{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T01:44:59Z","timestamp":1789523099567,"version":"build-2803163510"},"reference-count":59,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T00:00:00Z","timestamp":1746662400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Stress urinary incontinence (SUI) is characterized by the involuntary leakage of urine during activities that increase intra-abdominal pressure. The management of SUI encompasses surgical treatments, such as colposuspension and sling procedures, and nonsurgical ones that involve pelvic floor muscle treatment, behavioral therapies, as well as pharmacological interventions. By exploring nonsurgical options initially, individuals have the opportunity to address the root causes of stress urinary incontinence and strengthen pelvic floor muscles. Background\/Objectives: This article delves into the conservative measures in managing SUI among women and the options of minimally invasive strategies for SUI, such as the injection of platelet-rich plasma, stem cells, bulking agents, and laser and radiofrequency therapy. Methods: A search of the literature from 2010 until January 2024 was carried out on PubMed, Cochrane Library, and Web of Science research databases. Results: A total of 34 studies on human females assessing the roles of platelet-rich plasma, laser and radiofrequency therapy, bulking agents, and stem cell therapy were included. Conclusions: The shortcoming of most conservative techniques seems to be represented by the temporary effects and the necessity of repeated treatments. To establish effective medical techniques, adopting more standardized procedures and conducting comprehensive randomized controlled trials is imperative.<\/jats:p>","DOI":"10.3390\/jcm14103268","type":"journal-article","created":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T04:06:21Z","timestamp":1746677181000},"page":"3268","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Modern Conservative Management Strategies for Female Stress Urinary Incontinence: A Systematic Review"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4890-0978","authenticated-orcid":false,"given":"Aida","family":"Petca","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 8 Eroii Sanitari Blvd., 050474 Bucharest, Romania"},{"name":"Department of Obstetrics and Gynecology, Elias University Emergency Hospital, 17 M\u0103r\u0103\u0219ti Blvd., 050474 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-7691-6949","authenticated-orcid":false,"given":"Andreea","family":"Fot\u0103","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 8 Eroii Sanitari Blvd., 050474 Bucharest, Romania"},{"name":"Department of Obstetrics and Gynecology, Elias University Emergency Hospital, 17 M\u0103r\u0103\u0219ti Blvd., 050474 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4496-1535","authenticated-orcid":false,"given":"R\u0103zvan-Cosmin","family":"Petca","sequence":"additional","affiliation":[{"name":"Department of Urology, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 8 Eroii Sanitari Blvd., 050474 Bucharest, Romania"},{"name":"Department of Urology, \u201cProf. Dr. Th. Burghele\u201d Clinical Hospital, 20 Panduri Str., 050659 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7700-2384","authenticated-orcid":false,"given":"Ioana Cristina","family":"Rotar","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology I, Mother and Child Department, \u201cIuliu Hatieganu\u201d University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania"},{"name":"Obstetrics and Gynecology I Clinic, Emergency County Hospital, 400006 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,5,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s00192-009-0976-9","article-title":"An International Urogynecological Association (IUGA)\/International Continence Society (ICS) joint report on the terminology for female pelvic floor dysfunction","volume":"21","author":"Haylen","year":"2009","journal-title":"Int. Urogynecol. J."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.2147\/IJWH.S383651","article-title":"Impact of female stress urinary incontinence on quality of life, mental health, work limitation, and healthcare seeking in China, Taiwan, and South Korea (LUTS Asia): Results from a cross-sectional, population-based study","volume":"14","author":"Chow","year":"2022","journal-title":"Int. J. Women\u2019s Health"},{"key":"ref_3","unstructured":"Eurostat (2023, January 31). Eurostat. Available online: https:\/\/ec.europa.eu\/eurostat\/web\/products-eurostat-news\/-\/ddn-20210224-1."},{"key":"ref_4","unstructured":"UNECE (2023, December 19). UNECE. Available online: https:\/\/w3.unece.org\/PXWeb\/en\/Table?IndicatorCode=34."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1007\/s00192-023-05506-4","article-title":"Retropubic slings are more efficient than transobturator at 10-year follow-up: A Swedish register-based study","volume":"34","author":"Alexandridis","year":"2023","journal-title":"Int. Urogynecol. J."