{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T23:07:45Z","timestamp":1784761665354,"version":"3.55.0"},"reference-count":33,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T00:00:00Z","timestamp":1745971200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Complex Program of Basic Research under the Siberian Branch of the Russian Academy of Sciences within the Basic Research Topic of Research Institute for Complex Issues of Cardiovascular Diseases","award":["0419-2022-0002"],"award-info":[{"award-number":["0419-2022-0002"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background\/Objectives: Patients with coronary artery disease undergoing coronary artery bypass grafting (CABG) have a high prevalence of type 2 diabetes mellitus (T2DM) and prediabetes. Glucose metabolism disorders (GMDs) are often asymptomatic and remain undetected, but untreated they can have adverse effects. To evaluate the possibilities of active screening in identifying T2DM and prediabetes before CABG and to assess the impact of GMD on the incidence of postoperative complications. Methods: This study included 1021 patients who underwent CABG in 2016\u20132018 at the department of cardiovascular surgery, whose glycemic status was determined. All patients had their glycated hemoglobin (HbA1c) levels measured; those without a previous diagnosis of diabetes underwent an oral glucose tolerance test. The frequency of newly diagnosed diabetes and prediabetes was evaluated. Postoperative complication rates were analyzed among patient groups with various types of GMDs and normal blood glucose levels. Results: Screening before CABG increased the number of patients with established type 2 diabetes from 20.9 to 27.8% and the number of people with prediabetes from 2.7% to 31.7%. When analyzing hospital complications, patients with type 2 diabetes compared to patients with normoglycemia were significantly more likely to develop heart failure (p = 0.010), multiple organ failure (p = 0.002), require extracorporeal homeostasis correction (p = 0.011), and wound dehiscence (p = 0.004). Nine patients (0.9%) died following CABG without being discharged from the hospital, with 90% of these deaths occurring in patients with GMDs. Any GMD (diabetes or prediabetes) was associated with an increased incidence of postoperative heart failure (OR 1.259; p = 0.011), rhythm disturbances (OR 1.236; p = 0.010), major cardiovascular complications and\/or heart failure (OR 1.193; p = 0.039), and all cardiovascular complications (OR 1.455; p = 0.002). In the presence of any GMD, the risk of multiple organ failure increased by 2.5 times (OR 2.506; p = 0.014), extracorporeal correction of homeostasis increased by 1.8 times (OR 1.821; p = 0.034), and diastasis of the wound edges increased by 1.3 times (OR 1.266; p = 0.005). It is important that, when adjusting for gender and age, the effect of GMD on the described complications remained significant. Conclusions: Active preoperative detection established an extremely high prevalence of GMD in patients with multivessel coronary artery disease (59.5%). T2DM and prediabetes are significant predictors of postoperative complications of coronary artery bypass grafting.<\/jats:p>","DOI":"10.3390\/jcm14093123","type":"journal-article","created":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T09:16:12Z","timestamp":1746090972000},"page":"3123","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Active Detection of Glucose Metabolism Disorders Prior to Coronary Artery Bypass Grafting: Associations with In-Hospital Postoperative Complications"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0963-4793","authenticated-orcid":false,"given":"Alexey N.","family":"Sumin","sequence":"first","affiliation":[{"name":"Federal State Budgetary Scientific Institution \u201cResearch Institute for Complex Issues of Cardiovascular Diseases\u201d, Academician L.S. Barbarash Boulevard, 6, Kemerovo 650002, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9396-4575","authenticated-orcid":false,"given":"Natalia A.","family":"Bezdenezhnykh","sequence":"additional","affiliation":[{"name":"Federal State Budgetary Scientific Institution \u201cResearch Institute for Complex Issues of Cardiovascular Diseases\u201d, Academician L.S. Barbarash Boulevard, 6, Kemerovo 