{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:50:57Z","timestamp":1787028657052,"version":"build-2736575974"},"reference-count":51,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2025,3,30]],"date-time":"2025-03-30T00:00:00Z","timestamp":1743292800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background and objectives: The prevalence of uterine malformations, affecting up to 7% of the general population, is associated with high rates of pregnancy complications, such as infertility, miscarriage, preterm delivery, malpresentation, ectopic pregnancy, and other complications, with high rates of both maternal and fetal morbidity and mortality. Surgical procedures have been proposed to remediate these anomalies, with different outcomes. In this context, our study aimed to emphasize the complications encountered in our department and the pregnancy results. Materials and Methods: A retrospective cohort study was performed on all the women who delivered in one university-affiliated medical center between 2010 and 2017 with congenital uterine malformations. A total of 62 women were included: 26 with uterine malformations and 36 as controls. Statistical analyses were performed with the level of statistical significance set at p &lt; 0.05. Results: Only 53.8% of the pregnancies in women with uterine malformations ended in a live birth. The cesarean section rate was 64.3% in the study group. The only successful surgical procedure performed to restore fertility was cerclage. A lower Apgar score and a higher rate of neonate admission into the intensive care unit were observed in the study group, at 11.5% compared to 0 in the control group. The most important complication encountered with statistical significance was preterm delivery. Conclusions: This study demonstrated that uterine congenital malformations are an independent risk factor for pregnancy complications.<\/jats:p>","DOI":"10.3390\/jcm14072379","type":"journal-article","created":{"date-parts":[[2025,3,31]],"date-time":"2025-03-31T02:50:16Z","timestamp":1743389416000},"page":"2379","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Birth Outcomes in Pregnancies with Uterine Malformations: A Single-Center Retrospective Study"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7378-5756","authenticated-orcid":false,"given":"Corneliu Florin","family":"Buicu","sequence":"first","affiliation":[{"name":"Public Health Department, \u201cGeorge Emil Palade\u201d University of Medicine, Pharmacy, Sciences and Technology, 540142 Targu Mures, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1596-6353","authenticated-orcid":false,"given":"Melinda Ildiko","family":"Mitranovici","sequence":"additional","affiliation":[{"name":"Public Health Department, \u201cGeorge Emil Palade\u201d University of Medicine, Pharmacy, Sciences and Technology, 540142 Targu Mures, Romania"},{"name":"Department of Obstetrics and Gynecology, Emergency County Hospital Hunedoara, 14 Victoriei Street, 331057 Hunedoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4108-0452","authenticated-orcid":false,"given":"Dan","family":"Dumitrascu Biris","sequence":"additional","affiliation":[{"name":"Public Health Department, \u201cGeorge Emil Palade\u201d University of Medicine, Pharmacy, Sciences and Technology, 540142 Targu Mures, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marius","family":"Craina","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, \u201cVictor Babes\u201d University of Medicine and Pharmacy, 300041 Timi\u0219oara, Romania"},{"name":"Ist Clinic of Obstetrics and Gynecology, \u201cPius Brinzeu\u201d County Clinical Emergency Hospital, 300723 Timi\u0219oara, Romania"},{"name":"Center for Laparoscopy, Laparoscopic Surgery and In Vitro Fertilization, \u201cVictor Babes\u201d University of Medicine and Pharmacy, 300041 Timi\u0219oara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1084-2714","authenticated-orcid":false,"given":"Elena Silvia","family":"Bernad","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, \u201cVictor Babes\u201d University of Medicine and Pharmacy, 300041 Timi\u0219oara, Romania"},{"name":"Ist Clinic of Obstetrics and Gynecology, \u201cPius Brinzeu\u201d County Clinical Emergency Hospital, 300723 Timi\u0219oara, Romania"},{"name":"Center for Laparoscopy, Laparoscopic Surgery and In Vitro Fertilization, \u201cVictor Babes\u201d University of Medicine and Pharmacy, 300041 Timi\u0219oara, Romania"},{"name":"Center for Neuropsychology and Behavioral Medicine, \u201cVictor Babes\u201d University of Medicine and Pharmacy, 300041 Timi\u0219oara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,3,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1097\/OGX.0000000000000444","article-title":"Uterine malformations: An update of diagnosis, management, and outcomes","volume":"72","author":"Bhagavath","year":"2017","journal-title":"Obstet. Gynecol. Surv."