{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T14:17:47Z","timestamp":1787494667107,"version":"build-2736575974"},"reference-count":43,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T00:00:00Z","timestamp":1744848000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Nazarbayev University School of Medicine"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background\/Objectives: Tumor lysis syndrome (TLS) is a life-threatening oncologic emergency that occurs in pediatric patients undergoing chemotherapy. Severe complications, including acute respiratory distress syndrome (ARDS), acute kidney injury (AKI), and cardiogenic shock, may require extracorporeal membrane oxygenation (ECMO) support. Methods: This paper is a nonsystematic review of cases that synthesizes available case reports to evaluate the efficacy and outcomes of ECMO in pediatric TLS. Results: A systematic search identified five cases in which ECMO was used with a mean duration of 14 days. Survival rates were favorable and ECMO played a critical role in bridging these patients through multi-organ failure. Conclusions: While ECMO is a viable rescue therapy for severe TLS, associated complications, such as infections, bleeding, and neurological impairment, warrant careful patient selection and management. Future studies should explore standardized guidelines for the use of ECMO in pediatric oncology patients.<\/jats:p>","DOI":"10.3390\/jcm14082771","type":"journal-article","created":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T06:53:46Z","timestamp":1744872826000},"page":"2771","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Extracorporeal Membrane Oxygenation in the Management of Tumor Lysis Syndrome in Children: A Review of Cases"],"prefix":"10.3390","volume":"14","author":[{"given":"Zere","family":"Aidynbek","sequence":"first","affiliation":[{"name":"Department of Medicine, School of Medicine, Nazarbayev University, Kerey Zhanibek Handar Street 5\/1, Astana Z05K4F4, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erken","family":"Kakenov","sequence":"additional","affiliation":[{"name":"Pediatric Anesthesiology and Intensive Care Unit, Mother and Child Health Center, University Medical Center, Turan 32, Astana Z05G9F0, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Mironova","sequence":"additional","affiliation":[{"name":"Pediatric Anesthesiology and Intensive Care Unit, Mother and Child Health Center, University Medical Center, Turan 32, Astana Z05G9F0, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karlygash","family":"Ydyrysheva","sequence":"additional","affiliation":[{"name":"Pediatric Anesthesiology and Intensive Care Unit, Mother and Child Health Center, University Medical Center, Turan 32, Astana Z05G9F0, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3581-4843","authenticated-orcid":false,"given":"Tatyana","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Intensive Care, Heart Center, University Medical Center, Turan 38, Astana Z05G9F9, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0437-4694","authenticated-orcid":false,"given":"Vitaliy","family":"Sazonov","sequence":"additional","affiliation":[{"name":"Pediatric Anesthesiology and Intensive Care Unit, Mother and Child Health Center, University Medical Center, Turan 32, Astana Z05G9F0, Kazakhstan"},{"name":"Department of Surgery, School of Medicine, Nazarbayev University, Kerey Zhanibek Handar Street 5\/1, Astana Z05K4F4, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,4,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1093\/jnci\/djad115","article-title":"Counts, incidence rates, and trends of pediatric cancer in the United States, 2003\u20132019","volume":"115","author":"Siegel","year":"2023","journal-title":"J. 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