{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:50:57Z","timestamp":1787028657647,"version":"build-2736575974"},"reference-count":29,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2025,5,25]],"date-time":"2025-05-25T00:00:00Z","timestamp":1748131200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Myopericytoma is a rare benign vascular tumour characterised by concentric spindle cell proliferation around blood vessels, often misdiagnosed due to its resemblance to other soft tissue masses. Dupuytren\u2019s disease (DD), a fibroproliferative disorder of the palmar fascia, causes progressive contractures, typically affecting the ring and little fingers. While these conditions are well-documented individually, their coexistence in the same region is rare and diagnostically challenging. Case Presentation: This report highlights a 67-year-old male with longstanding DD and a recurrent palmar mass initially attributed to fibrosis. Magnetic resonance imaging revealed hallmark vascular features suggestive of myopericytoma, confirmed by histopathological analysis showing spindle cell proliferation and immunohistochemical positivity for alpha-smooth muscle actin and h-caldesmon. Concurrent DD, characterised by fibrosis and activated myofibroblasts, further complicated the clinical picture. Methodology: PubMed, Scopus, Web of Science, and Embase databases were searched from January 1901 to December 2024, and 20 studies were found, reporting 41 cases of myopericytoma in hand and upper extremity. Histopathological analysis consistently showed spindle cell proliferation and smooth muscle actin positivity. Coexistence with DD was rare, highlighting the need for detailed imaging and histological evaluation for accurate diagnosis. Conclusions: This case emphasises the complexity of differentiating overlapping pathologies. Surgical excision of myopericytoma and tailored DD management yielded favourable outcomes. Further research into shared fibroinflammatory pathways, including tumour necrosis factor-alpha and interleukin-6, may enhance diagnostic accuracy and treatment strategies for overlapping conditions.<\/jats:p>","DOI":"10.3390\/jcm14113703","type":"journal-article","created":{"date-parts":[[2025,5,25]],"date-time":"2025-05-25T20:26:50Z","timestamp":1748204810000},"page":"3703","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Myopericytoma Masquerading as Dupuytren\u2019s Disease: A Case Report and Systematic Literature Review"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8621-8216","authenticated-orcid":false,"given":"Gianluca","family":"Marcaccini","sequence":"first","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, University of Siena, 53100 Siena, Italy"},{"name":"Faculty of Medicine and Surgery, Peninsula Clinical School, Monash University, Clayton, VIC 3199, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5444-8925","authenticated-orcid":false,"given":"Ishith","family":"Seth","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Surgery, Peninsula Clinical School, Monash University, Clayton, VIC 3199, Australia"},{"name":"Department of Plastic and Reconstructive Surgery, Peninsula Health, Frankston, Melbourne, VIC 3199, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-3919-904X","authenticated-orcid":false,"given":"Jennifer","family":"Novo","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Surgery, Notre Dame University, Notre Dame, NSW 2002, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus","family":"Bautista","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Peninsula Health, Frankston, Melbourne, VIC 3199, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lakal","family":"Ruhunage","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Peninsula Health, Frankston, Melbourne, VIC 3199, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8746-4259","authenticated-orcid":false,"given":"Saiuj","family":"Bhat","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Royal Perth Hospital, Perth, WA 6000, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8396-095X","authenticated-orcid":false,"given":"Roberto","family":"Cuomo","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, University of Siena, 53100 Siena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4092-182X","authenticated-orcid":false,"given":"Warren M.","family":"Rozen","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Peninsula Health, Frankston, Melbourne, VIC 3199, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,5,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1097\/00000478-199805000-00001","article-title":"Myofibromatosis in adults, glomangiopericytoma, and myopericytoma: A spectrum of tumors showing perivascular myoid differentiation","volume":"22","author":"Granter","year":"1998","journal-title":"Am. 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