{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:16:09Z","timestamp":1760058969094,"version":"build-2065373602"},"reference-count":31,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T00:00:00Z","timestamp":1746748800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Dunarea de Jos University Galati, Romania"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Introduction: The occurrence of a second primary lung cancer after head and neck cancer is a challenge for multidisciplinary teams, since the development of a second lung cancer negatively affects the survival rate of patients with head and neck cancer. Case Presentation: This article presents the case of a patient with a double location of cancer: inoperable stage III nasopharyngeal carcinoma, biopsied in December 2017 (non-keratinizing nasopharyngeal carcinoma), treated by means of radiotherapy and chemotherapy (2018\u20132021), and stage IV lung cancer (squamous carcinoma) with lung metastases, diagnosed in December 2021, treated using polychemotherapy, subsequent maintenance monochemotherapy, radiotherapy of the thorax, and subsequent maintenance monochemotherapy with a favorable result. The patient was still under treatment as of February 2025, the date of the preparation of the current article. Discussion and Literature Review: Regarding the location of the second metachronous cancer, studies show that the most frequent locations are the lungs and the esophagus, with the main causes being alcohol consumption and smoking. Therefore, these patients should be monitored by screening the respiratory and digestive tracts, especially in men, in order to identify a second cancer, either synchronous or metachronous, in an early stage. Conclusions: Educating the patient with head and neck cancer regarding quitting smoking and cutting out alcohol, as well as conducting a follow-up survey, may reduce the incidence of multiple primaries. Moreover, the multidisciplinary management of second primary lung malignancies in patients with head and neck cancer may lead to long-term disease monitoring.<\/jats:p>","DOI":"10.3390\/jcm14103299","type":"journal-article","created":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T06:18:51Z","timestamp":1746771531000},"page":"3299","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Long-Term Survival in Metachronous Primary Malignancies: Stage III Nasopharyngeal Cancer and Stage IV Non-Small-Cell Lung Cancer"],"prefix":"10.3390","volume":"14","author":[{"given":"Gabriela","family":"Rahnea-Nita","sequence":"first","affiliation":[{"name":"Specific Disciplines Department, Faculty of Nursery and Midwifery, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 020021 Bucharest, Romania"},{"name":"M Hospital\u2014M Care, 077190 Voluntari, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandru","family":"Nechifor","sequence":"additional","affiliation":[{"name":"Clinical Department, Faculty of Medicine and Pharmacy, \u201cDunarea de Jos\u201d University of Galati, 800008 Galati, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1601-0580","authenticated-orcid":false,"given":"Mihai-Teodor","family":"Georgescu","sequence":"additional","affiliation":[{"name":"Clinical Department, Faculty of Medicine, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 020021 Bucharest, Romania"},{"name":"Department of Radiotherapy, Oncological Institute \u201cProf. Dr. Alexandru Trestioreanu\u201d, 022328 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorel","family":"Firescu","sequence":"additional","affiliation":[{"name":"Clinical Department, Faculty of Medicine and Pharmacy, \u201cDunarea de Jos\u201d University of Galati, 800008 Galati, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrian-Cornel","family":"Maier","sequence":"additional","affiliation":[{"name":"Clinical Department, Faculty of Medicine and Pharmacy, \u201cDunarea de Jos\u201d University of Galati, 800008 Galati, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Radu-Valeriu","family":"Toma","sequence":"additional","affiliation":[{"name":"Clinical Department, Faculty of Medicine, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 020021 Bucharest, Romania"},{"name":"Department of Radiotherapy, Oncological Institute \u201cProf. Dr. Alexandru Trestioreanu\u201d, 022328 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentin Titus","family":"Grigorean","sequence":"additional","affiliation":[{"name":"Clinical Department, Faculty of Medicine, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 020021 Bucharest, Romania"},{"name":"Department of General Surgery, \u201cBagdasar-Arseni\u201d Clinical Emergency Hospital, 041915 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liliana-Florina","family":"Andronache","sequence":"additional","affiliation":[{"name":"Preclinical Department, Faculty of Medicine, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 020021 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roxana-Andreea","family":"Rahnea-Nita","sequence":"additional","affiliation":[{"name":"Clinical Department, Faculty of Medicine, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 020021 Bucharest, Romania"},{"name":"M Hospital\u2014M Oncology, 077190 Voluntari, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0535-7100","authenticated-orcid":false,"given":"Ionut Simion","family":"Coman","sequence":"additional","affiliation":[{"name":"Clinical Department, Faculty of Medicine, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 020021 Bucharest, Romania"},{"name":"Department of General Surgery, \u201cBagdasar-Arseni\u201d Clinical Emergency Hospital, 041915 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura-Florentina","family":"Rebegea","sequence":"additional","affiliation":[{"name":"Clinical Department, Faculty of Medicine and Pharmacy, \u201cDunarea de Jos\u201d University of Galati, 800008 Galati, Romania"},{"name":"Department of Radiotherapy, \u201cSf. Apostol Andrei\u201d Hospital, 800578 Galati, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,5,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Pan, S.-Y., Huang, C.-P., and Chen, W.-C. (2022). Synchronous\/Metachronous Multiple Primary Malignancies: Review of Associated Risk Factors. Diagnostics, 12.","DOI":"10.3390\/diagnostics12081940"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1093\/annonc\/mdn003","article-title":"The incidence and risk of second primary cancers in patients with nasopharyngeal carcinoma: A population-based study in Taiwan over a 25-year period (1979\u20132003)","volume":"19","author":"Chen","year":"2008","journal-title":"Ann. Oncol."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Coyte, A., Morrison, D.S., and McLoone, P. (2014). 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