{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T10:38:10Z","timestamp":1792406290207,"version":"4.4.0"},"reference-count":119,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T00:00:00Z","timestamp":1746489600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Introduction: Platelet-rich fibrin (PRF) and platelet-rich plasma (PRP) utilize autologous blood and share the objective of leveraging blood-derived growth factors to enhance the body\u2019s natural healing process. A large extensive use has been made in various branches of dentistry. Methods: A total of 4175 records were identified from the electronic search, specifically 291 from BioMed Central, 3406 from MEDLINE\/PubMed, 304 from the Cochrane library databases, and 174 from the PROSPERO register. This review was performed in relation to the PRISMA flow chart and was annotated in the PROSPERO register. Results: In total, 3416 title abstracts were screened, and a total of 40 systematic reviews were finally included in the present umbrella review. Conclusions: Research supports the use of PRF and PRP in different fields of dentistry. This is a huge potential for the patient but also for the doctor as these products are from the patient and have zero cost. However, further studies are needed, especially RCTs, to have clearer evidence on the role of PRF and PRP.<\/jats:p>","DOI":"10.3390\/jcm14093224","type":"journal-article","created":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T09:08:56Z","timestamp":1746522536000},"page":"3224","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["PRF and PRP in Dentistry: An Umbrella Review"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-1387-7303","authenticated-orcid":false,"given":"Alfonso","family":"Acerra","sequence":"first","affiliation":[{"name":"Department of Medicine, Surgery and Dentistry, University of Salerno, 84084 Salerno, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3163-7170","authenticated-orcid":false,"given":"Mario","family":"Caggiano","sequence":"additional","affiliation":[{"name":"Department of Medicine, Surgery and Dentistry, University of Salerno, 84084 Salerno, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-4410-7473","authenticated-orcid":false,"given":"Andrea","family":"Chiacchio","sequence":"additional","affiliation":[{"name":"Department of Medicine, Surgery and Dentistry, University of Salerno, 84084 Salerno, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-1267-1843","authenticated-orcid":false,"given":"Bruno","family":"Scognamiglio","sequence":"additional","affiliation":[{"name":"Department of Medicine, Surgery and Dentistry, University of Salerno, 84084 Salerno, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6161-9067","authenticated-orcid":false,"given":"Francesco","family":"D\u2019Ambrosio","sequence":"additional","affiliation":[{"name":"Department of Medicine, Surgery and Dentistry, University of Salerno, 84084 Salerno, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,5,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/S0750-7658(05)80503-9","article-title":"Platelet-rich plasma","volume":"14","author":"Waller","year":"1995","journal-title":"Ann. Fr. Anesth. Reanim."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.jormas.2019.07.001","article-title":"Optimized Centrifugation Preparation of the Platelet Rich Plasma: Literature Review","volume":"121","author":"Joly","year":"2020","journal-title":"J. Stomatol. Oral Maxillofac. Surg."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1111\/prd.12550","article-title":"Differences between First- and Second-Generation Autologous Platelet Concentrates","volume":"97","author":"Calciolari","year":"2025","journal-title":"Periodontology 2000"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.cden.2019.12.012","article-title":"Clinical Uses of Platelet-Rich Fibrin in Oral and Maxillofacial Surgery","volume":"64","author":"Fan","year":"2020","journal-title":"Dent. Clin. N. Am."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1111\/prd.12555","article-title":"Essential Principles for Blood Centrifugation","volume":"97","author":"Quirynen","year":"2025","journal-title":"Periodontology 2000"},{"key":"ref_6","first-page":"e62","article-title":"Une Opportunit\u00e9 En Paro-Implantologie: Le PRF","volume":"42","author":"Choukroun","year":"2001","journal-title":"Implantodontie"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.1007\/s00784-018-2673-x","article-title":"The Effect of Age, Gender, and Time between Blood Draw and Start of Centrifugation on the Size Outcomes of Platelet-Rich Fibrin (PRF) Membranes","volume":"23","author":"Miron","year":"2019","journal-title":"Clin. Oral Investig."