650002, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3996-3325","authenticated-orcid":false,"given":"Ekaterina. V.","family":"Belik","sequence":"additional","affiliation":[{"name":"Federal State Budgetary Scientific Institution \u201cResearch Institute for Complex Issues of Cardiovascular Diseases\u201d, Academician L.S. Barbarash Boulevard, 6, Kemerovo 650002, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4420-4350","authenticated-orcid":false,"given":"Andrew V.","family":"Bezdenezhnykh","sequence":"additional","affiliation":[{"name":"Limited Liability Company \u201cFamily Health and Reproduction Center Krasnaya Gorka\u201d, Suvorova St., 3A, Kemerovo 650044, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga V.","family":"Gruzdeva","sequence":"additional","affiliation":[{"name":"Federal State Budgetary Scientific Institution \u201cResearch Institute for Complex Issues of Cardiovascular Diseases\u201d, Academician L.S. Barbarash Boulevard, 6, Kemerovo 650002, Russia"},{"name":"Federal State Budgetary Educational Institution of Higher Education, Kemerovo State Medical University, Voroshilova St., 22A, Kemerovo 650056, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4642-3610","authenticated-orcid":false,"given":"Olga L.","family":"Barbarash","sequence":"additional","affiliation":[{"name":"Federal State Budgetary Scientific Institution \u201cResearch Institute for Complex Issues of Cardiovascular Diseases\u201d, Academician L.S. Barbarash Boulevard, 6, Kemerovo 650002, Russia"},{"name":"Federal State Budgetary Educational Institution of Higher Education, Kemerovo State Medical University, Voroshilova St., 22A, Kemerovo 650056, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,4,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1093\/eurheartj\/ehz486","article-title":"2019 ESC Guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD","volume":"41","author":"Cosentino","year":"2020","journal-title":"Eur. Heart J."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"107843","DOI":"10.1016\/j.diabres.2019.107843","article-title":"Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: Results from the International Diabetes Federation Diabetes Atlas, 9th edition","volume":"157","author":"Saeedi","year":"2019","journal-title":"Diabetes Res. Clin. Pract."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"e14669","DOI":"10.1097\/MD.0000000000014669","article-title":"In-hospital, short-term and long-term adverse clinical outcomes observed in patients with type 2 diabetes mellitus vs non-diabetes mellitus following percutaneous coronary intervention: A meta-analysis including 139,774 patients","volume":"98","author":"Zhuo","year":"2019","journal-title":"Medicine"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"25","DOI":"10.17802\/2306-1278-2021-10-2-25-35","article-title":"Current trends in routine myocardial revascularization","volume":"10","author":"Ivanov","year":"2021","journal-title":"Complex Issues Cardiovasc. Diseases."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1055\/a-0684-9601","article-title":"The Prognostic Importance of Impaired Fasting Glycemia in Chronic Coronary Heart Disease Patients","volume":"129","author":"Mayer","year":"2021","journal-title":"Exp. Clin. Endocrinol. Diabetes"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1186\/s12933-024-02356-2","article-title":"A high-volume study on the impact of diabetes mellitus on clinical outcomes after surgical and percutaneous cardiac interventions","volume":"23","author":"Slingerland","year":"2024","journal-title":"Cardiovasc. Diabetol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1186\/s13098-019-0506-y","article-title":"Clinical outcome comparison of percutaneous coronary intervention and bypass surgery in diabetic patients with coronary artery disease: A meta-analysis of randomized controlled trials and observational studies","volume":"11","author":"Zhai","year":"2019","journal-title":"Diabetol. Metab. Syndr."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"4646","DOI":"10.1111\/jocs.17046","article-title":"Long-term outcomes of percutaneous versus surgical revascularization in patients with diabetes and left main coronary artery disease: A meta-analysis of randomized controlled trials","volume":"37","author":"Carvalho","year":"2022","journal-title":"J. Card. Surg."