{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,3]],"date-time":"2026-01-03T22:54:56Z","timestamp":1767480896536,"version":"build-2065373602"},"reference-count":36,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T00:00:00Z","timestamp":1744675200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background\/Objectives: To measure the peri-dialytic serum lactate, sodium, potassium, calcium, and pH and base excess in chronic hemodialysis patients with and without post-dialysis fatigue (PDF). Methods: Patients were asked \u201cDo you feel fatigued after dialysis?\u201d Each patient was invited to rate the intensity, duration, and frequency of PDF from one to five. The recovery time after the hemodialysis session (TIRD) was calculated, and inviting patients were to answer the following single open-ended question: \u201cHow long does it take you to recover from a dialysis session?\u201d Pre- and post-dialysis arterial blood was sampled, and pH, bicarbonates, base excess, sodium, calcium, potassium, and lactate were measured. Results: One hundred fifty-eight patients were included in the study. One hundred seventeen patients declared to suffer from PDF and forty-one did not. Median [range] PDF frequency, intensity, duration, and TIRD were 5 (1\u20135), 4 (1\u20135), 3 (1\u20135), and 12 h (1\u201348), respectively. Seventy patients had a TIRD \u2264 12 h and forty-seven had a TIRD &gt; 12 h. Median post-dialysis and post-dialysis\/pre-dialysis difference serum lactate levels (mmol\/L) did not differ between patients with and without PDF (p = 0.111 and p = 0.395, respectively). In addition, the distribution of patients according to post-dialysis serum lactate levels was similar in the presence or absence of PDF. The median post-dialysis and post-dialysis\/pre-dialysis difference serum lactate concentrations did not differ significantly according to the score of the PDF intensity and PDF duration (p = 0.928 and 0.935, p = 0.610 and 0.548, respectively). Finally, we stratified patients into two groups according to the length of TIRD: \u226412 h and &gt;12 h. The median post-dialysis serum lactate concentrations did not differ significantly between the two groups (p = 0.862) as well as the median post-dialysis\/pre-dialysis difference (p = 0.583). Also, the distribution of patients according to post-dialysis serum lactate levels was similar in the two groups. Conclusions: PDF and TIRD are not associated with peri-dialytic changes in serum lactate in patients on chronic hemodialysis.<\/jats:p>","DOI":"10.3390\/jcm14082706","type":"journal-article","created":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T08:11:39Z","timestamp":1744704699000},"page":"2706","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Post-Dialysis Fatigue Is Not Associated with Serum Lactate Levels in Patients on Chronic Hemodialysis"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1627-0235","authenticated-orcid":false,"given":"Maurizio","family":"Bossola","sequence":"first","affiliation":[{"name":"Servizio Emodialisi, Dipartimento di Scienze Mediche e Chirurgiche, Universit\u00e0 Cattolica del Sacro Cuore, 00168 Roma, Italy"},{"name":"Policlinico Universitario Fondazione Agostino Gemelli IRCCS, 00168 Roma, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nunzia","family":"Ciferri","sequence":"additional","affiliation":[{"name":"Policlinico Universitario Fondazione Agostino Gemelli IRCCS, 00168 Roma, Italy"},{"name":"Divisione di Nefrologia, Servizio Emodialisi, Dipartimento di Scienze Mediche e Chirurgiche, Universit\u00e0 Cattolica del Sacro Cuore, 00168 Roma, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-4188-9032","authenticated-orcid":false,"given":"Ilaria","family":"Mariani","sequence":"additional","affiliation":[{"name":"Policlinico Universitario Fondazione Agostino Gemelli IRCCS, 00168 Roma, Italy"},{"name":"Divisione di Nefrologia, Servizio Emodialisi, Dipartimento di Scienze Mediche e Chirurgiche, Universit\u00e0 Cattolica del Sacro Cuore, 00168 Roma, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tania","family":"Monteburini","sequence":"additional","affiliation":[{"name":"Dipartimento di Nefrologia, Ospedale \u201cCarlo Urbani\u201d Jesi, 60035 Jesi, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"Santarelli","sequence":"additional","affiliation":[{"name":"Dipartimento di Nefrologia, Ospedale \u201cCarlo Urbani\u201d Jesi, 60035 Jesi, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrico","family":"Di Stasio","sequence":"additional","affiliation":[{"name":"Policlinico Universitario Fondazione Agostino Gemelli IRCCS, 00168 Roma, Italy"},{"name":"Dipartimento di Scienze Biotecnologiche di Base, Cliniche Intensivologiche e Perioperatorie, Universit\u00e0 Cattolica del Sacro Cuore, 00168 Roma, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,4,15]]},"reference":[{"key":"ref_1","first-page":"292","article-title":"Prevalence and Risk Factors of Postdialysis Fatigue in Patients Under Maintenance Hemodialysis: A Systematic Review and Meta-Analysis","volume":"16","author":"You","year":"2022","journal-title":"Asian Nurs. 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