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Castro, A.B., Andrade, C., Li, X., Pinto, N., Teughels, W., and Quirynen, M. (2021). Impact of g Force and Timing on the Characteristics of Platelet-Rich Fibrin Matrices. Sci. Rep., 11.","DOI":"10.1038\/s41598-021-85736-y"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1111\/prd.12538","article-title":"Ten Years of Injectable Platelet-Rich Fibrin","volume":"94","author":"Miron","year":"2024","journal-title":"Periodontology 2000"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"n71","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 Statement: An Updated Guideline for Reporting Systematic Reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/2046-4053-1-2","article-title":"The Nuts and Bolts of PROSPERO: An International Prospective Register of Systematic Reviews","volume":"1","author":"Booth","year":"2012","journal-title":"Syst. Rev."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"j4008","DOI":"10.1136\/bmj.j4008","article-title":"AMSTAR 2: A Critical Appraisal Tool for Systematic Reviews That Include Randomised or Non-Randomised Studies of Healthcare Interventions, or Both","volume":"358","author":"Shea","year":"2017","journal-title":"BMJ"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1038\/sj.ebd.6401347","article-title":"Autologous Platelet Concentrates to Improve Post Extraction Outcomes","volume":"19","author":"Shah","year":"2018","journal-title":"Evid. Based Dent."},{"key":"ref_14","first-page":"CD006968","article-title":"Local Interventions for the Management of Alveolar Osteitis (Dry Socket)","volume":"9","author":"Daly","year":"2022","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"e691","DOI":"10.4317\/medoral.24256","article-title":"Clinical Management of Alveolar Osteitis. A Systematic Review","volume":"26","author":"Garola","year":"2021","journal-title":"Med. Oral Patol Oral Cir. Bucal"},{"key":"ref_16","first-page":"e416","article-title":"Systematic Review of Surgical Regenerative Treatment for Apicomarginal Lesions in Periapical Surgery","volume":"29","year":"2024","journal-title":"Med. Oral Patol Oral Cir. Bucal"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1177\/19433875211016203","article-title":"Platelet-Rich Fibrin in Third Molar Surgery: Systematic Review and Meta-Analysis Protocol","volume":"15","author":"Salas","year":"2022","journal-title":"Craniomaxillofacial Trauma Reconstr."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.ijom.2018.07.007","article-title":"Platelet-Rich Fibrin in Oral Surgical Procedures: A Systematic Review and Meta-Analysis","volume":"48","author":"Canellas","year":"2019","journal-title":"Int. J. Oral Maxillofac. Surg."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"3321","DOI":"10.1007\/s00784-023-05012-3","article-title":"Effectiveness of the Platelet-Rich Fibrin in the Control of Pain Associated with Alveolar Osteitis: A Scoping Review","volume":"27","author":"Priolo","year":"2023","journal-title":"Clin. Oral Investig."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1016\/j.jcms.2020.06.012","article-title":"Intrasocket Interventions to Prevent Alveolar Osteitis after Mandibular Third Molar Surgery: A Systematic Review and Network Meta-Analysis","volume":"48","author":"Canellas","year":"2020","journal-title":"J. Cranio-Maxillofac. Surg."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"D\u2019Ambrosio, F., Caggiano, M., Acerra, A., Pisano, M., and Giordano, F. (2023). Is Ozone a Valid Adjuvant Therapy for Periodontitis and Peri-Implantitis? A Systematic Review. J. Pers. Med., 13.","DOI":"10.3390\/jpm13040646"},{"key":"ref_22","first-page":"49","article-title":"Bisphosphonate-Associated Osteonecrosis of the Jaw","volume":"70","author":"Ferreira","year":"2021","journal-title":"Minerva Dent. Oral Sci."},{"key":"ref_23","first-page":"CD012432","article-title":"Interventions for Managing Medication-Related Osteonecrosis of the Jaw","volume":"7","author":"Mayer","year":"2022","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_24","first-page":"CD008455","article-title":"Interventions for Treating Bisphosphonate-Related Osteonecrosis of the Jaw (BRONJ)","volume":"2","author":"Rollason","year":"2016","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"3732","DOI":"10.1111\/odi.14902","article-title":"Efficacy of Adjunctive Modalities during Tooth Extraction for the Prevention of Osteoradionecrosis: A Systematic Review and Meta-Analysis","volume":"30","author":"Quah","year":"2024","journal-title":"Oral Dis."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Motta, C., Cavagnetto, D., Amoroso, F., Baldi, I., and Mussano, F. (2023). Bioactive Glass for Periodontal Regeneration: A Systematic Review. BMC Oral Health, 23.","DOI":"10.1186\/s12903-023-02898-z"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1002\/JPER.22-0120","article-title":"Efficacy of Biologics for the Treatment of Periodontal Infrabony Defects: An American Academy of Periodontology Best Evidence Systematic Review and Network Meta-Analysis","volume":"93","author":"Tavelli","year":"2022","journal-title":"J. Periodontol."