{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T08:25:51Z","timestamp":1781684751654,"version":"3.54.5"},"reference-count":128,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:00:00Z","timestamp":1747180800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background\/Objective: Infertility affects approximately 10\u201315% couples in industrialized countries. It has numerous causes, including genetic and environmental factors, lifestyle choices, and physiological disorders. The increasing prevalence of infertility underlines the importance of research into interventions to improve reproductive health, with a strong focus on physical activity. Infertility research was traditionally mainly directed toward female health. Although the male factor is being increasingly accepted as being equally important, this area remains under-researched. The current review focuses on the impact of physical activity on male fertility through its effects on immune function, the cardiovascular system, hormonal balance, metabolism, and physical interaction with the male reproductive system. Materials and Methods: A comprehensive literature review of studies addressing the effects of physical activity on male fertility was conducted using PubMed\/Medline, Scopus, and the Web of Science. Mostly recent studies were included, with a small number of older ones included in cases when their content remains relevant. The review focused on articles studying the processes involved and associations between physical activity and male fertility through immune and cardiovascular effects, endocrine modulation, the influence on obesity and insulin metabolism, and the physical impact on the body. Results: The findings revealed the existence of a fairly strong consensus that moderate physical activity enhances semen quality, hormonal balance, and metabolic health, positively influencing male fertility. Physical activity reduces inflammation and oxidative stress, enhances cardiovascular functioning, and contributes to oxygen and nutrient supply to the reproductive organs. On the contrary, strenuous training can adversely affect fertility, mostly through hormonal disruption and oxidative stress. It can also have various indirect effects on fertility through sports-related behavior and incidents, such as wearing tight-fitting clothes or overheating. Conclusions: Physical activity can affect male fertility in numerous ways, positively influencing reproductive health when performed at a moderate intensity. Understanding the balance between beneficial and excessive exercise as well as the impact of incidental factors related to performing sports regularly are, thus, extremely important in optimizing lifestyle-oriented interventions aimed at male fertility improvement.<\/jats:p>","DOI":"10.3390\/jcm14103442","type":"journal-article","created":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T12:22:17Z","timestamp":1747225337000},"page":"3442","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The Impact of Physical Exercise on Male Fertility Through Its Association with Various Processes and Aspects of Human Biology"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4445-5173","authenticated-orcid":false,"given":"Adrianna","family":"Za\u0144ko","sequence":"first","affiliation":[{"name":"Department of Biostatistics and Medical Informatics, Medical University of Bia\u0142ystok, 15-295 Bia\u0142ystok, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0046-4633","authenticated-orcid":false,"given":"Micha\u0142","family":"Paw\u0142owski","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Medical Informatics, Medical University of Bia\u0142ystok, 15-295 Bia\u0142ystok, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6241-8283","authenticated-orcid":false,"given":"Robert","family":"Milewski","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Medical Informatics, Medical University of Bia\u0142ystok, 15-295 Bia\u0142ystok, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,5,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1017\/S0021932017000244","article-title":"Prevalence and risk factors of infertility in turkey: Evidence from demographic and health surveys, 1993\u20132013","volume":"50","author":"Sarac","year":"2018","journal-title":"J. Biosoc. Sci."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"14433","DOI":"10.1111\/and.14433","article-title":"Influence of physical activity on male fertility","volume":"54","author":"Minas","year":"2022","journal-title":"Andrologia"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Abedpoor, N., Taghian, F., and Hajibabaie, F. (2024). Exploring the dynamics of exercise intensity on male fertility and reproductive health: Advancements and implications for fertility research. Front. Reprod. Health, 6.","DOI":"10.3389\/frph.2024.1423916"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2781","DOI":"10.1093\/humrep\/dew265","article-title":"Men\u2019s knowledge of their own fertility: A population-based survey examining the awareness of factors that are associated with male infertility","volume":"31","author":"Daumler","year":"2016","journal-title":"Hum. Reprod."