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1111\/1753-0407.13108","article-title":"Glycemic control and risk factors for in-hospital mortality and vascular complications after coronary artery bypass grafting in patients with and without preexisting diabetes","volume":"13","author":"Chen","year":"2021","journal-title":"J. Diabetes"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s13098-023-00984-4","article-title":"Effect of glycemic control and glucose fluctuation on in-hospital adverse outcomes after on-pump coronary artery bypass grafting in patients with diabetes: A retrospective study","volume":"15","author":"You","year":"2023","journal-title":"Diabetol. Metab. Syndr."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"e001217","DOI":"10.1136\/openhrt-2019-001217","article-title":"Preoperative disturbances of glucose metabolism and mortality after coronary artery bypass grafting","volume":"7","author":"Djupsjo","year":"2020","journal-title":"Open Heart"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Sumin, A.N., Bezdenezhnykh, N.A., Bezdenezhnykh, A.V., Osokina, A.V., Kuz\u2019mina, A.A., Tsepokina, A.V., and Barbarash, O.L. (2021). Screening for Glucose Metabolism Disorders, Assessment the Disse Insulin Resistance Index and Hospital Prognosis of Coronary Artery Bypass Surgery. J. Pers. Med., 11.","DOI":"10.3390\/jpm11080802"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"e29557","DOI":"10.1097\/MD.0000000000029557","article-title":"Newly diagnosed diabetes based on an oral glucose tolerance test predicts cardiovascular outcomes in patients with coronary artery disease: An observational study","volume":"101","author":"Chen","year":"2022","journal-title":"Medicine"},{"key":"ref_14","unstructured":"Bezdenezhnyh, N.A., Bezdenezhnyh, A.V., Gruzdeva, O.V., Sumin, A.N., Barbarash, O.L., and Shamina, O.A. (2021). Screening of carbohydrate metabolism disorders before coronary artery bypass grafting. (2021613682), Certificate of registration of the computer program RU Patent, 11 March 2021. Application \u2116 2021612467."},{"key":"ref_15","unstructured":"World Health Organization (2006). Definition and Diagnosis of Diabetes Mellitus and Intermediate Hyperglycemia: Report of a WHO\/IDF Consultation, World Health Organization."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.14341\/DM7078","article-title":"Standards of specialized diabetes care","volume":"18","author":"Dedov","year":"2015","journal-title":"Diabetes Mellit."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"e14777","DOI":"10.1111\/dme.14777","article-title":"Assessment of glycaemic status in adult hospital patients for the detection of undiagnosed diabetes mellitus: A systematic review","volume":"39","author":"Armitage","year":"2022","journal-title":"Diabet Med."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s12933-023-01761-3","article-title":"Prevalence of prediabetes and undiagnosed diabetes in a large urban middle-aged population: The CARVAR 92 cohort","volume":"22","author":"Hergault","year":"2023","journal-title":"Cardiovasc. Diabetol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"e14829","DOI":"10.1111\/dme.14829","article-title":"Undiagnosed diabetes: Prevalence and cardiovascular risk profile in a population-based study of 52,856 individuals. The HUNT Study, Norway","volume":"39","author":"Haug","year":"2022","journal-title":"Diabet. Med."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Lapi\u0107, I., Rogi\u0107, D., Nikolac Gabaj, N., Kaji\u0107, K., Peran, N., Surjan, L., \u0110uras, A., Cesar Kocijan, V., Bilopavlovi\u0107, N., and Smai\u0107, F. (2022). Haemoglobin A1c-based screening for prediabetes and diabetes mellitus: A multi-center study in Croatian adult population. Biochem. Med., 32.","DOI":"10.11613\/BM.2022.010903"},{"key":"ref_21","first-page":"e65567","article-title":"Glycosylated Hemoglobin (HbA1C) as a Predictor of Early Postoperative Outcomes After Coronary Artery Bypass Grafting: A Single-Center Observational Study","volume":"16","author":"Alshair","year":"2024","journal-title":"Cureus"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1186\/s12933-024-02421-w","article-title":"High proportion of undiagnosed diabetes in patients surgically treated for infrarenal abdominal aortic aneurysm: Findings from the multicentre Norwegian Aortic Aneurysm and Diabetes (ABANDIA) Study","volume":"23","author":"Wesche","year":"2024","journal-title":"Cardiovasc. Diabetol."