{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T16:57:27Z","timestamp":1782233847848,"version":"3.54.5"},"reference-count":47,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T00:00:00Z","timestamp":1746748800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Today, endoscopy plays a crucial role not only in the detection of precancerous and malignant colorectal lesions, but also in the treatment of even widespread adenomas and T1 early cancers. In addition to classic polypectomy and endoscopic mucosal resection (EMR) using a snare, in recent years, endoscopic submucosal dissection (ESD) has become increasingly important. Marking, submucosal injection, circumferential incision of the mucosa around the lesion, tunneling, and submucosal dissection using a short diathermic knife facilitate the \u2018en bloc\u2019 resection of lesions larger than 3 cm, difficult to resect in one piece using a snare. Lesions with high-grade dysplasia or mucosal carcinoma are other good candidates aside from widespread adenomata with a high risk of recurrence after piecemeal resection. ESD allows R0 resection rates of more than 90% in specialized centers. Lesions of 20 cm have been removed \u2018en bloc\u2019 by expert endoscopists. ESD provides an optimal histopathologic yield and has a risk of recurrence as low as 3%. Endoscopic full-thickness resection using a special device (eFTRD) is another addition to the resection armamentarium. It is especially suitable for circumscribed lesions up to 2 cm in the middle and upper rectum. Endoscopic intermuscular dissection (EID) is a recent modification of ESD primarily in the rectum, including the inner, circular muscular layer into the resection specimen. In this way, it allows a histopathologic analysis of the entire submucosa beyond the mucosal and upper submucosal layer such as in ESD. This is especially important for T1 cancers invading the submucosa without any other risk factors of invasion.<\/jats:p>","DOI":"10.3390\/jcm14103322","type":"journal-article","created":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T11:25:53Z","timestamp":1746789953000},"page":"3322","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Endoscopic Resection Techniques for Widespread Precancerous Lesions and Early Carcinomas in the Rectum"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5522-1271","authenticated-orcid":false,"given":"Juergen","family":"Hochberger","sequence":"first","affiliation":[{"name":"Department of Medicine, Hepatology and Gastroenterology, Campus Virchow Klinikum, Charit\u00e9 University Medicine, 13353 Berlin, Germany"},{"name":"Department of Gastroenterology, Vivantes Klinikum im Friedrichshain, 10249 Berlin, Germany"},{"name":"Medical Clinic I\u2014Gastroenterology, Friedrich-Alexander University Erlangen-Nuremberg, 91054 Erlangen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Loss","sequence":"additional","affiliation":[{"name":"Department of General and Visceral Surgery, Vivantes Klinikum im Friedrichshain, 10249 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Kruse","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Asklepios Westklinikum, 22559 Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Kouladouros","sequence":"additional","affiliation":[{"name":"Department of Medicine, Hepatology and Gastroenterology, Campus Virchow Klinikum, Charit\u00e9 University Medicine, 13353 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,5,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1038\/s41575-023-00847-3","article-title":"Reduction in colorectal cancer incidence by screening endoscopy","volume":"21","author":"Brenner","year":"2023","journal-title":"Nat. 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