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Huang, B., Wang, Z., Kong, Y., Jin, M., and Ma, L. (2023). Global, regional and national burden of male infertility in 204 countries and territories between 1990 and 2019: An analysis of global burden of disease study. BMC Public. Health, 23.","DOI":"10.1186\/s12889-023-16793-3"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1093\/humupd\/dmx005","article-title":"Men\u2019s knowledge, attitudes and behaviours relating to fertility","volume":"23","author":"Hammerberg","year":"2017","journal-title":"Human Reprod. Update"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1111\/andr.13530","article-title":"A metabolomic perspective on the mechanisms by which environmental pollutants and lifestyle lead to male infertility","volume":"12","author":"Yang","year":"2023","journal-title":"Andrology"},{"key":"ref_8","unstructured":"World Health Organization (2021). WHO Laboratory Manual for the Examination and Processing of Human Semen, WHO. [6th ed.]."},{"key":"ref_9","unstructured":"Leslie, S.W., Soon-Sutton, T.L., and Khan, M.A.B. (2025). Male Infertility, StatPearls."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"56","DOI":"10.5603\/GP.a2017.0012","article-title":"Manual vs. computer-assisted sperm analysis: Can CASA replace manual assessment of human semen in clinical practice?","volume":"88","author":"Berger","year":"2017","journal-title":"Ginekol. Pol."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Boitrelle, F., Shah, R., Saleh, R., Henkel, R., Kandil, H., Chung, E., Vogiatzi, P., Zini, A., Arafa, M., and Agarwal, A. (2021). The Sixth Edition of the WHO Manualfor Human Semen Analysis: A Critical Review and SWOT Analysis. Life, 11.","DOI":"10.3390\/life11121368"},{"key":"ref_12","unstructured":"Jungwirth, A., Dohle, G.R., Diemer, T., Kopa, Z., and Tournaye, H. (2017). EAU Guidelines of Male Infertility, European Association of Urology."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0140-6736(12)61031-9","article-title":"Effect of physical inactivity on major non-communicable diseases worldwide: An analysis of burden of disease and life expectancy","volume":"380","author":"Lee","year":"2012","journal-title":"Lancet"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1093\/humrep\/det428","article-title":"The relationship between male BMI and waist circumference on semen quality: Data from the LIFE study","volume":"29","author":"Eisenberg","year":"2014","journal-title":"Hum. Reprod."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1016\/j.fertnstert.2014.06.032","article-title":"Physical activity is not related to semen quality in young healthy men","volume":"102","author":"Chavarro","year":"2014","journal-title":"Fertil. Steril."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"482","DOI":"10.5534\/wjmh.220199","article-title":"Male Fertility and Physical Exercise","volume":"41","author":"Balladelli","year":"2023","journal-title":"World J. Mens. Health"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1177\/19417381211055399","article-title":"Effectiveness of Exercise Training on Male Factor Infertility: A Systematic Review and Network Meta-analysis","volume":"14","author":"Maleki","year":"2022","journal-title":"Sports Health"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"555","DOI":"10.5534\/wjmh.230106","article-title":"Effects of Physical Activity on Fertility Parameters: A Meta-Analysis of Randomized Controlled Trials","volume":"42","author":"Giudice","year":"2024","journal-title":"World J. Mens. Health"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"151","DOI":"10.4314\/mmj.v27i4.7","article-title":"Semen profiles of young men involved as bicycle taxi cyclists in Mangochi District, Malawi: A case-control study","volume":"27","author":"Kipandula","year":"2015","journal-title":"Malawi Med. J."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1016\/S0015-0282(16)57983-7","article-title":"Prospective study of hormonal and semen profiles in marathon runners","volume":"64","author":"Jensen","year":"1995","journal-title":"Fertil. Steril."