{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T13:08:49Z","timestamp":1791378529792,"version":"4.3.2"},"reference-count":18,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T00:00:00Z","timestamp":1746748800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Popliteal venous aneurysms (PVA) are an uncommon but potentially severe condition due to their association with increased risk of recurrent pulmonary embolisms. Because of their rarity, their aetiology, natural history, and optimal treatment strategies have been poorly defined. The aim of this paper is to report a comprehensive systematic review on the treatment strategies and outcomes in PVA, summarizing current evidence. Methods: A systematic literature search was conducted in PubMed, Scopus, and Web of Science, covering studies published from database inception through February 2025 (protocol registered on PROSPERO CRD420251008927). The primary endpoint was the analysis of outcomes and complications associated with surgical and conservative management. Results: Nine studies, including 173 adult patients with popliteal venous aneurysms, were included. The mean age was 56 years (range 18\u201386 years, mean aneurysm diameter 25.4 mm). Most of the patients were female (73, 42.2%). Overall, 85 (49.1%) aneurysms were saccular and 74 (42.8%) fusiform, although morphology was not consistently reported across all studies. Intraluminal thrombus was reported in 26 cases (15.0%), and pulmonary embolism upon presentation in 21 (12.1%). Surgical treatment was performed in 119 patients (68.8%), while 54 (31.2%) were managed conservatively. Fifteen patients (13.0%) experienced postoperative complications, including wound infections (4, 3.5%), hematomas (7, 6.0%), and nerve injury (4, 3.5%), but no cases of postoperative pulmonary embolisms were observed. Following surgery, anticoagulation was indicated in most cases for 3\u20136 months or a long life. During follow-up (mean 35 months, range 1\u2013262), thrombosis of the surgical reconstruction was observed in 1 patient (0.8%). Death occurred in 3 cases (5.5%), all in the non-surgical group: 2 (3.7%) due to malignancy and 1 (1.9%) from myocardial infarction. Conclusions: PVA is a rarely described condition potentially associated with the risk of PE. In their management, surgical strategies in association with oral anticoagulation represent the most commonly described approach, allowing for satisfactory results and a low rate of complications.<\/jats:p>","DOI":"10.3390\/jcm14103296","type":"journal-article","created":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T06:18:51Z","timestamp":1746771531000},"page":"3296","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Popliteal Venous Aneurysms: A Systematic Review of Treatment Strategies and Outcomes"],"prefix":"10.3390","volume":"14","author":[{"given":"Ottavia","family":"Borghese","sequence":"first","affiliation":[{"name":"Unit of Vascular Surgery, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5804-2284","authenticated-orcid":false,"given":"Domenico","family":"Pascucci","sequence":"additional","affiliation":[{"name":"Section of Hygiene, Department of Life Science and Public Health, Universit\u00e0 Cattolica del Sacro Cuore, 00168 Rome, Italy"},{"name":"Health Management, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicol\u00f2","family":"Peluso","sequence":"additional","affiliation":[{"name":"Unit of Vascular Surgery, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy"},{"name":"Unit of Vascular Surgery, Department of Cardiovascular Sciences, Universit\u00e0 Cattolica del Sacro Cuore, 00168 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-4642-9058","authenticated-orcid":false,"given":"Francesco","family":"Sposato","sequence":"additional","affiliation":[{"name":"Unit of Vascular Surgery, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy"},{"name":"Unit of Vascular Surgery, Department of Cardiovascular Sciences, Universit\u00e0 Cattolica del Sacro Cuore, 00168 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonino","family":"Marzullo","sequence":"additional","affiliation":[{"name":"Unit of Vascular Surgery, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy"},{"name":"Unit of Vascular Surgery, Department of Cardiovascular Sciences, Universit\u00e0 Cattolica del Sacro Cuore, 00168 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4484-2176","authenticated-orcid":false,"given":"Tommaso","family":"Donati","sequence":"additional","affiliation":[{"name":"Unit of Vascular Surgery, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-5299-1333","authenticated-orcid":false,"given":"Laura","family":"Rascio","sequence":"additional","affiliation":[{"name":"Unit of Vascular Surgery, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy"},{"name":"Unit of Vascular Surgery, Department of Cardiovascular Sciences, Universit\u00e0 Cattolica del Sacro Cuore, 00168 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7304-7553","authenticated-orcid":false,"given":"Yamume","family":"Tshomba","sequence":"additional","affiliation":[{"name":"Unit of Vascular Surgery, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy"},{"name":"Unit of Vascular Surgery, Department of Cardiovascular Sciences, Universit\u00e0 Cattolica del Sacro Cuore, 00168 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,5,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1067\/mva.2000.110353","article-title":"Management of symptomatic and asymptomatic popliteal venous aneurysms: A retrospective analysis of 25 patients and review of the literature","volume":"32","author":"Sessa","year":"2000","journal-title":"J. Vasc. Surg."