{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:18:03Z","timestamp":1760059083112,"version":"build-2065373602"},"reference-count":12,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T00:00:00Z","timestamp":1747612800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Pfizer"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background\/Objectives: A 43-year-old male presented with neurological symptoms and asymptomatic cardiac dysfunction, left ventricular hypertrophy, and impaired global longitudinal strain with apical sparing, associated with elevated NT-proBNP. Methods: Multimodality imaging (bone scintigraphy and cardiac magnetic resonance) revealed cardiac amyloid deposition. Genetic testing confirmed variant transthyretin amyloidosis (ATTR) with mixed phenotype. Results: Treatment with tafamidis 20 mg for stage I polyneuropathy, available at that moment, was initiated with good neurological outcome. Three years later, cardiac function deteriorated, following a moderate COVID-19 infection, with heart failure symptoms and reduced ventricular and atrial functions. For progressive ATTR cardiomyopathy, we intensified therapy to tafamidis free acid 61 mg, associated with SGLT2 inhibitor, spironolactone, and furosemide with subsequent improvements of symptoms and stabilization of imaging findings. Conclusions: This case emphasizes the importance of multimodal imaging in early detection, monitoring, and guiding individualized management in ATTR cardiomyopathy.<\/jats:p>","DOI":"10.3390\/jcm14103547","type":"journal-article","created":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T06:31:29Z","timestamp":1747636289000},"page":"3547","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Multimodality Imaging Leading the Way to a Prompt Diagnosis and Management of Transthyretin Amyloidosis"],"prefix":"10.3390","volume":"14","author":[{"given":"Anca","family":"B\u0103lini\u0219teanu","sequence":"first","affiliation":[{"name":"Cardiology Department, University Emergency Hospital, 050098 Bucharest, Romania"},{"name":"Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roxana Cristina","family":"Rimba\u0219","sequence":"additional","affiliation":[{"name":"Cardiology Department, University Emergency Hospital, 050098 Bucharest, Romania"},{"name":"Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alina Ioana","family":"Nicula","sequence":"additional","affiliation":[{"name":"Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania"},{"name":"Radiology Department, University Emergency Hospital, 050098 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana","family":"Piroiu","sequence":"additional","affiliation":[{"name":"Radiology Department, University Emergency Hospital, 050098 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3784-7355","authenticated-orcid":false,"given":"Adrian","family":"Dumitru","sequence":"additional","affiliation":[{"name":"Anatomo-Pathology Department, University Emergency Hospital, 050098 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amalia","family":"Ene","sequence":"additional","affiliation":[{"name":"Neurology Department, University Emergency Hospital, 050098 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Drago\u0219","family":"Vinereanu","sequence":"additional","affiliation":[{"name":"Cardiology Department, University Emergency Hospital, 050098 Bucharest, Romania"},{"name":"Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,5,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1056\/NEJMoa1805689","article-title":"Tafamidis treatment for patients with transthyretin amyloid cardiomyopathy","volume":"379","author":"Maurer","year":"2018","journal-title":"N. Eng. J. Med."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Rimbas, R.C., Balinisteanu, A., Magda, S.L., Visoiu, S.I., Beganu, E., Nicula, A.I., and Vinereanu, D. (2022). New advanced imaging parameters and biomarkers\u2014A step forward in the diagnosis and prognosis of TTR cardiomyopathy. J. Clin. Med., 11.","DOI":"10.3390\/jcm11092360"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Licordari, R., Trimarchi, G., Teresi LRestelli, D., Lofrumento, F., Perna, A., Campisi, M., de Gregorio, C., Grimaldi, P., Calabr\u00f2, D., and Costa, F. (2023). Cardiac Magnetic Resonance in HCM Phenocopies: From Diagnosis to Risk Stratification and Therapeutic Management. J. Clin. Med., 12.","DOI":"10.3390\/jcm12103481"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.amjcard.2023.09.055","article-title":"Myocardial Work Appraisal in Transthyretin Cardiac Amyloidosis and Nonobstructive Hypertrophic Cardiomyopathy","volume":"208","author":"Trimarchi","year":"2023","journal-title":"Am. J. Cardiol."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Pugliatti, P., Trimarchi, G., Barocelli, F., Pizzino, F., Di Spigno, F., Tedeschi, A., Piccione, M.C., Irrera, P., Aschieri, D., and Niccoli, G. (2024). Advancing Cardiac Amyloidosis Care Through Insights from Cardiopulmonary Exercise Testing. J. Clin. Med., 13.","DOI":"10.3390\/jcm13237285"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10741-020-10008-2","article-title":"Heart failure and COVID-19","volume":"26","author":"Bader","year":"2021","journal-title":"Heart Fail Rev."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1007\/s00277-022-04964-y","article-title":"Amyloidosis and COVID-19 experience from an amyloid program in Canada","volume":"101","author":"Lewis","year":"2022","journal-title":"Ann. Hematol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.medcli.2023.06.025","article-title":"Impact of SARS-CoV-2 infection in patients with cardiac amyloidosis: Results of a multicentre registry","volume":"161","author":"Lalario","year":"2023","journal-title":"Med. Clin."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"3599","DOI":"10.1093\/eurheartj\/ehab368","article-title":"2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure","volume":"42","author":"McDonagh","year":"2021","journal-title":"Eur. Heart J."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1002\/ejhf.2027","article-title":"Efficacy and safety of tafamidis doses in the tafamidis in transthyretin cardiomyopathy clinical trial (ATTR-ACT) and long-term extension study","volume":"23","author":"Damy","year":"2021","journal-title":"Eur. J. Heart Fail."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.cjca.2019.12.034","article-title":"Canadian Cardiovascular Society\/Canadian Heart Failure Society joint position statement on the evaluation and management of patients with cardiac amyloidosis","volume":"36","author":"Fine","year":"2020","journal-title":"Can. J. Cardiol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.ijcard.2020.01.021","article-title":"Multidisciplinary evaluation and management of obstructive hypertrophic cardiomyopathy in 2020, towards the HCM heart team","volume":"304","author":"Pelliccia","year":"2020","journal-title":"Int. J. 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