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Xu, Z., Qin, Y., Lv, B., Tian, Z., and Zhang, B. (2022). Effects of moderate-intensity continuous training and high-intensity interval training on testicular oxidative stress, apoptosis and m6A Methylation in obese male mice. Antioxidants, 11.","DOI":"10.3390\/antiox11101874"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Ilacqua, A., Izzo, G., Emerenziani, G.P., Baldari, C., and Aversa, A. (2018). Lifestyle and fertility: The influence of stress and quality of life on male fertility. Reprod. Biol. Endocrinol., 16.","DOI":"10.1186\/s12958-018-0436-9"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1007\/s11934-018-0805-0","article-title":"The role of lifestyle in male infertility: Diet, physical activity, and body habitus","volume":"19","author":"Hayden","year":"2018","journal-title":"Curr. Urol. Rep."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1046\/j.1365-201X.2003.01095.x","article-title":"Effect of intensive exercise-induced testicular gametogenic and steroidogenic disorders in mature male Wistar strain rats: A correlative approach to oxidative stress","volume":"178","author":"Manna","year":"2003","journal-title":"Acta Physiol. Scand."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"3267","DOI":"10.1007\/s00421-011-2304-6","article-title":"Physically active men show better semen parameters and hormone values than sedentary men","volume":"112","author":"Vaamonde","year":"2012","journal-title":"Eur. J. Appl. Physiol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.fertnstert.2024.08.323","article-title":"Intensity and type of physical activity and semen quality in healthy young men","volume":"123","author":"Donato","year":"2024","journal-title":"Fertil. Steril."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"2330","DOI":"10.1093\/humrep\/dez226","article-title":"Physical activity and sedentary time in relation to semen quality in healthy men screened as potential sperm donors","volume":"34","author":"Sun","year":"2019","journal-title":"Hum. Reprod."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1016\/j.fertnstert.2023.10.017","article-title":"The impact of obesity and metabolic health on male fertility: A systematic review","volume":"120","author":"Service","year":"2023","journal-title":"Fertil. Steril."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Sansone, A., Sansone, M., Vaamonde, D., Sgr\u00f2, P., Salzano, C., Romanelli, F., Lenzi, A., and Di Luigi, L. (2018). Sport, doping and male fertility. Reprod. Biol. Endocrinol., 16.","DOI":"10.1186\/s12958-018-0435-x"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.cell.2007.05.047","article-title":"Endocrine regulation of energy metabolism by the skeleton","volume":"130","author":"Lee","year":"2007","journal-title":"Cell"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1530\/ror.0.0040038","article-title":"Hormonal and genetic control of germ cell apoptosis in the testis","volume":"4","author":"Hikim","year":"1999","journal-title":"Rev. Reprod."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/j.steroids.2008.11.017","article-title":"Molecular mechanisms of testosterone action in spermatogenesis","volume":"74","author":"Walker","year":"2009","journal-title":"Steroids"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1016\/j.cmet.2016.05.004","article-title":"Osteocalcin signaling in myofibers is necessary and sufficient for optimum adaptation to exercise","volume":"23","author":"Mera","year":"2016","journal-title":"Cell Metab."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Leisegang, K., Opuwari, C.S., Moichela, F., and Finelli, R. (2023). Traditional, Complementary and Alternative Medicines in the Treatment of Ejaculatory Disorders: A Systematic Review. Medicina, 59.","DOI":"10.3390\/medicina59091607"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"686","DOI":"10.21037\/tau.2018.06.20","article-title":"Contemporary management of ejaculatory dysfunction","volume":"7","author":"Gray","year":"2018","journal-title":"Transl. Androl. Urol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1097\/JSM.0000000000000122","article-title":"Long-term low-to-intensive cycling training: Impact on semen parameters and seminal cytokines","volume":"6","author":"Maleki","year":"2015","journal-title":"Clin. J. Sport Med."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Ye, L., Huang, W., Liu, S., Cai, S., Hong, L., Xiao, W., Thiele, K., Zeng, Y., Song, M., and Diao, L. (2021). Impacts of Immunometabolism on Male Reproduction. Front. Immunol., 12.","DOI":"10.3389\/fimmu.2021.658432"},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Za\u0144ko, A., Siewko, K., Kr\u0119towski, A.J., and Milewski, R. (2022). Lifestyle, Insulin Resistance and Semen Quality as Co-Dependent Factors of Male Infertility. Int. J. Environ. Res. Public. Health, 20.","DOI":"10.3390\/ijerph20010732"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1046\/j.1439-0272.2003.00537.x","article-title":"Immune-Endocrine Interactions and Leydig Cell Function: The Role of Cytokines","volume":"35","author":"Diemer","year":"2003","journal-title":"Andrologia"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/0012-1606(77)90178-6","article-title":"Appearance of cell surface auto- and isoantigens during spermatogenesis in the rabbit","volume":"55","author":"Romrell","year":"1977","journal-title":"Dev. Biol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"2707","DOI":"10.1007\/s43032-021-00721-0","article-title":"Somatic-Immune Cells Crosstalk In-The-Making of Testicular Immune Privilege","volume":"29","author":"Dutta","year":"2022","journal-title":"Reprod. Sci."