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Zhou, S., Sun, C., Huang, S., Wu, X., Zhao, Y., Pan, C., Wang, H., Liu, J., Li, Q., and Kou, Y. (2018). Efficacy of Adjunctive Bioactive Materials in the Treatment of Periodontal Intrabony Defects: A Systematic Review and Meta-Analysis. Biomed. Res. Int., 2018.","DOI":"10.1155\/2018\/8670832"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1002\/JPER.22-0075","article-title":"Efficacy of Biologics in Root Coverage and Gingival Augmentation Therapy: An American Academy of Periodontology Best Evidence Systematic Review and Network Meta-Analysis","volume":"93","author":"Chambrone","year":"2022","journal-title":"J. Periodontol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.jormas.2017.09.005","article-title":"Alternatives to Connective Tissue Graft in the Treatment of Localized Gingival Recessions: A Systematic Review","volume":"119","author":"Amine","year":"2018","journal-title":"J. Stomatol. Oral Maxillofac. Surg."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.1002\/JPER.22-0069","article-title":"Efficacy of Biologics for Alveolar Ridge Preservation\/Reconstruction and Implant Site Development: An American Academy of Periodontology Best Evidence Systematic Review","volume":"93","author":"Monje","year":"2022","journal-title":"J. Periodontol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.jdsr.2022.02.003","article-title":"The Application of Injectable Platelet-Rich Fibrin in Regenerative Dentistry: A Systematic Scoping Review of In Vitro and In Vivo Studies","volume":"58","author":"Farshidfar","year":"2022","journal-title":"JPN Dent. Sci. Rev."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Malcangi, G., Patano, A., Palmieri, G., Di Pede, C., Latini, G., Inchingolo, A.D., Hazballa, D., de Ruvo, E., Garofoli, G., and Inchingolo, F. (2023). Maxillary Sinus Augmentation Using Autologous Platelet Concentrates (Platelet-Rich Plasma, Platelet-Rich Fibrin, and Concentrated Growth Factor) Combined with Bone Graft: A Systematic Review. Cells, 12.","DOI":"10.3390\/cells12131797"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"3658","DOI":"10.1111\/odi.14874","article-title":"Efficacy of Autologous Platelet Concentrate Products for Alveolar Preservation: A Meta-Analysis","volume":"30","author":"Zhang","year":"2024","journal-title":"Oral Dis."},{"key":"ref_35","first-page":"CD008397","article-title":"Interventions for Replacing Missing Teeth: Augmentation Procedures of the Maxillary Sinus","volume":"2014","author":"Esposito","year":"2014","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_36","first-page":"139","article-title":"Does the Adjunctive Use of Platelet-Rich Plasma to Bone Graft during Sinus Augmentation Reduce Implant Failure and Complication? Systematic Review and Meta-Analysis","volume":"49","author":"Abdalla","year":"2018","journal-title":"Quintessence Int."},{"key":"ref_37","first-page":"1217","article-title":"The Effect of Advanced Platelet-Rich Fibrin in Tissue Regeneration in Reconstructive and Graft Surgery: Systematic Review","volume":"34","year":"2023","journal-title":"J. Craniofac. Surg."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1016\/j.ijom.2016.02.012","article-title":"Effectiveness of Platelet-Rich Plasma as an Adjunctive Material to Bone Graft: A Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials","volume":"45","author":"Pocaterra","year":"2016","journal-title":"Int. J. Oral Maxillofac. Surg."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"8546568","DOI":"10.1155\/2018\/8546568","article-title":"Ridge Preservation Procedures after Tooth Extractions: A Systematic Review","volume":"2018","author":"Balli","year":"2018","journal-title":"Int. J. Dent."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1007\/s13770-021-00428-y","article-title":"Regenerative Potential of Platelet Rich Fibrin (PRF) in Socket Preservation in Comparison with Conventional Treatment Modalities: A Systematic Review and Meta-Analysis","volume":"19","author":"Alrayyes","year":"2022","journal-title":"Tissue Eng. Regen. Med."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"e2","DOI":"10.5037\/jomr.2019.10102","article-title":"Alveolar Ridge Preservation after Tooth Extraction Using Different Bone Graft Materials and Autologous Platelet Concentrates: A Systematic Review","volume":"10","author":"Stumbras","year":"2019","journal-title":"J. Oral Maxillofac. Res."