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/j.eururo.2010.08.004","article-title":"Tension-free vaginal tape versus transobturator suburethral tape: Five-year follow-up results of a prospective, randomised trial","volume":"58","author":"Angioli","year":"2010","journal-title":"Eur. Urol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"101713","DOI":"10.1016\/j.cont.2024.101713","article-title":"Complications associated with the use of mesh to treat female urinary incontinence and pelvic organ prolapse","volume":"12","author":"Welk","year":"2024","journal-title":"Continence"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"226","DOI":"10.4240\/wjgs.v7.i10.226","article-title":"Mesh implants: An overview of crucial mesh parameters","volume":"7","author":"Zhu","year":"2015","journal-title":"World J. Gastrointest. Surg."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1002\/nau.25365","article-title":"Autologous platelet rich plasma (A-PRP) combined with pelvic floor muscle training for the treatment of female stress urinary incontinence (SUI): A randomized control clinical trial","volume":"43","author":"Saraluck","year":"2023","journal-title":"Neurourol. Urodyn."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Long, C., Lin, K., Shen, C., Ker, C., Liu, Y., Loo, Z., Hsiao, H.-H., and Lee, Y.-C. (2021). A pilot study: Effectiveness of local injection of autologous platelet-rich plasma in treating women with stress urinary incontinence. Sci. Rep., 11.","DOI":"10.1038\/s41598-020-80598-2"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"e668","DOI":"10.1097\/SPV.0000000000001100","article-title":"The Use of Platelet-rich Plasma as a Novel Nonsurgical Treatment of the Female Stress Urinary Incontinence: A Prospective Pilot Study","volume":"27","author":"Athanasiou","year":"2021","journal-title":"Female Pelvic Med. Reconstr. Surg."},{"key":"ref_12","first-page":"42","article-title":"Platelet-Rich Plasma for the Treatment of Stress Urinary Incontinence\u2014A Randomized Trial","volume":"30","author":"Grigoriadis","year":"2024","journal-title":"Urogynecology"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Behnia-Willison, F., Nguyen, T., Norbury, A., Mohamadi, B., Salvatore, S., and Lam, A. (2019). Promising impact of platelet rich plasma and carbon dioxide laser for stress urinary incontinence. Eur. J. Obstet. Gynecol. Reprod. Biol. X, 5.","DOI":"10.1016\/j.eurox.2019.100099"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"2827","DOI":"10.1007\/s00192-023-05655-6","article-title":"Fractional CO2 laser treatment for women with stress predominant urinary incontinence: A randomized controlled trial","volume":"34","author":"Temtanakitpaisan","year":"2023","journal-title":"Int. Urogynecol. J."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1002\/lsm.22416","article-title":"Novel minimally invasive laser treatment of urinary incontinence in women","volume":"47","author":"Ogrinc","year":"2015","journal-title":"Lasers Surg. Med."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1016\/j.ajog.2022.05.054","article-title":"CO2 surgical laser for treatment of stress urinary incontinence in women: A randomized controlled trial","volume":"227","author":"Alexander","year":"2022","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2157","DOI":"10.1007\/s10103-021-03474-z","article-title":"Vaginal erbium laser for treatment of stress urinary incontinence: Optimization of treatment regimen for a sustained long-term effect","volume":"37","author":"Gaspar","year":"2022","journal-title":"Lasers Med. Sci."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"3499","DOI":"10.1007\/s00192-022-05103-x","article-title":"The efficacy and safety of a single maintenance laser treatment for stress urinary incontinence: A double-blinded randomized controlled trial","volume":"33","author":"Lauterbach","year":"2022","journal-title":"Int. Urogynecol. J."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1007\/s10103-017-2170-5","article-title":"Non-ablative erbium YAG laser for the treatment of type III stress urinary incontinence (intrinsic sphincter deficiency)","volume":"32","author":"Gaspar","year":"2017","journal-title":"Lasers Med. Sci."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/j.tjog.2017.10.020","article-title":"Effect of non-ablative laser treatment on overactive bladder symptoms, urinary incontinence and sexual function in women with urodynamic stress incontinence","volume":"56","author":"Lin","year":"2017","journal-title":"Taiwan. J. Obstet. Gynecol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1002\/nau.25244","article-title":"A randomized trial comparing vaginal laser therapy and pelvic floor physical therapy for treating women with stress urinary incontinence","volume":"42","author":"Giarreta","year":"2023","journal-title":"Neurourol. Urodyn."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1007\/s10103-023-03919-7","article-title":"Effect of photobiomodulation associated with strengthening pelvic floor muscles in volunteers with urinary incontinence: A randomized, double-blinded, and placebo-controlled clinical trial","volume":"38","author":"Oliveira","year":"2023","journal-title":"Lasers Med. Sci."