{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:07:39Z","timestamp":1792789659025,"version":"4.5.0"},"reference-count":32,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T00:00:00Z","timestamp":1747267200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Quidel Germany GmBH"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background\/Objective: The measurement of troponin is recommended for acute myocardial infarction (AMI) diagnosis. Yet, hs-cardiac troponin T (hs-cTnT) can be elevated due to non-cardiac conditions, such as skeletal muscle injury, chronic kidney disease (CKD) or pulmonary embolism. The aim of our study was to compare the diagnostic accuracy of a bedside rapid hs-cardiac troponin I (hs-cTnI) assay (Quidel TriageTrue\u00ae) with hs-cTnT measured in a routine laboratory (Roche Elecsys). Methods: This prospective monocentric study was conducted in an acute cardiac outpatient unit at a tertiary hospital. Hs-cTnI was measured via a point-of-care test from whole blood, while hs-cTnT was measured from plasma through the routine laboratory facility. Results: In 129 patients (65.1% male, 61.8 \u00b1 15.6 years) with acute chest pain, results for hs-cTnI were available 14 \u00b1 11 min after the first clinical presentation, which was 74 \u00b1 54 min earlier than for hs-cTnT. Coronary angiography confirmed AMI in 17 patients (13.28%). The relative risk of AMI patients with elevated hs-cTnI results was 6.59 compared to 2.29 for hs-cTnT. Hs-cTnI exhibited an equivalent negative predictive value to hs-cTnT (99%) for AMI but had a comparatively higher positive predictive value (50.0 vs. 25.8%). In 39 patients with at least CKD stage 3a, median hs-cTnT was pathological (27.0 ng\/L), in contrast with hs-cTnI (11.2 ng\/L). Further, hs-cTnI was less likely elevated in patients with CKD and no AMI. Conclusions: The diagnostic value of hs-cTnI was comparable to that of hs-cTnT, and the blood sampling-to-result time was shorter than routine hs-cTnT.<\/jats:p>","DOI":"10.3390\/jcm14103456","type":"journal-article","created":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T06:59:16Z","timestamp":1747292356000},"page":"3456","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A High-Sensitivity Troponin I Rapid Assay vs. a High-Sensitivity Troponin T Routine Assay in Acute Chest Pain Patients: A Prospective Monocentric Study"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3064-1277","authenticated-orcid":false,"given":"Emilie","family":"Han","sequence":"first","affiliation":[{"name":"Department of Cardiology, University Clinic of Internal Medicine 2, Medical University of Vienna, W\u00e4hringer G\u00fcrtel 18\u201320, 1090 Vienna, Austria"},{"name":"Department of Transfusion Medicine and Cell Therapy, Medical University of Vienna, W\u00e4hringer G\u00fcrtel 18\u201320, 1090 Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7083-2107","authenticated-orcid":false,"given":"Mariann","family":"Gy\u00f6ngy\u00f6si","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Clinic of Internal Medicine 2, Medical University of Vienna, W\u00e4hringer G\u00fcrtel 18\u201320, 1090 Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9492-6688","authenticated-orcid":false,"given":"Elaaha","family":"Anwari","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Clinic of Internal Medicine 2, Medical University of Vienna, W\u00e4hringer G\u00fcrtel 18\u201320, 1090 Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-4859-8988","authenticated-orcid":false,"given":"Vian","family":"Kokabi","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Clinic of Internal Medicine 2, Medical University of Vienna, W\u00e4hringer G\u00fcrtel 18\u201320, 1090 Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Gramser","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Clinic of Internal Medicine 2, Medical University of Vienna, W\u00e4hringer G\u00fcrtel 18\u201320, 1090 Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9819-0361","authenticated-orcid":false,"given":"Andreas","family":"Spannbauer","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Clinic of Internal Medicine 2, Medical University of Vienna, W\u00e4hringer G\u00fcrtel 18\u201320, 1090 Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Fritzer-Szekeres","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Medical University of Vienna, W\u00e4hringer G\u00fcrtel 18\u201320, 1090 Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2591-1380","authenticated-orcid":false,"given":"Jutta","family":"Bergler-Klein","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Clinic of Internal Medicine 2, Medical University of Vienna, W\u00e4hringer G\u00fcrtel 18\u201320, 1090 Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,5,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.pcad.2004.07.003","article-title":"Biology of the Troponin Complex in Cardiac Myocytes","volume":"47","author":"Parmacek","year":"2004","journal-title":"Prog. 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