{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:09:24Z","timestamp":1760058564629,"version":"build-2065373602"},"reference-count":54,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T00:00:00Z","timestamp":1744848000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background\/Objectives: Current evidence suggests that levosimendan may have a beneficial effect in the treatment of acute heart failure (AHF) or cardiogenic shock following primary percutaneous coronary intervention (PCI). However, there is a paucity of data on the use of levosimendan prior to PCI. Therefore, our pilot study aimed to assess the short-term prognosis of a new therapeutic protocol involving preprocedural infusion of levosimendan in patients with reduced left ventricular ejection fraction undergoing high-risk PCI for acute coronary syndrome (ACS). Methods: The study is a retrospective observational study, and the population includes all subjects who received levosimendan infusion prior to high-risk PCI for ACS. Subjects requiring urgent revascularization (cardiogenic shock, cardiac arrest) or with mechanical complications of ACS were excluded. Results: The study cohort consisted of 90 subjects, predominantly men (91.1%) with significantly reduced left ventricular function (28.7% (12)) and advanced coronary artery disease, mean SYNTAX Score 25.8 (19.3\u201333). During in-hospital follow-up, we observed 2 primary outcomes\u2014death. The major adverse cardiac and cerebrovascular events (MACCE) rate was 7.8%. Two clinical adverse events that did not lead to discontinuation were observed during the in-hospital period. Both were related to hypotension. Conclusions: In short-term observation, novel therapeutic approach in the management of high-risk PCI in ACS patients\u2014pre-procedural levosimendan\u2014was a relatively safe approach. No significant adverse events were reported.<\/jats:p>","DOI":"10.3390\/jcm14082761","type":"journal-article","created":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T06:53:46Z","timestamp":1744872826000},"page":"2761","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pre-Procedural Use of Levosimendan in High-Risk ACS-PCI Patients with Reduced Left Ventricle Ejection Fraction\u2014Short-Term Outcomes"],"prefix":"10.3390","volume":"14","author":[{"given":"Karol","family":"Turkiewicz","sequence":"first","affiliation":[{"name":"Department of Cardiology, The Copper Health Centre (MCZ), 59-301 Lubin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6670-6044","authenticated-orcid":false,"given":"Jan Jakub","family":"Kulczycki","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Copper Health Centre (MCZ), 59-301 Lubin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0963-2712","authenticated-orcid":false,"given":"Piotr","family":"Rola","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Wroclaw University of Science and Technology, 50-981 Wroclaw, Poland"},{"name":"Department of Cardiology, Provincial Specialized Hospital, 59-220 Legnica, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9886-0310","authenticated-orcid":false,"given":"Szymon","family":"W\u0142odarczak","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Copper Health Centre (MCZ), 59-301 Lubin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9112-8012","authenticated-orcid":false,"given":"Mateusz","family":"Barycki","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Provincial Specialized Hospital, 59-220 Legnica, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-5719-385X","authenticated-orcid":false,"given":"Piotr","family":"W\u0142odarczak","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Copper Health Centre (MCZ), 59-301 Lubin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u0141ukasz","family":"Furtan","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Provincial Specialized Hospital, 59-220 Legnica, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pawe\u0142","family":"Kozak","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Copper Health Centre (MCZ), 59-301 Lubin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5472-028X","authenticated-orcid":false,"given":"Adrian","family":"Doroszko","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Wroclaw University of Science and Technology, 50-981 Wroclaw, Poland"},{"name":"Department of Cardiology, Center for Heart Diseases, 4th Military Hospital, Faculty of Medicine, Wroclaw University of Science and Technology, 50-981 Wroclaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0702-7508","authenticated-orcid":false,"given":"Waldemar","family":"Banasiak","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Wroclaw University of Science and Technology, 50-981 Wroclaw, Poland"},{"name":"Department of Cardiology, Center for Heart Diseases, 4th Military Hospital, Faculty of Medicine, Wroclaw University of Science and Technology, 50-981 Wroclaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2630-5016","authenticated-orcid":false,"given":"Maciej","family":"Lesiak","sequence":"additional","affiliation":[{"name":"1st Department of Cardiology, University of Medical Sciences, 61-848 Poznan, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3104-7728","authenticated-orcid":false,"given":"Adrian","family":"W\u0142odarczak","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Copper Health Centre (MCZ), 59-301 Lubin, Poland"},{"name":"Faculty of Medicine, Wroclaw University of Science and Technology, 50-981 Wroclaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,4,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.ijcard.2016.05.009","article-title":"The role of levosimendan in acute heart failure complicating acute coronary syndrome: A review and expert consensus opinion","volume":"218","author":"Nieminen","year":"2016","journal-title":"Int. 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