordanova","year":"2021","journal-title":"Prilozi"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/7\/2366\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T17:05:31Z","timestamp":1760029531000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/7\/2366"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,29]]},"references-count":33,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2025,4]]}},"alternative-id":["jcm14072366"],"URL":"https:\/\/doi.org\/10.3390\/jcm14072366","relation":{},"ISSN":["2077-0383"],"issn-type":[{"type":"electronic","value":"2077-0383"}],"subject":[],"published":{"date-parts":[[2025,3,29]]}}}