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1002\/uog.20291","article-title":"Septate uterus according to ESHRE\/ESGE, ASRM and CUME definitions: Association with infertility and miscarriage, cost and warnings for women and healthcare systems","volume":"54","author":"Ludwin","year":"2019","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.tjog.2020.01.003","article-title":"Diagnosis and treatment of m\u00fcllerian malformations","volume":"59","author":"Passos","year":"2020","journal-title":"Taiwan. J. Obstet. Gynecol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1093\/oxfordjournals.humrep.a137860","article-title":"Reproductive performance of women with uterine malformations","volume":"8","year":"1993","journal-title":"Hum. Reprod."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Kim, M.-A., Kim, H.S., and Kim, Y.-H. (2021). Reproductive, obstetric and neonatal outcomes in women with congenital uterine anomalies: A systematic review and meta-analysis. J. Clin. Med., 10.","DOI":"10.3390\/jcm10204797"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"101396","DOI":"10.1016\/j.ajogmf.2024.101396","article-title":"Obstetric outcomes of women with congenital uterine anomalies in the United States","volume":"6","author":"Mandelbaum","year":"2024","journal-title":"Am. J. Obstet. Gynecol. MFM"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"7406","DOI":"10.1080\/14767058.2021.1949446","article-title":"The association between congenital uterine anomalies and perinatal outcomes\u2013does type of defect matters?","volume":"35","author":"Naeh","year":"2022","journal-title":"J. Matern. Fetal Neonatal Med."},{"key":"ref_8","first-page":"64","article-title":"Congenital uterine anomalies: Impact on perinatal outcomes","volume":"15","author":"Gliozheni","year":"2021","journal-title":"Orion"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"3862","DOI":"10.18203\/2320-1770.ijrcog20203869","article-title":"Case series on obstetrical outcomes in patient with uterine malformations","volume":"9","author":"Solanki","year":"2020","journal-title":"Int. J. Reprod. Contracept. Obstet. Gynecol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.fertnstert.2019.06.023","article-title":"Bioengineered uterus: A path toward ectogenesis","volume":"112","author":"Bulletti","year":"2019","journal-title":"Fertil. Steril."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"81","DOI":"10.4103\/GMIT.GMIT_13_19","article-title":"Management of mullerian development anomalies: 9 years\u2019 experience of a tertiary care center","volume":"9","author":"Goyal","year":"2020","journal-title":"Gynecol. Minim. Invasive Ther."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1093\/humrep\/dey043","article-title":"ESHRE\/ESGE female genital tract anomalies classification system\u2014The potential impact of discarding arcuate uterus on clinical practice","volume":"33","author":"Knez","year":"2018","journal-title":"Hum. Reprod."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"S52","DOI":"10.4103\/mjbl.mjbl_352_23","article-title":"Impact of Congenital Uterine Anomalies on Ectopic Pregnancy: A Cross-Sectional Observational Study of 510 Cases","volume":"21","author":"Rahmatullah","year":"2024","journal-title":"Med. J. Babylon"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S1083-3188(02)00136-5","article-title":"A comparison of MRI and laparoscopy in detecting pelvic structures in cases of vaginal agenesis","volume":"15","author":"Economy","year":"2002","journal-title":"J. Pediatr. Adolesc. Gynecol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1097\/GCO.0b013e32833e4a4a","article-title":"Update in M\u00fcllerian anomalies: Diagnosis, management, and outcomes","volume":"22","author":"Vallerie","year":"2010","journal-title":"Curr. Opin. Obstet. Gynecol."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Wang, L., Chen, X.-J., Liang, J.-H., Zhang, Z.-K., Cao, T.-S., and Zhang, L. (2022). Preliminary application of three-dimensional printing in congenital uterine anomalies based on three-dimensional transvaginal ultrasonographic data. BMC Women\u2019s Health, 22.","DOI":"10.1186\/s12905-022-01873-0"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.jmig.2013.10.014","article-title":"Diagnostic imaging modalities for M\u00fcllerian anomalies: The case for a new gold standard","volume":"21","author":"Berger","year":"2014","journal-title":"J. Minim. Invasive Gynecol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1046\/j.1469-0705.2000.00015-1-69.x","article-title":"F69Three-dimensional ultrasound in the diagnosis of uterine malformations","volume":"16","author":"Montenegro","year":"2000","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/s40001-023-01544-2","article-title":"Impact of congenital uterine anomalies on reproductive outcomes of IVF\/ICSI-embryo transfer: A retrospective study","volume":"29","author":"Kang","year":"2024","journal-title":"Eur. J. Med. Res."