{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T15:07:31Z","timestamp":1782832051822,"version":"3.54.5"},"reference-count":22,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T00:00:00Z","timestamp":1747612800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: To compare the efficacy and safety of the XEN\u00ae 63 \u00b5m and 45 \u00b5m devices with the ab externo open conjunctiva with a 30G needle approach. Methods: A retrospective, non-randomized and single-center study was conducted. Consecutive eyes undergoing a XEN\u00ae 63 \u00b5m implant were compared with a matched cohort of cases with a XEN\u00ae 45 \u00b5m implant. Standalone and combined procedures with phacoemulsification were included. Results: A total of 28 XEN\u00ae 45 \u00b5m and 28 XEN\u00ae 63 \u00b5m were included. Complete surgical success was achieved in 17 cases (60.7%) in the 45 \u00b5m group and in 20 cases (71.4%) in the 63 \u00b5m group, with no statistical differences. One year after the surgery, the mean IOP was 13.8 \u00b1 3.3 mmHg for the 45 \u00b5m group and 12.4 \u00b1 4.2 mmHg for the 63 \u00b5m group (p-value &gt; 0.05). Likewise, the use of glaucoma medication was lowered in the 63 \u00b5m device (0.32 \u00b1 0.87) compared to the 45 \u00b5m device (0.39 \u00b1 0.86), with no statistical significance. Postoperative hypotony was more frequent in the 63 \u00b5m device (39.3%) than in the 45 \u00b5m group (28.6%), with no statistical differences. However, hypotony-associated complications (including choroidal detachment, hypotony keratopathy, and hypotony maculopathy) were significantly higher in the 63 \u00b5m group (p = 0.011). Conclusions: Although the XEN\u00ae 63 \u00b5m may offer a greater IOP-lowering effect with better complete surgical success, no significant differences were detected compared to the 45 \u00b5m device. Hypotony-related complications were higher in the XEN 63 \u00b5m, although most of them resolved with conservative management.<\/jats:p>","DOI":"10.3390\/jcm14103545","type":"journal-article","created":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T06:31:29Z","timestamp":1747636289000},"page":"3545","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Efficacy and Safety of Open-Conjunctiva Ab Externo 63 \u00b5m vs. 45 \u00b5m XEN\u00ae Gel Stent in Glaucoma Surgery: One-Year Follow-Up"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7161-8372","authenticated-orcid":false,"given":"Yann","family":"Bertolani","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Vall d\u2019Hebron University Hospital, 08035 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaume","family":"Rigo-Quera","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Vall d\u2019Hebron University Hospital, 08035 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"S\u00e1nchez-Vela","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Vall d\u2019Hebron University Hospital, 08035 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia","family":"Pujol-Carreras","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Vall d\u2019Hebron University Hospital, 08035 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Amilburu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Vall d\u2019Hebron University Hospital, 08035 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Dou","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Vall d\u2019Hebron University Hospital, 08035 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6832-4496","authenticated-orcid":false,"given":"Marta","family":"Castany","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Vall d\u2019Hebron University Hospital, 08035 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,5,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1136\/bjophthalmol-2021-egsguidelines","article-title":"European Glaucoma Society Terminology and Guidelines for Glaucoma, 5th Edition","volume":"105","author":"Spaeth","year":"2021","journal-title":"Br. 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