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.jebdp.2018.11.003","article-title":"Adjunctive Use of Plasma Rich in Growth Factors for Improving Alveolar Socket Healing: A Systematic Review","volume":"19","author":"Panda","year":"2019","journal-title":"J. Evid. Based Dent. Pract."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.ijom.2015.07.012","article-title":"Effects of Platelet-Rich Plasma in Association with Bone Grafts in Maxillary Sinus Augmentation: A Systematic Review and Meta-Analysis","volume":"45","author":"Lemos","year":"2016","journal-title":"Int. J. Oral Maxillofac. Surg."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Anitua, E., Allende, M., Eguia, A., and Alkhraisat, M.H. (2022). Bone-Regenerative Ability of Platelet-Rich Plasma Following Sinus Augmentation with Anorganic Bovine Bone: A Systematic Review with Meta-Analysis. Bioengineering, 9.","DOI":"10.3390\/bioengineering9100597"},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Liu, R., Yan, M., Chen, S., Huang, W., Wu, D., and Chen, J. (2019). Effectiveness of Platelet-Rich Fibrin as an Adjunctive Material to Bone Graft in Maxillary Sinus Augmentation: A Meta-Analysis of Randomized Controlled Trails. Biomed. Res. Int., 2019.","DOI":"10.1155\/2019\/7267062"},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Pereira, V.B.S., Lago, C.A.P., Almeida, R.d.A.C., da S. Barbirato, D., and do E. Vasconcelos, B.C. (2023). Biological and Cellular Properties of Advanced Platelet-Rich Fibrin (A-PRF) Compared to Other Platelet Concentrates: Systematic Review and Meta-Analysis. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25010482"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1007\/s00784-024-05817-w","article-title":"The Efficacy of Platelet and Leukocyte Rich Fibrin (L-PRF) in the Healing Process and Bone Repair in Oral and Maxillofacial Surgeries: A Systematic Review","volume":"28","author":"Ribeiro","year":"2024","journal-title":"Clin. Oral Investig."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1111\/cid.12114","article-title":"Clinical Efficacy of Growth Factors to Enhance Tissue Repair in Oral and Maxillofacial Reconstruction: A Systematic Review","volume":"17","author":"Schliephake","year":"2015","journal-title":"Clin. Implant Dent. Relat. Res."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1111\/clr.13275","article-title":"The Use of Platelet-Rich Fibrin to Enhance the Outcomes of Implant Therapy: A Systematic Review","volume":"29","author":"Strauss","year":"2018","journal-title":"Clin. Oral Implants Res."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Qu, C., Luo, F., Hong, G., and Wan, Q. (2021). Effects of Platelet Concentrates on Implant Stability and Marginal Bone Loss: A Systematic Review and Meta-Analysis. BMC Oral Health, 21.","DOI":"10.1186\/s12903-021-01929-x"},{"key":"ref_51","first-page":"137","article-title":"Efficacy of Autogenous Platelet Concentrates in Immediate Implant Therapy: A Systematic Review and Meta-Analysis of Prospective Controlled Clinical Trials","volume":"17","author":"Sabri","year":"2024","journal-title":"Int. J. Oral Implantol."},{"key":"ref_52","first-page":"e142","article-title":"Efficacy of Platelet-Rich Plasma Applied to Post-Extraction Retained Lower Third Molar Alveoli. A Systematic Review","volume":"19","year":"2014","journal-title":"Med. Oral Patol. Oral Cir. Bucal."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1111\/clr.13275","article-title":"The Use of Platelet-Rich Plasma to Enhance the Outcomes of Implant Therapy: A Systematic Review","volume":"29","author":"Strauss","year":"2018","journal-title":"Clin. Oral Implants Res."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Hou, X., Yuan, J., Aisaiti, A., Liu, Y., and Zhao, J. (2016). The Effect of Platelet-Rich Plasma on Clinical Outcomes of the Surgical Treatment of Periodontal Intrabony Defects: A Systematic Review and Meta-Analysis. BMC Oral Health, 16.","DOI":"10.1186\/s12903-016-0261-5"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.sdentj.2023.10.017","article-title":"Effectiveness of I-PRF in Periodontal Regeneration\u2014A Systematic Review and Meta-Analysis","volume":"36","author":"Pullishery","year":"2024","journal-title":"Saudi Dent. J."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.oooo.2015.06.035","article-title":"Platelet-Rich Plasma for Periodontal Regeneration in the Treatment of Intrabony Defects: A Meta-Analysis on Prospective Clinical Trials","volume":"120","author":"Monje","year":"2015","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1007\/s10266-024-00949-7","article-title":"Regeneration of Periodontal Intrabony Defects Using Platelet-Rich Fibrin (PRF): A Systematic Review and Network Meta-Analysis","volume":"112","author":"Silva","year":"2024","journal-title":"Odontology"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/jicd.12117","article-title":"Additive Effect of Autologous Platelet Concentrates in Treatment of Intrabony Defects: A Systematic Review and Meta-Analysis","volume":"7","author":"Panda","year":"2016","journal-title":"J. Investig. Clin. Dent."