{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T18:01:41Z","timestamp":1787680901198,"version":"build-2784847793"},"reference-count":24,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T00:00:00Z","timestamp":1745798400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: This study compares the cost-utility, visual acuity, and humanistic outcomes of phacoemulsification surgery performed during international outreach campaigns to outcomes in the U.S. Objective: Humanitarian organizations frequently perform cataract surgeries in underserved regions, yet the outcomes of phacoemulsification in these settings remain unexplored. This study aims to compare the visual acuity outcomes, quality-of-life outcomes, and cost of phacoemulsification surgery during international outreach campaigns with those in the U.S. Methods: This retrospective review analyzed 344 cases from Women for World Health (W4WH) missions and 305 consecutive cases from the academic practice of the lead surgeon of W4WH in the US. The pre-operative (pre-op) visual acuity, post-operative (post-op) visual acuity at day 1, and best-corrected visual acuity (BCVA) at post-op month 1 were compared to baseline. The change in visual acuity was compared between the two groups. Complication rates, cost per case, and quality-of-life measures were evaluated for the mission group compared to cataract surgery outcomes in the developed world. Results: The mission cohort had worse baseline visual acuity than the U.S. cohort (1.36 logMAR vs. 0.50 logMAR, p &lt; 0.0001) and showed greater mean improvement (1.24 logMAR vs. 0.35 logMAR, p &lt; 0.0001). Both cohorts achieved similar BCVA at post-op month 1 (0.13 logMAR). The cost for the mission group was USD 276 per surgery. A total of 93.94% of patients in the mission group achieved a BCVA of 20\/40 or better, which is comparable to the U.S. outcomes. Conclusions: The dramatic impact, immediacy, and enduring effect of cataract surgery using phacoemusification on quality of life, mental health, and economic return on investment make it the ideal procedure for humanitarian settings. Considering all of the available metrics, our data support the continued expansion of humanitarian efforts by cataract surgery organizations worldwide.<\/jats:p>","DOI":"10.3390\/jcm14093037","type":"journal-article","created":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T09:39:47Z","timestamp":1745833187000},"page":"3037","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Comparison of Cost-Utility, Visual Acuity, and Humanistic Outcomes of Cataract Surgery Performed in the United States Versus International Outreach Campaigns"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5835-5646","authenticated-orcid":false,"given":"Lauren E.","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Gavin Herbert Eye Institute, University of California Irvine, Irvine, CA 92617, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryka","family":"Vahidi","sequence":"additional","affiliation":[{"name":"University of California Los Angeles, Emergency Medical Services, Los Angeles, CA 90095, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Kesler-Diaz","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Palo Alto Medical Foundation, Santa Cruz, CA 95060, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sameh","family":"Mosaed","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Gavin Herbert Eye Institute, University of California Irvine, Irvine, CA 92617, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,4,28]]},"reference":[{"key":"ref_1","unstructured":"GBD 2019 Blindness, Vision Impairment Collaborators, and Vision Loss Expert Group of the Global Burden of Disease Study (2021). Causes of blindness and vision impairment in 2020 and trends over 30 years, and prevalence of avoidable blindness in relation to VISION 2020: The Right to Sight: An analysis for the Global Burden of Disease Study. Lancet Glob. Health, 9, e144\u2013e160."},{"key":"ref_2","unstructured":"Velez, G., Fortenbach, C.R., and Oetting, T.A. (2025, March 10). Global Causes of Preventable Blindness and Vision Impairment. EyeRounds.org. Available online: https:\/\/eyerounds.org\/tutorials\/global-blindness\/index.htm."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"5872","DOI":"10.1167\/iovs.16-19894","article-title":"Cataract Surgical Rate and Socioeconomics: A Global Study","volume":"57","author":"Wang","year":"2016","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1097\/ICU.0000000000001092","article-title":"Global prevalence of cataract surgery","volume":"36","author":"Hashemi","year":"2024","journal-title":"Curr. Opin. Ophthalmol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1111\/ceo.13430","article-title":"Longitudinal changes in global cataract surgery rate inequality and associations with socioeconomic indices","volume":"47","author":"Yan","year":"2018","journal-title":"Clin. Exp. Ophthalmol."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Vision Loss Expert Group of the Global Burden of Disease Study, and GBD 2019 Blindness and Vision Impairment Collaborators (2024). Global estimates on the number of people blind or visually impaired by cataract: A meta-analysis from 2000 to 2020. Eye, 38, 2156\u20132172. Erratum in Eye 2024, 38, 2229\u20132231. https:\/\/doi.org\/10.1038\/s41433-024-03161-7.","DOI":"10.1038\/s41433-024-03161-7"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1001\/archopht.120.6.774","article-title":"How does visual impairment affect performance on tasks of everyday life? The SEE Project","volume":"120","author":"West","year":"2002","journal-title":"Salisb. Eye Eval. Arch. Ophthalmol."