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"37","DOI":"10.3109\/13697137.2015.1071126","article-title":"First assessment of short-term efficacy of Er:YAG laser treatment on stress urinary incontinence in women: Prospective cohort study","volume":"18","author":"Fistonic","year":"2015","journal-title":"Climacteric"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"757","DOI":"10.3109\/13697137.2015.1045485","article-title":"Vaginal erbium laser: The second-generation thermotherapy for the genitourinary syndrome of menopause","volume":"18","author":"Gambacciani","year":"2015","journal-title":"Climacteric"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"3535","DOI":"10.1007\/s00192-022-05091-y","article-title":"CO2 Laser and radiofrequency compared to a sham control group in treatment of stress urinary incontinence (LARF study arm 3). A randomized controlled trial","volume":"33","author":"Seki","year":"2022","journal-title":"Int. Urogynecol. J."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1002\/nau.20875","article-title":"Nonsurgical transurethral collagen denaturation for stress urinary incontinence in women: 18-month results from a prospective long-term study","volume":"29","author":"Elser","year":"2010","journal-title":"Neurourol. Urodyn."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/j.juro.2014.03.109","article-title":"Efficacy and safety of Bulkamid in the treatment of female stress incontinence: A randomized, prospective multicenter North-American study","volume":"192","author":"Sokol","year":"2014","journal-title":"J. Urol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1016\/j.juro.2009.12.038","article-title":"Durability of urethral bulking agent injection for female stress urinary incontinence: 2-year multicenter study results","volume":"183","author":"Ghoniem","year":"2010","journal-title":"J. Urol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.maturitas.2009.11.022","article-title":"An ultra-miniinvasive treatment for stress urinary incontinence in complicated older patients","volume":"65","author":"Zullo","year":"2010","journal-title":"Maturitas"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1002\/nau.24589","article-title":"Seven-year efficacy and safety outcomes of Bulkamid for the treatment of stress urinary incontinence","volume":"40","author":"Brosche","year":"2021","journal-title":"Neurourol. Urodyn."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s00404-013-2718-y","article-title":"Outpatient periurethral injections of polyacrylamide hydrogel for the treatment of female stress urinary incontinence: Effectiveness and safety","volume":"288","author":"Maggiore","year":"2013","journal-title":"Arch. Gynecol. Obstet."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1590\/s1677-5538.ibju.2019.0070","article-title":"Macroplastique for women with stress urinary incontinence secondary to intrinsic sphincter deficiency","volume":"45","author":"Carroll","year":"2019","journal-title":"Int. Braz. J. Urol."},{"key":"ref_33","first-page":"428","article-title":"Durability, safety and efficacy of polyacrylamide hydrogel (Bulkamid\u00ae) in the management of stress and mixed urinary incontinence: Three year follow up outcomes","volume":"68","author":"Pai","year":"2015","journal-title":"Cent. Eur. J. Urol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1097\/GME.0000000000001068","article-title":"Long-term follow-up of bulking agents for stress urinary incontinence in older patients","volume":"25","author":"Plotti","year":"2018","journal-title":"Menopause"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1111\/bju.14550","article-title":"Efficacy and safety of polydimethylsiloxane injection (Macroplastique\u00ae) for the treatment of female stress urinary incontinence: Results of a series of 85 patients with \u22653 years of follow-up","volume":"123","author":"Serati","year":"2019","journal-title":"BJU Int."},{"key":"ref_36","first-page":"368","article-title":"Concomitant Transurethral and Transvaginal-Periurethral Injection of Autologous Adipose Derived Stem Cells for Treatment of Female Stress Urinary Incontinence: A Phase One Clinical Trial","volume":"55","author":"Arjmand","year":"2017","journal-title":"Acta Med. Iran."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"276","DOI":"10.2174\/1574888X17666220330010453","article-title":"Short and Medium-Term Results of the Autologous Adult Mucosa Stem Cell Therapy Compared with Mini-Sling Surgery in the Treatment of Women\u2019s Stress Urinary Incontinence; A Randomized Clinical Trial","volume":"18","author":"Mahboubeh","year":"2023","journal-title":"Curr. Stem Cell Res. Ther."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1002\/sctm.19-0431","article-title":"Two phase I\/II clinical trials for the treatment of urinary incontinence with autologous mesenchymal stem cells","volume":"9","author":"Bravo","year":"2020","journal-title":"Stem Cells Transl. Med."},{"key":"ref_39","first-page":"482","article-title":"Autologous Muscle-derived Cell Injection for Treatment of Female Stress Urinary Incontinence: A Single-Arm Clinical Trial with 24-months Follow-Up","volume":"16","author":"Sharifiaghdas","year":"2019","journal-title":"Urol. J."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1016\/j.juro.2014.04.005","article-title":"Intraurethral injection of autologous minced skeletal muscle: A simple surgical treatment for stress urinary incontinence","volume":"192","author":"Klarskov","year":"2014","journal-title":"J. Urol."},{"key":"ref_41","first-page":"323","article-title":"Autologous Muscle-Derived Cells for the Treatment of Female Stress Urinary Incontinence: A 2-Year Follow-Up of a Polish Investigation","volume":"33","author":"Jarocha","year":"2014","journal-title":"Neurourol. Urodyn."