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1016\/j.jcms.2016.05.004","article-title":"Medication-Related Osteonecrosis of the Jaw: Is Autologous Platelet Concentrate Application Effective for Prevention and Treatment? A Systematic Review","volume":"44","author":"Tobias","year":"2016","journal-title":"J. Craniomaxillofac. Surg."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/j.jcms.2024.01.007","article-title":"The Effectiveness of Autologous Platelet Concentrates in Prevention and Treatment of Medication-Related Osteonecrosis of the Jaws: A Systematic Review","volume":"52","author":"Nowak","year":"2024","journal-title":"J. Craniomaxillofac. Surg."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1007\/s10006-021-01030-1","article-title":"Autologous Platelet Concentrates in Extraction Sockets for the Prevention of Osteoradionecrosis: A Systematic Review of Controlled Clinical Trials","volume":"26","author":"Serrano","year":"2022","journal-title":"Oral Maxillofac. Surg."},{"key":"ref_62","first-page":"181","article-title":"Efficacy of Platelet-Rich Fibrin on Bone Formation, Part 1: Alveolar Ridge Preservation","volume":"14","author":"Miron","year":"2021","journal-title":"Int. J. Oral Implantol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/j.joms.2023.01.004","article-title":"Does the Choice of Preparation Protocol for Platelet-Rich Fibrin Have Consequences for Healing and Alveolar Ridge Preservation After Tooth Extraction? A Meta-Analysis","volume":"81","author":"Bierbaum","year":"2023","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Damsaz, M., Castagnoli, C.Z., Eshghpour, M., Alamdari, D.H., Alamdari, A.H., Noujeim, Z.E.F., and Haidar, Z.S. (2020). Evidence-Based Clinical Efficacy of Leukocyte and Platelet-Rich Fibrin in Maxillary Sinus Floor Lift, Graft and Surgical Augmentation Procedures. Front. Surg., 7.","DOI":"10.3389\/fsurg.2020.537138"},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Ortega-Mejia, H., Estrugo-Devesa, A., Saka-Herr\u00e1n, C., Ayuso-Montero, R., L\u00f3pez-L\u00f3pez, J., and Velasco-Ortega, E. (2020). Platelet-Rich Plasma in Maxillary Sinus Augmentation: Systematic Review. Materials, 13.","DOI":"10.3390\/ma13030622"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.jcms.2019.01.012","article-title":"Plasma Rich in Growth Factors (PRGF) in Intraoral Bone Grafting Procedures: A Systematic Review","volume":"47","author":"Dragonas","year":"2019","journal-title":"J. Craniomaxillofac. Surg."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1111\/jcpe.12658","article-title":"Regenerative Potential of Leucocyte- and Platelet-Rich Fibrin. Part B: Sinus Floor Elevation, Alveolar Ridge Preservation and Implant Therapy. A Systematic Review","volume":"44","author":"Castro","year":"2017","journal-title":"J. Clin. Periodontol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.jobcr.2022.11.002","article-title":"Does the Use of Platelet-Rich Plasma in Sinus Augmentation Improve the Survival of Dental Implants? A Systematic Review and Meta-Analysis","volume":"13","author":"Sivakumar","year":"2023","journal-title":"J. Oral Biol. Craniofac. Res."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1563\/AAID-JOI-D-14-00167","article-title":"Platelet-Rich Fibrin in Maxillary Sinus Augmentation: A Systematic Review","volume":"41","author":"Ali","year":"2015","journal-title":"J. Oral Implantol."},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Gasparro, R., Di Lauro, A.E., Campana, M.D., Rosiello, N., Mariniello, M., Sammartino, G., and Marenzi, G. (2024). Effectiveness of Autologous Platelet Concentrates in the Sinus Lift Surgery: Findings from Systematic Reviews and Meta-Analyses. Dent. J., 12.","DOI":"10.3390\/dj12040101"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"2215","DOI":"10.1016\/j.joms.2021.07.003","article-title":"Does Platelet-Rich Fibrin Prevent Hemorrhagic Complications After Dental Extractions in Patients Using Oral Anticoagulant Therapy?","volume":"79","author":"Filho","year":"2021","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_72","first-page":"605","article-title":"Application of Platelet-Rich Fibrin on Mandibular Third Molar Extraction: Systematic Review and Meta-Analysis","volume":"39","author":"Bao","year":"2021","journal-title":"Hua Xi Kou Qiang Yi Xue Za Zhi"},{"key":"ref_73","first-page":"357","article-title":"The Use of Platelet-Rich Plasma in Oral Surgery: A Systematic Review and Meta-Analysis","volume":"17","author":"Franchini","year":"2019","journal-title":"Blood Transfus."