{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T02:05:31Z","timestamp":1774922731470,"version":"3.50.1"},"reference-count":32,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T00:00:00Z","timestamp":1743984000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Objective: This multicenter study compares outcomes of open thoracoabdominal aortic aneurysm (TAAA) repair in patients &lt; 60 years with (n = 106), versus without (n = 167), hereditary aortopathy. Methods: We conducted a retrospective analysis of 273 consecutive open TAAA repairs (2000\u20132024) at two European centers. The primary endpoint was early outcome. We used a Kaplan\u2013Meier curve to assess survival, and logistic regression to identify predictors. Results: Operative death rates were similar (hereditary: 13\/106 [12.3%] vs. non-hereditary: 22\/167 [13.2%], p = 0.83). Hereditary aortopathy patients were younger (median 42 vs. 54 years, p &lt; 0.001) with lower BMI (24.1 vs. 28.4 kg\/m2, p &lt; 0.001). Non-genetic patients had higher rates of chronic kidney insufficiency (58\/167 (34.7%) vs. 14\/106 (13.2%), p &lt; 0.001), coronary artery disease (43\/167 (25.7%) vs. 9\/106 (8.5%), p &lt; 0.001), and prior myocardial infarction (31\/167 (18.6%) vs. 4\/106 (3.8%), p &lt; 0.001). Hereditary aortopathy patients suffered more often from post-dissection TAAA (68\/106 [64.2%] vs. 44\/167 [26.3%], p &lt; 0.001) and prior aortic surgery (81\/106 (76.4%) vs. 79\/167 (47.3%), p &lt; 0.001). Pulmonary complications (67.0% vs. 61.1%, p = 0.32), acute kidney injury (25.5% vs. 22.8%, p = 0.61), and spinal cord ischemia (6.6% vs. 10.2%, p = 0.31) were comparable between groups. Overall 5-year survival was 65.7%; the rate of any reintervention during follow up was 21.2%. Logistic regression identified no predictors for perioperative mortality. Conclusions: Open TAAA repair in patients &lt; 60 years carries relevant perioperative mortality, which is comparable between hereditary and non-hereditary groups; non-hereditary patients had impaired preoperative cardiopulmonary status.<\/jats:p>","DOI":"10.3390\/jcm14072513","type":"journal-article","created":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T10:06:28Z","timestamp":1744020388000},"page":"2513","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Outcome Following Open Repair of Hereditary and Non-Hereditary Thoracoabdominal Aortic Aneurysm in Patients Under 60 Years Old\u2014A Multicenter Study"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8416-4624","authenticated-orcid":false,"given":"Jelle","family":"Frankort","sequence":"first","affiliation":[{"name":"Department of Vascular Surgery, Medical Faculty, RWTH Aachen University, 52074 Aachen, Germany"},{"name":"Department of Vascular Surgery, MUMC+ Maastricht, 6229 HX Maastricht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siebe","family":"Frankort","sequence":"additional","affiliation":[{"name":"Institute of Statistics Netherlands (CBS), 6401 CZ Heerlen, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4876-4873","authenticated-orcid":false,"given":"Panagiotis","family":"Doukas","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, Medical Faculty, RWTH Aachen University, 52074 Aachen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Uhl","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, Medical Faculty, RWTH Aachen University, 52074 Aachen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael J.","family":"Jacobs","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, Medical Faculty, RWTH Aachen University, 52074 Aachen, Germany"},{"name":"Department of Vascular Surgery, MUMC+ Maastricht, 6229 HX Maastricht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6545-5813","authenticated-orcid":false,"given":"Barend M. E.","family":"Mees","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, MUMC+ Maastricht, 6229 HX Maastricht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8451-2913","authenticated-orcid":false,"given":"Alexander","family":"Gombert","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, Medical Faculty, RWTH Aachen University, 52074 Aachen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,4,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/j.ejvs.2022.02.003","article-title":"Outcome of Elective and Emergency Open Thoraco-Abdominal Aortic Aneurysm Repair in 255 Cases: A Retrospective Single Centre Study","volume":"63","author":"Gombert","year":"2022","journal-title":"Eur. J. Vasc. Endovasc. 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