{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T11:13:30Z","timestamp":1787224410513,"version":"build-2736575974"},"reference-count":29,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T00:00:00Z","timestamp":1746662400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008039","name":"Erasmus Medical Center MRACE","doi-asserted-by":"publisher","award":["386070"],"award-info":[{"award-number":["386070"]}],"id":[{"id":"10.13039\/501100008039","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008039","name":"Erasmus Medical Center MRACE","doi-asserted-by":"publisher","award":["01C-202"],"award-info":[{"award-number":["01C-202"]}],"id":[{"id":"10.13039\/501100008039","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Dutch Heart Foundation","award":["386070"],"award-info":[{"award-number":["386070"]}]},{"name":"Dutch Heart Foundation","award":["01C-202"],"award-info":[{"award-number":["01C-202"]}]},{"DOI":"10.13039\/501100002996","name":"Center for Translational Molecular Medicine","doi-asserted-by":"publisher","award":["386070"],"award-info":[{"award-number":["386070"]}],"id":[{"id":"10.13039\/501100002996","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002996","name":"Center for Translational Molecular Medicine","doi-asserted-by":"publisher","award":["01C-202"],"award-info":[{"award-number":["01C-202"]}],"id":[{"id":"10.13039\/501100002996","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Intracranial artery calcification detected on CT imaging is a recognized risk factor for ischemic cerebrovascular diseases, but the underlying etiology of this association remains unclear. Differences in objective morphometric characteristics of these calcifications may partially explain this association, yet these measurements are largely absent in the literature. We investigated intracranial artery calcification morphometry in patients with recent anterior ischemic stroke or TIA, assessing potential differences between calcifications in both intracranial carotid arteries (ICAs) located ipsilateral and contralateral to the cerebral ischemia. Methods: Among 100 patients (mean age 69.6 (SD 8.8) years) presenting to academic neurology departments, 3D reconstructions of both ICAs were based on clinical CT-angiography images. On these reconstructions, a luminal centerline and cross-sections perpendicular to this centerline were created, facilitating the assessment of calcification morphometry, spatial orientation and stenosis severity. Differences in calcification characteristics between ICAs were assessed using two-sided Wilcoxon signed-rank and \u03c72 tests. Results: Among 200 arteries, a median of four (IQR 2\u20136) individual calcifications were counted, with a mean area of 1.8 (IQR 1.2\u20132.7) mm2, a mean arc width of 43.5 (IQR 32.3\u201353.2) degrees, and median longitudinal extent of 15.4 (IQR 5.9\u201327.0) mm. Calcifications were most often present in the anatomical C4 section (56.0%), with predominantly posterosuperior orientation (38.5%) and 42.0% had a local stenosis severity &gt; 70%. None of these aspects significantly differed between ICAs, and this remained after restricting analyses to patients with undetermined etiology. Conclusions: We found no differences in morphometrical or spatial aspects of calcifications between ICAs ipsilateral and contralateral to the cerebral ischemia.<\/jats:p>","DOI":"10.3390\/jcm14103274","type":"journal-article","created":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T06:47:15Z","timestamp":1746686835000},"page":"3274","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Morphometry of Intracranial Carotid Artery Calcifications in Patients with Recent Cerebral Ischemia"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5101-0132","authenticated-orcid":false,"given":"Bernhard P.","family":"Berghout","sequence":"first","affiliation":[{"name":"Department of Epidemiology, Erasmus MC\u2013University Medical Center Rotterdam, 3015 GD Rotterdam, The Netherlands"},{"name":"Department of Radiology and Nuclear Medicine, Erasmus MC\u2013University Medical Center Rotterdam, 3015 GD Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-3116-4947","authenticated-orcid":false,"given":"Federica","family":"Fontana","sequence":"additional","affiliation":[{"name":"Department of Biomechanical Engineering, Delft University of Technology, 2628 CD Delft, The Netherlands"},{"name":"Department of Cardiology, Biomedical Engineering, Cardiovascular Institute, Thorax Center, Erasmus MC\u2013University Medical Center Rotterdam, 3015 GD Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fennika","family":"Huijben","sequence":"additional","affiliation":[{"name":"Department of Biomechanical Engineering, Delft University of Technology, 2628 CD Delft, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suze-Anne","family":"Korteland","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Biomedical Engineering, Cardiovascular Institute, Thorax Center, Erasmus MC\u2013University Medical Center Rotterdam, 3015 GD Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7562-5724","authenticated-orcid":false,"given":"M. Eline","family":"Kooi","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine, Cardiovascular Research Institute in Maastricht (CARIM), Maastricht University Medical Center+, 6229 ET Maastricht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul J.","family":"Nederkoorn","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Medical Center Amsterdam, 1081 HV Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pim A.","family":"de Jong","sequence":"additional","affiliation":[{"name":"Department of Radiology, University Medical Center Utrecht, Utrecht University, 3584 CX Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank J.","family":"Gijsen","sequence":"additional","affiliation":[{"name":"Department of Biomechanical Engineering, Delft University of Technology, 2628 CD Delft, The Netherlands"},{"name":"Department of Cardiology, Biomedical Engineering, Cardiovascular Institute, Thorax Center, Erasmus MC\u2013University Medical Center Rotterdam, 3015 GD Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selene","family":"Pirola","sequence":"additional","affiliation":[{"name":"Department of Biomechanical Engineering, Delft University of Technology, 2628 CD Delft, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Kamran","family":"Ikram","sequence":"additional","affiliation":[{"name":"Department of Neurology, Erasmus MC\u2013University Medical Center Rotterdam, 3015 GD Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Bos","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Erasmus MC\u2013University Medical Center Rotterdam, 3015 GD Rotterdam, The Netherlands"},{"name":"Department of Radiology and Nuclear Medicine, Erasmus MC\u2013University Medical Center Rotterdam, 3015 GD Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5900-0425","authenticated-orcid":false,"given":"Ali C.","family":"Akyildiz","sequence":"additional","affiliation":[{"name":"Department of Biomechanical Engineering, Delft University of Technology, 2628 CD Delft, The Netherlands"},{"name":"Department of Cardiology, Biomedical Engineering, Cardiovascular Institute, Thorax Center, Erasmus MC\u2013University Medical Center Rotterdam, 3015 GD Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,5,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1002\/alz.13496","article-title":"Intracranial arteriosclerosis and the risk of dementia: A population-based cohort study","volume":"20","author":"Wolters","year":"2024","journal-title":"Alzheimer\u2019s Dement."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1001\/jamaneurol.2013.6223","article-title":"Intracranial carotid artery atherosclerosis and the risk of stroke in whites: The Rotterdam Study","volume":"71","author":"Bos","year":"2014","journal-title":"JAMA Neurol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1161\/STROKEAHA.121.036213","article-title":"Morphological Subtypes of Intracranial Internal Carotid Artery Arteriosclerosis and the Risk of Stroke","volume":"53","author":"Vernooij","year":"2022","journal-title":"Stroke"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1016\/j.jacc.2020.07.056","article-title":"Intracranial Arterial Calcification: Prevalence, Risk Factors, and Consequences: JACC Review Topic of the Week","volume":"76","author":"Bartstra","year":"2020","journal-title":"J. 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