{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T11:45:04Z","timestamp":1785325504521,"version":"3.55.0"},"reference-count":72,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T00:00:00Z","timestamp":1745798400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Instituto de Salud Carlos III (ISCIII)","award":["PI18\/00468"],"award-info":[{"award-number":["PI18\/00468"]}]},{"name":"Instituto de Salud Carlos III (ISCIII)","award":["PI22\/01082"],"award-info":[{"award-number":["PI22\/01082"]}]},{"name":"Instituto de Salud Carlos III (ISCIII)","award":["PLEC2022-009290"],"award-info":[{"award-number":["PLEC2022-009290"]}]},{"name":"Instituto de Salud Carlos III (ISCIII)","award":["2021SGR\/00810"],"award-info":[{"award-number":["2021SGR\/00810"]}]},{"name":"European Union","award":["PI18\/00468"],"award-info":[{"award-number":["PI18\/00468"]}]},{"name":"European Union","award":["PI22\/01082"],"award-info":[{"award-number":["PI22\/01082"]}]},{"name":"European Union","award":["PLEC2022-009290"],"award-info":[{"award-number":["PLEC2022-009290"]}]},{"name":"European Union","award":["2021SGR\/00810"],"award-info":[{"award-number":["2021SGR\/00810"]}]},{"name":"MCIN\/AEI\/10.13039\/501100011033","award":["PI18\/00468"],"award-info":[{"award-number":["PI18\/00468"]}]},{"name":"MCIN\/AEI\/10.13039\/501100011033","award":["PI22\/01082"],"award-info":[{"award-number":["PI22\/01082"]}]},{"name":"MCIN\/AEI\/10.13039\/501100011033","award":["PLEC2022-009290"],"award-info":[{"award-number":["PLEC2022-009290"]}]},{"name":"MCIN\/AEI\/10.13039\/501100011033","award":["2021SGR\/00810"],"award-info":[{"award-number":["2021SGR\/00810"]}]},{"name":"Ag\u00e8ncia de Gesti\u00f3 d\u2019Ajuts Universitaris i de Recerca (AGAUR), Departament de Recerca i Universitats de la Generalitat de Catalunya, Spain","award":["PI18\/00468"],"award-info":[{"award-number":["PI18\/00468"]}]},{"name":"Ag\u00e8ncia de Gesti\u00f3 d\u2019Ajuts Universitaris i de Recerca (AGAUR), Departament de Recerca i Universitats de la Generalitat de Catalunya, Spain","award":["PI22\/01082"],"award-info":[{"award-number":["PI22\/01082"]}]},{"name":"Ag\u00e8ncia de Gesti\u00f3 d\u2019Ajuts Universitaris i de Recerca (AGAUR), Departament de Recerca i Universitats de la Generalitat de Catalunya, Spain","award":["PLEC2022-009290"],"award-info":[{"award-number":["PLEC2022-009290"]}]},{"name":"Ag\u00e8ncia de Gesti\u00f3 d\u2019Ajuts Universitaris i de Recerca (AGAUR), Departament de Recerca i Universitats de la Generalitat de Catalunya, Spain","award":["2021SGR\/00810"],"award-info":[{"award-number":["2021SGR\/00810"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background\/Objectives: This study aimed to evaluate the results of continuous intracranial pressure (ICP) monitoring in children with macrocephaly or rapidly increasing head circumference (HC) diagnosed as benign external hydrocephalus (BEH). Here, we report the absolute ICP measurements, ICP pulsatility, and slow ICP waves after at least 48 h of continuous monitoring in a cohort of 36 children diagnosed with BEH. Methods: A prospective study of continuous ICP monitoring was performed in 36 consecutive children with macrocephaly (HC above the 97.5th percentile) or rapidly increasing HC (at least crossing two percentile curves), diagnosed with BEH (22 boys and 14 girls with a mean age of 23.6 \u00b1 13.3 months, minimum: 6, maximum 65), using an epidural sensor. For the first four children in the study, hard copies of the ICP values were obtained using an analog recorder. Starting from the fifth patient, the ICP signal was sampled at 200 Hz and stored on a computer using a computer-based data acquisition and analysis system (LabChart v8.1 software). Results: Clinical signs or symptoms were identified in 20 patients (55.6%). Delayed motor or language development was noted in 18 (50%) and 20 (55.6%) patients, respectively. In 13 patients, the enlargement of the subarachnoid spaces was found to be associated with an additional condition. The median of mean ICP values for the entire cohort was 17 mmHg, with a minimum of 6.7 mmHg and a maximum of 29 mmHg. All patients exhibited a percentage of B waves exceeding 20% during the night, with a median value of 47.4% (min: 23.2, max: 75). Three children had nocturnal plateau waves. At night, regular ICP recordings alternated with periods of significant increases in ICP, often exceeding 10 mmHg above baseline values. High-amplitude B waves were noted during these episodes, and the amplitude of the cardiac waveform at the peak of the B waves was consistently greater than 5 mmHg, displaying an abnormal morphology (P2 &gt; P1). A ventriculoperitoneal shunt was implanted in 30 of the 36 patients. Conclusions: Patients with BEH may present significant abnormalities in ICP. Monitoring this variable in certain cases can assist in determining the necessity for surgical treatment.