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.mce.2010.03.022","article-title":"Immunological, paracrine and endocrine aspects of testicular immune privilege","volume":"335","author":"Meinhardt","year":"2011","journal-title":"Mol. Cell Endocrinol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.mce.2013.09.022","article-title":"The immune privilege of testis and gravid uterus: Same difference?","volume":"382","author":"Arck","year":"2014","journal-title":"Mol. Cell Endocrinol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1111\/obr.12469","article-title":"Obesogens and Male Fertility","volume":"18","author":"Cardoso","year":"2017","journal-title":"Obes. Rev."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/cen.13723","article-title":"Hypogonadism and Male Obesity: Focus on Unresolved Questions","volume":"89","author":"Grossmann","year":"2018","journal-title":"Clin. Endocrinol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"103984","DOI":"10.1016\/j.jri.2023.103984","article-title":"A review on immunological aspects in male reproduction: An immune cells and cytokines","volume":"158","author":"Wanjari","year":"2023","journal-title":"J. Reprod. Immunol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.jri.2013.09.005","article-title":"In vitro reconstruction of inflammatory reaction in human semen: Effect on sperm DNA fragmentation","volume":"100","author":"Fraczek","year":"2013","journal-title":"J. Reprod. Immunol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"85","DOI":"10.2164\/jandrol.107.003319","article-title":"Proinflammatory cytokines as an intermediate factor enhancing lipid sperm membrane peroxidation in in vitro conditions","volume":"29","author":"Fraczek","year":"2008","journal-title":"J. Androl."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Ihim, S.A., Abubakar, S.D., Zian, Z., Sasaki, T., Saffarioun, M., Maleknia, S., and Azizi, G. (2022). Interleukin-18 cytokine in immunity, inflammation, and autoimmunity: Biological role in induction, regulation, and treatment. Front. Immunol., 13.","DOI":"10.3389\/fimmu.2022.919973"},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Nieman, D.C., Groen, A.J., Pugachev, A., and Vacca, G. (2018). Detection of functional overreaching in endurance athletes using proteomics. Proteomes, 6.","DOI":"10.3390\/proteomes6030033"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1249\/01.MSS.0000149808.38194.21","article-title":"Immune response to a 30-minute walk","volume":"37","author":"Nieman","year":"2005","journal-title":"Med. Sci. Sports Exerc."},{"key":"ref_52","first-page":"8","article-title":"Cytokine expression and secretion by skeletal muscle cells: Regulatory mechanisms and exercise effects","volume":"21","author":"Peake","year":"2015","journal-title":"Exerc. Immunol. Rev."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.jshs.2018.09.009","article-title":"The compelling link between physical activity and the body\u2019s defense system","volume":"8","author":"Nieman","year":"2019","journal-title":"J. Sport Health Sci."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1152\/japplphysiol.00316.2004","article-title":"Effects of Exercise on Gene Expression in Human Peripheral Blood Mononuclear Cells","volume":"97","author":"Connolly","year":"2004","journal-title":"J. Appl. Physiol."},{"key":"ref_55","first-page":"405","article-title":"Esp\u00e8ces R\u00e9actives de l\u2019oxyg\u00e8ne et Stress Oxydant","volume":"27","author":"Migdal","year":"2011","journal-title":"M\u00e9d.\/Sci."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Guo, Y., Wang, A., Liu, X., and Li, E. (2019). Effects of resveratrol on reducing spermatogenic dysfunction caused by high-intensity exercise. Reprod. Biol. Endocrinol., 17.","DOI":"10.1186\/s12958-019-0486-7"},{"key":"ref_57","first-page":"816","article-title":"Effect of different intensities of swimming exercise on testicular oxidative stress and reproductive dysfunction in mature male albino Wistar rats","volume":"42","author":"Manna","year":"2004","journal-title":"Indian. J. Exp. Biol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0928-4680(00)00057-2","article-title":"Acute immune response in respect to exercise-induced oxidative