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"e16623","DOI":"10.1097\/MD.0000000000016623","article-title":"Fertility and pregnancy outcomes following hysteroscopic metroplasty of different sized uterine septa: A retrospective cohort study protocol","volume":"98","author":"Wang","year":"2019","journal-title":"Medicine"},{"key":"ref_21","first-page":"e73430","article-title":"Maternofetal Outcomes in Women with Congenital Uterine Anomalies","volume":"16","author":"Ganti","year":"2024","journal-title":"Cureus"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1002\/uog.18923","article-title":"Congenital Uterine Malformation by Experts (CUME): Better criteria for distinguishing between normal\/arcuate and septate uterus?","volume":"51","author":"Ludwin","year":"2018","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1002\/uog.24905","article-title":"ASRM M\u00fcllerian Anomalies Classification 2021: A critical review","volume":"60","author":"Ludwin","year":"2022","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1089\/154099904322836438","article-title":"Reproductive outcomes in women with uterine anomalies","volume":"13","author":"Lin","year":"2004","journal-title":"J. Women\u2019s Health"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"De Angelis, C., and Caserta, D. (2015). Pregnancy outcome in women with uterine anomalies. Female Genital Tract Congenital Malformations: Classification, Diagnosis and Management, Springer.","DOI":"10.1007\/978-1-4471-5146-3_14"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.ejogrb.2010.11.015","article-title":"Determinants of fertility and reproductive success after hysteroscopic septoplasty for women with unexplained primary infertility: A prospective analysis of 88 cases","volume":"155","author":"Shokeir","year":"2011","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"S\u00e1nchez-Santiuste, M., R\u00edos, M., Calles, L., Cuesta, R.d.l., Engels, V., Pereira, A., and P\u00e9rez-Medina, T. (2020). Dysmorphic uteri: Obstetric results after hysteroscopic office metroplasty in infertile and recurrent pregnancy loss patients. a prospective observational study. J. Clin. Med., 9.","DOI":"10.3390\/jcm9092857"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"e86","DOI":"10.1111\/1471-0528.18054","article-title":"Reproductive Implications and Management of Congenital Uterine Anomalies (2024 Second Edition) Scientific Impact Paper No. 62","volume":"132","author":"Akhtar","year":"2025","journal-title":"BJOG Int. J. Obstet. Gynaecol."},{"key":"ref_29","first-page":"167","article-title":"Arcuate uterus as an independent risk factor for adverse pregnancy outcomes","volume":"41","author":"Connolly","year":"2021","journal-title":"Am. J. Perinatol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"10494","DOI":"10.1080\/14767058.2022.2130240","article-title":"What type of uterine anomalies had an additional effect on pregnancy outcomes, compared to other uterine anomalies? An evaluation of a large population database","volume":"35","author":"Badeghiesh","year":"2022","journal-title":"J. Matern. Fetal Neonatal Med."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.1007\/s00404-024-07666-0","article-title":"Assisted reproductive technology outcomes in women with congenital uterine anomalies: A systematic review","volume":"310","author":"Fedele","year":"2024","journal-title":"Arch. Gynecol. Obstet."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Li, X., Peng, P., Liu, X., Chen, W., Liu, J., Yang, J., and Bian, X. (2019). The pregnancy outcomes of patients with rudimentary uterine horn: A 30-year experience. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0210788"},{"key":"ref_33","first-page":"105","article-title":"Uterine Horn","volume":"17","author":"Tufail","year":"2007","journal-title":"J. Coll. Physicians Surg. Pak. JCPSP"},{"key":"ref_34","first-page":"e76199","article-title":"Ruptured Ectopic Pregnancy in a Non-communicating Rudimentary Horn at 18 Weeks of Gestation","volume":"16","author":"Aman","year":"2024","journal-title":"Cureus"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"e9708","DOI":"10.1002\/ccr3.9708","article-title":"Cornual Pregnancy as a Rare Entity of Ectopic Pregnancy After Assisted Reproductive Therapy-Embryo Transfer (ART-ET): A Case Report","volume":"12","author":"Keikha","year":"2024","journal-title":"Clin. Case Rep."