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1016\/j.joms.2017.01.022","article-title":"Efficacy of Platelet-Rich Fibrin After Mandibular Third Molar Extraction: A Systematic Review and Meta-Analysis","volume":"75","year":"2017","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"e367","DOI":"10.1016\/j.jormas.2022.03.014","article-title":"Treatment of Oroantral Communication with Platelet-Rich Fibrin: A Systematic Review","volume":"123","author":"Uribarri","year":"2022","journal-title":"J. Stomatol. Oral Maxillofac. Surg."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"2497","DOI":"10.1016\/j.joms.2017.05.034","article-title":"Local Application of Platelet-Rich Fibrin During Lower Third Molar Extraction Improves Treatment Outcomes","volume":"75","author":"He","year":"2017","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1016\/j.ijom.2021.11.014","article-title":"The Use of Advanced Platelet-Rich Fibrin after Surgical Removal of Mandibular Third Molars: A Systematic Review and Meta-Analysis","volume":"51","author":"Vitenson","year":"2022","journal-title":"Int. J. Oral Maxillofac. Surg."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"2421","DOI":"10.1016\/j.joms.2021.07.006","article-title":"Application of Platelet-Rich Fibrin Derivatives for Mandibular Third Molar Extraction Related Post-Operative Sequelae: A Systematic Review and Network Meta-Analysis","volume":"79","author":"Bao","year":"2021","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1016\/j.joms.2022.03.011","article-title":"Do the New Protocols of Platelet-Rich Fibrin Centrifugation Allow Better Control of Postoperative Complications and Healing After Surgery of Impacted Lower Third Molar? A Systematic Review and Meta-Analysis","volume":"80","author":"Ramos","year":"2022","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Xiang, X., Shi, P., Zhang, P., Shen, J., and Kang, J. (2019). Impact of Platelet-Rich Fibrin on Mandibular Third Molar Surgery Recovery: A Systematic Review and Meta-Analysis. BMC Oral Health, 19.","DOI":"10.1186\/s12903-019-0824-3"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1016\/j.ijom.2017.04.006","article-title":"Evaluation of Postoperative Complications after Mandibular Third Molar Surgery with the Use of Platelet-Rich Fibrin: A Systematic Review and Meta-Analysis","volume":"46","author":"Canellas","year":"2017","journal-title":"Int. J. Oral Maxillofac. Surg."},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Campana, M.D., Aliberti, A., Acerra, A., Sammartino, P., Dolce, P., Sammartino, G., and Gasparro, R. (2023). The Effectiveness and Safety of Autologous Platelet Concentrates as Hemostatic Agents after Tooth Extraction in Patients on Anticoagulant Therapy: A Systematic Review of Randomized, Controlled Trials. J. Clin. Med., 12.","DOI":"10.3390\/jcm12165342"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.ijom.2020.08.014","article-title":"Effect of Platelet-Rich Fibrin on the Control of Alveolar Osteitis, Pain, Trismus, Soft Tissue Healing, and Swelling Following Mandibular Third Molar Surgery: An Updated Systematic Review and Meta-Analysis","volume":"50","author":"Zhu","year":"2021","journal-title":"Int. J. Oral Maxillofac. Surg."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/s00784-024-05641-2","article-title":"Use of Platelet- and Leukocyte-Rich Fibrin (L-PRF) as a Healing Agent in the Postoperative Period of Third Molar Removal Surgeries: A Systematic Review","volume":"28","author":"Ribeiro","year":"2024","journal-title":"Clin. Oral Investig."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1016\/j.bjoms.2021.01.001","article-title":"Effect of Leukocyte and Platelet Rich Fibrin (L-PRF) on Stability of Dental Implants. A Systematic Review and Meta-Analysis","volume":"59","author":"Lyris","year":"2021","journal-title":"Br. J. Oral Maxillofac. Surg."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"e13196","DOI":"10.1016\/j.heliyon.2023.e13196","article-title":"Clinical Application of Platelet-Rich Fibrin to Enhance Dental Implant Stability: A Systematic Review and Meta-Analysis","volume":"9","author":"Guan","year":"2023","journal-title":"Heliyon"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"2543","DOI":"10.1007\/s00784-020-03400-7","article-title":"Use of Platelet-Rich Fibrin for the Treatment of Gingival Recessions: A Systematic Review and Meta-Analysis","volume":"24","author":"Miron","year":"2020","journal-title":"Clin. Oral Investig."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"e190","DOI":"10.4317\/jced.57451","article-title":"Platelet-Rich Fibrin for Wound Healing of Palatal Donor Sites of Free Gingival Grafts: Systematic Review and Meta-Analysis","volume":"13","author":"Gusman","year":"2021","journal-title":"J. Clin. Exp. Dent."