{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T19:50:03Z","timestamp":1785527403355,"version":"3.56.0"},"reference-count":65,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Cerebral vasospasm after craniotomy tumor (CVACT) is a rare complication that can occur following tumor craniotomy and significantly affects the outcome of patients. Unfortunately, it is not well understood, leading to delayed and ineffective management. This study aims to investigate CVACT by examining the factors contributing to its occurrence, its underlying mechanisms, diagnostic approaches, management strategies, and outcomes. The goal is to identify the characteristics and risk factors associated with CVACT, its clinical symptoms, diagnostic methods, management options, and potential outcomes. Methods: A systematic search used relevant keywords to identify cases of \u201ccerebral vasospasm\u201d after tumor resection in PubMed and Science Direct databases. Relevant cross-references were added by manually searching the references of all retrieved articles. Result: We included 60 inclusion patients from 14 case reports and 13 case series with 33 (55%) females and 27 (45%) males with a mean age of 44.05 \u00b1 16.8 years. The most common tumors were pituitary adenomas, which were found in 22 (36.66%), the most common tumor location was the middle cranial fossa (75%), and the most common surgery technique used was transsphenoidal surgery (50%). Most of those who experience vasospasm have a craniotomy with the TSS technique (50%) with complications of intraoperative bleeding. The range of onset of VS symptoms postoperatively was 0\u201330 days (mean 6.59 d). The symptoms included asymptomatic, headache, loss of vision, hemiparesis, diplopia, etc. The vascular involvement was mainly anterior circulation (78.33%). The diagnostic tools most commonly used were angiography and transcranial doppler (TCD). The most common management of VS from the included studies was pharmacology. The survival rate was 61.66%. We found the tumor location and vascular-affected vasospasm were significantly correlated with mortality rates: p = 0.015 and p = 0.02. Conclusions: Cerebral vasospasm after craniotomy tumor removal (CVACT) frequently arises in tumors situated in the medial cranial fossa, predominantly pituitary adenomas and meningiomas. The minimally invasive surgical approach of TSS may contribute to the mechanism of CVACT incidence. The existence of preoperative vascular pathology, as encasement or narrowing, appears to be a predictor alongside the incidence of intra- or postoperative hemorrhage. The vascular structures most susceptible to vasospasm are located in the anterior circulation of the Willis circle, which appears to correlate with the vascular problems that typically undergo preoperative encasement of the internal carotid artery (ICA). The most reliable and real time diagnostic instrument employed is TCD, while imaging continues to be the gold standard. Nimodipine treatment continues to be a viable therapeutic option that can enhance patient outcomes.<\/jats:p>","DOI":"10.3390\/jcm14072415","type":"journal-article","created":{"date-parts":[[2025,4,2]],"date-time":"2025-04-02T04:06:05Z","timestamp":1743566765000},"page":"2415","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Cerebral Vasospasm as a Critical Yet Overlooked Complication Following Tumor Craniotomy: A Systematic Review of Case Reports and Case Series"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-6354-2279","authenticated-orcid":false,"given":"Khairunnisai","family":"Tarimah","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Intensive Therapy Subdivision Neuroanesthesia and Critical Care, Dr Hasan Sadikin Hospital, Padjadjaran University, Bandung 40161, West Java, Indonesia"},{"name":"Department of Anesthesiology and Intensive Therapy, RSUD Kota Mataram, Al-Azhar Islamic University Mataram, Mataram 83127, West Nusa Tenggara, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dewi Yulianti","family":"Bisri","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Therapy Subdivision Neuroanesthesia and Critical Care, Dr Hasan Sadikin Hospital, Padjadjaran University, Bandung 40161, West Java, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radian Ahmad","family":"Halimi","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Therapy Subdivision Neuroanesthesia and Critical Care, Dr Hasan Sadikin Hospital, Padjadjaran University, Bandung 40161, West Java, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5676-7804","authenticated-orcid":false,"given":"Elvan","family":"Wiyarta","sequence":"additional","affiliation":[{"name":"Intensive Care Department, University of Indonesia Hospital, Depok 16424, West Jawa, Indonesia"},{"name":"Service Department, Risetku, South Jakarta 12820, Jakarta, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,4,1]]},"reference":[{"key":"ref_1","first-page":"961","article-title":"Hypertonic saline achieves superior brain relaxation in tumor craniotomy: An updated systematic-network meta-analysis","volume":"19","author":"Tarimah","year":"2024","journal-title":"J. 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