{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T22:34:00Z","timestamp":1791326040517,"version":"4.3.1"},"reference-count":65,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2025,5,3]],"date-time":"2025-05-03T00:00:00Z","timestamp":1746230400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Spondyloarthropathies (SpAs) represent a diverse group of seronegative immune-mediated inflammatory diseases characterized by a genetic predisposition and an association with human leukocyte antigen-B27. This narrative review aims to explore juvenile spondyloarthropathies (JSpAs), their classification, clinical manifestations, diagnostic challenges, and contemporary treatment strategies. According to the International League of Associations for Rheumatology criteria, JSpAs include several specific forms: enthesitis-related arthritis, psoriatic arthritis, and undifferentiated arthritis. Despite established classifications, the terms and definitions surrounding these conditions can often lead to confusion among healthcare professionals. This ambiguity underscores the need for a standardized approach to nosological classification. The clinical presentation of JSpAs can be multifaceted, encompassing both articular and extra-articular manifestations. Articular symptoms may include enthesitis and varying forms of arthritis, while extra-articular involvement can range from uveitis to gastrointestinal, cardiovascular, pulmonary, neurological, and renal complications. These diverse manifestations highlight the systemic nature of the disease and the importance of a holistic approach to diagnosis and treatment. While laboratory tests for SpAs are often non-specific, imaging modalities such as musculoskeletal ultrasound and magnetic resonance imaging play a crucial role in the early detection of inflammatory lesions. These imaging techniques can provide valuable insights into disease progression and aid in the formulation of appropriate treatment plans. Current treatment guidelines advocate for a \u201cstepwise\u201d approach to therapy, beginning with nonsteroidal anti-inflammatory drugs and progressing to glucocorticoids, disease-modifying antirheumatic drugs, and biological agents, particularly anti-tumor necrosis factor alpha agents. The primary objective of treatment is to achieve clinical remission or, at a minimum, to attain low disease activity. Regular monitoring of disease activity is imperative; however, the lack of validated assessment tools for the pediatric population remains a significant challenge. JSpAs pose unique challenges in terms of diagnosis and management due to their diverse manifestations and the complexities of their classification. Ongoing research and clinical efforts are essential to refine our understanding of these conditions, improve treatment outcomes, and enhance quality of life for affected children and their families. Effective management hinges on early detection, individualized treatment plans, and continuous monitoring, ensuring that patients receive the most appropriate care tailored to their specific needs.<\/jats:p>","DOI":"10.3390\/jcm14093166","type":"journal-article","created":{"date-parts":[[2025,5,4]],"date-time":"2025-05-04T20:10:27Z","timestamp":1746389427000},"page":"3166","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Juvenile Spondyloarthropathies: Diagnostic and Therapeutic Advances\u2014A Narrative Review"],"prefix":"10.3390","volume":"14","author":[{"given":"C\u0103lin","family":"Laz\u0103r","sequence":"first","affiliation":[{"name":"1st Paediatric Clinic, Emergency Clinical Hospital for Children, 400370 Cluj-Napoca, Romania"},{"name":"1st Department of Paediatrics, \u201cIuliu Ha\u021bieganu\u201d University of Medicine and Pharmacy, 400370 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirela","family":"Cri\u0219an","sequence":"additional","affiliation":[{"name":"1st Paediatric Clinic, Emergency Clinical Hospital for Children, 400370 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2826-3112","authenticated-orcid":false,"given":"Oana-Iulia","family":"Man","sequence":"additional","affiliation":[{"name":"1st Paediatric Clinic, Emergency Clinical Hospital for Children, 400370 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8846-2685","authenticated-orcid":false,"given":"Lucia Maria","family":"Sur","sequence":"additional","affiliation":[{"name":"1st Paediatric Clinic, Emergency Clinical Hospital for Children, 400370 Cluj-Napoca, Romania"},{"name":"1st Department of Paediatrics, \u201cIuliu Ha\u021bieganu\u201d University of Medicine and Pharmacy, 400370 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7645-0716","authenticated-orcid":false,"given":"Gabriel","family":"Sama\u0219ca","sequence":"additional","affiliation":[{"name":"Department of Immunology, \u201cIuliu Ha\u021bieganu\u201d University of Medicine and Pharmacy, 400162 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2064-9969","authenticated-orcid":false,"given":"Alexandru Cristian","family":"Bolundu\u021b","sequence":"additional","affiliation":[{"name":"1st Department of Paediatrics, \u201cIuliu Ha\u021bieganu\u201d University of Medicine and Pharmacy, 400370 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,5,3]]},"reference":[{"key":"ref_1","unstructured":"Petty, R.E., Laxer, R.M., Lindsley, C.B., Wedderburn, L.R., Mellins, E.D., and Fuhlbrigge, R.C. 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