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.advms.2023.09.009","article-title":"Adjunctive Use of Platelet-Rich Fibrin in Surgical Treatment of Furcation Defects: A Systematic Review","volume":"68","author":"Skurska","year":"2023","journal-title":"Adv. Med. Sci."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1111\/jcpe.12643","article-title":"Regenerative Potential of Leucocyte- and Platelet-Rich Fibrin. Part A: Intra-Bony Defects, Furcation Defects and Periodontal Plastic Surgery. A Systematic Review and Meta-Analysis","volume":"44","author":"Castro","year":"2017","journal-title":"J. Clin. Periodontol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"4239","DOI":"10.1007\/s00784-021-03933-5","article-title":"Is the Use of Platelet-Rich Fibrin Effective in the Healing, Control of Pain, and Postoperative Bleeding in the Palatal Area after Free Gingival Graft Harvesting? A Systematic Review of Randomized Clinical Studies","volume":"25","author":"Furquim","year":"2021","journal-title":"Clin. Oral Investig."},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"Panda, S., Satpathy, A., Chandra Das, A., Kumar, M., Mishra, L., Gupta, S., Srivastava, G., Lukomska-Szymanska, M., Taschieri, S., and Del Fabbro, M. (2020). Additive Effect of Platelet Rich Fibrin with Coronally Advanced Flap Procedure in Root Coverage of Miller\u2019s Class I and II Recession Defects-A PRISMA Compliant Systematic Review and Meta-Analysis. Materials, 13.","DOI":"10.3390\/ma13194314"},{"key":"ref_93","first-page":"23","article-title":"Autologous Platelet Concentrates in Treatment of Medication Related Osteonecrosis of the Jaw","volume":"22","author":"Rusilas","year":"2020","journal-title":"Stomatologija"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1097\/ID.0000000000000797","article-title":"Effects of Platelet Concentrates Used in Alveolar Ridge Preservation: A Systematic Review","volume":"27","author":"Niu","year":"2018","journal-title":"Implant. Dent."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1007\/s00784-017-2133-z","article-title":"Use of Platelet-Rich Fibrin in Regenerative Dentistry: A Systematic Review","volume":"21","author":"Miron","year":"2017","journal-title":"Clin. Oral Investig."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"2461","DOI":"10.1007\/s00784-021-03825-8","article-title":"Use of Platelet-Rich Fibrin for the Treatment of Periodontal Intrabony Defects: A Systematic Review and Meta-Analysis","volume":"25","author":"Miron","year":"2021","journal-title":"Clin. Oral Investig."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1186\/s40729-021-00393-0","article-title":"Efficacy of Platelet-Rich Fibrin in Promoting the Healing of Extraction Sockets: A Systematic Review","volume":"7","author":"Becker","year":"2021","journal-title":"Int. J. Implant. Dent."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1016\/j.ijom.2014.12.010","article-title":"Effect of Autologous Platelet Concentrates for Alveolar Socket Preservation: A Systematic Review","volume":"44","author":"Moraschini","year":"2015","journal-title":"Int. J. Oral Maxillofac. Surg."},{"key":"ref_99","first-page":"S171","article-title":"The Fate of Marginal Bone around Axial vs. Tilted Implants: A Systematic Review","volume":"7","author":"Ceresoli","year":"2014","journal-title":"Eur. J. Oral Implantol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1016\/j.joms.2017.02.009","article-title":"Healing of Postextraction Sockets Preserved With Autologous Platelet Concentrates. A Systematic Review and Meta-Analysis","volume":"75","author":"Bucchi","year":"2017","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1089\/ten.teb.2016.0233","article-title":"Platelet-Rich Fibrin and Soft Tissue Wound Healing: A Systematic Review","volume":"23","author":"Miron","year":"2017","journal-title":"Tissue Eng. Part B Rev."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.ijom.2018.06.003","article-title":"Effects of Leukocyte-Platelet-Rich Fibrin (L-PRF) in Different Intraoral Bone Grafting Procedures: A Systematic Review","volume":"48","author":"Dragonas","year":"2019","journal-title":"Int. J. Oral Maxillofac. Surg."},{"key":"ref_103","doi-asserted-by":"crossref","unstructured":"Anitua, E., Allende, M., and Alkhraisat, M.H. (2022). Unravelling Alveolar Bone Regeneration Ability of Platelet-Rich Plasma: A Systematic Review with Meta-Analysis. Bioengineering, 9.","DOI":"10.3390\/bioengineering9100506"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1016\/j.adaj.2019.04.025","article-title":"Effect of Platelet-Rich Fibrin on Alveolar Ridge Preservation: A Systematic Review","volume":"150","author":"Pan","year":"2019","journal-title":"J. Am. Dent. Assoc."