{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T10:46:27Z","timestamp":1784889987522,"version":"3.55.0"},"reference-count":35,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background\/Objectives: To assess the association between moderate N-terminal natriuretic peptide (NT-proBNP) and cardiac alterations and prognosis in septuagenarians without heart failure (HF). Methods: From the STROKESTOP II screening study, 230 individuals aged 75\/76 years with NT-proBNP &lt; 900 ng\/L were randomly selected. Subjects with persistent atrial fibrillation (AF), more than mild valvular disease, or HF were excluded. Echocardiography was performed. NT-proBNP \u2265 125 ng\/L and paroxysmal AF (pAF) on thumb ECG were used as grouping variables. Participants were followed up during a median of 5 years for cardiovascular mortality, HF, AF, and cerebrovascular events. Cox regression analysis was employed for prognostic assessment. Results: Three groups were identified: SR \u2265 125 (n = 94, no pAF and NT-proBNP \u2265 125 ng\/L), pAF (n = 77, pAF and NT-proBNP \u2265 125 ng\/L), and controls (n = 30, no pAF and NT-proBNP &lt; 125 ng\/L). NT-proBNP was not associated with structural (left atrial volume and left ventricular (LV) mass) or functional (E\/e\u2019, LV strain) alterations in any group (p &gt; 0.05). Cardiovascular risk factors (HR: 4.6; CI = 1.7\u201312.3; p = 0.002), but not NT-proBNP (HR: 1.9; CI = 0.7\u20135.1; p = 0.2), entailed a prognostic value for the composite endpoint of HF, AF, and cardiovascular death. Conclusions: In septuagenarians without HF, modest NT-proBNP elevation was not associated with echocardiographic changes or prognosis<\/jats:p>","DOI":"10.3390\/jcm14072407","type":"journal-article","created":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T11:08:40Z","timestamp":1743505720000},"page":"2407","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Modest NT-proBNP Elevation in Septuagenarians Without Heart Failure Is Not Associated with Cardiac Alterations or Cardiovascular Outcomes"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-4774-4011","authenticated-orcid":false,"given":"Cristina Oliveira","family":"da Silva","sequence":"first","affiliation":[{"name":"Department of Medicine, Karolinska Institutet, 17177 Stockholm, Sweden"},{"name":"Heart and Vascular Center, Unit of Heart Failure, Arrhythmia and GUCH, Karolinska University Hospital, 17177 Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4142-2416","authenticated-orcid":false,"given":"Camilla","family":"Hage","sequence":"additional","affiliation":[{"name":"Department of Medicine, Karolinska Institutet, 17177 Stockholm, Sweden"},{"name":"Heart and Vascular Center, Unit of Heart Failure, Arrhythmia and GUCH, Karolinska University Hospital, 17177 Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5156-2535","authenticated-orcid":false,"given":"Jonas","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Medicine, Karolinska Institutet, 17177 Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0853-5141","authenticated-orcid":false,"given":"Magnus","family":"B\u00e4ck","sequence":"additional","affiliation":[{"name":"Department of Medicine, Karolinska Institutet, 17177 Stockholm, Sweden"},{"name":"Heart and Vascular Center, Unit of Heart Failure, Arrhythmia and GUCH, Karolinska University Hospital, 17177 Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anik\u00f3 I.","family":"Nagy","sequence":"additional","affiliation":[{"name":"Heart and Vascular Center, Unit of Heart Failure, Arrhythmia and GUCH, Karolinska University Hospital, 17177 Stockholm, Sweden"},{"name":"Heart and Vascular Center, Semmelweis University, 1085 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Svennberg","sequence":"additional","affiliation":[{"name":"Heart and Vascular Center, Unit of Heart Failure, Arrhythmia and GUCH, Karolinska University Hospital, 17177 Stockholm, Sweden"},{"name":"Department of Medicine Huddinge, Karolinska Institutet, 17177 Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7767-4159","authenticated-orcid":false,"given":"Larissa","family":"Bastos","sequence":"additional","affiliation":[{"name":"Department Clinical Sciences, Karolinska Institutet, Danderyd Hospital, 17177 Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1677-7215","authenticated-orcid":false,"given":"Johan","family":"Engdahl","sequence":"additional","affiliation":[{"name":"Department Clinical Sciences, Karolinska Institutet, Danderyd Hospital, 17177 Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faris","family":"Al-Khalili","sequence":"additional","affiliation":[{"name":"Department Clinical Sciences, Karolinska Institutet, Danderyd Hospital, 17177 Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1411-4482","authenticated-orcid":false,"given":"Lars","family":"Lund","sequence":"additional","affiliation":[{"name":"Department of Medicine, Karolinska Institutet, 17177 Stockholm, Sweden"},{"name":"Heart and Vascular Center, Unit of Heart Failure, Arrhythmia and GUCH, Karolinska University Hospital, 17177 Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aristomenis","family":"Manouras","sequence":"additional","affiliation":[{"name":"Department of Medicine, Karolinska Institutet, 17177 Stockholm, Sweden"},{"name":"Heart and Vascular Center, Unit of Heart Failure, Arrhythmia and GUCH, Karolinska University Hospital, 17177 Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,4,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3599","DOI":"10.1093\/eurheartj\/ehab368","article-title":"2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure","volume":"42","author":"McDonagh","year":"2021","journal-title":"Eur. 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