stress","volume":"7","author":"Vider","year":"2001","journal-title":"Pathophysiology"},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Nieman, D.C., and Mitmesser, S.H. (2017). Potential impact of nutrition on immune system recovery from heavy exertion: A metabolomics perspective. Nutrients, 9.","DOI":"10.3390\/nu9050513"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1146\/annurev-food-032818-121316","article-title":"Immunometabolism: A multi-omics approach to interpreting the influence of exercise and diet on the immune system","volume":"10","author":"Nieman","year":"2019","journal-title":"Ann. Rev. Food Sci. Technol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1111\/eci.12781","article-title":"Anti-inflammatory effects of exercise: Role in diabetes and cardiovascular disease","volume":"47","author":"Pedersen","year":"2017","journal-title":"Eur. J. Clin. Investig."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/bs.pmbts.2015.08.001","article-title":"Exercise and the regulation of immune functions","volume":"135","author":"Simpson","year":"2015","journal-title":"Prog. Mol. Biol. Transl. Sci."},{"key":"ref_63","first-page":"58","article-title":"Metabolic signals and innate immune activation in obesity and exercise","volume":"21","author":"Ringseis","year":"2015","journal-title":"Exerc. Immunol. Rev."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Mateus, F.G., Moreira, S., Martins, A.D., Oliveira, P.F., Alves, M.G., and de Lourdes Pereira, M. (2023). L-Carnitine and Male Fertility: Is Supplementation Beneficial?. J. Clin. Med., 12.","DOI":"10.3390\/jcm12185796"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1152\/japplphysiol.00599.2016","article-title":"Recovery responses of testosterone, growth hormone, and IGF-1 after resistance exercise","volume":"3","author":"Kraemer","year":"2017","journal-title":"J. Appl. Physiol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.physbeh.2004.02.007","article-title":"Energy balance and reproduction","volume":"2","author":"Schneider","year":"2004","journal-title":"Physiol. Behav."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1152\/japplphysiol.91235.2008","article-title":"Effect of resistance exercise on muscle steroidogenesis","volume":"105","author":"Vingren","year":"2008","journal-title":"J. Appl. Physiol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1016\/S0015-0282(16)48622-X","article-title":"Anthropomorphic, hormonal, and psychologic correlates of semen quality in endurance-trained male athletes","volume":"43","author":"Ayers","year":"1985","journal-title":"Fertil. Steril."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"2627","DOI":"10.1152\/jappl.1996.81.6.2627","article-title":"Reproductive function in male endurance athletes: Sperm analysis and hormonal profile","volume":"81","author":"Chicharro","year":"1996","journal-title":"J. Appl. Physiol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1055\/s-2007-1021075","article-title":"Gonadal hormones and semen quality in male runners","volume":"15","author":"Arce","year":"1994","journal-title":"Int. J. Sports Med."},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Molsted, S., Andersen, J.L., Eidemak, I., Harrison, A.P., and J\u00f8rgensen, N. (2014). Resistance training and testosterone levels in male patients with chronic kidney disease undergoing dialysis. Biomed. Res. Int., 2014.","DOI":"10.1155\/2014\/121273"},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Wu, S., Chen, W., Cai, Y., and Xia, W. (2024). Dose-response association between 24-hour total movement activity and testosterone deficiency in adult males. Front. Endocrinol., 14.","DOI":"10.3389\/fendo.2023.1280841"},{"key":"ref_73","first-page":"259","article-title":"The effects of intensive, long-term treadmill running on reproductive hormones, hypothalamus-pituitary-testis axis, and semen quality: A randomized controlled study","volume":"3","author":"Safarinejad","year":"2009","journal-title":"J. Endocrinol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1111\/j.1365-2265.1990.tb00486.x","article-title":"Gonadotrophin-releasing hormone and human chorionic gonadotrophin tests reveal that both hypothalamic and testicular endocrine functions are suppressed during acute prolonged physical exercise","volume":"33","author":"Kujala","year":"1990","journal-title":"Clin. Endocrinol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1249\/MSS.0b013e31828d3767","article-title":"Postresistance exercise ethanol ingestion and acute testosterone bioavailability","volume":"45","author":"Vingren","year":"2013","journal-title":"Med. Sci. Sports Exerc."