{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:39:23Z","timestamp":1787791163427,"version":"build-2784847793"},"reference-count":33,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2025,4,18]],"date-time":"2025-04-18T00:00:00Z","timestamp":1744934400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Wroclaw Medical University statutory funds","award":["SUBK.C160.24.056"],"award-info":[{"award-number":["SUBK.C160.24.056"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: The number of senior chronic kidney disease (CKD) patients is steadily increasing worldwide. Falls are more frequent in this group than in the general population, and they are associated with a variety of complications ranging from minor (bruises) to severe (fracture, brain injury, or death). The significant burden of comorbidities, particularly cardiovascular disorders, impacts coordination. The aim of the study was to assess coordination disorders in CKD patients in the context of cardiovascular complications and vascular status. Methods: In this prospective study, 132 patients with CKD 2\u20135, including 40 (30%) hemodialysis patients, were enrolled. The short form physiological profile assessment (S-PPA) was used to assess coordination. Results: During a 2-year follow-up period, 49 individuals experienced 84 falls. The median S-PPA score (Z score) was 3.36. Based on this, we divided our cohort into two groups: a Z score of &lt;3.36 and a Z score of \u22653.36. The groups with high scores (\u22653.36) characterized by higher parameters of vessel stiffness, including AIx@75, augmentation pressure, and PWV, experienced considerably greater numbers of falls (41 vs. 8, p &lt; 0.001), CV events (10 vs. 2, p &lt; 0.05), and deaths (14 vs. 0, p &lt; 0.001). Conclusions: Coordination impairments and the associated risk of falls in CKD patients are directly related to cardiovascular diseases and vascular conditions. Lower arterial compliance has been linked with the largest coordination disorder. Visual impairments, especially contrast sensitivity, are an independent risk factor for falls.<\/jats:p>","DOI":"10.3390\/jcm14082804","type":"journal-article","created":{"date-parts":[[2025,4,18]],"date-time":"2025-04-18T08:24:07Z","timestamp":1744964647000},"page":"2804","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Motor Coordination Disorders in Patients with Chronic Kidney Disease"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9004-184X","authenticated-orcid":false,"given":"Patryk","family":"Jerzak","sequence":"first","affiliation":[{"name":"Clinical Department of Nephrology, Transplantation Medicine and Internal Diseases, Wroclaw Medical University, 50-367 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6502-0374","authenticated-orcid":false,"given":"Mariusz","family":"Kusztal","sequence":"additional","affiliation":[{"name":"Clinical Department of Nephrology, Transplantation Medicine and Internal Diseases, Wroclaw Medical University, 50-367 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3511-7623","authenticated-orcid":false,"given":"Wioletta","family":"Dziubek","sequence":"additional","affiliation":[{"name":"Faculty of Physiotherapy, Wroclaw University of Health and Sport Sciences, 51-612 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9747-3098","authenticated-orcid":false,"given":"\u0141ukasz","family":"Rogowski","sequence":"additional","affiliation":[{"name":"Faculty of Health and Physical Culture Sciences, Witelon Collegium State University, 59-220 Legnica, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo\u017cena","family":"Ostrowska","sequence":"additional","affiliation":[{"name":"Faculty of Physiotherapy, Wroclaw University of Health and Sport Sciences, 51-612 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maciej","family":"Go\u0142\u0119biowski","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Wroclaw Medical University, 50-367 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulina","family":"Bronikowska","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Wroclaw Medical University, 50-367 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Chumadevska","sequence":"additional","affiliation":[{"name":"Clinical Department of Nephrology, Transplantation Medicine and Internal Diseases, Wroclaw Medical University, 50-367 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0527-2190","authenticated-orcid":false,"given":"Jakub","family":"Stojanowski","sequence":"additional","affiliation":[{"name":"Clinical Department of Nephrology, Transplantation Medicine and Internal Diseases, Wroclaw Medical University, 50-367 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5477-2020","authenticated-orcid":false,"given":"Tomasz","family":"Go\u0142\u0119biowski","sequence":"additional","affiliation":[{"name":"Clinical Department of Nephrology, Transplantation Medicine and Internal Diseases, Wroclaw Medical University, 