{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T17:40:36Z","timestamp":1789926036025,"version":"4.0.1"},"reference-count":32,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T00:00:00Z","timestamp":1744070400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Food cobalamin malabsorption (FCM) represents a prevalent, often underdiagnosed, etiology of vitamin B12 deficiency, particularly within an aging population. Unlike pernicious anemia, an autoimmune disorder targeting intrinsic factor, FCM stems from the impaired release of cobalamin from food proteins, primarily due to age-related gastric changes, medication-induced gastric hypochlorhydria, metformin, or non-immune atrophic gastritis. The clinical presentation of FCM mirrors that of general cobalamin deficiency, encompassing a spectrum of neurological (peripheral neuropathy, cognitive decline), hematological (megaloblastic anemia), and gastrointestinal (glossitis, anorexia) manifestations. Given the potential for irreversible neurological sequelae, early detection and intervention are paramount. High-dose oral cobalamin (125\u2013250 mcg daily) has demonstrated efficacy, offering a convenient and cost-effective alternative to parenteral administration.<\/jats:p>","DOI":"10.3390\/jcm14082550","type":"journal-article","created":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T11:05:02Z","timestamp":1744110302000},"page":"2550","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Unraveling the Enigma: Food Cobalamin Malabsorption and the Persistent Shadow of Cobalamin Deficiency"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7914-7616","authenticated-orcid":false,"given":"Emmanuel","family":"Andr\u00e8s","sequence":"first","affiliation":[{"name":"Service de M\u00e9decine Interne, H\u00f4pitaux Universitaires de Strasbourg, 67000 Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean Edouard","family":"Terrade","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Interne, H\u00f4pitaux Universitaires de Strasbourg, 67000 Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Bel\u00e9n","family":"Alonso Ortiz","sequence":"additional","affiliation":[{"name":"Servicio de Medicina Interna, Hospital Universitario de Gran Canaria Dr Negrin, 35010 Las Palmas de Gran Canaria, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0830-8897","authenticated-orcid":false,"given":"Manuel","family":"M\u00e9ndez-Bail\u00f3n","sequence":"additional","affiliation":[{"name":"Servicio de Medicina Interna, Hospital Universitario Cl\u00ednico San Carlos, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cosmina","family":"Ghiura","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Interne, H\u00f4pitaux Universitaires de Strasbourg, 67000 Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chal\u00e8ne","family":"Habib","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Interne, H\u00f4pitaux Universitaires de Strasbourg, 67000 Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5384-072X","authenticated-orcid":false,"given":"Thierry","family":"Lavigne","sequence":"additional","affiliation":[{"name":"Service d\u2019Hygi\u00e8ne Hospitali\u00e8re, H\u00f4pitaux Universitaires de Strasbourg, 67000 Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7166-9057","authenticated-orcid":false,"given":"Xavier","family":"Jannot","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Interne, H\u00f4pitaux Universitaires de Strasbourg, 67000 Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noel","family":"Lorenzo-Villalba","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Interne, H\u00f4pitaux Universitaires de Strasbourg, 67000 Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,4,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/bs.vh.2022.01.016","article-title":"Chapter Nine\u2014Vitamin B12 absorption and malabsorption","volume":"Volume 119","author":"Litwack","year":"2022","journal-title":"Vitamins and Hormones"},{"key":"ref_2","unstructured":"NICE (2023, December 29). 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