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1007\/s12011-010-8676-3","article-title":"Effects of magnesium supplementation on testosterone levels of athletes and sedentary subjects at rest and after exhaustion","volume":"140","author":"Cinar","year":"2011","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1519\/JSC.0000000000003349","article-title":"Effects of Training With Free Weights Versus Machines on Muscle Mass, Strength, Free Testosterone, and Free Cortisol Levels","volume":"34","author":"Schwanbeck","year":"2020","journal-title":"J. Strength. Cond. Res."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1249\/MSS.0000000000002175","article-title":"Accelerometer-measured Physical Activity, Reproductive Hormones, and DNA Methylation","volume":"52","author":"Wu","year":"2020","journal-title":"Med. Sci. Sports Exerc."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1111\/andr.12169","article-title":"Cross-sectional association between physical activity and serum testosterone levels in US men: Results from NHANES 1999\u20132004","volume":"4","author":"Steeves","year":"2016","journal-title":"Andrology"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1159\/000445154","article-title":"Training, and the Hypothalamic-Pituitary-Gonadal Axis in Men and Women","volume":"47","author":"Sokoloff","year":"2016","journal-title":"Front. Horm. Res."},{"key":"ref_81","first-page":"357","article-title":"The effect of endurance training on reproductive function in male runners. A \u2018volume threshold\u2019 hypothesis","volume":"6","author":"Miller","year":"1997","journal-title":"Sports Med."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1007\/s10552-021-01466-6","article-title":"Physical activity in relation to circulating hormone concentrations in 117,100 men in UK Biobank","volume":"32","author":"Watts","year":"2021","journal-title":"Cancer Causes Control"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00421-018-3989-6","article-title":"Exploring the effect of exercise training on testicular function","volume":"119","author":"Matos","year":"2019","journal-title":"Eur. J. Appl. Physiol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"e13457","DOI":"10.1111\/and.13457","article-title":"Moderate-intensity exercise training ameliorates the diabetes-suppressed spermatogenesis and improves sperm parameters: Insole and simultaneous with insulin","volume":"51","author":"Samadian","year":"2019","journal-title":"Andrologia"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"2957","DOI":"10.1007\/s43032-024-01676-8","article-title":"Meta-Analytical and Meta-Regression Evaluation of Subclinical Hyperthyroidism\u2019s Effect on Male Reproductive Health: Hormonal and Seminal Perspectives","volume":"31","author":"Bahreiny","year":"2024","journal-title":"Reprod. Sci."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1159\/000512790","article-title":"European thyroid association guideline on thyroid disorders prior to and during assisted reproduction","volume":"9","author":"Poppe","year":"2021","journal-title":"Eur. Thyroid. J."},{"key":"ref_87","doi-asserted-by":"crossref","unstructured":"Wu, K., Zhou, Y., Ke, S., Huang, J., Gao, X., Li, B., Lin, X., Liu, X., Liu, X., and Ma, L. (2021). Lifestyle is associated with thyroid function in subclinical hypothyroidism: A cross-sectional study. BMC Endocr. Disord., 21.","DOI":"10.1186\/s12902-021-00772-z"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1159\/000181828","article-title":"Reproductive endocrine functions in men with primary hypothyroidism: Effect of thyroxine replacement","volume":"34","author":"Kumar","year":"1990","journal-title":"Horm. Res."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"6472","DOI":"10.1210\/jc.2005-1135","article-title":"Multicenter study on the prevalence of sexual symptoms in male hypo- and hyperthyroid patients","volume":"90","author":"Carani","year":"2005","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_90","doi-asserted-by":"crossref","unstructured":"Phillips, K.J. (2019). Beige Fat, Adaptive Thermogenesis, and Its Regulation by Exercise and Thyroid Hormone. Biology, 3.","DOI":"10.3390\/biology8030057"},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Fiore, M., Cristaldi, A., Okatyeva, V., Bianco, S.L., Conti, G.O., Zuccarello, P., Copat, C., Caltabiano, R., Cannizzaro, M., and Ferrante, M. (2019). Physical Activity and Thyroid Cancer Risk: A Case-Control Study in Catania (South Italy). Int. J. Environ. Res. Public. Health, 16.","DOI":"10.3390\/ijerph16081428"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.pcad.2022.11.004","article-title":"The associations between exercise and lipid biomarkers","volume":"75","author":"Sulague","year":"2022","journal-title":"Prog. Cardiovasc. Dis."