50-367 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,4,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Lin, P., Wan, B., Zhong, J., Wang, M., Tang, F., Wang, L., Guo, J., Ye, Y., Liu, X., and Peng, L. (2024). Risk of fall in patients with chronic kidney disease: Results from the China health and retirement longitudinal study (CHARLS). BMC Public Health, 24.","DOI":"10.1186\/s12889-024-17982-4"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"L\u00f3pez-Soto, P.J., De Giorgi, A., Senno, E., Tiseo, R., Ferraresi, A., Canella, C., Rodr\u00edguez-Borrego, M.A., Manfredini, R., and Fabbian, F. (2015). Renal disease and accidental falls: A review of published evidence. BMC Nephrol., 16.","DOI":"10.1186\/s12882-015-0173-7"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.2215\/CJN.00880114","article-title":"Nondisease-specific problems and all-cause mortality among older adults with CKD: The REGARDS Study","volume":"9","author":"Bowling","year":"2014","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"E82","DOI":"10.5888\/pcd15.170518","article-title":"Falls and Fall-Related Injuries Among US Adults Aged 65 or Older with Chronic Kidney Disease","volume":"15","author":"Kistler","year":"2018","journal-title":"Prev. Chronic Dis."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1093\/ndt\/gfm778","article-title":"Geriatric comorbidities, such as falls, confer an independent mortality risk to elderly dialysis patients","volume":"23","author":"Li","year":"2008","journal-title":"Nephrol. Dial. Transplant."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1093\/ptj\/83.3.237","article-title":"A physiological profile approach to falls risk assessment and prevention","volume":"83","author":"Lord","year":"2003","journal-title":"Phys. Ther."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Lin, Y., Yang, C., Chu, H., Wu, J., Lin, K., Shi, Y., Wang, H., Kong, G., and Zhang, L. (2019). Association between the Charlson Comorbidity Index and the risk of 30-day unplanned readmission in patients receiving maintenance dialysis. BMC Nephrol., 20.","DOI":"10.1186\/s12882-019-1538-0"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Zanotto, T., Mercer, T.H., van der Linden, M.L., Rush, R., Traynor, J.P., Petrie, C.J., Doyle, A., Chalmers, K., Allan, N., and Shilliday, I. (2020). The relative importance of frailty, physical and cardiovascular function as exercise-modifiable predictors of falls in haemodialysis patients: A prospective cohort study. BMC Nephrol., 21.","DOI":"10.1186\/s12882-020-01759-z"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/s10157-023-02403-4","article-title":"Low muscle strength and physical function contribute to falls in hemodialysis patients, but not muscle mass","volume":"28","author":"Shirai","year":"2024","journal-title":"Clin. Exp. Nephrol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.2215\/CJN.01650506","article-title":"Falls and fall-related injuries in older dialysis patients","volume":"1","author":"Cook","year":"2006","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1007\/s40620-018-0484-4","article-title":"Functional impairment and risk of mortality in patients on chronic hemodialysis: Results of the Lazio Dialysis Registry","volume":"31","author":"Bossola","year":"2008","journal-title":"J. Nephrol."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Doshi, S., Moorthi, R.N., Fried, L.F., Sarnak, M.J., Satterfield, S., Shlipak, M., Lange-Maia, B.S., Newman, A.B., and Strotmeyer, E.S. (2020). Chronic kidney disease as a risk factor for peripheral nerve impairment in older adults: A longitudinal analysis of Health, Aging and Body Composition (Health ABC) study. PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0242406"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"33","DOI":"10.22540\/JFSF-02-033","article-title":"Risk of falls in chronic kidney disease","volume":"2","author":"Papakonstantinopoulou","year":"2017","journal-title":"J. Frailty Sarcopenia Falls"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Zhang, F., Wang, H., Bai, Y., Zhang, Y., Huang, L., and Zhang, H. (2023). Prevalence of physical frailty and impact on survival in patients with chronic kidney disease: A systematic review and meta-analysis. BMC Nephrol., 24.","DOI":"10.1186\/s12882-023-03303-1"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.jamda.2020.09.033","article-title":"Frailty as a Predictor of Negative Health Outcomes in Chronic Kidney Disease: A Systematic Review and Meta-Analysis","volume":"22","author":"Mei","year":"2021","journal-title":"J. Am. Med. Dir. Assoc."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1681\/ASN.2019020117","article-title":"Arterial Stiffness in the Heart Disease of CKD","volume":"30","author":"Zanoli","year":"2019","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1038\/s41371-019-0275-y","article-title":"Relationship between Arterial Stiffness and Chronic Kidney Disease in Patients with Primary Hypertension","volume":"34","author":"Zuo","year":"2020","journal-title":"J. Hum. Hypertens."