<\/jats:p>","DOI":"10.3390\/jcm14093042","type":"journal-article","created":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T09:39:47Z","timestamp":1745833187000},"page":"3042","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Continuous Intracranial Pressure Monitoring in Children with \u2018Benign\u2019 External Hydrocephalus"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3831-0536","authenticated-orcid":false,"given":"Maria A.","family":"Poca","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Vall d\u2019Hebron University Hospital, Passeig Vall d\u2019Hebron 119-129, 08035 Barcelona, Spain"},{"name":"Neurotraumatology and Neurosurgery Research Unit, Vall d\u2019Hebron Institut de Recerca (VHIR), Vall d\u2019Hebron Hospital Universitari, Vall d\u2019Hebron Barcelona Hospital Campus, Passeig Vall d\u2019Hebron 119-129, 08035 Barcelona, Spain"},{"name":"Department of Surgery (Neurosurgery), Universitat Aut\u00f2noma de Barcelona, 08193 Bellaterra, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego","family":"Lopez-Bermeo","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Vall d\u2019Hebron University Hospital, Passeig Vall d\u2019Hebron 119-129, 08035 Barcelona, Spain"},{"name":"Neurotraumatology and Neurosurgery Research Unit, Vall d\u2019Hebron Institut de Recerca (VHIR), Vall d\u2019Hebron Hospital Universitari, Vall d\u2019Hebron Barcelona Hospital Campus, Passeig Vall d\u2019Hebron 119-129, 08035 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Cano","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Vall d\u2019Hebron University Hospital, Passeig Vall d\u2019Hebron 119-129, 08035 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Maruccia","sequence":"additional","affiliation":[{"name":"Neurotraumatology and Neurosurgery Research Unit, Vall d\u2019Hebron Institut de Recerca (VHIR), Vall d\u2019Hebron Hospital Universitari, Vall d\u2019Hebron Barcelona Hospital Campus, Passeig Vall d\u2019Hebron 119-129, 08035 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Fajardo","sequence":"additional","affiliation":[{"name":"ICFO\u2014Institut de Ciencies Fotoniques, The Barcelona Institute of Science and Technology, 08860 Castelldefels, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignacio","family":"Delgado","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neuroradiology, Vall d\u2019Hebron Hospital Universitari, Vall d\u2019Hebron Barcelona Hospital Campus, Passeig Vall d\u2019Hebron 119-129, 08035 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisca","family":"Munar","sequence":"additional","affiliation":[{"name":"Neurotraumatology and Neurosurgery Research Unit, Vall d\u2019Hebron Institut de Recerca (VHIR), Vall d\u2019Hebron Hospital Universitari, Vall d\u2019Hebron Barcelona Hospital Campus, Passeig Vall d\u2019Hebron 119-129, 08035 Barcelona, Spain"},{"name":"Pediatric Anesthesiology Department, Vall d\u2019Hebron Hospital Universitari, Vall d\u2019Hebron Barcelona Hospital Campus, Passeig Vall d\u2019Hebron 119-129, 08035 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Garcia-Merino","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Vall d\u2019Hebron University Hospital, Passeig Vall d\u2019Hebron 119-129, 08035 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0713-5875","authenticated-orcid":false,"given":"Juan","family":"Sahuquillo","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Vall d\u2019Hebron University Hospital, Passeig Vall d\u2019Hebron 119-129, 08035 Barcelona, Spain"},{"name":"Neurotraumatology and Neurosurgery Research Unit, Vall d\u2019Hebron Institut de Recerca (VHIR), Vall d\u2019Hebron Hospital Universitari, Vall d\u2019Hebron Barcelona Hospital Campus, Passeig Vall d\u2019Hebron 119-129, 08035 Barcelona, Spain"},{"name":"Department of Surgery (Neurosurgery), Universitat Aut\u00f2noma de Barcelona, 08193 Bellaterra, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,4,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"504","DOI":"10.3171\/jns.1981.54.4.0504","article-title":"Benign enlargement of the subarachnoid spaces in the infant","volume":"54","author":"Ment","year":"1981","journal-title":"J. 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