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/S0090-4295(00)00614-2","article-title":"Modifiable risk factors and erectile dysfunction: Can lifestyle changes modify risk?","volume":"56","author":"Derby","year":"2000","journal-title":"Urology"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"e13264","DOI":"10.1111\/and.13264","article-title":"Erectile dysfunction, physical activity and physical exercise: Recommendations for clinical practice","volume":"51","author":"Duca","year":"2019","journal-title":"Andrologia"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1007\/s40618-017-0652-8","article-title":"Sport and male sexuality","volume":"40","year":"2017","journal-title":"J. Endocrinol. Investig."},{"key":"ref_96","first-page":"150","article-title":"The effect of physical activity on fertility: A mini-review","volume":"4","author":"Mussawar","year":"2023","journal-title":"F S Rep."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"e13325","DOI":"10.1111\/obr.13325","article-title":"The effectiveness of weight-loss lifestyle interventions for improving fertility in women and men with overweight or obesity and infertility: A systematic review update of evidence from randomized controlled trials","volume":"22","author":"Hunter","year":"2021","journal-title":"Obes. Rev."},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Za\u0144ko, A., Martynowicz, I., Citko, A., Konopka, P., Paszko, A., Paw\u0142owski, M., Szczerbi\u0144ski, \u0141., Siewko, K., Kr\u0119towski, A.J., and Kuczy\u0144ski, W. (2024). The Influence of Lifestyle on Male Fertility in the Context of Insulin Resistance-Identification of Factors That Influence Semen Quality. J. Clin. Med., 13.","DOI":"10.3390\/jcm13102797"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1055\/s-0043-117497","article-title":"Vigorous Physical Activity is Associated with Regular Aerobic Exercise-Induced Increased Serum Testosterone Levels in Overweight\/Obese Men","volume":"50","author":"Kumagai","year":"2018","journal-title":"Horm. Metab. Res."},{"key":"ref_100","doi-asserted-by":"crossref","unstructured":"La Vignera, S., Condorelli, R.A., Cannarella, R., Duca, Y., and Calogero, A.E. (2019). Sport, doping and female fertility. Reprod. Biol. Endocrinol., 16.","DOI":"10.1186\/s12958-018-0437-8"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1007\/s12020-012-9655-6","article-title":"Andrological aspects of physical exercise and sport medicine","volume":"42","author":"Romanelli","year":"2012","journal-title":"Endocrine"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"265","DOI":"10.3109\/13685538.2010.544344","article-title":"Aerobic physical activity improves endothelial function in the middle-aged patients with erectile dysfunction","volume":"14","author":"Candorelli","year":"2011","journal-title":"Aging Male"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"154","DOI":"10.2164\/jandrol.111.013649","article-title":"Physical activity and erectile dysfunction in middle-aged men","volume":"33","author":"Condorelli","year":"2012","journal-title":"J. Androl."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.1111\/andr.12849","article-title":"The association between guideline-based exercise thresholds and low testosterone among men in the United States","volume":"8","author":"Fantus","year":"2020","journal-title":"Andrology"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/S0015-0282(16)59959-2","article-title":"Effect of age on the composition of seminiferous tubular boundary tissue and on the volume of each component in humans","volume":"6","author":"Johnson","year":"1988","journal-title":"Fertil. Steril."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1177\/1557988312440718","article-title":"The Effect of Paternal Age on Fetal Birth Outcomes","volume":"5","author":"Alio","year":"2012","journal-title":"Am. J. Men\u2019s Health"},{"key":"ref_107","first-page":"648","article-title":"Paternal age and the occurrence of birth defects","volume":"39","author":"Lian","year":"1986","journal-title":"Am. J. Hum. Genet."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1210\/jcem-59-4-756","article-title":"Leydig cell numbers, daily sperm production, and serum gonadotropin levels in aging men","volume":"59","author":"Neaves","year":"1984","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"162","DOI":"10.2337\/dbi23-0004","article-title":"Molecular Insights From Multiomics Studies of Physical Activity","volume":"73","author":"Wei","year":"2024","journal-title":"Diabetes"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.mce.2005.12.026","article-title":"Oxidative stress, sperm survival and fertility control","volume":"250","author":"Aitken","year":"2006","journal-title":"Mol. Cell Endocrinol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"1884","DOI":"10.1016\/j.fertnstert.2008.12.065","article-title":"Effect of high environmental temperature on semen parameters among fertile men","volume":"93","author":"Momen","year":"2010","journal-title":"Fertil. Steril."