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"9","DOI":"10.5414\/CN108020","article-title":"Relationship between heart rate variability and pulse wave velocity and their association with patient outcomes in chronic kidney disease","volume":"81","author":"Chandra","year":"2014","journal-title":"Clin. Nephrol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1161\/HYPERTENSIONAHA.117.10648","article-title":"Association of Pulse Wave Velocity With Chronic Kidney Disease Progression and Mortality","volume":"71","author":"Townsend","year":"2018","journal-title":"Hypertension"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.gaitpost.2020.08.128","article-title":"Association of postural balance and falls in adult patients receiving haemodialysis: A prospective cohort study","volume":"82","author":"Zanotto","year":"2020","journal-title":"Gait Posture"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1111\/jch.13350","article-title":"Arterial damage and cognitive decline in chronic kidney disease patients","volume":"20","author":"Karasavvidou","year":"2018","journal-title":"J. Clin. Hypertens."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Aimagambetova, B., Ariko, T., Merritt, S., and Rundek, T. (2024). Arterial stiffness measured by pulse wave velocity correlated with cognitive decline in hypertensive individuals: A systematic review. BMC Neurol., 24.","DOI":"10.1186\/s12883-024-03905-8"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1111\/jgs.12931","article-title":"High Arterial Pulse Wave Velocity Is a Risk Factor for Falls in Community-Dwelling Older People","volume":"62","author":"Wong","year":"2014","journal-title":"J. Am. Geriatr. Soc."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1093\/gerona\/glad060","article-title":"Association Between Contrast Sensitivity and Physical Function in Cognitively Healthy Older Adults: The Brain Networks and Mobility Function Study","volume":"78","author":"Thompson","year":"2023","journal-title":"J. Gerontol. Ser. A"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.jamda.2016.10.008","article-title":"Falls, Cognitive Impairment, and Gait Performance: Results From the GOOD Initiative","volume":"18","author":"Allali","year":"2017","journal-title":"J. Am. Med. Dir. Assoc."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1167\/iovs.08-1942","article-title":"Postural stability and gait among older adults with age-related maculopathy","volume":"50","author":"Wood","year":"2009","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_27","first-page":"2099","article-title":"Increased Burden of Vision Impairment and Eye Diseases in Patients with Chronic Kidney Disease","volume":"56","author":"Wai","year":"2015","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1111\/jgs.18879","article-title":"Association between vision impairment and increased prevalence of falls in older US adults","volume":"72","author":"Jin","year":"2024","journal-title":"J. Am. Geriatr. Soc."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1053\/j.ajkd.2018.12.047","article-title":"Vision Impairment in CKD Patients: Epidemiology, Mechanisms, Differential Diagnoses, and Prevention","volume":"73","author":"Nusinovici","year":"2019","journal-title":"Am. J. Kidney Dis."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.2215\/CJN.10321110","article-title":"Vision-threatening retinal abnormalities in chronic kidney disease stages 3 to 5","volume":"6","author":"Deva","year":"2011","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Capossela, L., Ferretti, S., D\u2019alonzo, S., Di Sarno, L., Pansini, V., Curatola, A., Chiaretti, A., and Gatto, A. (2023). Bone Disorders in Pediatric Chronic Kidney Disease: A Literature Review. Biology, 12.","DOI":"10.20944\/preprints202309.2108.v1"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.survophthal.2022.09.001","article-title":"Co-occurrence of chronic kidney disease and glaucoma: Epidemiology and etiological mechanisms","volume":"68","author":"Liu","year":"2023","journal-title":"Surv. Ophthalmol."},{"key":"ref_33","first-page":"e244868","article-title":"Long-Term Blood Pressure Variability and Visual Field Progression in Glaucoma","volume":"14","author":"Pham","year":"2024","journal-title":"JAMA Ophthalmol"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/8\/2804\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T17:17:24Z","timestamp":1760030244000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/8\/2804"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,18]]},"references-count":33,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2025,4]]}},"alternative-id":["jcm14082804"],"URL":"https:\/\/doi.org\/10.3390\/jcm14082804","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,18]]}}}