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.jpag.2006.08.003","article-title":"Obstructive Mullerian anomalies and modern laparoscopic management","volume":"20","author":"Strawbridge","year":"2007","journal-title":"J. Pediatr. Adolesc. Gynecol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1016\/j.fertnstert.2015.06.019","article-title":"Reliability of the European Society of Human Reproduction and Embryology\/European Society for Gynaecological Endoscopy and American Society for Reproductive Medicine classification systems for congenital uterine anomalies detected using three-dimensional ultrasonography","volume":"104","author":"Ludwin","year":"2015","journal-title":"Fertil. Steril."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1002\/uog.20845","article-title":"Congenital Uterine Malformation by Experts (CUME): Diagnostic criteria for T-shaped uterus","volume":"55","author":"Ludwin","year":"2020","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"e23","DOI":"10.1016\/j.fertnstert.2022.09.256","article-title":"Obstetric outcomes in women with congenital uterine anomalies: A big data approach","volume":"118","author":"Violette","year":"2022","journal-title":"Fertil. Steril."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1002\/ijgo.15961","article-title":"Diagnosis of arcuate uterus using three-dimensional transvaginal ultrasound and investigation of its association with perinatal complications","volume":"168","author":"Yoshihara","year":"2025","journal-title":"Int. J. Gynecol. Obstet."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1097\/OGX.0000000000000408","article-title":"Diagnosis and management of congenital uterine anomalies in pregnancy","volume":"72","author":"Vaz","year":"2017","journal-title":"Obstet. Gynecol. Surv."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1186\/s13256-024-04524-0","article-title":"An unusual case of severe asphyxia with the fetal position unexpectedly inverted in a malformed uterus: A case report","volume":"18","author":"Abe","year":"2024","journal-title":"J. Med. Case Rep."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"2431109","DOI":"10.1080\/14647273.2024.2431109","article-title":"Risk of adverse pregnancy outcomes after abnormal hysterosalpingography","volume":"28","author":"Gandelsman","year":"2025","journal-title":"Hum. Fertil."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"2382309","DOI":"10.1080\/14767058.2024.2382309","article-title":"Association of congenital uterine anomaly with abnormal placental cord insertion and adverse pregnancy complications: A retrospective cohort study","volume":"37","author":"Yoshihara","year":"2024","journal-title":"J. Matern. Fetal Neonatal Med."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1080\/14767058.2017.1370703","article-title":"The association between M\u00fcllerian anomalies and perinatal outcome","volume":"32","author":"Sheiner","year":"2019","journal-title":"J. Matern. Fetal Neonatal Med."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"S185","DOI":"10.1016\/j.ajog.2023.11.347","article-title":"325 Adverse pregnancy outcomes in patients with congenital uterine anomalies: Evaluation of a large population database","volume":"230","author":"Silsby","year":"2024","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"15","DOI":"10.46969\/EZH.1442545","article-title":"How Often Do We Discover an Abnormality of The Uterus at Delivery? Single Center Experience","volume":"6","author":"Celik","year":"2024","journal-title":"T\u00fcrk Kad\u0131n Sa\u011fl\u0131\u011f\u0131 Ve Neonatoloji Derg."},{"key":"ref_48","first-page":"153","article-title":"A Study of Mullerian Anomalies in Pregnancy: Case Series in a Tertiary Care Centre","volume":"14","author":"Abhinaya","year":"2024","journal-title":"Int. J. Med. Public Health"},{"key":"ref_49","first-page":"e66937","article-title":"A Full-Term Pregnancy in a Patient with Uterus Didelphys","volume":"16","author":"Gaily","year":"2024","journal-title":"Cureus"},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Moraru, L., Mitranovici, M.-I., Chiorean, D.M., Moraru, R., Caravia, L., Tiron, A.T., and Cotoi, O.S. (2023). Adenomyosis and Its Possible Malignancy: A Review of the Literature. Diagnostics, 13.","DOI":"10.3390\/diagnostics13111883"},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Etrusco, A., Buzzaccarini, G., Lagan\u00e0, A.S., Chiantera, V., Vitale, S.G., Angioni, S., D\u2019alterio, M.N., Nappi, L., Sorrentino, F., and Vitagliano, A. (2024). Use of diode laser in hysteroscopy for the management of intrauterine pathology: A systematic review. Diagnostics, 14.","DOI":"10.3390\/diagnostics14030327"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/7\/2379\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T17:05:54Z","timestamp":1760029554000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/7\/2379"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,30]]},"references-count":51,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2025,4]]}},"alternative-id":["jcm14072379"],"URL":"https:\/\/doi.org\/10.3390\/jcm14072379","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,30]]}}}