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"845","DOI":"10.11607\/jomi.7300","article-title":"Effect of Platelet-Rich Fibrin on Ridge Preservation in Perspective of Bone Healing: A Systematic Review and Meta-Analysis","volume":"34","author":"Lin","year":"2019","journal-title":"Int. J. Oral Maxillofac. Implants"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"4131","DOI":"10.1007\/s00784-023-05126-8","article-title":"Effect of the Use of Platelet Concentrates on New Bone Formation in Alveolar Ridge Preservation: A Systematic Review, Meta-Analysis, and Trial Sequential Analysis","volume":"27","author":"Caponio","year":"2023","journal-title":"Clin. Oral Investig."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1080\/09537104.2016.1226497","article-title":"The Impact of Autologous Platelet Concentrates on Endodontic Healing: A Systematic Review","volume":"27","author":"Meschi","year":"2016","journal-title":"Platelets"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"100596","DOI":"10.1016\/j.ortho.2021.10.004","article-title":"The Adjunctive Effect of Autologous Platelet Concentrates on Orthodontic Tooth Movement: A Systematic Review and Meta-Analysis of Current Randomized Controlled Trials","volume":"20","author":"Farshidfar","year":"2022","journal-title":"Int. Orthod."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"22","DOI":"10.4103\/njms.njms_504_21","article-title":"Platelet-Rich Plasma Protein as a Therapeutic Regimen for Oral Lichen Planus: An Evidence-Based Systematic Review","volume":"14","author":"Maddheshiya","year":"2023","journal-title":"Natl. J. Maxillofac. Surg."},{"key":"ref_110","first-page":"e51626","article-title":"Effectiveness of Injectable Platelet-Rich Fibrin in the Treatment of Oral Lichen Planus: A Systematic Review and Meta-Analysis","volume":"16","author":"Gupta","year":"2024","journal-title":"Cureus"},{"key":"ref_111","doi-asserted-by":"crossref","unstructured":"Niemczyk, W., Janik, K., \u017burek, J., Skaba, D., and Wiench, R. (2024). Platelet-Rich Plasma (PRP) and Injectable Platelet-Rich Fibrin (i-PRF) in the Non-Surgical Treatment of Periodontitis-A Systematic Review. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25126319"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1563\/aaid-joi-D-14-00138","article-title":"Advanced Platelet-Rich Fibrin: A New Concept for Cell-Based Tissue Engineering by Means of Inflammatory Cells","volume":"40","author":"Ghanaati","year":"2014","journal-title":"J. Oral Implantol."},{"key":"ref_113","doi-asserted-by":"crossref","unstructured":"Niemczyk, W., \u017burek, J., Niemczyk, S., K\u0119pa, M., Zi\u0119ba, N., Misio\u0142ek, M., and Wiench, R. (2025). Antibiotic-Loaded Platelet-Rich Fibrin (AL-PRF) as a New Carrier for Antimicrobials: A Systematic Review of In Vitro Studies. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26052140"},{"key":"ref_114","doi-asserted-by":"crossref","unstructured":"Pantaleo, G., Acerra, A., Giordano, F., D\u2019Ambrosio, F., Langone, M., and Caggiano, M. (2022). Immediate Loading of Fixed Prostheses in Fully Edentulous Jaws: A 7-Year Follow-Up from a Single-Cohort Retrospective Study. Appl. Sci., 12.","DOI":"10.3390\/app122312427"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"685","DOI":"10.11607\/prd.4522","article-title":"Guided Bone Regeneration with Nonresorbable Membranes in the Rehabilitation of Partially Edentulous Atrophic Arches: A Retrospective Study on 122 Implants with a 3- to 7-Year Follow-Up","volume":"40","author":"Pistilli","year":"2020","journal-title":"Int. J. Periodontics Restor. Dent."},{"key":"ref_116","doi-asserted-by":"crossref","unstructured":"Caggiano, M., D\u2019Ambrosio, F., Giordano, F., Acerra, A., Sammartino, P., and Iandolo, A. (2022). The \u201cSling\u201d Technique for Horizontal Guided Bone Regeneration: A Retrospective Case Series. Appl. Sci., 12.","DOI":"10.3390\/app12125889"},{"key":"ref_117","doi-asserted-by":"crossref","unstructured":"di Lauro, A.E., Valletta, A., Aliberti, A., Cangiano, M., Dolce, P., Sammartino, G., and Gasparro, R. (2023). The Effectiveness of Autologous Platelet Concentrates in the Clinical and Radiographic Healing after Endodontic Surgery: A Systematic Review. Materials, 16.","DOI":"10.3390\/ma16227187"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.jdsr.2022.03.003","article-title":"Effectiveness of Surgical Procedures in the Acceleration of Orthodontic Tooth Movement: Findings from Systematic Reviews and Meta-analyses","volume":"58","author":"Gasparro","year":"2022","journal-title":"JPN Dent. Sci. Rev."},{"key":"ref_119","doi-asserted-by":"crossref","unstructured":"Caggiano, M., Di Spirito, F., Acerra, A., Galdi, M., and Sisalli, L. (2023). Multiple-Drugs-Related Osteonecrosis of the Jaw in a Patient Affected by Multiple Myeloma: A Case Report. Dent. 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