{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T06:49:45Z","timestamp":1782283785480,"version":"3.54.5"},"reference-count":41,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T00:00:00Z","timestamp":1747958400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Sel Sanayi Urunleri Ticaret ve Pazarlama AS, Istanbul, Turkey"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Objectives: This study aims to evaluate the efficacy and safety of oral supplementation with hydrolyzed collagen peptides (HCP) type I and type III (CollaSel PRO\u00ae) in reducing joint pain and stiffness and improving physical function in patients with osteoarthritis (OA). Methods: In this randomized, double-blind, placebo-controlled trial (ClinicalTrials.gov Identifier: NCT05369780; approved by the Institutional Review Board), 160 adult patients with OA (mean age 52.4 \u00b1 4.3 years; 111 females, 49 males) were randomly assigned to receive either 10 g\/day of CollaSel PRO\u00ae (n = 80) or placebo (maltodextrin, n = 80) for 8 weeks. The Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) was used to evaluate knee and hip joints, and the American Orthopaedic Foot and Ankle Society Ankle-Hindfoot Scale (AOFAS-AHFS) was used for ankle joints. Assessments were conducted at baseline and at weeks 1, 4, and 8. Results: In the CollaSel PRO\u00ae group, a significant decrease in WOMAC scores (mean \u00b1 SD 50.5 \u00b1 17.0, 40.7 \u00b1 16.9 and 33.8 \u00b1 16.5 vs. 53.7 \u00b1 16.9, respectively, p &lt; 0.001 for each) and significant increase in AOFAS-AHFS scores (64.2 \u00b1 13.1, 73.6 \u00b1 12.3 and 80.8 \u00b1 9.9 vs. 61.8 \u00b1 13.9, respectively, p &lt; 0.001 for each) were noted at weeks 1, 4, and 8 compared to the baseline scores. WOMAC scores were significantly lower in comparing HCP and placebo, and AOFAS-AHFS scores were higher in the HCP group compared to the placebo group at weeks 4 and 8 (all p &lt; 0.001). Conclusions: CollaSel PRO\u00ae appears to be a safe and effective option for the symptomatic management of osteoarthritis. It significantly improved joint pain, stiffness, and physical function in multiple joints. These improvements are not only statistically significant but also clinically meaningful, supporting the need for longer-term evaluation.<\/jats:p>","DOI":"10.3390\/jcm14113655","type":"journal-article","created":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T06:16:03Z","timestamp":1747980963000},"page":"3655","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Evaluation of the Efficacy and Safety of CollaSel PRO\u00ae Type I and Type III Hydrolyzed Collagen Peptides in the Treatment of Osteoarthritis: A Double-Blind, Placebo-Controlled, Randomized Clinical Trial"],"prefix":"10.3390","volume":"14","author":[{"given":"Devrim","family":"Demir-Dora","sequence":"first","affiliation":[{"name":"Department of Medical Pharmacology, Faculty of Medicine, Akdeniz University, 07070 Antalya, Turkey"},{"name":"Department of Gene and Cell Therapy, Faculty of Medicine, Akdeniz University, 07070 Antalya, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serpil","family":"Tuna","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy and Rehabilitation, Faculty of Medicine, Akdeniz University, 07070 Antalya, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5131-960X","authenticated-orcid":false,"given":"Emel Dogan","family":"Kurtoglu","sequence":"additional","affiliation":[{"name":"Novagenix Bioanalytical Drug R&D Centre, 06750 Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Savas","family":"Gursoy","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy and Rehabilitation, Faculty of Medicine, Gaziantep University, 27310 Gaziantep, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nilufer","family":"Balci","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy and Rehabilitation, Faculty of Medicine, Akdeniz University, 07070 Antalya, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selim","family":"Tezman","sequence":"additional","affiliation":[{"name":"Sel Sanayi Urunleri Ticaret ve Pazarlama AS, 34440 Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9277-1333","authenticated-orcid":false,"given":"Aydin","family":"Erenmemisoglu","sequence":"additional","affiliation":[{"name":"Alpan Farma R&D Ltd., 38039 Kayseri, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,5,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1093\/bmb\/lds038","article-title":"Epidemiology and burden of osteoarthritis","volume":"105","author":"Litwic","year":"2013","journal-title":"Br. 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