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.cell.2015.12.020","article-title":"Electron Transport Chain Remodeling by GSK3 during Oogenesis Connects Nutrient State to Reproduction","volume":"164","author":"Sieber","year":"2016","journal-title":"Cell"},{"key":"ref_113","first-page":"750","article-title":"Effects of prolonged autovehicle driving on male reproduction function: A study among taxi drivers","volume":"6","author":"Cini","year":"1996","journal-title":"Am. J. Ind. Med."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1093\/humrep\/det020","article-title":"Seminal and molecular evidence that sauna exposure affects human spermatogenesis","volume":"28","author":"Garolla","year":"2013","journal-title":"Hum. Reprod."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1016\/j.fertnstert.2013.05.046","article-title":"Age thresholds for changes in semen parameters in men","volume":"100","author":"Stone","year":"2013","journal-title":"Fertil. Steril."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S0015-0282(00)01679-4","article-title":"Effects of male age on semen quality and fertility: A review of the literature","volume":"75","author":"Kidd","year":"2001","journal-title":"Fertil. Steril."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1002\/j.1939-4640.1985.tb00830.x","article-title":"Testicular size: The effects of aging, malnutrition, and illness","volume":"6","author":"Handelsman","year":"1985","journal-title":"J. Androl."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1016\/j.mayocp.2016.04.022","article-title":"Adult-Onset Hypogonadism","volume":"91","author":"Khera","year":"2016","journal-title":"Mayo Clin. Proc."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1007\/s10815-011-9537-5","article-title":"The effects of male aging on semen quality, sperm DNA fragmentation and chromosomal abnormalities in an infertile population","volume":"28","author":"Brahem","year":"2011","journal-title":"J. Assist. Reprod. Genet."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/j.exger.2013.05.063","article-title":"Effects of moderate exercise over different phases on age-related physiological dysfunction in testes of SAMP8 mice","volume":"48","author":"Zhao","year":"2013","journal-title":"Exp. Gerontol."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1677\/JOE-08-0306","article-title":"Lifelong running reduces oxidative stress and degenerative changes in the testes of mice","volume":"199","author":"Chigurupati","year":"2008","journal-title":"J. Endocrinol."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1055\/s-2007-1021240","article-title":"Acute hormonal responses in elite junior weightlifters","volume":"13","author":"Kraemer","year":"1992","journal-title":"Int. J. Sports Med."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1093\/gerona\/55.2.B95","article-title":"Basal concentrations and acute responses of serum hormones andstrength development during heavy resistance training in middle-aged andelderly men and women","volume":"55","author":"Hakkinen","year":"2000","journal-title":"J. Gerontol. Ser. A"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.fertnstert.2011.03.111","article-title":"Physical exercise at high altitude is associated with a testicular dysfunction leading to reduced sperm concentration but healthy sperm quality","volume":"96","author":"Pelliccione","year":"2011","journal-title":"Fertil. Steril."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1046\/j.1365-2605.2000.00216.x","article-title":"Impact of a deep saturation dive on semen quality","volume":"23","author":"Aitken","year":"2000","journal-title":"Int. J. Androl."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.anireprosci.2011.02.010","article-title":"Effects of racing on equine fertility","volume":"124","author":"Sairanen","year":"2011","journal-title":"Anim. Reprod. Sci."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.eururo.2004.10.024","article-title":"The vicious cycling: Bicycling related urogenital disorders","volume":"47","author":"Leibovitch","year":"2005","journal-title":"Eur. Urol."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1111\/j.1365-2605.1995.tb00400.x","article-title":"Tight underpants and trousers and risk of dyspermia","volume":"18","author":"Parazzini","year":"1995","journal-title":"Int. J. Androl."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/10\/3442\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T17:32:50Z","timestamp":1760031170000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/10\/3442"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,14]]},"references-count":128,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2025,5]]}},"alternative-id":["jcm14103442"],"URL":"https:\/\/doi.org\/10.3390\/jcm14103442","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,14]]}}}