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1007\/BF02000255","article-title":"Bilateral Popliteal Vein Aneurysms","volume":"7","author":"McDevitt","year":"1993","journal-title":"Ann. Vasc. Surg."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.jvsv.2018.12.013","article-title":"Treatment of popliteal vein aneurysms","volume":"7","author":"Noppeney","year":"2019","journal-title":"J. Vasc. Surg. Venous Lymphat. Disord."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/s00268-005-7982-y","article-title":"Popliteal Venous Aneurysm\u2014A Systematic Review","volume":"30","author":"Bergqvist","year":"2006","journal-title":"World J. Surg."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"A12-3","DOI":"10.7326\/ACPJC-1995-123-3-A12","article-title":"The well-built clinicalquestion: A key to evidence-based decisions","volume":"123","author":"Richardson","year":"1995","journal-title":"ACP J. Club"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"n160","DOI":"10.1136\/bmj.n160","article-title":"PRISMA2020 explanation elaboration: Updated guidance exemplars for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"b2535","DOI":"10.1136\/bmj.b2535","article-title":"Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement","volume":"339","author":"Moher","year":"2009","journal-title":"BMJ"},{"key":"ref_8","unstructured":"National Institutes of Health (2020, July 16). Quality Assessment of Controlled Interventionstudies, Available online: https:\/\/www.nhlbi.nih.gov\/health-topics\/study-quality-assessment-tools."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"2210","DOI":"10.1007\/s11606-018-4658-5","article-title":"Hospitalized patients\u2019 knowledge of care: A systematic review","volume":"33","author":"Sommer","year":"2018","journal-title":"J. Gen. Intern. Med."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.avsg.2012.07.005","article-title":"Popliteal venous aneurysms: Results of surgical treatment","volume":"27","year":"2013","journal-title":"Ann. Vasc. Surg."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1016\/j.avsg.2015.02.009","article-title":"Surgical treatment of popliteal venous aneurysms","volume":"29","author":"Johnstone","year":"2015","journal-title":"Ann. Vasc. Surg."},{"key":"ref_12","first-page":"1","article-title":"Our experience of symptomatic and asymptomatic popliteal venous aneurysm","volume":"4","author":"Zhao","year":"2017","journal-title":"J. Vasc. Surg. Cases Innov. Tech."},{"key":"ref_13","first-page":"23","article-title":"Institutional Experience with Venous Aneurysms\u2014Insights on the Natural History and Outcomes of Surgical Treatment","volume":"30","author":"Machado","year":"2023","journal-title":"Port. J. Card. Thorac. Vasc. Surg."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1016\/j.jvsv.2022.06.011","article-title":"Contemporary management and outcomes of peripheral venous aneurysms: A multi-institutional study","volume":"10","author":"Patel","year":"2022","journal-title":"J. Vasc. Surg. Venous Lymphat. Disord."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.jvsv.2020.04.026","article-title":"Closed plication is a safe and effective method for treating popliteal vein aneurysm","volume":"9","author":"Beaulieu","year":"2021","journal-title":"J. Vasc. Surg. Venous Lymphat. Disord."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1816","DOI":"10.1016\/j.avsg.2014.06.065","article-title":"Popliteal venous aneurysms: Characteristics, management strategies, and clinical outcomes\u2014A modern single-center series","volume":"28","author":"Donaldson","year":"2014","journal-title":"Ann. Vasc. Surg."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1177\/1538574407305096","article-title":"Popliteal Vein Aneurysm: A Case Report and Review of Literature","volume":"41","author":"Nasr","year":"2008","journal-title":"Vasc. Endovasc. Surg."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/0741-5214(93)90081-V","article-title":"Popliteal venous aneurysm: Report of two cases and review of the world literature","volume":"18","author":"Aldridge","year":"1993","journal-title":"J. Vasc. Surg."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/10\/3296\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T17:29:55Z","timestamp":1760030995000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/10\/3296"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,9]]},"references-count":18,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2025,5]]}},"alternative-id":["jcm14103296"],"URL":"https:\/\/doi.org\/10.3390\/jcm14103296","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,9]]}}}