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"van Wilpe, R., van Zuylen, M.L., Hermanides, J., DeVries, J.H., Preckel, B., and Hulst, A.H. (2024). Preoperative Glycosylated Haemoglobin Screening to Identify Older Adult Patients with Undiagnosed Diabetes Mellitus-A Retrospective Cohort Study. J. Pers. Med., 14.","DOI":"10.3390\/jpm14020219"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"440","DOI":"10.2337\/dc19-1683","article-title":"Glycated Hemoglobin, Prediabetes, and the Links to Cardiovascular Disease: Data From UK Biobank","volume":"43","author":"Welsh","year":"2020","journal-title":"Diabetes Care"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"744","DOI":"10.21470\/1678-9741-2020-0188","article-title":"Glycated Haemoglobin Levels and Its Effect on Outcomes in Cardiac Surgery","volume":"37","author":"Ansari","year":"2022","journal-title":"Braz. J. Cardiovasc. Surg."},{"key":"ref_26","first-page":"e64487","article-title":"The Relation of Preoperative HbA1c Level With Intraoperative and Postoperative Complications in Type-2 Diabetic Patients: An Observational Study","volume":"16","author":"Shivganesh","year":"2024","journal-title":"Cureus"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.carrev.2023.11.015","article-title":"Elevated glycosylated hemoglobin levels are associated with severe acute kidney injury following coronary artery bypass surgery","volume":"62","author":"Skendelas","year":"2024","journal-title":"Cardiovasc. Revasc. Med."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"160","DOI":"10.4103\/aca.aca_46_22","article-title":"Use of pre-operative hemoglobin a1c to predict early post-operative renal failure and infection risks in patients who are not diabetics and undergoing elective off pump coronary artery bypass graft surgery","volume":"26","author":"Madhu","year":"2023","journal-title":"Ann. Card. Anaesth."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"3547491","DOI":"10.1155\/2020\/3547491","article-title":"Effects of Preoperative HbA1c Levels on the Postoperative Outcomes of Coronary Artery Disease Surgical Treatment in Patients with Diabetes Mellitus and Nondiabetic Patients: A Systematic Review and Meta-Analysis","volume":"2020","author":"Wang","year":"2020","journal-title":"J. Diabetes Res."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Mattina, A., Raffa, G.M., Giusti, M.A., Conoscenti, E., Morsolini, M., Mularoni, A., Fazzina, M.L., Di Carlo, D., Cipriani, M., and Musumeci, F. (2024). Impact of systematic diabetes screening on peri-operative infections in patients undergoing cardiac surgery. Sci. Rep., 14.","DOI":"10.1038\/s41598-024-65064-7"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.jacasi.2021.11.009","article-title":"Influence of Baseline HbA1c and Antiplatelet Therapy on 1-Year Vein Graft Outcome","volume":"2","author":"Zhu","year":"2022","journal-title":"JACC Asia"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1097\/HPC.0000000000000174","article-title":"Mid-term Outcome and Prognosis of Prediabetic Patients after Coronary Artery Bypass Graft Surgery, Regardless of the First Month After Surgery","volume":"18","author":"Hosseini","year":"2019","journal-title":"Crit. Pathw. Cardiol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s12933-020-00996-8","article-title":"Increased risk of cardiovascular mortality by strict glycemic control (pre-procedural HbA1c < 6.5%) in Japanese medically-treated diabetic patients following percutaneous coronary intervention: A 10-year follow-up study","volume":"19","author":"Funamizu","year":"2020","journal-title":"Cardiovasc. Diabetol."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/9\/3123\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T17:25:24Z","timestamp":1760030724000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/9\/3123"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,30]]},"references-count":33,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2025,5]]}},"alternative-id":["jcm14093123"],"URL":"https:\/\/doi.org\/10.3390\/jcm14093123","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,30]]}}}