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1007\/s00192-012-1963-0","article-title":"Ultrasound-guided autologous myoblast injections into the extrinsic urethral sphincter: Tissue engineering for the treatment of stress urinary incontinence","volume":"24","author":"Blaganje","year":"2012","journal-title":"Int. Urogynecol. J."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Everts, P., Onishi, K., Jayaram, P., Lana, J., and Mautner, K. (2020). Platelet-Rich Plasma: New Performance Understandings and Therapeutic Considerations in 2020. Int. J. Mol. Sci., 21.","DOI":"10.20944\/preprints202010.0069.v1"},{"key":"ref_44","unstructured":"Ekinci, D. (2015). Current Concepts and Translational Uses of Platelet Rich Plasma Biotechnology. Biotechnology, InTech."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1007\/s10517-017-3650-0","article-title":"Structural Reorganization of the Vaginal Mucosa in Stress Urinary Incontinence under Conditions of Er:YAG Laser Treatment","volume":"162","author":"Lapii","year":"2017","journal-title":"Bull. Exp. Biol. Med."},{"key":"ref_46","first-page":"48","article-title":"Comparison of new minimally invasive Er: YAG laser treatment and hormonal replacement therapy in the treatment of vaginal atrophy","volume":"17","author":"Gaspar","year":"2014","journal-title":"Climacteric"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1097\/JU.0000000000003435","article-title":"Updates to surgical treatment of female stress urinary incontinence (SUI): AUA\/SUFU guideline (2023)","volume":"209","author":"Kobashi","year":"2023","journal-title":"J. Urol."},{"key":"ref_48","first-page":"339","article-title":"Urinary Incontinence in Women: Evaluation and Management","volume":"100","author":"Hu","year":"2019","journal-title":"Am. Fam. Physician"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/j.eururo.2017.12.031","article-title":"EAU Guidelines on Assessment and Nonsurgical Management of Urinary Incontinence","volume":"73","author":"Nambiar","year":"2018","journal-title":"Eur. Urol."},{"key":"ref_50","unstructured":"Royal Australian and New Zealand College of Obstetricians and Gynecologists, and Urological Society of Australia and New Zealand (2024, March 23). Treatment Options for Stress Urinary Incontinence. Available online: https:\/\/usanz.org.au\/publicassets\/d163f1bf-0246-e911-a2c2-b75c2fd918c5\/Patient-information---Treatment-options-for-stress-urinary-incontinence-SUI-Information-2018.pdf."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1067\/mob.2000.111251","article-title":"Cost-effectiveness of urodynamic testing before surgery for women with pelvic organ prolapse and stress urinary incontinence","volume":"183","author":"Weber","year":"2000","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_52","first-page":"345","article-title":"Management of Urinary incontinence","volume":"37","author":"Demaagd","year":"2012","journal-title":"Pharm. Ther."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/S0090-4295(00)01019-0","article-title":"Injectable agents in the treatment of stress urinary incontinence in women: Where are we now?","volume":"56","author":"Dmchowski","year":"2000","journal-title":"Urology"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"S152","DOI":"10.5489\/cuaj.4612","article-title":"Periurethral bulking agents for female stress urinary incontinence in Canada","volume":"11","author":"Mamut","year":"2017","journal-title":"Can. Urol. Assoc. J."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1007\/s11255-024-04229-9","article-title":"Platelet-rich plasma for treatment of female stress urinary incontinence","volume":"57","author":"Pourebrahimi","year":"2024","journal-title":"Int. Urol. Nephrol."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Dankova, I., Pyrgidis, N., Tishukov, M., and Georgiadou, E. (2023). Efficacy and Safety of Platelet-Rich Plasma Injections for the Treatment of Female Sexual Dysfunction and Stress Urinary Incontinence: A Systematic Review. Biomedicines, 11.","DOI":"10.3390\/biomedicines11112919"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"103","DOI":"10.6118\/jmm.22017","article-title":"Vaginal Laser Therapy for Stress Urinary Incontinence: A Systematic Review of Prospective Randomized Clinical Trials","volume":"28","author":"Ranjbar","year":"2022","journal-title":"J. Menopausal Med."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.ejogrb.2023.05.014","article-title":"What women want now!","volume":"286","author":"Shah","year":"2023","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1097\/01.spv.0000095060.05452.3f","article-title":"What Do Women Want?: Interpretation of the Concept of Cure","volume":"9","author":"Robinson","year":"2003","journal-title":"Female Pelvic Med. Reconstr. Surg."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/10\/3268\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T17:29:05Z","timestamp":1760030945000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/10\/3268"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,8]]},"references-count":59,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2025,5]]}},"alternative-id":["jcm14103268"],"URL":"https:\/\/doi.org\/10.3390\/jcm14103268","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,8]]}}}