},{"key":"ref_8","first-page":"500","article-title":"Visual acuity thresholds associated with activity limitations in the elderly","volume":"92","author":"Daien","year":"2014","journal-title":"Pathol. Ocul. Li\u00e9es \u00e0 L\u2019age Study Acta Ophthalmol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.oftal.2024.10.004","article-title":"Implementation of SICS (small incision cataract surgery) in humanitarian campaigns: Description of the surgical technique and review of the literature","volume":"100","author":"Berrones","year":"2025","journal-title":"Arch. Soc. Esp. Oftalmol. (Engl. Ed.)"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/j.jcrs.2019.02.006","article-title":"Cost-utility analysis of cataract surgery in the United States for the year 2018","volume":"45","author":"Brown","year":"2019","journal-title":"J. Cataract. Refract. Surg."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.ajo.2020.08.025","article-title":"Cataract Surgery Complexity and Surgical Complication Rates Among Medicare Beneficiaries With and Without Dementia","volume":"221","author":"Pershing","year":"2020","journal-title":"Am. J. Ophthalmol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.ophtha.2019.10.007","article-title":"Cataract Surgery Volumes and Complications per Surgeon and Clinical Unit: Data from the Swedish National Cataract Register 2007 to 2016","volume":"127","author":"Zetterberg","year":"2019","journal-title":"Ophthalmology"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1016\/j.jcrs.2009.05.026","article-title":"Capsule complication during cataract surgery: Case-control study of preoperative and intraoperative risk factors: Swedish Capsule Rupture Study Group report 2","volume":"35","author":"Behndig","year":"2009","journal-title":"J. Cataract. Refract. Surg."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.ophtha.2008.10.028","article-title":"Risk factors for intraoperative complications in resident-performed phacoemulsification surgery","volume":"116","author":"Rutar","year":"2009","journal-title":"Ophthalmology"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"3234","DOI":"10.1038\/s41433-023-02498-9","article-title":"Fruit and vegetable intake and the risk of cataract: Insights from the UK Biobank study","volume":"37","author":"Fan","year":"2023","journal-title":"Eye"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1111\/ceo.13892","article-title":"Cataract and systemic disease: A review","volume":"49","author":"Ang","year":"2021","journal-title":"Clin. Exp. Ophthalmol."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Li, L., Wan, X.H., and Zhao, G.H. (2014). Meta-analysis of the risk of cataract in type 2 diabetes. BMC Ophthalmol., 14.","DOI":"10.1186\/1471-2415-14-94"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0377-1237(17)30406-9","article-title":"Study of Traumatic Cataract in Occupational and Environmental Trauma and Its Management","volume":"54","author":"Parihar","year":"2017","journal-title":"Med. J. Armed Forces India"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"2300","DOI":"10.1097\/JS9.0000000000001105","article-title":"The association between cataract surgery and mental health in older adults: A review","volume":"110","author":"Wang","year":"2024","journal-title":"Int. J. Surg."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1503\/cmaj.060962","article-title":"The consequences of waiting for cataract surgery: A systematic review","volume":"176","author":"Hodge","year":"2007","journal-title":"CMAJ"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.4103\/ijo.IJO_871_17","article-title":"Corneal edema after phacoemulsification","volume":"65","author":"Sharma","year":"2017","journal-title":"Indian J. Ophthalmol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"3765","DOI":"10.4103\/ijo.IJO_1266_22","article-title":"Health economics and manual small-incision cataract surgery: An illustrative mini review","volume":"70","author":"Bali","year":"2022","journal-title":"Indian J. Ophthalmol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1097\/ICU.0000000000000228","article-title":"Carbon footprint and cost\u2013effectiveness of cataract surgery","volume":"27","author":"Venkatesh","year":"2016","journal-title":"Curr. Opin. Ophthalmol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.oftal.2023.12.001","article-title":"Humanitarian missions and visual outcomes in cataract surgery: A literature review","volume":"99","author":"Urbinati","year":"2024","journal-title":"Arch. Soc. Esp. Oftalmol. (Engl. Ed.)"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/9\/3037\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T17:23:16Z","timestamp":1760030596000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/9\/3037"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,28]]},"references-count":24,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2025,5]]}},"alternative-id":["jcm14093037"],"URL":"https:\/\/doi.org\/10.3390\/jcm14093037","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,28]]}}}